Core metabolic pathways dictate potency and persistence in adoptive T cell therapy

In this webinar Dr. John Connolly, Chief Scientific Officer from Tessa Therapeutics, will present a novel flow cytometry-based method to demonstrate the importance of metabolic change in memory T cell differentiation and highlight these factors as critical quality attributes of adoptive T cell therapy. A complex interaction of anabolic and catabolic metabolism underpins T cell polarization and memory differentiation. The capacity of these cells to respond and adapt to changing environments by metabolic reprogramming is crucial to their effector function.

Tune in to learn more about how:

  • A novel flow cytometry-based method that captures the metabolic state of immune cells by targeting key proteins and rates
  • The use cell metabolomics, demonstrating the ability to simultaneously measure divergent metabolic profiles and dynamic remodeling in human T cells
  • The identification of a T cell central memory subpopulation that shows unique glycolytic dependence and proinflammatory phenotype

Date:
Wednesday, October 23, 2019

Time:
08:00 PDT (Los Angeles)
11:00 EDT (New York)
16:00 BST (London)

Presented by:


A/Prof John Connolly, PhD Chief Scientific Officer,
Tessa Therapeutics Ltd
Research Director, Institute of Molecular and Cellular Biology (IMCB)
Associate Professor, NUSMed-A*STAR Special Joint Appointment

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For Research Use Only. Not for use in diagnostic procedures.

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