XF Publications Alert - May 2020

The Publications Alert gathers and compiles a list of all the most recent peer-reviewed publications containing Seahorse XF and Soluble Sensor data, based solely on user-generated content.

Aging Research

Developmental ROS individualizes organismal stress resistance and lifespan
Bazopoulou, D., Knoefler, D., Zheng, Y., Ulrich, K., Oleson, B. J., Xie, L., Kim, M., Kaufmann, A., Lee, Y. T., Dou, Y., Chen, Y., Quan, S. and Jakob, U.
Nature. 2019 Dec, 576(7786):301-305.

Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions
Gong, J., Cai, H., Team, N. G. S. C. A., Noggle, S., Paull, D., Rizzolo, L. J., Del Priore, L. V. and Fields, M. A.
Stem Cells Transl Med. 2020 Mar, 9(3):364-376.

Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span
Laitakari, A., Huttunen, R., Kuvaja, P., Hannuksela, P., Szabo, Z., Heikkila, M., Kerkela, R., Myllyharju, J., Dimova, E. Y., Serpi, R. and Koivunen, P.
FASEB J. 2020 Apr, 34(4):5590-5609.

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo
Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. and McGee-Lawrence, M. E.
Exp Gerontol. 2020 Feb, 130:110818.

Cancer Research

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells
Alshangiti, A. M., Tuboly, E., Hegarty, S. V., McCarthy, C. M., Sullivan, A. M. and O'Keeffe, G. W.
Oxid Med Cell Longev. 2019 Dec 5, 2019:1670759.

KRAS4A directly regulates hexokinase 1
Amendola, C. R., Mahaffey, J. P., Parker, S. J., Ahearn, I. M., Chen, W. C., Zhou, M., Court, H., Shi, J., Mendoza, S. L., Morten, M. J., Rothenberg, E., Gottlieb, E., Wadghiri, Y. Z., Possemato, R., Hubbard, S. R., Balmain, A., Kimmelman, A. C. and Philips, M. R.
Nature. 2019 Dec, 576(7787):482-486.

Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect
Cheng, A., Zhang, P., Wang, B., Yang, D., Duan, X., Jiang, Y., Xu, T., Jiang, Y., Shi, J., Ding, C., Wu, G., Sang, Z., Wu, Q., Wang, H., Wu, M., Zhang, Z., Pan, X., Pan, Y. Y., Gao, P., Zhang, H., Zhou, C. Z., Guo, J. and Yang, Z.
Nat Commun. 2019 Dec 5, 10(1):5566.

SerpinB3 Differently Up-Regulates Hypoxia Inducible Factors -1alpha and -2alpha in Hepatocellular Carcinoma: Mechanisms Revealing Novel Potential Therapeutic Targets
Cannito, S., Foglia, B., Villano, G., Turato, C., Delgado, T. C., Morello, E., Pin, F., Novo, E., Napione, L., Quarta, S., Ruvoletto, M., Fasolato, S., Zanus, G., Colombatto, S., Lopitz-Otsoa, F., Fernandez-Ramos, D., Bussolino, F., Sutti, S., Albano, E., Martinez-Chantar, M. L., Pontisso, P. and Parola, M.
Cancers (Basel). 2019 Dec 4, 11(12).

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment
Halaby, M. J., Hezaveh, K., Lamorte, S., Ciudad, M. T., Kloetgen, A., MacLeod, B. L., Guo, M., Chakravarthy, A., Medina, T. D. S., Ugel, S., Tsirigos, A., Bronte, V., Munn, D. H., Pugh, T. J., De Carvalho, D. D., Butler, M. O., Ohashi, P. S., Brooks, D. G. and McGaha, T. L.
Sci Immunol. 2019 Dec 13, 4(42).

Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer
Deng, X., Wang, Q., Cheng, M., Chen, Y., Yan, X., Guo, R., Sun, L., Li, Y. and Liu, Y.
J Cancer. 2020 Jan 1, 11(4):962-973.

Cancerrelated fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction
Feng, L. R., Wolff, B. S., Liwang, J., Regan, J. M., Alshawi, S., Raheem, S. and Saligan, L. N.
Int J Mol Med. 2020 Feb, 45(2):485-496.


Mesothelial Cell HIF1alpha Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk
Hart, P. C., Kenny, H. A., Grassl, N., Watters, K. M., Litchfield, L. M., Coscia, F., Blazenovic, I., Ploetzky, L., Fiehn, O., Mann, M., Lengyel, E. and Romero, I. L.
Cell Rep. 2019 Dec 17, 29(12):4086-4098 e6.

CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies
Feng, W. W., Wilkins, O., Bang, S., Ung, M., Li, J., An, J., Del Genio, C., Canfield, K., DiRenzo, J., Wells, W., Gaur, A., Robey, R. B., Guo, J. Y., Powles, R. L., Sotiriou, C., Pusztai, L., Febbraio, M., Cheng, C., Kinlaw, W. B. and Kurokawa, M.
Cell Rep. 2019 Dec 10, 29(11):3405-3420 e5.

Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells
Gonzalez-Llorente, L., Santacatterina, F., Garcia-Aguilar, A., Nuevo-Tapioles, C., Gonzalez-Garcia, S., Tirpakova, Z., Toribio, M. L. and Cuezva, J. M.
Cancers (Basel). 2019 Dec 19, 12(1).

p53 regulates mitochondrial dynamics by inhibiting Drp1 translocation into mitochondria during cellular senescence
Kim, Y. Y., Um, J. H., Yoon, J. H., Lee, D. Y., Lee, Y. J., Kim, D. H., Park, J. I. and Yun, J.
FASEB J. 2020 Feb, 34(2):2451-2464.

CircMYC Regulates Glycolysis and Cell Proliferation in Melanoma
Jin, C., Dong, D., Yang, Z., Xia, R., Tao, S. and Piao, M.
Cell Biochem Biophys. 2020 Mar, 78(1):77-88.

Androgen-induced expression of DRP1 regulates mitochondrial metabolic reprogramming in prostate cancer
Lee, Y. G., Nam, Y., Shin, K. J., Yoon, S., Park, W. S., Joung, J. Y., Seo, J. K., Jang, J., Lee, S., Nam, D., Caino, M. C., Suh, P. G. and Chan Chae, Y.
Cancer Lett. 2020 Feb 28, 471:72-87.

Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2)
James, A. D., Richardson, D. A., Oh, I. W., Sritangos, P., Attard, T., Barrett, L. and Bruce, J. I. E.
Br J Cancer. 2020 Jan, 122(2):266-278.

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
Khan, H., Anshu, A., Prasad, A., Roy, S., Jeffery, J., Kittipongdaja, W., Yang, D. T. and Schieke, S. M.
Cell Rep. 2019 Dec 3, 29(10):3009-3018 e4.


Transcription factor NFAT5 contributes to the glycolytic phenotype rewiring and pancreatic cancer progression via transcription of PGK1
Jiang, Y., He, R., Jiang, Y., Liu, D., Tao, L., Yang, M., Lin, C., Shen, Y., Fu, X., Yang, J., Li, J., Huo, Y., Hua, R., Liu, W., Zhang, J., Shen, B., Zhang, Z. and Sun, Y.
Cell Death Dis. 2019 Dec 11, 10(12):948.

A novel metadherinDelta7 splice variant enhances triple negative breast cancer aggressiveness by modulating mitochondrial function via NFkB-SIRT3 axis
Neeli, P. K., Gollavilli, P. N., Mallappa, S., Hari, S. G. and Kotamraju, S.
Oncogene. 2020 Mar, 39(10):2088-2102.

Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I
Madhusudhan, N., Hu, B., Mishra, P., Calva-Moreno, J. F., Patel, K., Boriack, R., Ready, J. M. and Nijhawan, D.
ACS Chem Biol. 2020 Jan 17, 15(1):158-170.

Oncogenic K-ras Induces Mitochondrial OPA3 Expression to Promote Energy Metabolism in Pancreatic Cancer Cells
Meng, N., Glorieux, C., Zhang, Y., Liang, L., Zeng, P., Lu, W. and Huang, P.
Cancers (Basel). 2019 Dec 25, 12(1).

A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines
Martin, S. D. and McGee, S. L.
Cancer Metab. 2019 Dec 27, 7:12.

ANKRD22, a novel tumor microenvironment-induced mitochondrial protein promotes metabolic reprogramming of colorectal cancer cells
Pan, T., Liu, J., Xu, S., Yu, Q., Wang, H., Sun, H., Wu, J., Zhu, Y., Zhou, J. and Zhu, Y.
Theranostics. 2020 Jan 1, 10(2):516-536.

Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain
Ripani, P., Delp, J., Bode, K., Delgado, M. E., Dietrich, L., Betzler, V. M., Yan, N., von Scheven, G., Mayer, T. U., Leist, M. and Brunner, T.
Oncogene. 2020 Mar, 39(11):2345-2357.

Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment
Nelson, G. L., Ronayne, C. T., Solano, L. N., Jonnalagadda, S. K., Jonnalagadda, S., Rumbley, J., Holy, J., Rose-Hellekant, T., Drewes, L. R. and Mereddy, V. R.
Sci Rep. 2019 Dec 4, 9(1):18266.

Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target
Pandey, R., Zhou, M., Islam, S., Chen, B., Barker, N. K., Langlais, P., Srivastava, A., Luo, M., Cooke, L. S., Weterings, E. and Mahadevan, D.
Sci Rep. 2019 Dec 4, 9(1):18347.

Inflammation Associated Pancreatic Tumorigenesis: Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth of Pancreatic Ductal Epithelial Cells
Rahn, S., Barbosa, P. D., Moller, J. L., Ammar, N., Demetrowitsch, T., Helm, O., Wesch, D., Sipos, B., Rocken, C., Schwarz, K., Schafer, H. and Sebens, S.
Cancers (Basel). 2019 Dec 21, 12(1).

Cardiovascular Research

Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides
Chen, C.-y., Li, Y., Jia, T., He, L., Hare, A. A., Silberstein, A., Gallagher, J., Martinez, T. F., Stiles, J. W., Olenyuk, B., Dervan, P. B. and Stiles, B. L.
Medicinal Chemistry Research. 2020 29(4):607-616.

LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
Carpenter, K. J., Valfort, A. C., Steinauer, N., Chatterjee, A., Abuirqeba, S., Majidi, S., Sengupta, M., Di Paolo, R. J., Shornick, L. P., Zhang, J. and Flaveny, C. A.
Sci Rep. 2019 Dec 20, 9(1):19530.

Bi-Allelic UQCRFS1 Variants Are Associated with Mitochondrial Complex III Deficiency, Cardiomyopathy, and Alopecia Totalis
Gusic, M., Schottmann, G., Feichtinger, R. G., Du, C., Scholz, C., Wagner, M., Mayr, J. A., Lee, C. Y., Yepez, V. A., Lorenz, N., Morales-Gonzalez, S., Panneman, D. M., Rotig, A., Rodenburg, R. J. T., Wortmann, S. B., Prokisch, H. and Schuelke, M.
Am J Hum Genet. 2020 Jan 2, 106(1):102-111.


Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way
Ding, M., Liu, C., Shi, R., Yu, M., Zeng, K., Kang, J., Fu, F. and Mi, M.
Acta Physiol (Oxf). 2020 May, 229(1):e13428.

Metabolic modulation regulates cardiac wall morphogenesis in zebrafish
Fukuda, R., Aharonov, A., Ong, Y. T., Stone, O. A., El-Brolosy, M., Maischein, H. M., Potente, M., Tzahor, E. and Stainier, D. Y.
Elife. 2019 Dec 23, 8.


Mitochondrial 4-HNE derived from MAO-A promotes mitoCa(2+) overload in chronic postischemic cardiac remodeling
Santin, Y., Fazal, L., Sainte-Marie, Y., Sicard, P., Maggiorani, D., Tortosa, F., Yucel, Y. Y., Teyssedre, L., Rouquette, J., Marcellin, M., Vindis, C., Shih, J. C., Lairez, O., Burlet-Schiltz, O., Parini, A., Lezoualc'h, F. and Mialet-Perez, J.
Cell Death Differ. 2019 Dec 9, [epub ahead of print]

Circadian light-mediated endothelial metabolic reprogramming
Oyama, Y., Bartman, C. M., Bonney, S., Lee, J. S., Walker, L. A., Han, J., Borchers, C. H., Buttrick, P. M., Aherne, C. M., Clendenen, N., Colgan, S. P. and Eckle, T.
bioRxiv. 2019 May 15, [epub ahead of print]

Cell Physiology Research

Blood-based bioenergetics: An emerging translational and clinical tool
Braganza, A., Annarapu, G. K. and Shiva, S.
Mol Aspects Med. 2020 Feb, 71:100835.

Comparative profiling of skeletal muscle models reveals heterogeneity of transcriptome and metabolism
Abdelmoez, A. M., Sardon Puig, L., Smith, J. A. B., Gabriel, B. M., Savikj, M., Dollet, L., Chibalin, A. V., Krook, A., Zierath, J. R. and Pillon, N. J.
Am J Physiol Cell Physiol. 2020 Mar 1, 318(3):C615-C626.

beta-guanidinopropionic acid and metformin differentially impact autophagy, mitochondria and cellular morphology in developing C2C12 muscle cells
Crocker, C. L., Baumgarner, B. L. and Kinsey, S. T.
J Muscle Res Cell Motil. 2019 Dec 13, [epub ahead of print]

Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
Fu, H., Zhou, H., Yu, X., Xu, J., Zhou, J., Meng, X., Zhao, J., Zhou, Y., Chisholm, A. D. and Xu, S.
Nat Commun. 2020 Feb 26, 11(1):1050.

Energy metabolism of the equine cumulus oocyte complex during in vitro maturation
Lewis, N., Hinrichs, K., Leese, H. J., Mc, G. A. C., Brison, D. R. and Sturmey, R.
Sci Rep. 2020 Feb 26, 10(1):3493.


Ca(2+) mobilization-dependent reduction of the endoplasmic reticulum lumen is due to influx of cytosolic glutathione
Lizak, B., Birk, J., Zana, M., Kosztyi, G., Kratschmar, D. V., Odermatt, A., Zimmermann, R., Geiszt, M., Appenzeller-Herzog, C. and Banhegyi, G.
BMC Biol. 2020 Feb 26, 18(1):19.

Kynurenine suppresses osteoblastic cell energetics in vitro and osteoblast numbers in vivo
Pierce, J. L., Roberts, R. L., Yu, K., Kendall, R. K., Kaiser, H., Davis, C., Johnson, M. H., Hill, W. D., Isales, C. M., Bollag, W. B., Hamrick, M. W. and McGee-Lawrence, M. E.
Exp Gerontol. 2020 Feb, 130:110818.


ALCAT1 Overexpression Affects Supercomplex Formation and Increases ROS in Respiring Mitochondria
Rieger, B., Krajcova, A., Duwe, P. and Busch, K. B.
Oxid Med Cell Longev. 2019 Dec 6, 2019:9186469.

Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming
Quattrocelli, M., Zelikovich, A. S., Jiang, Z., Peek, C. B., Demonbreun, A. R., Kuntz, N. L., Barish, G. D., Haldar, S. M., Bass, J. and McNally, E. M.
JCI Insight. 2019 Dec 19, 4(24).

Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
Owen, A. M., Patel, S. P., Smith, J. D., Balasuriya, B. K., Mori, S. F., Hawk, G. S., Stromberg, A. J., Kuriyama, N., Kaneki, M., Rabchevsky, A. G., Butterfield, T. A., Esser, K. A., Peterson, C. A., Starr, M. E. and Saito, H.
Elife. 2019 Dec 3, 8.

Drug Discovery

Target Discovery of Selective Non-Small-Cell Lung Cancer Toxins Reveals Inhibitors of Mitochondrial Complex I
Madhusudhan, N., Hu, B., Mishra, P., Calva-Moreno, J. F., Patel, K., Boriack, R., Ready, J. M. and Nijhawan, D.
ACS Chem Biol. 2020 Jan 17, 15(1):158-170.

Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning
Li, Y., Schwalie, P. C., Bast-Habersbrunner, A., Mocek, S., Russeil, J., Fromme, T., Deplancke, B. and Klingenspor, M.
Cell Rep. 2019 Dec 17, 29(12):4099-4113 e5.

Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain
Ripani, P., Delp, J., Bode, K., Delgado, M. E., Dietrich, L., Betzler, V. M., Yan, N., von Scheven, G., Mayer, T. U., Leist, M. and Brunner, T.
Oncogene. 2020 Mar, 39(11):2345-2357.

Apigenin Reverses Interleukin-1beta-Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes
Okla, M., Al Madani, J. O., Chung, S. and Alfayez, M.
Mol Nutr Food Res. 2020 Jan, 64(1):e1900925.

Development of Novel Silyl Cyanocinnamic Acid Derivatives as Metabolic Plasticity Inhibitors for Cancer Treatment
Nelson, G. L., Ronayne, C. T., Solano, L. N., Jonnalagadda, S. K., Jonnalagadda, S., Rumbley, J., Holy, J., Rose-Hellekant, T., Drewes, L. R. and Mereddy, V. R.
Sci Rep. 2019 Dec 4, 9(1):18266.

Food & Nutritional Research

Strawberry (Fragaria x ananassa cv. Romina) methanolic extract promotes browning in 3T3-L1 cells
Forbes-Hernandez, T. Y., Cianciosi, D., Ansary, J., Mezzetti, B., Bompadre, S., Quiles, J. L., Giampieri, F. and Battino, M.
Food Funct. 2020 Jan 29, 11(1):297-304.

High Fructose Diet Induces Sex-specific Modifications in Synaptic Respiration and Affective-like Behaviors in Rats
Kloster, A., Hyer, M. M., Dyer, S., Salome-Sanchez, C. and Neigh, G. N.
Neuroscience. 2019 Dec 24, [epub ahead of print]

Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARgamma signaling
Park, S. S., Lee, Y. J., Kang, H., Yang, G., Hong, E. J., Lim, J. Y., Oh, S. and Kim, E.
Sci Rep. 2019 Dec 27, 9(1):20152.

Hepatobiology Research

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity
Duan, L., Ramachandran, A., Akakpo, J. Y., Woolbright, B. L., Zhang, Y. and Jaeschke, H.
Toxicol Appl Pharmacol. 2020 Jan 15, 387:114849.

Decreased membrane cholesterol in liver mitochondria of the point mutation mouse model of juvenile Niemann-Pick C1, Npc1(nmf164)
Erickson, R. P., Aras, S., Purandare, N., Huttemann, M., Liu, J., Dragotto, J., Fiorenza, M. T. and Grossman, L. I.
Mitochondrion. 2020 Mar, 51:15-21.

Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARgamma expression
Li, L., Fu, J., Liu, D., Sun, J., Hou, Y., Chen, C., Shao, J., Wang, L., Wang, X., Zhao, R., Wang, H., Andersen, M. E., Zhang, Q., Xu, Y. and Pi, J.
Redox Biol. 2020 Feb, 30:101412.

miR146a improves hepatic lipid and glucose metabolism by targeting MED1
Li, K., Zhao, B., Wei, D., Wang, W., Cui, Y., Qian, L. and Liu, G.
Int J Mol Med. 2020 Feb, 45(2):543-555.

Immunology Research

ACE overexpression in myeloid cells increases oxidative metabolism and cellular ATP
Cao, D. Y., Spivia, W. R., Veiras, L. C., Khan, Z., Peng, Z., Jones, A. E., Bernstein, E. A., Saito, S., Okwan-Duodu, D., Parker, S. J., Giani, J. F., Divakaruni, A. S., Van Eyk, J. E. and Bernstein, K. E.
J Biol Chem. 2020 Jan 31, 295(5):1369-1384.

Class IIa Histone Deacetylases Drive Toll-like Receptor-Inducible Glycolysis and Macrophage Inflammatory Responses via Pyruvate Kinase M2
Das Gupta, K., Shakespear, M. R., Curson, J. E. B., Murthy, A. M. V., Iyer, A., Hodson, M. P., Ramnath, D., Tillu, V. A., von Pein, J. B., Reid, R. C., Tunny, K., Hohenhaus, D. M., Moradi, S. V., Kelly, G. M., Kobayashi, T., Gunter, J. H., Stevenson, A. J., Xu, W., Luo, L., Jones, A., Johnston, W. A., Blumenthal, A., Alexandrov, K., Collins, B. M., Stow, J. L., Fairlie, D. P. and Sweet, M. J.
Cell Rep. 2020 Feb 25, 30(8):2712-2728 e8.

LXR-inverse agonism stimulates immune-mediated tumor destruction by enhancing CD8 T-cell activity in triple negative breast cancer
Carpenter, K. J., Valfort, A. C., Steinauer, N., Chatterjee, A., Abuirqeba, S., Majidi, S., Sengupta, M., Di Paolo, R. J., Shornick, L. P., Zhang, J. and Flaveny, C. A.
Sci Rep. 2019 Dec 20, 9(1):19530.


Unique molecular signature in mucolipidosis type IV microglia
Cougnoux, A., Drummond, R. A., Fellmeth, M., Navid, F., Collar, A. L., Iben, J., Kulkarni, A. B., Pickel, J., Schiffmann, R., Wassif, C. A., Cawley, N. X., Lionakis, M. S. and Porter, F. D.
J Neuroinflammation. 2019 Dec 28, 16(1):276.

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment
Halaby, M. J., Hezaveh, K., Lamorte, S., Ciudad, M. T., Kloetgen, A., MacLeod, B. L., Guo, M., Chakravarthy, A., Medina, T. D. S., Ugel, S., Tsirigos, A., Bronte, V., Munn, D. H., Pugh, T. J., De Carvalho, D. D., Butler, M. O., Ohashi, P. S., Brooks, D. G. and McGaha, T. L.
Sci Immunol. 2019 Dec 13, 4(42).


Overexpression of Mitochondrial IF1 Prevents Metastatic Disease of Colorectal Cancer by Enhancing Anoikis and Tumor Infiltration of NK Cells
Gonzalez-Llorente, L., Santacatterina, F., Garcia-Aguilar, A., Nuevo-Tapioles, C., Gonzalez-Garcia, S., Tirpakova, Z., Toribio, M. L. and Cuezva, J. M.
Cancers (Basel). 2019 Dec 19, 12(1).


mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP
Hu, Y., Mai, W., Chen, L., Cao, K., Zhang, B., Zhang, Z., Liu, Y., Lou, H., Duan, S. and Gao, Z.
Glia. 2020 May, 68(5):1031-1045.


Hyperactive PI3Kdelta predisposes naive T cells to activation via aerobic glycolysis programs
Jia, Y., Yang, Q., Wang, Y., Li, W., Chen, X., Xu, T., Tian, Z., Feng, M., Zhang, L., Tang, W., Tian, N., Zhou, L., Song, W. and Zhao, X.
Cell Mol Immunol. 2020 Feb 25, [epub ahead of print]

High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system
Langley, M. R., Yoon, H., Kim, H. N., Choi, C. I., Simon, W., Kleppe, L., Lanza, I. R., LeBrasseur, N. K., Matveyenko, A. and Scarisbrick, I. A.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1, 1866(3):165630.

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase
Lauterbach, M. A., Hanke, J. E., Serefidou, M., Mangan, M. S. J., Kolbe, C. C., Hess, T., Rothe, M., Kaiser, R., Hoss, F., Gehlen, J., Engels, G., Kreutzenbeck, M., Schmidt, S. V., Christ, A., Imhof, A., Hiller, K. and Latz, E.
Immunity. 2019 Dec 17, 51(6):997-1011 e7.

Metabolic Rewiring in Response to Biguanides Is Mediated by mROS/HIF-1a in Malignant Lymphocytes
Khan, H., Anshu, A., Prasad, A., Roy, S., Jeffery, J., Kittipongdaja, W., Yang, D. T. and Schieke, S. M.
Cell Rep. 2019 Dec 3, 29(10):3009-3018 e4.

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology
Joshi, A. U., Van Wassenhove, L. D., Logas, K. R., Minhas, P. S., Andreasson, K. I., Weinberg, K. I., Chen, C. H. and Mochly-Rosen, D.
Acta Neuropathol Commun. 2019 Dec 12, 7(1):190.

YY1 control of mitochondrial-related genes does not account for regulation of immunoglobulin class switch recombination in mice
Nandi, S., Liang, G., Sindhava, V., Angireddy, R., Basu, A., Banerjee, S., Hodawadekar, S., Zhang, Y., Avadhani, N. G., Sen, R. and Atchison, M. L.
Eur J Immunol. 2020 Feb 24, [epub ahead of print]

Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles
Mai, X., Zhang, Y., Fan, H., Song, W., Chang, Y., Chen, B., Shi, J., Xin, X., Teng, Z., Sun, J. and Teng, G.
Biomaterials. 2020 Feb, 232:119699.


IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
Luckel, C., Picard, F., Raifer, H., Campos Carrascosa, L., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., Marini, F., Gloury, R., Kurschus, F. C., Chao, Y. Y., Bertrams, W., Sexl, V., Schmeck, B., Bonetti, L., Grusdat, M., Lohoff, M., Zielinski, C. E., Zipp, F., Kallies, A., Brenner, D., Berger, M., Bopp, T., Tackenberg, B. and Huber, M.
Nat Commun. 2019 Dec 16, 10(1):5722.

Altered Bioenergetics of Blood Cell Sub-Populations in Acute Pancreatitis Patients
Morton, J. C., Armstrong, J. A., Sud, A., Tepikin, A. V., Sutton, R. and Criddle, D. N.
J Clin Med. 2019 Dec 13, 8(12).

Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis
Marin, E., Bouchet-Delbos, L., Renoult, O., Louvet, C., Nerriere-Daguin, V., Managh, A. J., Even, A., Giraud, M., Vu Manh, T. P., Aguesse, A., Beriou, G., Chiffoleau, E., Alliot-Licht, B., Prieur, X., Croyal, M., Hutchinson, J. A., Obermajer, N., Geissler, E. K., Vanhove, B., Blancho, G., Dalod, M., Josien, R., Pecqueur, C., Cuturi, M. C. and Moreau, A.
Cell Metab. 2019 Dec 3, 30(6):1075-1090 e8.

Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus, P., Lecoutre, S., Dollet, L., Wiel, C., Sulen, A., Gao, H., Tavira, B., Laurencikiene, J., Rooyackers, O., Checa, A., Douagi, I., Wheelock, C. E., Arner, P., McCarthy, M., Bergo, M. O., Edgar, L., Choudhury, R. P., Aouadi, M., Krook, A. and Ryden, M.
Cell Metab. 2020 Feb 4, 31(2):375-390 e11.

Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target
Pandey, R., Zhou, M., Islam, S., Chen, B., Barker, N. K., Langlais, P., Srivastava, A., Luo, M., Cooke, L. S., Weterings, E. and Mahadevan, D.
Sci Rep. 2019 Dec 4, 9(1):18347.


Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model
Owen, A. M., Patel, S. P., Smith, J. D., Balasuriya, B. K., Mori, S. F., Hawk, G. S., Stromberg, A. J., Kuriyama, N., Kaneki, M., Rabchevsky, A. G., Butterfield, T. A., Esser, K. A., Peterson, C. A., Starr, M. E. and Saito, H.
Elife. 2019 Dec 3, 8.


Compromised Metabolic Reprogramming Is an Early Indicator of CD8(+) T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection
Russell, S. L., Lamprecht, D. A., Mandizvo, T., Jones, T. T., Naidoo, V., Addicott, K. W., Moodley, C., Ngcobo, B., Crossman, D. K., Wells, G. and Steyn, A. J. C.
Cell Rep. 2019 Dec 10, 29(11):3564-3579 e5.

Kinin B1 Receptor Blockade Prevents Angiotensin II-induced Neuroinflammation and Oxidative Stress in Primary Hypothalamic Neurons
Parekh, R. U., Robidoux, J. and Sriramula, S.
Cell Mol Neurobiol. 2019 Dec 21, [epub ahead of print]

Inflammation Associated Pancreatic Tumorigenesis: Upregulation of Succinate Dehydrogenase (Subunit B) Reduces Cell Growth of Pancreatic Ductal Epithelial Cells
Rahn, S., Barbosa, P. D., Moller, J. L., Ammar, N., Demetrowitsch, T., Helm, O., Wesch, D., Sipos, B., Rocken, C., Schwarz, K., Schafer, H. and Sebens, S.
Cancers (Basel). 2019 Dec 21, 12(1).

Infectious Disease Research

Compromised Metabolic Reprogramming Is an Early Indicator of CD8(+) T Cell Dysfunction during Chronic Mycobacterium tuberculosis Infection
Russell, S. L., Lamprecht, D. A., Mandizvo, T., Jones, T. T., Naidoo, V., Addicott, K. W., Moodley, C., Ngcobo, B., Crossman, D. K., Wells, G. and Steyn, A. J. C.
Cell Rep. 2019 Dec 10, 29(11):3564-3579 e5.

In Vitro Selection Predicts Malaria Parasite Resistance to Dihydroorotate Dehydrogenase Inhibitors in a Mouse Infection Model
Mandt, R. E. K., Lafuente-Monasterio M. J., Sakata-Kato, T., Luth, M. R., Segura, D,. Pablos-Tanarro, A., Viera, S., Magan, N., Ottilie, S., Winzeler, E. A., Lukens, A. K., Gamo, F. J., Wirth, D.
Sci Transl Med. 2019 Dec 4;11(521):eaav1636. 

Microbial Research

Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARgamma signaling
Park, S. S., Lee, Y. J., Kang, H., Yang, G., Hong, E. J., Lim, J. Y., Oh, S. and Kim, E.
Sci Rep. 2019 Dec 27, 9(1):20152.

Mitochondrial Research

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel
Bevers, R. P. J., Litovchenko, M., Kapopoulou, A., Braman, V. S., Robinson, M. R., Auwerx, J., Hollis, B. and Deplancke, B.
Nature Metabolism. 2019 Dec 9, 1(12):1226-1242.

Overexpression of mitochondrial histidyl-tRNA synthetase restores mitochondrial dysfunction caused by a deafness-associated tRNA(His) mutation
Gong, S., Wang, X., Meng, F., Cui, L., Yi, Q., Zhao, Q., Cang, X., Cai, Z., Mo, J. Q., Liang, Y. and Guan, M. X.
J Biol Chem. 2020 Jan 24, 295(4):940-954.


Bi-Allelic UQCRFS1 Variants Are Associated with Mitochondrial Complex III Deficiency, Cardiomyopathy, and Alopecia Totalis
Gusic, M., Schottmann, G., Feichtinger, R. G., Du, C., Scholz, C., Wagner, M., Mayr, J. A., Lee, C. Y., Yepez, V. A., Lorenz, N., Morales-Gonzalez, S., Panneman, D. M., Rotig, A., Rodenburg, R. J. T., Wortmann, S. B., Prokisch, H. and Schuelke, M.
Am J Hum Genet. 2020 Jan 2, 106(1):102-111.

Higd1a improves respiratory function in the models of mitochondrial disorder
Nagao, T., Shintani, Y., Hayashi, T., Kioka, H., Kato, H., Nishida, Y., Yamazaki, S., Tsukamoto, O., Yashirogi, S., Yazawa, I., Asano, Y., Shinzawa-Itoh, K., Imamura, H., Suzuki, T., Suzuki, T., Goto, Y. I. and Takashima, S.
FASEB J. 2020 Jan, 34(1):1859-1871.

Mitochondrial Respiratory Measurements in Patient-derived Fibroblasts
Mishra, P., Zhang, T., Guo, M. and Chan, D.
Bio-Protocol. 2019 Dec 5, 9(23).

Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes
Paul, B. T., Tesfay, L., Winkler, C. R., Torti, F. M. and Torti, S. V.
Sci Rep. 2019 Dec 23, 9(1):19634.

Model Organisms

Developmental ROS individualizes organismal stress resistance and lifespan
Bazopoulou, D., Knoefler, D., Zheng, Y., Ulrich, K., Oleson, B. J., Xie, L., Kim, M., Kaufmann, A., Lee, Y. T., Dou, Y., Chen, Y., Quan, S. and Jakob, U.
Nature. 2019 Dec, 576(7786):301-305.

Mitochondrial haplotypes affect metabolic phenotypes in the Drosophila Genetic Reference Panel
Bevers, R. P. J., Litovchenko, M., Kapopoulou, A., Braman, V. S., Robinson, M. R., Auwerx, J., Hollis, B. and Deplancke, B.
Nature Metabolism. 2019 Dec 9, 1(12):1226-1242.

Wounding triggers MIRO-1 dependent mitochondrial fragmentation that accelerates epidermal wound closure through oxidative signaling
Fu, H., Zhou, H., Yu, X., Xu, J., Zhou, J., Meng, X., Zhao, J., Zhou, Y., Chisholm, A. D. and Xu, S.
Nat Commun. 2020 Feb 26, 11(1):1050.


Metabolic modulation regulates cardiac wall morphogenesis in zebrafish
Fukuda, R., Aharonov, A., Ong, Y. T., Stone, O. A., El-Brolosy, M., Maischein, H. M., Potente, M., Tzahor, E. and Stainier, D. Y.
Elife. 2019 Dec 23, 8.

Higd1a improves respiratory function in the models of mitochondrial disorder
Nagao, T., Shintani, Y., Hayashi, T., Kioka, H., Kato, H., Nishida, Y., Yamazaki, S., Tsukamoto, O., Yashirogi, S., Yazawa, I., Asano, Y., Shinzawa-Itoh, K., Imamura, H., Suzuki, T., Suzuki, T., Goto, Y. I. and Takashima, S.
FASEB J. 2020 Jan, 34(1):1859-1871.

Neurobiology Research

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
Cordes, T., Lucas, A., Divakaruni, A. S., Murphy, A. N., Cabrales, P. and Metallo, C. M.
Mol Metab. 2020 Feb, 32:122-135.

The LRRC8 volume-regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel
Afzal, A., Figueroa, E. E., Kharade, S. V., Bittman, K., Matlock, B. K., Flaherty, D. K. and Denton, J. S.
Physiol Rep. 2019 Dec, 7(23):e14303.

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells
Alshangiti, A. M., Tuboly, E., Hegarty, S. V., McCarthy, C. M., Sullivan, A. M. and O'Keeffe, G. W.
Oxid Med Cell Longev. 2019 Dec 5, 2019:1670759.


Unique molecular signature in mucolipidosis type IV microglia
Cougnoux, A., Drummond, R. A., Fellmeth, M., Navid, F., Collar, A. L., Iben, J., Kulkarni, A. B., Pickel, J., Schiffmann, R., Wassif, C. A., Cawley, N. X., Lionakis, M. S. and Porter, F. D.
J Neuroinflammation. 2019 Dec 28, 16(1):276.


Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS
Chao, C. C., Gutierrez-Vazquez, C., Rothhammer, V., Mayo, L., Wheeler, M. A., Tjon, E. C., Zandee, S. E. J., Blain, M., de Lima, K. A., Takenaka, M. C., Avila-Pacheco, J., Hewson, P., Liu, L., Sanmarco, L. M., Borucki, D. M., Lipof, G. Z., Trauger, S. A., Clish, C. B., Antel, J. P., Prat, A. and Quintana, F. J.
Cell. 2019 Dec 12, 179(7):1483-1498 e22.

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
Chumarina, M., Russ, K., Azevedo, C., Heuer, A., Pihl, M., Collin, A., Frostner, E. A., Elmer, E., Hyttel, P., Cappelletti, G., Zini, M., Goldwurm, S. and Roybon, L.
Acta Neuropathol Commun. 2019 Dec 16, 7(1):208.

Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus that are Necessary for Synapse Function
Gokhale, A., Lee, C. E., Zlatic, S. A., Freeman, A. A. H., Shearing, N., Hartwig, C., Ogunbona, O., Bassell, J. L., Wynne, M. E., Werner, E., Xu, C., Wen, Z., Seyfried, N., Bearden, C. E., Glausier, J., Lewis, D. A. and Faundez, V.
bioRxiv. 2020 Feb 25, [epub ahead of print]

Psychological Stress Phenocopies Brain Mitochondrial Dysfunction and Motor Deficits as Observed in a Parkinsonian Rat Model
Grigoruta, M., Martinez-Martinez, A., Dagda, R. Y. and Dagda, R. K.
Mol Neurobiol. 2020 Apr, 57(4):1781-1798.

African and Asian Mitochondrial DNA Haplogroups Confer Resistance Against Diabetic Stresses on Retinal Pigment Epithelial Cybrid Cells In Vitro
Dolinko, A. H., Chwa, M., Atilano, S. R. and Kenney, M. C.
Mol Neurobiol. 2020 Mar, 57(3):1636-1655.

Existing and Emerging Metabolomic Tools for ALS Research
Germeys, C., Vandoorne, T., Bercier, V. and Van Den Bosch, L.
Genes (Basel). 2019 Dec 5, 10(12).


Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy
Kingsbury, C., Heyck, M., Bonsack, B., Lee, J. Y. and Borlongan, C. V.
Neural Regen Res. 2020 Jun, 15(6):1014-1018.

Twist1 Plays an Anti-apoptotic Role in Mutant Huntingtin Expression Striatal Progenitor Cells
Jen, W. P., Chen, H. M., Lin, Y. S., Chern, Y. and Lee, Y. C.
Mol Neurobiol. 2020 Mar, 57(3):1688-1703.

Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Igoillo-Esteve, M., Oliveira, A. F., Cosentino, C., Fantuzzi, F., Demarez, C., Toivonen, S., Hu, A., Chintawar, S., Lopes, M., Pachera, N., Cai, Y., Abdulkarim, B., Rai, M., Marselli, L., Marchetti, P., Tariq, M., Jonas, J. C., Boscolo, M., Pandolfo, M., Eizirik, D. L. and Cnop, M.
JCI Insight. 2020 Jan 30, 5(2).

mTOR-mediated metabolic reprogramming shapes distinct microglia functions in response to lipopolysaccharide and ATP
Hu, Y., Mai, W., Chen, L., Cao, K., Zhang, B., Zhang, Z., Liu, Y., Lou, H., Duan, S. and Gao, Z.
Glia. 2020 May, 68(5):1031-1045.

Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator
Kawashima, H., Ozawa, Y., Toda, E., Homma, K., Osada, H., Narimatsu, T., Nagai, N. and Tsubota, K.
FASEB J. 2020 Apr, 34(4):5016-5026.

High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system
Langley, M. R., Yoon, H., Kim, H. N., Choi, C. I., Simon, W., Kleppe, L., Lanza, I. R., LeBrasseur, N. K., Matveyenko, A. and Scarisbrick, I. A.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1, 1866(3):165630.


TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis
Lanznaster, D., Bourgeais, J., Bruno, C., Hergesheimer, R. C., Thepault, R. A., Vourc'h, P., Corcia, P., Andres, C. R., Herault, O. and Blasco, H.
Cells. 2019 Dec 26, 9(1).

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology
Joshi, A. U., Van Wassenhove, L. D., Logas, K. R., Minhas, P. S., Andreasson, K. I., Weinberg, K. I., Chen, C. H. and Mochly-Rosen, D.
Acta Neuropathol Commun. 2019 Dec 12, 7(1):190.


Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis
Namba, T., Doczi, J., Pinson, A., Xing, L., Kalebic, N., Wilsch-Brauninger, M., Long, K. R., Vaid, S., Lauer, J., Bogdanova, A., Borgonovo, B., Shevchenko, A., Keller, P., Drechsel, D., Kurzchalia, T., Wimberger, P., Chinopoulos, C. and Huttner, W. B.
Neuron. 2020 Mar 4, 105(5):867-881 e9.

IL-17(+) CD8(+) T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis
Luckel, C., Picard, F., Raifer, H., Campos Carrascosa, L., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., Marini, F., Gloury, R., Kurschus, F. C., Chao, Y. Y., Bertrams, W., Sexl, V., Schmeck, B., Bonetti, L., Grusdat, M., Lohoff, M., Zielinski, C. E., Zipp, F., Kallies, A., Brenner, D., Berger, M., Bopp, T., Tackenberg, B. and Huber, M.
Nat Commun. 2019 Dec 16, 10(1):5722.


Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations in vivo 
Liu, Y.-T., Huang, X., Nguyen, D., Dombi, E., Springer, D. A., Poulton, J., Sekine, S. and Narendra, D. P.
bioRxiv. 2019 Sep 18, 773135.

Mitochondrial nucleoid morphology and respiratory function are altered in Drp1-deficient HeLa cells
Ota, A., Ishihara, T. and Ishihara, N.
J Biochem. 2020 Mar 1, 167(3):287-294.

Kinin B1 Receptor Blockade Prevents Angiotensin II-induced Neuroinflammation and Oxidative Stress in Primary Hypothalamic Neurons
Parekh, R. U., Robidoux, J. and Sriramula, S.
Cell Mol Neurobiol. 2019 Dec 21, [epub ahead of print]

Obesity, Diabetes & Metabolic Diseases

Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue
Bettedi, L., Yan, A., Schuster, E., Alic, N. and Foukas, L. C.
Sci Rep. 2020 Feb 25, 10(1):3418.

Dysregulation of Amyloid Precursor Protein Impairs Adipose Tissue Mitochondrial Function and Promotes Obesity
An, Y. A., Crewe, C., Asterholm, I. W., Sun, K., Chen, S., Zhang, F., Shao, M., Funcke, J. B., Zhang, Z., Straub, L., Klein, S., Kusminski, C. M. and Scherer, P. E.
Nat Metab. 2019 Dec, 1(12):1243-1257.

African and Asian Mitochondrial DNA Haplogroups Confer Resistance Against Diabetic Stresses on Retinal Pigment Epithelial Cybrid Cells In Vitro
Dolinko, A. H., Chwa, M., Atilano, S. R. and Kenney, M. C.
Mol Neurobiol. 2020 Mar, 57(3):1636-1655.

Acetate and Butyrate Improve beta-cell Metabolism and Mitochondrial Respiration under Oxidative Stress
Hu, S., Kuwabara, R., de Haan, B. J., Smink, A. M. and de Vos, P.
Int J Mol Sci. 2020 Feb 24, 21(4).

Strawberry (Fragaria x ananassa cv. Romina) methanolic extract promotes browning in 3T3-L1 cells
Forbes-Hernandez, T. Y., Cianciosi, D., Ansary, J., Mezzetti, B., Bompadre, S., Quiles, J. L., Giampieri, F. and Battino, M.
Food Funct. 2020 Jan 29, 11(1):297-304.


Mitochondrial fusion promoter restores mitochondrial dynamics balance and ameliorates diabetic cardiomyopathy in an optic atrophy 1-dependent way
Ding, M., Liu, C., Shi, R., Yu, M., Zeng, K., Kang, J., Fu, F. and Mi, M.
Acta Physiol (Oxf). 2020 May, 229(1):e13428.


Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Igoillo-Esteve, M., Oliveira, A. F., Cosentino, C., Fantuzzi, F., Demarez, C., Toivonen, S., Hu, A., Chintawar, S., Lopes, M., Pachera, N., Cai, Y., Abdulkarim, B., Rai, M., Marselli, L., Marchetti, P., Tariq, M., Jonas, J. C., Boscolo, M., Pandolfo, M., Eizirik, D. L. and Cnop, M.
JCI Insight. 2020 Jan 30, 5(2).

PRMT1 Is Required for the Maintenance of Mature beta-Cell Identity
Kim, H., Yoon, B. H., Oh, C. M., Lee, J., Lee, K., Song, H., Kim, E., Yi, K., Kim, M. Y., Kim, H., Kim, Y. K., Seo, E. H., Heo, H., Kim, H. J., Lee, J., Suh, J. M., Koo, S. H., Seong, J. K., Kim, S., Ju, Y. S., Shong, M., Kim, M. and Kim, H.
Diabetes. 2020 Mar, 69(3):355-368.

High fat diet consumption results in mitochondrial dysfunction, oxidative stress, and oligodendrocyte loss in the central nervous system
Langley, M. R., Yoon, H., Kim, H. N., Choi, C. I., Simon, W., Kleppe, L., Lanza, I. R., LeBrasseur, N. K., Matveyenko, A. and Scarisbrick, I. A.
Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1, 1866(3):165630.


Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARgamma expression
Li, L., Fu, J., Liu, D., Sun, J., Hou, Y., Chen, C., Shao, J., Wang, L., Wang, X., Zhao, R., Wang, H., Andersen, M. E., Zhang, Q., Xu, Y. and Pi, J.
Redox Biol. 2020 Feb, 30:101412.


miR146a improves hepatic lipid and glucose metabolism by targeting MED1
Li, K., Zhao, B., Wei, D., Wang, W., Cui, Y., Qian, L. and Liu, G.
Int J Mol Med. 2020 Feb, 45(2):543-555.

Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning
Li, Y., Schwalie, P. C., Bast-Habersbrunner, A., Mocek, S., Russeil, J., Fromme, T., Deplancke, B. and Klingenspor, M.
Cell Rep. 2019 Dec 17, 29(12):4099-4113 e5.


Apigenin Reverses Interleukin-1beta-Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes
Okla, M., Al Madani, J. O., Chung, S. and Alfayez, M.
Mol Nutr Food Res. 2020 Jan, 64(1):e1900925.


Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus, P., Lecoutre, S., Dollet, L., Wiel, C., Sulen, A., Gao, H., Tavira, B., Laurencikiene, J., Rooyackers, O., Checa, A., Douagi, I., Wheelock, C. E., Arner, P., McCarthy, M., Bergo, M. O., Edgar, L., Choudhury, R. P., Aouadi, M., Krook, A. and Ryden, M.
Cell Metab. 2020 Feb 4, 31(2):375-390 e11.


Palmitate and oleate modify membrane fluidity and kinase activities of INS-1E beta-cells alongside altered metabolism-secretion coupling
Oberhauser, L., Granziera, S., Colom, A., Goujon, A., Lavallard, V., Matile, S., Roux, A., Brun, T. and Maechler, P.
Biochim Biophys Acta Mol Cell Res. 2020 Feb, 1867(2):118619.

Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARgamma signaling
Park, S. S., Lee, Y. J., Kang, H., Yang, G., Hong, E. J., Lim, J. Y., Oh, S. and Kim, E.
Sci Rep. 2019 Dec 27, 9(1):20152.

Review Articles

Blood-based bioenergetics: An emerging translational and clinical tool
Braganza, A., Annarapu, G. K. and Shiva, S.
Mol Aspects Med. 2020 Feb, 71:100835.

Existing and Emerging Metabolomic Tools for ALS Research
Germeys, C., Vandoorne, T., Bercier, V. and Van Den Bosch, L.
Genes (Basel). 2019 Dec 5, 10(12).

Integrated approach for data acquisition, visualization and processing of analog polarographic systems for bioenergetics studies
L, P., D, K., J, K., Cl, H. and N, L.
Anal Biochem. 2020 Feb 1, 590:113515.

Stem Cell Biology

Itaconate modulates tricarboxylic acid and redox metabolism to mitigate reperfusion injury
Cordes, T., Lucas, A., Divakaruni, A. S., Murphy, A. N., Cabrales, P. and Metallo, C. M.
Mol Metab. 2020 Feb, 32:122-135.

4-Hydroxychalcone Induces Cell Death via Oxidative Stress in MYCN-Amplified Human Neuroblastoma Cells
Alshangiti, A. M., Tuboly, E., Hegarty, S. V., McCarthy, C. M., Sullivan, A. M. and O'Keeffe, G. W.
Oxid Med Cell Longev. 2019 Dec 5, 2019:1670759.


Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
Chumarina, M., Russ, K., Azevedo, C., Heuer, A., Pihl, M., Collin, A., Frostner, E. A., Elmer, E., Hyttel, P., Cappelletti, G., Zini, M., Goldwurm, S. and Roybon, L.
Acta Neuropathol Commun. 2019 Dec 16, 7(1):208.

Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions
Gong, J., Cai, H., Team, N. G. S. C. A., Noggle, S., Paull, D., Rizzolo, L. J., Del Priore, L. V. and Fields, M. A.
Stem Cells Transl Med. 2020 Mar, 9(3):364-376.

Strawberry (Fragaria x ananassa cv. Romina) methanolic extract promotes browning in 3T3-L1 cells
Forbes-Hernandez, T. Y., Cianciosi, D., Ansary, J., Mezzetti, B., Bompadre, S., Quiles, J. L., Giampieri, F. and Battino, M.
Food Funct. 2020 Jan 29, 11(1):297-304.


Metabolic modulation regulates cardiac wall morphogenesis in zebrafish
Fukuda, R., Aharonov, A., Ong, Y. T., Stone, O. A., El-Brolosy, M., Maischein, H. M., Potente, M., Tzahor, E. and Stainier, D. Y.
Elife. 2019 Dec 23, 8.

Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy
Kingsbury, C., Heyck, M., Bonsack, B., Lee, J. Y. and Borlongan, C. V.
Neural Regen Res. 2020 Jun, 15(6):1014-1018.

Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia
Igoillo-Esteve, M., Oliveira, A. F., Cosentino, C., Fantuzzi, F., Demarez, C., Toivonen, S., Hu, A., Chintawar, S., Lopes, M., Pachera, N., Cai, Y., Abdulkarim, B., Rai, M., Marselli, L., Marchetti, P., Tariq, M., Jonas, J. C., Boscolo, M., Pandolfo, M., Eizirik, D. L. and Cnop, M.
JCI Insight. 2020 Jan 30, 5(2).

Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer's disease related pathology
Joshi, A. U., Van Wassenhove, L. D., Logas, K. R., Minhas, P. S., Andreasson, K. I., Weinberg, K. I., Chen, C. H. and Mochly-Rosen, D.
Acta Neuropathol Commun. 2019 Dec 12, 7(1):190.


Energy metabolism of the equine cumulus oocyte complex during in vitro maturation
Lewis, N., Hinrichs, K., Leese, H. J., Mc, G. A. C., Brison, D. R. and Sturmey, R.
Sci Rep. 2020 Feb 26, 10(1):3493.

Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis
Namba, T., Doczi, J., Pinson, A., Xing, L., Kalebic, N., Wilsch-Brauninger, M., Long, K. R., Vaid, S., Lauer, J., Bogdanova, A., Borgonovo, B., Shevchenko, A., Keller, P., Drechsel, D., Kurzchalia, T., Wimberger, P., Chinopoulos, C. and Huttner, W. B.
Neuron. 2020 Mar 4, 105(5):867-881 e9.

Apigenin Reverses Interleukin-1beta-Induced Suppression of Adipocyte Browning via COX2/PGE2 Signaling Pathway in Human Adipocytes
Okla, M., Al Madani, J. O., Chung, S. and Alfayez, M.
Mol Nutr Food Res. 2020 Jan, 64(1):e1900925.


Carcinoembryonic antigen cell adhesion molecule 6 (CEACAM6) in Pancreatic Ductal Adenocarcinoma (PDA): An integrative analysis of a novel therapeutic target
Pandey, R., Zhou, M., Islam, S., Chen, B., Barker, N. K., Langlais, P., Srivastava, A., Luo, M., Cooke, L. S., Weterings, E. and Mahadevan, D.
Sci Rep. 2019 Dec 4, 9(1):18347.

Techniques & Methods

HIF-1 Signaling Pathway Implicated in Phenotypic Instability in a Chinese Hamster Ovary Production Cell Line
Lieske, P. L., Wei, W., Crowe, K. B., Figueroa, B. and Zhang, L.
Biotechnol J. 2020 Apr, 15(4):e1900306.

Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles
Mai, X., Zhang, Y., Fan, H., Song, W., Chang, Y., Chen, B., Shi, J., Xin, X., Teng, Z., Sun, J. and Teng, G.
Biomaterials. 2020 Feb, 232:119699.

A systematic flux analysis approach to identify metabolic vulnerabilities in human breast cancer cell lines
Martin, S. D. and McGee, S. L.
Cancer Metab. 2019 Dec 27, 7:12.


Mitochondrial Respiratory Measurements in Patient-derived Fibroblasts
Mishra, P., Zhang, T., Guo, M. and Chan, D.
Bio-Protocol. 2019 Dec 5, 9(23).

Bioenergetics underlying single-cell migration on aligned nanofiber scaffolds
Padhi, A., Thomson, A. H., Perry, J. B., Davis, G. N., McMillan, R. P., Loesgen, S., Kaweesa, E. N., Kapania, R., Nain, A. S. and Brown, D. A.
Am J Physiol Cell Physiol. 2020 Mar 1, 318(3):C476-C485.

Toxicology Research

Mice deficient in pyruvate dehydrogenase kinase 4 are protected against acetaminophen-induced hepatotoxicity
Duan, L., Ramachandran, A., Akakpo, J. Y., Woolbright, B. L., Zhang, Y. and Jaeschke, H.
Toxicol Appl Pharmacol. 2020 Jan 15, 387:114849.


TDP-43-Mediated Toxicity in HEK293T Cells: A Fast and Reproducible Protocol To Be Employed in the Search of New Therapeutic Options against Amyotrophic Lateral Sclerosis
Lanznaster, D., Bourgeais, J., Bruno, C., Hergesheimer, R. C., Thepault, R. A., Vourc'h, P., Corcia, P., Andres, C. R., Herault, O. and Blasco, H.
Cells. 2019 Dec 26, 9(1).

Translational Research

Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
Chumarina, M., Russ, K., Azevedo, C., Heuer, A., Pihl, M., Collin, A., Frostner, E. A., Elmer, E., Hyttel, P., Cappelletti, G., Zini, M., Goldwurm, S. and Roybon, L.
Acta Neuropathol Commun. 2019 Dec 16, 7(1):208.

Stem cell-derived retinal pigment epithelium from patients with age-related macular degeneration exhibit reduced metabolism and matrix interactions
Gong, J., Cai, H., Team, N. G. S. C. A., Noggle, S., Paull, D., Rizzolo, L. J., Del Priore, L. V. and Fields, M. A.
Stem Cells Transl Med. 2020 Mar, 9(3):364-376.

African and Asian Mitochondrial DNA Haplogroups Confer Resistance Against Diabetic Stresses on Retinal Pigment Epithelial Cybrid Cells In Vitro
Dolinko, A. H., Chwa, M., Atilano, S. R. and Kenney, M. C.
Mol Neurobiol. 2020 Mar, 57(3):1636-1655.

Cancerrelated fatigue during combined treatment of androgen deprivation therapy and radiotherapy is associated with mitochondrial dysfunction
Feng, L. R., Wolff, B. S., Liwang, J., Regan, J. M., Alshawi, S., Raheem, S. and Saligan, L. N.
Int J Mol Med. 2020 Feb, 45(2):485-496.

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