XF Publications Alert - October 2019

The Publications Alert gathers and compiles a list of all the most recent peer-reviewed publications containing Seahorse XF and Soluble Sensor data, based solely on user-generated content.

Aging Research

PGC1alpha repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state
Caporarello, N., Meridew, J. A., Jones, D. L., Tan, Q., Haak, A. J., Choi, K. M., Manlove, L. J., Prakash, Y. S., Tschumperlin, D. J. and Ligresti, G.
Thorax. 2019 Aug, 74(8):749-760.

Platelet bioenergetics correlate with muscle energetics and are altered in older adults
Braganza, A., Corey, C. G., Santanasto, A. J., Distefano, G., Coen, P. M., Glynn, N. W., Nouraie, S. M., Goodpaster, B. H., Newman, A. B. and Shiva, S.
JCI Insight. 2019 May 23, 5.

Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death
Chan, C. M., Huang, D. Y., Sekar, P., Hsu, S. H. and Lin, W. W.
J Biomed Sci. 2019 May 22, 26(1):40.

Cancer Research

Cationic block amphiphiles show anti-mitochondrial activity in multi-drug resistant breast cancer cells
Czupiel, P. P., Delplace, V. and Shoichet, M. S.
J Control Release. 2019 Jul 10, 305:210-219.

Intra-Tumoral Metabolic Zonation and Resultant Phenotypic Diversification Are Dictated by Blood Vessel Proximity
Kumar, S., Sharife, H., Kreisel, T., Mogilevsky, M., Bar-Lev, L., Grunewald, M., Aizenshtein, E., Karni, R., Paldor, I., Shlomi, T. and Keshet, E.
Cell Metab. 2019 Jul 2, 30(1):201-211 e6.

R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells
Sun, S., Xue, D., Chen, Z., Ou-Yang, Y., Zhang, J., Mai, J., Gu, J., Lu, W., Liu, X., Liu, W., Sheng, L., Lu, B., Lin, Y., Xing, F., Chen, Z., Mou, Y., Yan, G., Zhu, W. and Sai, K.
Cell Death Dis. 2019 May 1, 10(5):358.

MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma
Kao, Y. Y., Chou, C. H., Yeh, L. Y., Chen, Y. F., Chang, K. W., Liu, C. J., Fan Chiang, C. Y. and Lin, S. C.
Cancer Lett. 2019 Aug 1, 456:40-48.

Determination of Pyruvate Metabolic Fates Modulates Head and Neck Tumorigenesis
Chen, T. Y., Hsieh, Y. T., Huang, J. M., Liu, C. J., Chuang, L. T., Huang, P. C., Kuo, T. Y., Chia, H. Y., Chou, C. Y., Chang, C. W., Chen, Y. F., Chen, H. M., Lo, J. F. and Li, W. C.
Neoplasia. 2019 Jul, 21(7):641-652.

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc
Dong, H., Adams, N. M., Xu, Y., Cao, J., Allan, D. S. J., Carlyle, J. R., Chen, X., Sun, J. C. and Glimcher, L. H.
Nat Immunol. 2019 Jul, 20(7):865-878.

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Cheng, G., Zhang, Q., Pan, J., Lee, Y., Ouari, O., Hardy, M., Zielonka, M., Myers, C. R., Zielonka, J., Weh, K., Chang, A. C., Chen, G., Kresty, L., Kalyanaraman, B. and You, M.
Nat Commun. 2019 May 17, 10(1):2205.

Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment
Li, Y., Luo, J., Lin, M. T., Zhi, P., Guo, W. W., Han, M., You, J. and Gao, J. Q.
Mol Pharm. 2019 Jul 1, 16(7):2966-2979.

Myc-mediated transcriptional regulation of the mitochondrial chaperone TRAP1 controls primary and metastatic tumor growth
Agarwal, E., Altman, B. J., Seo, J. H., Ghosh, J. C., Kossenkov, A. V., Tang, H. Y., Krishn, S. R., Languino, L. R., Gabrilovich, D. I., Speicher, D. W., Dang, C. V. and Altieri, D. C.
J Biol Chem. 2019 Jul 5, 294(27):10407-10414.

Dynamic bioenergetic alterations in colorectal adenomatous polyps and adenocarcinomas
Lin, W. R., Chiang, J. M., Lim, S. N., Su, M. Y., Chen, T. H., Huang, S. W., Chen, C. W., Wu, R. C., Tsai, C. L., Lin, Y. H., Alison, M. R., Hsieh, S. Y., Yu, J. S., Chiu, C. T. and Yeh, C. T.
EBioMedicine. 2019 Jun, 44(334-345.

Inhibition of mitochondrial translation selectively targets osteosarcoma
Chen, J., Xu, X. and Fan, M.
Biochem Biophys Res Commun. 2019 Jul 12, 515(1):9-15.

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential
Stalinska, J., Zimolag, E., Pianovich, N. A., Zapata, A., Lassak, A., Rak, M., Dean, M., Ucar-Bilyeu, D., Wyczechowska, D., Culicchia, F., Marrero, L., Del Valle, L., Sarkaria, J., Peruzzi, F., Jursic, B. S. and Reiss, K.
Transl Oncol. 2019 Jul, 12(7):895-907.

HSP60 silencing promotes Warburg-like phenotypes and switches the mitochondrial function from ATP production to biosynthesis in ccRCC cells
Teng, R., Liu, Z., Tang, H., Zhang, W., Chen, Y., Xu, R., Chen, L., Song, J., Liu, X. and Deng, H.
Redox Biol. 2019 Jun, 24:101218.

Imaging intratumoral metabolic heterogeneity
Walsh, A. J., Sharick, J. T. and Skala, M. C.
Nat Biomed Eng. 2019 May, 3(5):333-334.

IL-17A-stimulated endothelial fatty acid beta-oxidation promotes tumor angiogenesis
Wang, R., Lou, X., Feng, G., Chen, J., Zhu, L., Liu, X., Yao, X., Li, P., Wan, J., Zhang, Y., Ni, C. and Qin, Z.
Life Sci. 2019 Jul 15, 229:46-56.

GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells
Wegner, M. S., Gruber, L., Schomel, N., Trautmann, S., Brachtendorf, S., Fuhrmann, D., Schreiber, Y., Olesch, C., Brune, B., Geisslinger, G. and Grosch, S.
Int J Biochem Cell Biol. 2019 Jul, 112:95-106.

Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation
Patten, D. A., Ouellet, M., Allan, D. S., Germain, M., Baird, S. D., Harper, M. E. and Richardson, R. B.
FASEB J. 2019 Aug, 33(8):9263-9278.

Type Igamma phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer
Peng, W., Huang, W., Ge, X., Xue, L., Zhao, W. and Xue, J.
EBioMedicine. 2019 Jun, 44(375-386.

Identifying the murine mammary cell target of metformin exposure
Shehata, M., Kim, H., Vellanki, R., Waterhouse, P. D., Mahendralingam, M., Casey, A. E., Koritzinsky, M. and Khokha, R.
Commun Biol. 2019 May 20, 2:192.

miR-613 inhibits Warburg effect in gastric cancer by targeting PFKFB2
Liu, H., Chen, K., Wang, L., Zeng, X., Huang, Z., Li, M., Dong, P. and Chen, X.
Biochem Biophys Res Commun. 2019 Jul 12, 515(1):37-43.

Analysis of miRNA-mRNA network reveals miR-140-5p as a suppressor of breast cancer glycolysis via targeting GLUT1
He, Y., Deng, F., Zhao, S., Zhong, S., Zhao, J., Wang, D., Chen, X., Zhang, J., Hou, J., Zhang, W., Ding, L., Tang, J. and Zhou, Z.
Epigenomics. 2019 Jul, 11(9):1021-1036.

Immunometabolic Responses of Natural Killer Cells to Inhibitory Tumor Microenvironment Checkpoints
Dao, T. N. and Matosevic, S.
Immunometabolism. 2019 May 23, 1(1):e190003.

Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAF(V600E) mutation bearing metastatic melanoma cells
Carpenter, E. L., Chagani, S., Nelson, D., Cassidy, P. B., Laws, M., Ganguli-Indra, G. and Indra, A. K.
Mol Carcinog. 2019 Sep, 58(9):1680-1690.

NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma
Dimri, M., Humphries, A., Laknaur, A., Elattar, S., Lee, T. J., Sharma, A., Kolhe, R. and Satyanarayana, A.
Hepatology. 2019 Jun 19, [epub ahead of print]

C/EBPbeta-LIP induces cancer-type metabolic reprogramming by regulating the let-7/LIN28B circuit in mice
Ackermann, T., Hartleben, G., Muller, C., Mastrobuoni, G., Groth, M., Sterken, B. A., Zaini, M. A., Youssef, S. A., Zuidhof, H. R., Krauss, S. R., Kortman, G., de Haan, G., de Bruin, A., Wang, Z. Q., Platzer, M., Kempa, S. and Calkhoven, C. F.
Commun Biol. 2019 Jun 14, 2:208.

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer
Civenni, G., Bosotti, R., Timpanaro, A., Vazquez, R., Merulla, J., Pandit, S., Rossi, S., Albino, D., Allegrini, S., Mitra, A., Mapelli, S. N., Vierling, L., Giurdanella, M., Marchetti, M., Paganoni, A., Rinaldi, A., Losa, M., Mira-Cato, E., D'Antuono, R., Morone, D., Rezai, K., D'Ambrosio, G., Ouafik, L., Mackenzie, S., Riveiro, M. E., Cvitkovic, E., Carbone, G. M. and Catapano, C. V.
Cell Metab. 2019 Aug 6, 30(2):303-318 e6.

HMGA1 promoting gastric cancer oncogenic and glycolytic phenotypes by regulating c-myc expression
Cao, X. P., Cao, Y., Zhao, H., Yin, J. and Hou, P.
Biochem Biophys Res Commun. 2019 Aug 20, 516(2):457-465.

Isoform-specific gene disruptions reveal a role for the V-ATPase subunit a4 isoform in the invasiveness of 4T1-12B breast cancer cells
McGuire, C. M., Collins, M. P., Sun-Wada, G., Wada, Y. and Forgac, M.
J Biol Chem. 2019 Jul 19, 294(29):11248-11258.

CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation
Itkonen, H. M., Poulose, N., Walker, S. and Mills, I. G.
Neoplasia. 2019 Jul, 21(7):713-720.

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
Lee, H. J., Li, C. F., Ruan, D., He, J., Montal, E. D., Lorenz, S., Girnun, G. D. and Chan, C. H.
Nat Commun. 2019 Jun 14, 10(1):2625.

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
Jin, N., Bi, A., Lan, X., Xu, J., Wang, X., Liu, Y., Wang, T., Tang, S., Zeng, H., Chen, Z., Tan, M., Ai, J., Xie, H., Zhang, T., Liu, D., Huang, R., Song, Y., Leung, E. L., Yao, X., Ding, J., Geng, M., Lin, S. H. and Huang, M.
Nat Commun. 2019 Jun 20, 10(1):2701.

Transcriptomic analysis reveals that BMP4 sensitizes glioblastoma tumor-initiating cells to mechanical cues
Hughes, J. H., Ewy, J. M., Chen, J., Wong, S. Y., Tharp, K. M., Stahl, A. and Kumar, S.
Matrix Biol. 2019 Jun 9, [epub ahead of print]

Snail-Overexpression Induces Epithelial-mesenchymal Transition and Metabolic Reprogramming in Human Pancreatic Ductal Adenocarcinoma and Non-tumorigenic Ductal Cells
Liu, M., Hancock, S. E., Sultani, G., Wilkins, B. P., Ding, E., Osborne, B., Quek, L. E. and Turner, N.
J Clin Med. 2019 Jun 8, 8(6).

Cannabidiol Overcomes Oxaliplatin Resistance by Enhancing NOS3- and SOD2-Induced Autophagy in Human Colorectal Cancer Cells
Jeong, S., Kim, B. G., Kim, D. Y., Kim, B. R., Kim, J. L., Park, S. H., Na, Y. J., Jo, M. J., Yun, H. K., Jeong, Y. A., Kim, H. J., Lee, S. I., Kim, H. D., Kim, D. H., Oh, S. C. and Lee, D. H.
Cancers (Basel). 2019 Jun 5, 11(6).

Cardiovascular Research

Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart
Mardani, I., Tomas Dalen, K., Drevinge, C., Miljanovic, A., Stahlman, M., Klevstig, M., Scharin Tang, M., Fogelstrand, P., Levin, M., Ekstrand, M., Nair, S., Redfors, B., Omerovic, E., Andersson, L., Kimmel, A. R., Boren, J. and Levin, M. C.
Sci Rep. 2019 May 6, 9(1):6909.

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Kanemoto, N., Okamoto, T., Tanabe, K., Shimada, T., Minoshima, H., Hidoh, Y., Aoyama, M., Ban, T., Kobayashi, Y., Ando, H., Inoue, Y., Itotani, M. and Sato, S.
Nat Commun. 2019 May 15, 10(1):2172.

Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
Schruf, E., Schroeder, V., Kuttruff, C. A., Weigle, S., Krell, M., Benz, M., Bretschneider, T., Holweg, A., Schuler, M., Frick, M., Nicklin, P., Garnett, J. P. and Sobotta, M. C.
Respir Res. 2019 May 9, 20(1):87.

Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs
Wu, J., Liu, M., Mang, G., Yu, S., Chen, Q., Li, T., Wang, Y., Meng, Y., Tang, X., Zheng, Y., Sun, Y., Zhang, M. and Yu, B.
Pharmacol Res. 2019 Aug, 146:104269.

PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria
Liu, D., Wang, Z., Nicolas, V., Lindner, M., Mika, D., Vandecasteele, G., Fischmeister, R. and Brenner, C.
Mitochondrion. 2019 Jul, 47:64-75.

PGC1alpha repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state
Caporarello, N., Meridew, J. A., Jones, D. L., Tan, Q., Haak, A. J., Choi, K. M., Manlove, L. J., Prakash, Y. S., Tschumperlin, D. J. and Ligresti, G.
Thorax. 2019 Aug, 74(8):749-760.

Dihomo-gamma-linolenic acid inhibits several key cellular processes associated with atherosclerosis
Gallagher, H., Williams, J. O., Ferekidis, N., Ismail, A., Chan, Y. H., Michael, D. R., Guschina, I. A., Tyrrell, V. J., O'Donnell, V. B., Harwood, J. L., Khozin-Goldberg, I., Boussiba, S. and Ramji, D. P.
Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1, 1865(9):2538-2550.

Nutritional preconditioning induced by astragaloside on isolated hearts and cardiomyocytes against myocardial ischemia injury via improving Bcl-2-mediated mitochondrial function
Luo, Y., Wan, Q., Xu, M., Zhou, Q., Chen, X., Yin, D., He, H. and He, M.
Chem Biol Interact. 2019 Aug 25, 309:108723.

ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure
Kunovac, A., Hathaway, Q. A., Pinti, M. V., Goldsmith, W. T., Durr, A. J., Fink, G. K., Nurkiewicz, T. R. and Hollander, J. M.
Part Fibre Toxicol. 2019 Jun 18, 16(1):24.

Cell Physiology Research

Differentiated fibrocytes assume a functional mesenchymal phenotype with regenerative potential
Ling, C., Nishimoto, K., Rolfs, Z., Smith, L. M., Frey, B. L. and Welham, N. V.
Sci Adv. 2019 May, 5(5):eaav7384.

Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis
Goron, A., Lamarche, F., Blanchet, S., Delangle, P., Schlattner, U., Fontaine, E. and Moinard, C.
J Cachexia Sarcopenia Muscle. 2019 Aug, 10(4):919-928.

mTORC1 amplifies the ATF4-dependent de novo serine-glycine pathway to supply glycine during TGF-beta1-induced collagen biosynthesis
Selvarajah, B., Azuelos, I., Plate, M., Guillotin, D., Forty, E. J., Contento, G., Woodcock, H. V., Redding, M., Taylor, A., Brunori, G., Durrenberger, P. F., Ronzoni, R., Blanchard, A. D., Mercer, P. F., Anastasiou, D. and Chambers, R. C.
Sci Signal. 2019 May 21, 12(582).

Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility
Tencerova, M., Frost, M., Figeac, F., Nielsen, T. K., Ali, D., Lauterlein, J. L., Andersen, T. L., Haakonsson, A. K., Rauch, A., Madsen, J. S., Ejersted, C., Hojlund, K. and Kassem, M.
Cell Rep. 2019 May 14, 27(7):2050-2062 e6.

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading
Nisr, R. B., Shah, D. S., Ganley, I. G. and Hundal, H. S.
Cell Mol Life Sci. 2019 May 17, [epub ahead of print]

Robust intrinsic differences in mitochondrial respiration and H2O2 emission between L6 and C2C12 cells
Robinson, M. M., Sather, B. K., Burney, E. R., Ehrlicher, S. E., Stierwalt, H. D., Franco, M. C. and Newsom, S. A.
Am J Physiol Cell Physiol. 2019 Aug 1, 317(2):C339-C347.

Platelet bioenergetics correlate with muscle energetics and are altered in older adults
Braganza, A., Corey, C. G., Santanasto, A. J., Distefano, G., Coen, P. M., Glynn, N. W., Nouraie, S. M., Goodpaster, B. H., Newman, A. B. and Shiva, S.
JCI Insight. 2019 May 23, 5.

Dynamic modelling of an ACADS genotype in fatty acid oxidation - Application of cellular models for the analysis of common genetic variants
Matejka, K., Stuckler, F., Salomon, M., Ensenauer, R., Reischl, E., Hoerburger, L., Grallert, H., Kastenmuller, G., Peters, A., Daniel, H., Krumsiek, J., Theis, F. J., Hauner, H. and Laumen, H.
PLoS One. 2019 May 23, 14(5):e0216110.

Essential role of the PGC-1alpha/PPARbeta axis in Ucp3 gene induction
Lima, T. I., Guimaraes, D., Sponton, C. H., Bajgelman, M. C., Palameta, S., Toscaro, J. M., Reis, O. and Silveira, L. R.
J Physiol. 2019 Aug, 597(16):4277-4291.

Regulation of lactate production through p53/beta-enolase axis contributes to statin-associated muscle symptoms
Huang, J., Du, J., Lin, W., Long, Z., Zhang, N., Huang, X., Xie, Y., Liu, L. and Ma, W.
EBioMedicine. 2019 Jul, 45:251-260.

Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease
Lai, J. H., Chen, K. Y., Wu, J. C., Olson, L., Brene, S., Huang, C. Z., Chen, Y. H., Kang, S. J., Ma, K. H., Hoffer, B. J., Hsieh, T. H. and Chiang, Y. H.
Brain Res. 2019 Oct 1, 1720:146301.

Drug Discovery

Monoamine receptor interaction profiles of 4-aryl-substituted 2,5-dimethoxyphenethylamines (2C-BI derivatives)
Luethi, D., Widmer, R., Trachsel, D., Hoener, M. C. and Liechti, M. E.
Eur J Pharmacol. 2019 Jul 15, 855:103-111.

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Cheng, G., Zhang, Q., Pan, J., Lee, Y., Ouari, O., Hardy, M., Zielonka, M., Myers, C. R., Zielonka, J., Weh, K., Chang, A. C., Chen, G., Kresty, L., Kalyanaraman, B. and You, M.
Nat Commun. 2019 May 17, 10(1):2205.

Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment
Li, Y., Luo, J., Lin, M. T., Zhi, P., Guo, W. W., Han, M., You, J. and Gao, J. Q.
Mol Pharm. 2019 Jul 1, 16(7):2966-2979.

Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites
Ackerson, T., Amberg, A., Atzrodt, J., Arabeyre, C., Defossa, E., Dorau, M., Dudda, A., Dwyer, J., Holla, W., Kissner, T., Kohlmann, M., Kurzel, U., Panczel, J., Rajanna, S., Riedel, J., Schmidt, F., Wase, K., Weitz, D. and Derdau, V.
J Biochem Mol Toxicol. 2019 Aug, 33(8):e22345.

Chemically Modified Variants of Fenofibrate with Antiglioblastoma Potential
Stalinska, J., Zimolag, E., Pianovich, N. A., Zapata, A., Lassak, A., Rak, M., Dean, M., Ucar-Bilyeu, D., Wyczechowska, D., Culicchia, F., Marrero, L., Del Valle, L., Sarkaria, J., Peruzzi, F., Jursic, B. S. and Reiss, K.
Transl Oncol. 2019 Jul, 12(7):895-907.

Human lung fibroblast-to-myofibroblast transformation is not driven by an LDH5-dependent metabolic shift towards aerobic glycolysis
Schruf, E., Schroeder, V., Kuttruff, C. A., Weigle, S., Krell, M., Benz, M., Bretschneider, T., Holweg, A., Schuler, M., Frick, M., Nicklin, P., Garnett, J. P. and Sobotta, M. C.
Respir Res. 2019 May 9, 20(1):87.

Mitochondrial complex I inhibitor deguelin induces metabolic reprogramming and sensitizes vemurafenib-resistant BRAF(V600E) mutation bearing metastatic melanoma cells
Carpenter, E. L., Chagani, S., Nelson, D., Cassidy, P. B., Laws, M., Ganguli-Indra, G. and Indra, A. K.
Mol Carcinog. 2019 Sep, 58(9):1680-1690.

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer
Civenni, G., Bosotti, R., Timpanaro, A., Vazquez, R., Merulla, J., Pandit, S., Rossi, S., Albino, D., Allegrini, S., Mitra, A., Mapelli, S. N., Vierling, L., Giurdanella, M., Marchetti, M., Paganoni, A., Rinaldi, A., Losa, M., Mira-Cato, E., D'Antuono, R., Morone, D., Rezai, K., D'Ambrosio, G., Ouafik, L., Mackenzie, S., Riveiro, M. E., Cvitkovic, E., Carbone, G. M. and Catapano, C. V.
Cell Metab. 2019 Aug 6, 30(2):303-318 e6.

CDK9 Inhibition Induces a Metabolic Switch that Renders Prostate Cancer Cells Dependent on Fatty Acid Oxidation
Itkonen, H. M., Poulose, N., Walker, S. and Mills, I. G.
Neoplasia. 2019 Jul, 21(7):713-720.

Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis
Kalia, N. P., Shi Lee, B., Ab Rahman, N. B., Moraski, G. C., Miller, M. J. and Pethe, K.
Sci Rep. 2019 Jun 13, 9(1):8608.

Food & Nutritional Research

Extracts of Maca (Lepidium meyenii) Root Induce Increased Glucose Uptake by Inhibiting Mitochondrial Function in an Adipocyte Cell Line
Chen, H., Han, Y., Jahan, I., Wu, S., Clark, B. C. and Wiseman, J. S.
Journal of Herbal Medicine. 2019 May 14, 100282.

Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes
Solsona-Vilarrasa, E., Fucho, R., Torres, S., Nunez, S., Nuno-Lambarri, N., Enrich, C., Garcia-Ruiz, C. and Fernandez-Checa, J. C.
Redox Biol. 2019 Jun, 24:101214.

Vitamin C promotes the proliferation and effector functions of human gammadelta T cells
Kouakanou, L., Xu, Y., Peters, C., He, J., Wu, Y., Yin, Z. and Kabelitz, D.
Cell Mol Immunol. 2019 Jun 6, [epub ahead of print]

Hepatobiology Research

Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration
Mazibuko-Mbeje, S. E., Dludla, P. V., Johnson, R., Joubert, E., Louw, J., Ziqubu, K., Tiano, L., Silvestri, S., Orlando, P., Opoku, A. R. and Muller, C. J. F.
PLoS One. 2019 May 2, 14(5):e0216172.

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Kanemoto, N., Okamoto, T., Tanabe, K., Shimada, T., Minoshima, H., Hidoh, Y., Aoyama, M., Ban, T., Kobayashi, Y., Ando, H., Inoue, Y., Itotani, M. and Sato, S.
Nat Commun. 2019 May 15, 10(1):2172.

Pilot study of mitochondrial bioenergetics in subjects with acute porphyrias
Dixon, N., Li, T., Marion, B., Faust, D., Dozier, S., Molina, A., Rudnick, S. and Bonkovsky, H. L.
Mol Genet Metab. 2019 May 20, [epub ahead of print]

Cholesterol enrichment in liver mitochondria impairs oxidative phosphorylation and disrupts the assembly of respiratory supercomplexes
Solsona-Vilarrasa, E., Fucho, R., Torres, S., Nunez, S., Nuno-Lambarri, N., Enrich, C., Garcia-Ruiz, C. and Fernandez-Checa, J. C.
Redox Biol. 2019 Jun, 24:101214.

Methionine Adenosyltransferase alpha1 Is Targeted to the Mitochondrial Matrix and Interacts with Cytochrome P450 2E1 to Lower Its Expression
Murray, B., Peng, H., Barbier-Torres, L., Robinson, A. E., Li, T. W. H., Fan, W., Tomasi, M. L., Gottlieb, R. A., Van Eyk, J., Lu, Z., Martinez-Chantar, M. L., Liangpunsakul, S., Skill, N. J., Mato, J. M. and Lu, S. C.
Hepatology. 2019 May 11, [epub ahead of print]

NAD(P)H Quinone Dehydrogenase 1 Ablation Inhibits Activation of the Phosphoinositide 3-Kinase/Akt Serine/Threonine Kinase and Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathways and Blocks Metabolic Adaptation in Hepatocellular Carcinoma
Dimri, M., Humphries, A., Laknaur, A., Elattar, S., Lee, T. J., Sharma, A., Kolhe, R. and Satyanarayana, A.
Hepatology. 2019 Jun 19, [epub ahead of print]

Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells
Bae, M., Lee, Y., Park, Y. K., Shin, D. G., Joshi, P., Hong, S. H., Alder, N., Koo, S. I. and Lee, J. Y.
J Nutr Biochem. 2019 Sep, 71:82-89.

In silico-guided optimisation of oxygen gradients in hepatic spheroids
Leedale, J., Colley, H. E., Gaskell, H., Williams, D. P., Bearon, R. N., Chadwick, A. E., Murdoch, C. and Webb, S. D.
Computational Toxicology. 2019 Nov, 12:100093.

Immunology Research

Akt and STAT5 mediate naive human CD4+ T-cell early metabolic response to TCR stimulation
Jones, N., Vincent, E. E., Cronin, J. G., Panetti, S., Chambers, M., Holm, S. R., Owens, S. E., Francis, N. J., Finlay, D. K. and Thornton, C. A.
Nat Commun. 2019 May 3, 10(1):2042.

Celiac disease-associated Neisseria flavescens decreases mitochondrial respiration in CaCo-2 epithelial cells: Impact of Lactobacillus paracasei CBA L74 on bacterial-induced cellular imbalance
Labruna, G., Nanayakkara, M., Pagliuca, C., Nunziato, M., Iaffaldano, L., D'Argenio, V., Colicchio, R., Budelli, A. L., Nigro, R., Salvatore, P., Barone, M. V. and Sacchetti, L.
Cell Microbiol. 2019 Aug, 21(8):e13035.

The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc
Dong, H., Adams, N. M., Xu, Y., Cao, J., Allan, D. S. J., Carlyle, J. R., Chen, X., Sun, J. C. and Glimcher, L. H.
Nat Immunol. 2019 Jul, 20(7):865-878.

Pilot study of mitochondrial bioenergetics in subjects with acute porphyrias
Dixon, N., Li, T., Marion, B., Faust, D., Dozier, S., Molina, A., Rudnick, S. and Bonkovsky, H. L.
Mol Genet Metab. 2019 May 20, [epub ahead of print]

Aedes aegypti saliva impairs M1-associated proinflammatory phenotype without promoting or affecting M2 polarization of murine macrophages
Barros, M. S., Lara, P. G., Fonseca, M. T., Moretti, E. H., Filgueiras, L. R., Martins, J. O., Capurro, M. L., Steiner, A. A. and Sa-Nunes, A.
Parasit Vectors. 2019 May 16, 12(1):239.

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2
Burgener, A. V., Bantug, G. R., Meyer, B. J., Higgins, R., Ghosh, A., Bignucolo, O., Ma, E. H., Loeliger, J., Unterstab, G., Geigges, M., Steiner, R., Enamorado, M., Ivanek, R., Hunziker, D., Schmidt, A., Muller-Durovic, B., Grahlert, J., Epple, R., Dimeloe, S., Lotscher, J., Sauder, U., Ebnother, M., Burger, B., Heijnen, I., Martinez-Cano, S., Cantoni, N., Brucker, R., Kahlert, C. R., Sancho, D., Jones, R. G., Navarini, A., Recher, M. and Hess, C.
Nat Immunol. 2019 Oct, 20(10):1311-1321.

Protosappanin A protects against experimental autoimmune myocarditis, and induces metabolically reprogrammed tolerogenic DCs
Wu, J., Liu, M., Mang, G., Yu, S., Chen, Q., Li, T., Wang, Y., Meng, Y., Tang, X., Zheng, Y., Sun, Y., Zhang, M. and Yu, B.
Pharmacol Res. 2019 Aug, 146:104269.

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading
Nisr, R. B., Shah, D. S., Ganley, I. G. and Hundal, H. S.
Cell Mol Life Sci. 2019 May 17, [epub ahead of print]

Immunometabolic Responses of Natural Killer Cells to Inhibitory Tumor Microenvironment Checkpoints
Dao, T. N. and Matosevic, S.
Immunometabolism. 2019 May 23, 1(1):e190003.

Dihomo-gamma-linolenic acid inhibits several key cellular processes associated with atherosclerosis
Gallagher, H., Williams, J. O., Ferekidis, N., Ismail, A., Chan, Y. H., Michael, D. R., Guschina, I. A., Tyrrell, V. J., O'Donnell, V. B., Harwood, J. L., Khozin-Goldberg, I., Boussiba, S. and Ramji, D. P.
Biochim Biophys Acta Mol Basis Dis. 2019 Sep 1, 1865(9):2538-2550.

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function
Bailis, W., Shyer, J. A., Zhao, J., Canaveras, J. C. G., Al Khazal, F. J., Qu, R., Steach, H. R., Bielecki, P., Khan, O., Jackson, R., Kluger, Y., Maher, L. J., 3rd, Rabinowitz, J., Craft, J. and Flavell, R. A.
Nature. 2019 Jul, 571(7765):403-407.

Vitamin C promotes the proliferation and effector functions of human gammadelta T cells
Kouakanou, L., Xu, Y., Peters, C., He, J., Wu, Y., Yin, Z. and Kabelitz, D.
Cell Mol Immunol. 2019 Jun 6, [epub ahead of print]

Effect of HIV infection and antiretroviral therapy on immune cellular functions
Korencak, M., Byrne, M., Richter, E., Schultz, B. T., Juszczak, P., Ake, J. A., Ganesan, A., Okulicz, J. F., Robb, M. L., de Los Reyes, B., Winning, S., Fandrey, J., Burgess, T. H., Esser, S., Michael, N. L., Agan, B. K. and Streeck, H.
JCI Insight. 2019 Jun 20, 4(12).

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide
Lee, C., Jeong, H., Bae, Y., Shin, K., Kang, S., Kim, H., Oh, J. and Bae, H.
J Immunother Cancer. 2019 Jun 7, 7(1):147.

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8(+) T Cells
Hu, Z., Qu, G., Yu, X., Jiang, H., Teng, X. L., Ding, L., Hu, Q., Guo, X., Zhou, Y., Wang, F., Li, H. B., Chen, L., Jiang, J., Su, B., Liu, J. and Zou, Q.
Cell Metab. 2019 Aug 6, 30(2):290-302 e5.

Regulation of Fatty Acid Oxidation by Twist 1 in the Metabolic Adaptation of T Helper Lymphocytes to Chronic Inflammation
Hradilkova, K., Maschmeyer, P., Westendorf, K., Schliemann, H., Husak, O., von Stuckrad, A. S. L., Kallinich, T., Minden, K., Durek, P., Grun, J. R., Chang, H. D. and Radbruch, A.
Arthritis Rheumatol. 2019 Oct, 71(10):1756-1765.

Infectious Disease Research

Celiac disease-associated Neisseria flavescens decreases mitochondrial respiration in CaCo-2 epithelial cells: Impact of Lactobacillus paracasei CBA L74 on bacterial-induced cellular imbalance
Labruna, G., Nanayakkara, M., Pagliuca, C., Nunziato, M., Iaffaldano, L., D'Argenio, V., Colicchio, R., Budelli, A. L., Nigro, R., Salvatore, P., Barone, M. V. and Sacchetti, L.
Cell Microbiol. 2019 Aug, 21(8):e13035.

Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria
Krishnamoorthy, G., Kaiser, P., Lozza, L., Hahnke, K., Mollenkopf, H. J. and Kaufmann, S. H. E.
MBio. 2019 May 21, 10(3).

Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis
Kalia, N. P., Shi Lee, B., Ab Rahman, N. B., Moraski, G. C., Miller, M. J. and Pethe, K.
Sci Rep. 2019 Jun 13, 9(1):8608.

Effect of HIV infection and antiretroviral therapy on immune cellular functions
Korencak, M., Byrne, M., Richter, E., Schultz, B. T., Juszczak, P., Ake, J. A., Ganesan, A., Okulicz, J. F., Robb, M. L., de Los Reyes, B., Winning, S., Fandrey, J., Burgess, T. H., Esser, S., Michael, N. L., Agan, B. K. and Streeck, H.
JCI Insight. 2019 Jun 20, 4(12).

Microbial Research

Celiac disease-associated Neisseria flavescens decreases mitochondrial respiration in CaCo-2 epithelial cells: Impact of Lactobacillus paracasei CBA L74 on bacterial-induced cellular imbalance
Labruna, G., Nanayakkara, M., Pagliuca, C., Nunziato, M., Iaffaldano, L., D'Argenio, V., Colicchio, R., Budelli, A. L., Nigro, R., Salvatore, P., Barone, M. V. and Sacchetti, L.
Cell Microbiol. 2019 Aug, 21(8):e13035.

Mycofactocin Is Associated with Ethanol Metabolism in Mycobacteria
Krishnamoorthy, G., Kaiser, P., Lozza, L., Hahnke, K., Mollenkopf, H. J. and Kaufmann, S. H. E.
MBio. 2019 May 21, 10(3).

Potential of Engineered Bacteriorhodopsins as Photoactivated Biomaterials in Modulating Neural Stem Cell Behavior
Han, H.-W., Ko, L.-N., Yang, C.-S. and Hsu, S.-h.
ACS Biomaterials Science & Engineering. 2019 May 22, 5(6):3068-3078.

Carbon metabolism modulates the efficacy of drugs targeting the cytochrome bc1:aa3 in Mycobacterium tuberculosis
Kalia, N. P., Shi Lee, B., Ab Rahman, N. B., Moraski, G. C., Miller, M. J. and Pethe, K.
Sci Rep. 2019 Jun 13, 9(1):8608.

Mitochondrial Disease Research

First-line Screening of OXPHOS Deficiencies Using Microscale Oxygraphy in Human Skin Fibroblasts: A Preliminary Study
Germain, N., Dessein, A. F., Vienne, J. C., Dobbelaere, D., Mention, K., Joncquel, M., Dekiouk, S., Laine, W., Kluza, J. and Marchetti, P.
Int J Med Sci. 2019 Jun 7, 16(7):931-938.

Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts
Lin, T. K., Chen, S. D., Chuang, Y. C., Lan, M. Y., Chuang, J. H., Wang, P. W., Hsu, T. Y., Wang, F. S., Tsai, M. H., Huang, S. T., Wang, X. W., Tsai, P. C., Lin, H. Y. and Liou, C. W.
Oxid Med Cell Longev. 2019 May 22, 2019:9537504.

Neurobiology Research

Monoamine receptor interaction profiles of 4-aryl-substituted 2,5-dimethoxyphenethylamines (2C-BI derivatives)
Luethi, D., Widmer, R., Trachsel, D., Hoener, M. C. and Liechti, M. E.
Eur J Pharmacol. 2019 Jul 15, 855:103-111.

Attenuation of Endoplasmic Reticulum Stress, Impaired Calcium Homeostasis, and Altered Bioenergetic Functions in MPP(+)-Exposed SH-SY5Y Cells Pretreated with Rutin
Enogieru, A. B., Haylett, W. L., Miller, H. C., van der Westhuizen, F. H., Hiss, D. C. and Ekpo, O. E.
Neurotox Res. 2019 May 4, [epub ahead of print]

Targeting lonidamine to mitochondria mitigates lung tumorigenesis and brain metastasis
Cheng, G., Zhang, Q., Pan, J., Lee, Y., Ouari, O., Hardy, M., Zielonka, M., Myers, C. R., Zielonka, J., Weh, K., Chang, A. C., Chen, G., Kresty, L., Kalyanaraman, B. and You, M.
Nat Commun. 2019 May 17, 10(1):2205.

Potential of Engineered Bacteriorhodopsins as Photoactivated Biomaterials in Modulating Neural Stem Cell Behavior
Han, H.-W., Ko, L.-N., Yang, C.-S. and Hsu, S.-h.
ACS Biomaterials Science & Engineering. 2019 May 22, 5(6):3068-3078.

Biogenic amines and activity levels alter the neural energetic response to aggressive social cues in the honey bee Apis mellifera
Rittschof, C. C., Vekaria, H. J., Palmer, J. H. and Sullivan, P. G.
J Neurosci Res. 2019 Aug, 97(8):991-1003.

Loss of PGC-1alpha in RPE induces mesenchymal transition and promotes retinal degeneration
Rosales, M. A. B., Shu, D. Y., Iacovelli, J. and Saint-Geniez, M.
Life Sci Alliance. 2019 May 17, 2(3).

Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death
Chan, C. M., Huang, D. Y., Sekar, P., Hsu, S. H. and Lin, W. W.
J Biomed Sci. 2019 May 22, 26(1):40.

Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects
Cheng, K.-C., Huang, C.-F., Wei, Y. and Hsu, S.-h.
NPG Asia Materials. 2019 Jun 7, 11(1).

eIF2B Mutations Cause Mitochondrial Malfunction in Oligodendrocytes
Herrero, M., Mandelboum, S. and Elroy-Stein, O.
Neuromolecular Med. 2019 Sep, 21(3):303-313.

Voluntary exercise delays progressive deterioration of markers of metabolism and behavior in a mouse model of Parkinson's disease
Lai, J. H., Chen, K. Y., Wu, J. C., Olson, L., Brene, S., Huang, C. Z., Chen, Y. H., Kang, S. J., Ma, K. H., Hoffer, B. J., Hsieh, T. H. and Chiang, Y. H.
Brain Res. 2019 Oct 1, 1720:146301.

Obesity, Diabetes & Metabolic Diseases

Aspalathin, a natural product with the potential to reverse hepatic insulin resistance by improving energy metabolism and mitochondrial respiration
Mazibuko-Mbeje, S. E., Dludla, P. V., Johnson, R., Joubert, E., Louw, J., Ziqubu, K., Tiano, L., Silvestri, S., Orlando, P., Opoku, A. R. and Muller, C. J. F.
PLoS One. 2019 May 2, 14(5):e0216172.

Cluh plays a pivotal role during adipogenesis by regulating the activity of mitochondria
Cho, E., Jung, W., Joo, H. Y., Park, E. R., Kim, M. Y., Kim, S. B., Kim, K. S., Lim, Y. B., Lee, K. H. and Shin, H. J.
Sci Rep. 2019 May 2, 9(1):6820.

Ectopic brown adipose tissue formation within skeletal muscle after brown adipose progenitor cell transplant augments energy expenditure
Liu, Y., Fu, W., Seese, K., Yin, A. and Yin, H.
FASEB J. 2019 Aug, 33(8):8822-8835.

Mesenchymal stem cells alleviate hypoxia-induced oxidative stress and enhance the pro-survival pathways in porcine islets
Tan, Y., Nie, W., Chen, C., He, X., Xu, Y., Ma, X., Zhang, J., Tan, M., Rong, P. and Wang, W.
Exp Biol Med (Maywood). 2019 Jun, 244(9):781-788.

Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler
Kanemoto, N., Okamoto, T., Tanabe, K., Shimada, T., Minoshima, H., Hidoh, Y., Aoyama, M., Ban, T., Kobayashi, Y., Ando, H., Inoue, Y., Itotani, M. and Sato, S.
Nat Commun. 2019 May 15, 10(1):2172.

Extracts of Maca (Lepidium meyenii) Root Induce Increased Glucose Uptake by Inhibiting Mitochondrial Function in an Adipocyte Cell Line
Chen, H., Han, Y., Jahan, I., Wu, S., Clark, B. C. and Wiseman, J. S.
Journal of Herbal Medicine. 2019 May 14, 100282.

Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility
Tencerova, M., Frost, M., Figeac, F., Nielsen, T. K., Ali, D., Lauterlein, J. L., Andersen, T. L., Haakonsson, A. K., Rauch, A., Madsen, J. S., Ejersted, C., Hojlund, K. and Kassem, M.
Cell Rep. 2019 May 14, 27(7):2050-2062 e6.

Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading
Nisr, R. B., Shah, D. S., Ganley, I. G. and Hundal, H. S.
Cell Mol Life Sci. 2019 May 17, [epub ahead of print]

Oxidative stress mediates depot-specific functional differences of human adipose-derived stem cells
Sriram, S., Yuan, C., Chakraborty, S., Tay, W., Park, M., Shabbir, A., Toh, S. A., Han, W. and Sugii, S.
Stem Cell Res Ther. 2019 May 21, 10(1):141.

Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic beta-cells
Haythorne, E., Rohm, M., van de Bunt, M., Brereton, M. F., Tarasov, A. I., Blacker, T. S., Sachse, G., Silva Dos Santos, M., Terron Exposito, R., Davis, S., Baba, O., Fischer, R., Duchen, M. R., Rorsman, P., MacRae, J. I. and Ashcroft, F. M.
Nat Commun. 2019 Jun 6, 10(1):2474.

"Beige" Cross Talk Between the Immune System and Metabolism
Banfai, K., Ernszt, D., Pap, A., Bai, P., Garai, K., Belharazem, D., Pongracz, J. E. and Kvell, K.
Front Endocrinol (Lausanne). 2019 Jun 18, 10:369.

The plant product quinic acid activates Ca(2+) -dependent mitochondrial function and promotes insulin secretion from pancreatic beta cells
Heikkila, E., Hermant, A., Thevenet, J., Bermont, F., Kulkarni, S. S., Ratajczak, J., Santo-Domingo, J., Dioum, E. H., Canto, C., Barron, D., Wiederkehr, A. and De Marchi, U.
Br J Pharmacol. 2019 Sep, 176(17):3250-3263.

Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction during tacrolimus-induced beta cell injury
Luo, K., Yu, J. H., Quan, Y., Shin, Y. J., Lee, K. E., Kim, H. L., Ko, E. J., Chung, B. H., Lim, S. W. and Yang, C. W.
Sci Rep. 2019 May 29, 9(1):7995.

Review Paper

The Whys and Hows of Calculating Total Cellular ATP Production Rate
Handel, M. E., Brand, M. D. and Mookerjee, S. A.
Trends Endocrinol Metab. 2019 Jul, 30(7):412-416.

Imaging intratumoral metabolic heterogeneity
Walsh, A. J., Sharick, J. T. and Skala, M. C.
Nat Biomed Eng. 2019 May, 3(5):333-334.

Stem Cell Biology

R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cells
Sun, S., Xue, D., Chen, Z., Ou-Yang, Y., Zhang, J., Mai, J., Gu, J., Lu, W., Liu, X., Liu, W., Sheng, L., Lu, B., Lin, Y., Xing, F., Chen, Z., Mou, Y., Yan, G., Zhu, W. and Sai, K.
Cell Death Dis. 2019 May 1, 10(5):358.

Progesterone induced Warburg effect in HEK293 cells is associated with post-translational modifications and proteasomal degradation of progesterone receptor membrane component 1
Sabbir, M. G.
J Steroid Biochem Mol Biol. 2019 Jul, 191:105376.

Mesenchymal stem cells alleviate hypoxia-induced oxidative stress and enhance the pro-survival pathways in porcine islets
Tan, Y., Nie, W., Chen, C., He, X., Xu, Y., Ma, X., Zhang, J., Tan, M., Rong, P. and Wang, W.
Exp Biol Med (Maywood). 2019 Jun, 244(9):781-788.

Delta9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts
Lojpur, T., Easton, Z., Raez-Villanueva, S., Laviolette, S., Holloway, A. C. and Hardy, D. B.
Reprod Toxicol. 2019 Aug, 87:21-31.

Differentiated fibrocytes assume a functional mesenchymal phenotype with regenerative potential
Ling, C., Nishimoto, K., Rolfs, Z., Smith, L. M., Frey, B. L. and Welham, N. V.
Sci Adv. 2019 May, 5(5):eaav7384.

Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux
Lees, J. G., Cliff, T. S., Gammilonghi, A., Ryall, J. G., Dalton, S., Gardner, D. K. and Harvey, A. J.
Stem Cells Int. 2019 May 18, 2019:8195614.

Mitochondrial adaptation in human mesenchymal stem cells following ionizing radiation
Patten, D. A., Ouellet, M., Allan, D. S., Germain, M., Baird, S. D., Harper, M. E. and Richardson, R. B.
FASEB J. 2019 Aug, 33(8):9263-9278.

Obesity-Associated Hypermetabolism and Accelerated Senescence of Bone Marrow Stromal Stem Cells Suggest a Potential Mechanism for Bone Fragility
Tencerova, M., Frost, M., Figeac, F., Nielsen, T. K., Ali, D., Lauterlein, J. L., Andersen, T. L., Haakonsson, A. K., Rauch, A., Madsen, J. S., Ejersted, C., Hojlund, K. and Kassem, M.
Cell Rep. 2019 May 14, 27(7):2050-2062 e6.

Loss of PGC-1alpha in RPE induces mesenchymal transition and promotes retinal degeneration
Rosales, M. A. B., Shu, D. Y., Iacovelli, J. and Saint-Geniez, M.
Life Sci Alliance. 2019 May 17, 2(3).

Oxidative stress mediates depot-specific functional differences of human adipose-derived stem cells
Sriram, S., Yuan, C., Chakraborty, S., Tay, W., Park, M., Shabbir, A., Toh, S. A., Han, W. and Sugii, S.
Stem Cell Res Ther. 2019 May 21, 10(1):141.

Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer
Civenni, G., Bosotti, R., Timpanaro, A., Vazquez, R., Merulla, J., Pandit, S., Rossi, S., Albino, D., Allegrini, S., Mitra, A., Mapelli, S. N., Vierling, L., Giurdanella, M., Marchetti, M., Paganoni, A., Rinaldi, A., Losa, M., Mira-Cato, E., D'Antuono, R., Morone, D., Rezai, K., D'Ambrosio, G., Ouafik, L., Mackenzie, S., Riveiro, M. E., Cvitkovic, E., Carbone, G. M. and Catapano, C. V.
Cell Metab. 2019 Aug 6, 30(2):303-318 e6.

Astaxanthin attenuates the increase in mitochondrial respiration during the activation of hepatic stellate cells
Bae, M., Lee, Y., Park, Y. K., Shin, D. G., Joshi, P., Hong, S. H., Alder, N., Koo, S. I. and Lee, J. Y.
J Nutr Biochem. 2019 Sep, 71:82-89.

Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects
Cheng, K.-C., Huang, C.-F., Wei, Y. and Hsu, S.-h.
NPG Asia Materials. 2019 Jun 7, 11(1).

Non-proteolytic ubiquitination of Hexokinase 2 by HectH9 controls tumor metabolism and cancer stem cell expansion
Lee, H. J., Li, C. F., Ruan, D., He, J., Montal, E. D., Lorenz, S., Girnun, G. D. and Chan, C. H.
Nat Commun. 2019 Jun 14, 10(1):2625.

ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure
Kunovac, A., Hathaway, Q. A., Pinti, M. V., Goldsmith, W. T., Durr, A. J., Fink, G. K., Nurkiewicz, T. R. and Hollander, J. M.
Part Fibre Toxicol. 2019 Jun 18, 16(1):24.

Harnessing Hematopoietic Stem Cell Low Intracellular Calcium Improves Their Maintenance In Vitro
Luchsinger, L. L., Strikoudis, A., Danzl, N. M., Bush, E. C., Finlayson, M. O., Satwani, P., Sykes, M., Yazawa, M. and Snoeck, H. W.
Cell Stem Cell. 2019 Aug 1, 25(2):225-240 e7.

IDO1 Maintains Pluripotency of Primed Human Embryonic Stem Cells by Promoting Glycolysis
Liu, X., Wang, M., Jiang, T., He, J., Fu, X. and Xu, Y.
Stem Cells. 2019 Sep, 37(9):1158-1165.

Techniques & Methods

Novel chitosan–cellulose nanofiber self-healing hydrogels to correlate self-healing properties of hydrogels with neural regeneration effects
Cheng, K.-C., Huang, C.-F., Wei, Y. and Hsu, S.-h.
NPG Asia Materials. 2019 Jun 7, 11(1).

Toxicology Research

Delta9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts
Lojpur, T., Easton, Z., Raez-Villanueva, S., Laviolette, S., Holloway, A. C. and Hardy, D. B.
Reprod Toxicol. 2019 Aug, 87:21-31.

Mechanistic investigations of the liver toxicity of the free fatty acid receptor 1 agonist fasiglifam (TAK875) and its primary metabolites
Ackerson, T., Amberg, A., Atzrodt, J., Arabeyre, C., Defossa, E., Dorau, M., Dudda, A., Dwyer, J., Holla, W., Kissner, T., Kohlmann, M., Kurzel, U., Panczel, J., Rajanna, S., Riedel, J., Schmidt, F., Wase, K., Weitz, D. and Derdau, V.
J Biochem Mol Toxicol. 2019 Aug, 33(8):e22345.

Arsenic-induced metabolic shift triggered by the loss of miR-199a-5p through Sp1-dependent DNA methylation
He, J., Liu, W., Ge, X., Wang, G. C., Desai, V., Wang, S., Mu, W., Bhardwaj, V., Seifert, E., Liu, L. Z., Bhushan, A., Peiper, S. C. and Jiang, B. H.
Toxicol Appl Pharmacol. 2019 Sep 1, 378:114606.

ROS promote epigenetic remodeling and cardiac dysfunction in offspring following maternal engineered nanomaterial (ENM) exposure
Kunovac, A., Hathaway, Q. A., Pinti, M. V., Goldsmith, W. T., Durr, A. J., Fink, G. K., Nurkiewicz, T. R. and Hollander, J. M.
Part Fibre Toxicol. 2019 Jun 18, 16(1):24.

Common E-Cigarette Flavoring Chemicals Impair Neutrophil Phagocytosis and Oxidative Burst
Hickman, E., Herrera, C. A. and Jaspers, I.
Chem Res Toxicol. 2019 Jun 17, 32(6):982-985.

Translational Research

Pilot study of mitochondrial bioenergetics in subjects with acute porphyrias
Dixon, N., Li, T., Marion, B., Faust, D., Dozier, S., Molina, A., Rudnick, S. and Bonkovsky, H. L.
Mol Genet Metab. 2019 May 20, [epub ahead of print]

SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2
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