XF Publications Alert - September 2019

The Publications Alert gathers and compiles a list of all the most recent peer-reviewed publications containing Seahorse XF and Soluble Sensor data, based solely on user-generated content.

Aging Research

STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice
Darling, R. J., Senapati, S., Kelly, S. M., Kohut, M. L., Narasimhan, B. and Wannemuehler, M. J.
Vaccine. 2019 May 6, 37(20):2721-2730.

High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD
Cai, H., Gong, J., Abriola, L., Hoyer, D., Nyscf Global Stem Cell Array, T., Noggle, S., Paull, D., Del Priore, L. V. and Fields, M. A.
Exp Eye Res. 2019 Aug 1, 185: 107641.

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve
Jassim, A. H., Coughlin, L., Harun-Or-Rashid, M., Kang, P. T., Chen, Y. R. and Inman, D. M.
Mol Neurobiol. 2019 Oct 1, 56(10):7097-7112.

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging
Gohlke, S., Zagoriy, V., Cuadros Inostroza, A., Meret, M., Mancini, C., Japtok, L., Schumacher, F., Kuhlow, D., Graja, A., Stephanowitz, H., Jahnert, M., Krause, E., Wernitz, A., Petzke, K. J., Schurmann, A., Kleuser, B. and Schulz, T. J.
Mol Metab. 2019 Jun 1, 24:1-17.

Oxidative stress-induced senescence markedly increases disc cell bioenergetics
Patil, P., Falabella, M., Saeed, A., Lee, D., Kaufman, B., Shiva, S., Croix, C. S., Van Houten, B., Niedernhofer, L. J., Robbins, P. D., Lee, J., Gwendolyn, S. and Vo, N. V.
Mech Ageing Dev. 2019 Jun 1, 180:97-106.

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
Tarantini, S., Valcarcel-Ares, M. N., Toth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M., Ballabh, P., Sule, Z., Farkas, E., Baur, J. A., Sinclair, D. A., Csiszar, A. and Ungvari, Z.
Redox Biol. 2019 Jun 1, 24:101192.

Assays under Hypoxia

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Ast, T., Meisel, J. D., Patra, S., Wang, H., Grange, R. M. H., Kim, S. H., Calvo, S. E., Orefice, L. L., Nagashima, F., Ichinose, F., Zapol, W. M., Ruvkun, G., Barondeau, D. P. and Mootha, V. K.
Cell. 2019 May 30, 177(6):1507-1521 e16.

Cancer Research

Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state
Echeverria, G. V., Ge, Z., Seth, S., Zhang, X., Jeter-Jones, S., Zhou, X., Cai, S., Tu, Y., McCoy, A., Peoples, M., Sun, Y., Qiu, H., Chang, Q., Bristow, C., Carugo, A., Shao, J., Ma, X., Harris, A., Mundi, P., Lau, R., Ramamoorthy, V., Wu, Y., Alvarez, M. J., Califano, A., Moulder, S. L., Symmans, W. F., Marszalek, J. R., Heffernan, T. P., Chang, J. T. and Piwnica-Worms, H.
Sci Transl Med. 2019 Apr 17, 11(488).

Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-кB signaling pathways and decreases metabolic phenotypes and metastatic activity in colon cancer cells
Afrin, S., Forbes-Hernández, T. Y., Cianciosi, D., Pistollato, F., Zhang, J., Pacetti, M., Amici, A., Reboredo-Rodríguez, P., Simal-Gandara, J., Bompadre, S., Quiles, J. L., Giampieri, F. and Battino, M.
Journal of Functional Foods. 2019 June 1, 57:477-487.

Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC
Ciaramella, V., Sasso, F. C., Di Liello, R., Corte, C. M. D., Barra, G., Viscardi, G., Esposito, G., Sparano, F., Troiani, T., Martinelli, E., Orditura, M., De Vita, F., Ciardiello, F. and Morgillo, F.
J Exp Clin Cancer Res. 2019 Apr 26, 38(1):178.

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells
Chakraborty, P., Chatterjee, S., Kesarwani, P., Thyagarajan, K., Iamsawat, S., Dalheim, A., Nguyen, H., Selvam, S. P., Nasarre, P., Scurti, G., Hardiman, G., Maulik, N., Ball, L., Gangaraju, V., Rubinstein, M. P., Klauber-DeMore, N., Hill, E. G., Ogretmen, B., Yu, X. Z., Nishimura, M. I. and Mehrotra, S.
J Biol Chem. 2019 Jun 7, 294(23):9198-9212. 

Oncogenic KRAS signaling activates mTORC1 through COUP-TFII-mediated lactate production
Byun, J. K., Park, M., Yun, J. W., Lee, J., Kim, J. S., Cho, S. J., Lee, Y. M., Lee, I. K., Choi, Y. K. and Park, K. G.
EMBO Rep. 2019 Jun 1, 20(6).

Transcriptional activation of SIRT6 via FKHRL1/FOXO3a inhibits the Warburg effect in glioblastoma cells
Dong, Z., Zhong, X., Lei, Q., Chen, F. and Cui, H. Cell Signal. 2019 Aug 1, 60:100-113.

Autophagy Regulation of Metabolism Is Required for CD8(+) T Cell Anti-tumor Immunity
DeVorkin, L., Pavey, N., Carleton, G., Comber, A., Ho, C., Lim, J., McNamara, E., Huang, H., Kim, P., Zacharias, L. G., Mizushima, N., Saitoh, T., Akira, S., Beckham, W., Lorzadeh, A., Moksa, M., Cao, Q., Murthy, A., Hirst, M., DeBerardinis, R. J. and Lum, J. J.
Cell Rep. 2019 Apr 9, 27(2):502-513 e5.

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3beta-MCL-1 Axis
Elgendy, M., Ciro, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. and Minucci, S.
Cancer Cell. 2019 May 13, 35(5):798-815 e5.

The miR-186-3p/EREG axis orchestrates tamoxifen resistance and aerobic glycolysis in breast cancer cells
He, M., Jin, Q., Chen, C., Liu, Y., Ye, X., Jiang, Y., Ji, F., Qian, H., Gan, D., Yue, S., Zhu, W. and Chen, T.
Oncogene. 2019 Jul 1, 38(28):5551-5565.

AMP-activated protein kinase regulates cancer cell growth and metabolism via nuclear and mitochondria events
Jiang, S., Wang, Y., Luo, L., Shi, F., Zou, J., Lin, H., Ying, Y., Luo, Y., Zhan, Z., Liu, P., Zhu, B., Huang, D. and Luo, Z.
J Cell Mol Med. 2019 Jun, 23(6):3951-3961.

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression
Jin, S., Guo, Y., Song, D., Zhu, Z., Zhang, Z., Sun, Y., Yang, T., Guo, Z. and Wang, X.
Inorg Chem. 2019 May 6, 58(9):6507-6516.

Repurposing the Electron Transfer Reactant Phenazine Methosulfate (PMS) for the Apoptotic Elimination of Malignant Melanoma Cells through Induction of Lethal Oxidative and Mitochondriotoxic Stress
Hua, A. B., Justiniano, R., Perer, J., Park, S. L., Li, H., Cabello, C. M. and Wondrak, G. T.
Cancers (Basel). 2019 Apr 27, 11(5).

LYRM2 directly regulates complex I activity to support tumor growth in colorectal cancer by oxidative phosphorylation
Huang, Q., Chen, Z., Cheng, P., Jiang, Z., Wang, Z., Huang, Y., Yang, C., Pan, J., Qiu, F. and Huang, J.
Cancer Lett. 2019 Jul 28, 455:36-47.

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-kappaB pathway
Han, C. J., Zheng, J. Y., Sun, L., Yang, H. C., Cao, Z. Q., Zhang, X. H., Zheng, L. T. and Zhen, X. C.
Acta Pharmacol Sin. 2019 Apr 23, [epub ahead of print]

Loss of PKM2 in Lgr5(+) intestinal stem cells promotes colitis-associated colorectal cancer
Kim, Y., Lee, Y. S., Kang, S. W., Kim, S., Kim, T. Y., Lee, S. H., Hwang, S. W., Kim, J., Kim, E. N., Ju, J. S., Park, Y. Y. and Kweon, M. N.
Sci Rep. 2019 Apr 17, 9(1):6212.

Autophagy-related 7 modulates tumor progression in triple-negative breast cancer
Li, M., Liu, J., Li, S., Feng, Y., Yi, F., Wang, L., Wei, S. and Cao, L.
Lab Invest. 2019 Sep 1, 99(9):1266-1274.

Cholesterol Induces CD8(+) T Cell Exhaustion in the Tumor Microenvironment
Ma, X., Bi, E., Lu, Y., Su, P., Huang, C., Liu, L., Wang, Q., Yang, M., Kalady, M. F., Qian, J., Zhang, A., Gupte, A. A., Hamilton, D. J., Zheng, C. and Yi, Q.
Cell Metab. 2019 Jul 2, 30(1):143-156 e5.

Transcriptional positive cofactor 4 promotes breast cancer proliferation and metastasis through c-Myc mediated Warburg effect
Luo, P., Zhang, C., Liao, F., Chen, L., Liu, Z., Long, L., Jiang, Z., Wang, Y., Wang, Z., Liu, Z., Miao, H. and Shi, C.
Cell Commun Signal. 2019 Apr 16, 17(1):36.

Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir
Manerba, M., Govoni, M., Manet, I., Leale, A., Comparone, A. and Di Stefano, G.
Biochim Biophys Acta Gen Subj. 2019 Jul, 1863(7):1177-1186.

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program
Thaventhiran, T., Wong, W., Alghanem, A. F., Alhumeed, N., Aljasir, M. A., Ramsey, S., Sethu, S., Yeang, H. X. A., Chadwick, A. E., Cross, M., Webb, S. D., Djouhri, L., Ball, C., Stebbings, R. and Sathish, J. G.
Monoclon Antib Immunodiagn Immunother. 2019 Apr 1, 38(2):60-69.

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model
Precazzini, F., Pancher, M., Gatto, P., Tushe, A., Adami, V., Anelli, V. and Mione, M. C.
Dev Biol. 2019 Apr 15, [epub ahead of print]

Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl alpha-Ketoglutarate
Sica, V., Bravo-San Pedro, J. M., Izzo, V., Pol, J., Pierredon, S., Enot, D., Durand, S., Bossut, N., Chery, A., Souquere, S., Pierron, G., Vartholomaiou, E., Zamzami, N., Soussi, T., Sauvat, A., Mondragon, L., Kepp, O., Galluzzi, L., Martinou, J. C., Hess-Stumpp, H., Ziegelbauer, K., Kroemer, G. and Maiuri, M. C.
Cell Rep. 2019 Apr 16, 27(3):820-834 e9.

Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk
Sheng, J., Shen, L., Sun, L., Zhang, X., Cui, R. and Wang, L.
Cell Prolif. 2019 May 1, 52(3):e12609.

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
Sundstrom, T., Prestegarden, L., Azuaje, F., Aasen, S. N., Rosland, G. V., Varughese, J. K., Bahador, M., Bernatz, S., Braun, Y., Harter, P. N., Skaftnesmo, K. O., Ingham, E. S., Mahakian, L. M., Tam, S., Tepper, C. G., Petersen, K., Ferrara, K. W., Tronstad, K. J., Lund-Johansen, M., Beschorner, R., Bjerkvig, R. and Thorsen, F.
Acta Neuropathol Commun. 2019 Apr 10, 7(1):55.

BA6 Induces Apoptosis via Stimulation of Reactive Oxygen Species and Inhibition of Oxidative Phosphorylation in Human Lung Cancer Cells
Cheng, M. H., Huang, H. L., Lin, Y. Y., Tsui, K. H., Chen, P. C., Cheng, S. Y., Chong, I. W., Sung, P. J., Tai, M. H., Wen, Z. H., Chen, N. F. and Kuo, H. M.
Oxid Med Cell Longev. 2019 May 7, 2019:6342104.

Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
Theodossiou, T. A., Ali, M., Grigalavicius, M., Grallert, B., Dillard, P., Schink, K. O., Olsen, C. E., Walchli, S., Inderberg, E. M., Kubin, A., Peng, Q. and Berg, K.
NPJ Breast Cancer. 2019 Apr 10, 5:13.

Fatty acid transport protein 2 reprograms neutrophils in cancer
Veglia, F., Tyurin, V. A., Blasi, M., De Leo, A., Kossenkov, A. V., Donthireddy, L., To, T. K. J., Schug, Z., Basu, S., Wang, F., Ricciotti, E., DiRusso, C., Murphy, M. E., Vonderheide, R. H., Lieberman, P. M., Mulligan, C., Nam, B., Hockstein, N., Masters, G., Guarino, M., Lin, C., Nefedova, Y., Black, P., Kagan, V. E. and Gabrilovich, D. I.
Nature. 2019 May, 569(7754):73-78.

Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma
Chen, D. P., Ning, W. R., Jiang, Z. Z., Peng, Z. P., Zhu, L. Y., Zhuang, S. M., Kuang, D. M., Zheng, L. and Wu, Y.
J Hepatol. 2019 Aug, 71(2):333-343.

Nf1 loss promotes Kras-driven lung adenocarcinoma and results in Psat1-mediated glutamate dependence
Wang, X., Min, S., Liu, H., Wu, N., Liu, X., Wang, T., Li, W., Shen, Y., Wang, H., Qian, Z., Xu, H., Zhao, C. and Chen, Y.
EMBO Mol Med. 2019 Jun, 11(6).

NKX2-8 deletion-induced reprogramming of fatty acid metabolism confers chemoresistance in epithelial ovarian cancer
Zhu, J., Wu, G., Song, L., Cao, L., Tan, Z., Tang, M., Li, Z., Shi, D., Zhang, S. and Li, J.
EBioMedicine. 2019 May, 43:238-252.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation
Vara-Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. and Hardie, D. G.
Cell Rep. 2019 Apr 16, 27(3):690-698 e4.

Zinc cooperates with p53 to inhibit the activity of mitochondrial aconitase through reactive oxygen species accumulation
Xue, Y. N., Liu, Y. N., Su, J., Li, J. L., Wu, Y., Guo, R., Yu, B. B., Yan, X. Y., Zhang, L. C., Sun, L. K. and Li, Y.
Cancer Med. 2019 May, 8(5):2462-2473.

SIRT3 elicited an anti-Warburg effect through HIF1alpha/PDK1/PDHA1 to inhibit cholangiocarcinoma tumorigenesis
Xu, L., Li, Y., Zhou, L., Dorfman, R. G., Liu, L., Cai, R., Jiang, C., Tang, D., Wang, Y., Zou, X., Wang, L. and Zhang, M.
Cancer Med. 2019 May, 8(5):2380-2391.

Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis
Aras, S., Maroun, M. C., Song, Y., Bandyopadhyay, S., Stark, A., Yang, Z. Q., Long, M. P., Grossman, L. I. and Fernandez-Madrid, F.
BMC Cancer. 2019 May 2, 19(1):411.

Cardiovascular Research

Glutamine Metabolism is Required for Collagen Protein Synthesis in Lung Fibroblasts
Hamanaka, R. B., O'Leary, E. M., Witt, L. J., Tian, Y., Gokalp, G. A., Meliton, A. Y., Dulin, N. O. and Mutlu, G. M.
Am J Respir Cell Mol Biol. 2019 Apr 11, [epub ahead of print]

Angiotensin II and TGF-beta1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
Gasiuniene, M., Petkus, G., Matuzevicius, D., Navakauskas, D. and Navakauskiene, R.
Int J Stem Cells. 2019 Jul 31, 12(2):251-264.

Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions
Thapa, D., Zhang, M., Manning, J. R., Guimaraes, D. A., Stoner, M. W., Lai, Y. C., Shiva, S. and Scott, I.
Physiol Rep. 2019 Apr, 7(8):e14054.

Acute exposure to triphenyl phosphate inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish embryos
Qi, Z., Chen, M., Song, Y., Wang, X., Li, B., Chen, Z. F., Tsang, S. Y. and Cai, Z.
J Cell Physiol. 2019 Nov, 234(11):21235-21248.

Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms
Wen, J., Wang, J., Li, P., Wang, R., Wang, J., Zhou, X., Zhang, L., Li, H., Wei, S., Cai, H. and Zhao, Y.
Biomed Pharmacother. 2019 Jul, 115:108881.

Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy
Tripathi, D., Biswas, B., Manhas, A., Singh, A., Goyal, D., Gaestel, M. and Jagavelu, K.
Arterioscler Thromb Vasc Biol. 2019 Jun, 39(6):1100-1112.

Cell Physiology Research

YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells
Chen, F., Zhou, J., Li, Y., Zhao, Y., Yuan, J., Cao, Y., Wang, L., Zhang, Z., Zhang, B., Wang, C. C., Cheung, T. H., Wu, Z., Wong, C. C., Sun, H. and Wang, H.
EMBO J. 2019 May 15, 38(10).

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A., Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. and Turek, F. W.
Science. 2019 Apr 12, 364(6436).

Oxidative stress-induced senescence markedly increases disc cell bioenergetics
Patil, P., Falabella, M., Saeed, A., Lee, D., Kaufman, B., Shiva, S., Croix, C. S., Van Houten, B., Niedernhofer, L. J., Robbins, P. D., Lee, J., Gwendolyn, S. and Vo, N. V.
Mech Ageing Dev. 2019 Jun 1, 180:97-106.

Loss of MCU prevents mitochondrial fusion in G1-S phase and blocks cell cycle progression and proliferation
Koval, O. M., Nguyen, E. K., Santhana, V., Fidler, T. P., Sebag, S. C., Rasmussen, T. P., Mittauer, D. J., Strack, S., Goswami, P. C., Abel, E. D. and Grumbach, I. M.
Sci Signal. 2019 Apr 30, 12(579).

Endothelium-Derived Factors Influence Differentiation of Fat-Derived Stromal Cells Post-Exercise in Subjects with Prediabetes
Kundu, N., Domingues, C. C., Nylen, E. S., Paal, E., Kokkinos, P. and Sen, S.
Metab Syndr Relat Disord. 2019 Apr 24, [epub ahead of print]

Metformin Delays Satellite Cell Activation and Maintains Quiescence
Pavlidou, T., Marinkovic, M., Rosina, M., Fuoco, C., Vumbaca, S., Gargioli, C., Castagnoli, L. and Cesareni, G.
Stem Cells Int. 2019 Apr 24, 2019:5980465.

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
Sala, D., Cunningham, T. J., Stec, M. J., Etxaniz, U., Nicoletti, C., Dall'Agnese, A., Puri, P. L., Duester, G., Latella, L. and Sacco, A.
Nat Commun. 2019 Apr 17, 10(1):1796.

NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy
Princely Abudu, Y., Pankiv, S., Mathai, B. J., Hakon Lystad, A., Bindesboll, C., Brenne, H. B., Yoke Wui Ng, M., Thiede, B., Yamamoto, A., Mutugi Nthiga, T., Lamark, T., Esguerra, C. V., Johansen, T. and Simonsen, A.
Dev Cell. 2019 May 20, 49(4):509-525 e12.

Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages
Angireddy, R., Kazmi, H. R., Srinivasan, S., Sun, L., Iqbal, J., Fuchs, S. Y., Guha, M., Kijima, T., Yuen, T., Zaidi, M. and Avadhani, N. G.
FASEB J. 2019 Aug, 33(8):9167-9181.

Drug Discovery

High-throughput screening identifies compounds that protect RPE cells from physiological stressors present in AMD

Cai, H., Gong, J., Abriola, L., Hoyer, D., Nyscf Global Stem Cell Array, T., Noggle, S., Paull, D., Del Priore, L. V. and Fields, M. A.
Exp Eye Res. 2019 Aug 1, 185: 107641.

Activity and molecular targets of pioglitazone via blockade of proliferation, invasiveness and bioenergetics in human NSCLC
Ciaramella, V., Sasso, F. C., Di Liello, R., Corte, C. M. D., Barra, G., Viscardi, G., Esposito, G., Sparano, F., Troiani, T., Martinelli, E., Orditura, M., De Vita, F., Ciardiello, F. and Morgillo, F.
J Exp Clin Cancer Res. 2019 Apr 26, 38(1):178.

Targeting Energy Metabolism by a Platinum(IV) Prodrug as an Alternative Pathway for Cancer Suppression
Jin, S., Guo, Y., Song, D., Zhu, Z., Zhang, Z., Sun, Y., Yang, T., Guo, Z. and Wang, X.
Inorg Chem. 2019 May 6, 58(9):6507-6516.

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism
Kelly, R. A., Leedale, J., Calleja, D., Enoch, S. J., Harrell, A., Chadwick, A. E. and Webb, S.
Sci Rep. 2019 Apr 19, 9(1):6333.

Metabolic activation triggered by cAMP in MCF-7 cells generates lethal vulnerability to combined oxamate/etomoxir
Manerba, M., Govoni, M., Manet, I., Leale, A., Comparone, A. and Di Stefano, G.
Biochim Biophys Acta Gen Subj. 2019 Jul, 1863(7):1177-1186.

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model
Precazzini, F., Pancher, M., Gatto, P., Tushe, A., Adami, V., Anelli, V. and Mione, M. C.
Dev Biol. 2019 Apr 15, [epub ahead of print]

Metabolomics reveals tepotinib-related mitochondrial dysfunction in MET-activating mutations-driven models
Poliakova, M., Felser, A., Pierzchala, K., Nuoffer, J. M., Aebersold, D. M., Zimmer, Y., Zamboni, N. and Medova, M.
FEBS J. 2019 Jul, 286(14):2692-2710.

Simultaneous defeat of MCF7 and MDA-MB-231 resistances by a hypericin PDT-tamoxifen hybrid therapy
Theodossiou, T. A., Ali, M., Grigalavicius, M., Grallert, B., Dillard, P., Schink, K. O., Olsen, C. E., Walchli, S., Inderberg, E. M., Kubin, A., Peng, Q. and Berg, K.
NPJ Breast Cancer. 2019 Apr 10, 5:13.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation
Vara-Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. and Hardie, D. G.
Cell Rep. 2019 Apr 16, 27(3):690-698 e4.

Protective effects of higenamine combined with [6]-gingerol against doxorubicin-induced mitochondrial dysfunction and toxicity in H9c2 cells and potential mechanisms
Wen, J., Wang, J., Li, P., Wang, R., Wang, J., Zhou, X., Zhang, L., Li, H., Wei, S., Cai, H. and Zhao, Y.
Biomed Pharmacother. 2019 Jul, 115:108881.

Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities
Wang, W., Wu, Y., Yang, K., Wu, C., Tang, R., Li, H. and Chen, L.
Eur J Med Chem. 2019 Jul 1, 173:282-293.

Food & Nutritional Research

Strawberry tree honey as a new potential functional food. Part 2: Strawberry tree honey increases ROS generation by suppressing Nrf2-ARE and NF-кB signaling pathways and decreases metabolic phenotypes and metastatic activity in colon cancer cells
Afrin, S., Forbes-Hernández, T. Y., Cianciosi, D., Pistollato, F., Zhang, J., Pacetti, M., Amici, A., Reboredo-Rodríguez, P., Simal-Gandara, J., Bompadre, S., Quiles, J. L., Giampieri, F. and Battino, M.
Journal of Functional Foods. 2019 June 1, 57:477-487.

Combination of Hypoglycemia and Metformin Impairs Tumor Metabolic Plasticity and Growth by Modulating the PP2A-GSK3beta-MCL-1 Axis
Elgendy, M., Ciro, M., Hosseini, A., Weiszmann, J., Mazzarella, L., Ferrari, E., Cazzoli, R., Curigliano, G., DeCensi, A., Bonanni, B., Budillon, A., Pelicci, P. G., Janssens, V., Ogris, M., Baccarini, M., Lanfrancone, L., Weckwerth, W., Foiani, M. and Minucci, S.
Cancer Cell. 2019 May 13, 35(5):798-815 e5.

Hepatobiology Research

Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1
Chen, L., Lang, A. L., Poff, G. D., Ding, W. X. and Beier, J. I.
Redox Biol. 2019 Jun 1, 24:101205.

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics
Brinkkoetter, P. T., Bork, T., Salou, S., Liang, W., Mizi, A., Ozel, C., Koehler, S., Hagmann, H. H., Ising, C., Kuczkowski, A., Schnyder, S., Abed, A., Schermer, B., Benzing, T., Kretz, O., Puelles, V. G., Lagies, S., Schlimpert, M., Kammerer, B., Handschin, C., Schell, C. and Huber, T. B.
Cell Rep. 2019 Apr 30, 27(5):1551-1566 e5.

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver
Cappel, D. A., Deja, S., Duarte, J. A. G., Kucejova, B., Inigo, M., Fletcher, J. A., Fu, X., Berglund, E. D., Liu, T., Elmquist, J. K., Hammer, S., Mishra, P., Browning, J. D. and Burgess, S. C.
Cell Metab. 2019 Jun 4, 29(6):1291-1305 e8.

Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells
Hao, Z., Zhang, Z., Lu, D., Ding, B., Shu, L., Zhang, Q. and Wang, C.
Chem Res Toxicol. 2019 Jun 17, 32(6):1250-1258.

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Kikuchi, K., Saigusa, D., Kanemitsu, Y., Matsumoto, Y., Thanai, P., Suzuki, N., Mise, K., Yamaguchi, H., Nakamura, T., Asaji, K., Mukawa, C., Tsukamoto, H., Sato, T., Oikawa, Y., Iwasaki, T., Oe, Y., Tsukimi, T., Fukuda, N. N., Ho, H. J., Nanto-Hara, F., Ogura, J., Saito, R., Nagao, S., Ohsaki, Y., Shimada, S., Suzuki, T., Toyohara, T., Mishima, E., Shima, H., Akiyama, Y., Akiyama, Y., Ichijo, M., Matsuhashi, T., Matsuo, A., Ogata, Y., Yang, C. C., Suzuki, C., Breeggemann, M. C., Heymann, J., Shimizu, M., Ogawa, S., Takahashi, N., Suzuki, T., Owada, Y., Kure, S., Mano, N., Soga, T., Wada, T., Kopp, J. B., Fukuda, S., Hozawa, A., Yamamoto, M., Ito, S., Wada, J., Tomioka, Y. and Abe, T.
Nat Commun. 2019 Apr 23, 10(1):1835.

Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk
Sheng, J., Shen, L., Sun, L., Zhang, X., Cui, R. and Wang, L.
Cell Prolif. 2019 May 1, 52(3):e12609.

[D-Ala(2), D-Leu(5)] Enkephalin Improves Liver Preservation During Normothermic Ex Vivo Perfusion
Beal, E. W., Kim, J. L., Reader, B. F., Akateh, C., Maynard, K., Washburn, W. K., Zweier, J. L., Whitson, B. A. and Black, S. M.
J Surg Res. 2019 Sep, 241:323-335.

Immunology Research

STING pathway stimulation results in a differentially activated innate immune phenotype associated with low nitric oxide and enhanced antibody titers in young and aged mice
Darling, R. J., Senapati, S., Kelly, S. M., Kohut, M. L., Narasimhan, B. and Wannemuehler, M. J.
Vaccine. 2019 May 6, 37(20):2721-2730.

Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells
Chakraborty, P., Chatterjee, S., Kesarwani, P., Thyagarajan, K., Iamsawat, S., Dalheim, A., Nguyen, H., Selvam, S. P., Nasarre, P., Scurti, G., Hardiman, G., Maulik, N., Ball, L., Gangaraju, V., Rubinstein, M. P., Klauber-DeMore, N., Hill, E. G., Ogretmen, B., Yu, X. Z., Nishimura, M. I. and Mehrotra, S.
J Biol Chem. 2019 Jun 7, 294(23):9198-9212. 

Autophagy Regulation of Metabolism Is Required for CD8(+) T Cell Anti-tumor Immunity
DeVorkin, L., Pavey, N., Carleton, G., Comber, A., Ho, C., Lim, J., McNamara, E., Huang, H., Kim, P., Zacharias, L. G., Mizushima, N., Saitoh, T., Akira, S., Beckham, W., Lorzadeh, A., Moksa, M., Cao, Q., Murthy, A., Hirst, M., DeBerardinis, R. J. and Lum, J. J.
Cell Rep. 2019 Apr 9, 27(2):502-513 e5.

Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
Dreschers, S., Ohl, K., Lehrke, M., Mollmann, J., Denecke, B., Costa, I., Vogl, T., Viemann, D., Roth, J., Orlikowsky, T. and Tenbrock, K.
Nat Commun. 2019 Apr 11, 10(1):1685.

Glia maturation factor-gamma regulates murine macrophage iron metabolism and M2 polarization through mitochondrial ROS
Aerbajinai, W., Ghosh, M. C., Liu, J., Kumkhaek, C., Zhu, J., Chin, K., Rouault, T. A. and Rodgers, G. P.
Blood Adv. 2019 Apr 23, 3(8):1211-1225.

Histaminergic transmission slows progression of amyotrophic lateral sclerosis
Apolloni, S., Amadio, S., Fabbrizio, P., Morello, G., Spampinato, A. G., Latagliata, E. C., Salvatori, I., Proietti, D., Ferri, A., Madaro, L., Puglisi-Allegra, S., Cavallaro, S. and Volonte, C.
J Cachexia Sarcopenia Muscle. 2019 Aug 1, 10(4):872-893.

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-kappaB pathway
Han, C. J., Zheng, J. Y., Sun, L., Yang, H. C., Cao, Z. Q., Zhang, X. H., Zheng, L. T. and Zhen, X. C.
Acta Pharmacol Sin. 2019 Apr 23, [epub ahead of print]

Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation
Ferreiros-Vidal, I., Carroll, T., Zhang, T., Lagani, V., Ramirez, R. N., Ing-Simmons, E., Gomez-Valades, A. G., Cooper, L., Liang, Z., Papoutsoglou, G., Dharmalingam, G., Guo, Y., Tarazona, S., Fernandes, S. J., Noori, P., Silberberg, G., Fisher, A. G., Tsamardinos, I., Mortazavi, A., Lenhard, B., Conesa, A., Tegner, J., Merkenschlager, M. and Gomez-Cabrero, D.
PLoS Biol. 2019 Apr 12, 17(4):e2006506.

Cholesterol Induces CD8(+) T Cell Exhaustion in the Tumor Microenvironment
Ma, X., Bi, E., Lu, Y., Su, P., Huang, C., Liu, L., Wang, Q., Yang, M., Kalady, M. F., Qian, J., Zhang, A., Gupte, A. A., Hamilton, D. J., Zheng, C. and Yi, Q.
Cell Metab. 2019 Jul 2, 30(1):143-156 e5.

Immunometabolic phenotype of BV-2 microglia cells upon murine cytomegalovirus infection
Kucic, N., Racki, V., Jurdana, K., Marcelic, M. and Grabusic, K.
J Neurovirol. 2019 Apr 25, [epub ahead of print]

Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection
Li, Y., Jia, A., Wang, Y., Dong, L., Wang, Y., He, Y., Wang, S., Cao, Y., Yang, H., Bi, Y. and Liu, G.
J Cell Physiol. 2019 Nov 1, 234(11):20298-20309.

Tricarboxylic Acid Cycle Activity and Remodeling of Glycerophosphocholine Lipids Support Cytokine Induction in Response to Fungal Patterns
Marquez, S., Fernandez, J. J., Mancebo, C., Herrero-Sanchez, C., Alonso, S., Sandoval, T. A., Rodriguez Prados, M., Cubillos-Ruiz, J. R., Montero, O., Fernandez, N. and Sanchez Crespo, M.
Cell Rep. 2019 Apr 9, 27(2):525-536 e4.

CD28 Superagonistic Activation of T Cells Induces a Tumor Cell-Like Metabolic Program
Thaventhiran, T., Wong, W., Alghanem, A. F., Alhumeed, N., Aljasir, M. A., Ramsey, S., Sethu, S., Yeang, H. X. A., Chadwick, A. E., Cross, M., Webb, S. D., Djouhri, L., Ball, C., Stebbings, R. and Sathish, J. G.
Monoclon Antib Immunodiagn Immunother. 2019 Apr 1, 38(2):60-69.

HIF1alpha-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia
Shao, C., Lin, S., Liu, S., Jin, P., Lu, W., Li, N., Zhang, Y., Bo, L. and Bian, J.
Oxid Med Cell Longev. 2019 Apr 28, 2019:7136585.

Fatty acid transport protein 2 reprograms neutrophils in cancer
Veglia, F., Tyurin, V. A., Blasi, M., De Leo, A., Kossenkov, A. V., Donthireddy, L., To, T. K. J., Schug, Z., Basu, S., Wang, F., Ricciotti, E., DiRusso, C., Murphy, M. E., Vonderheide, R. H., Lieberman, P. M., Mulligan, C., Nam, B., Hockstein, N., Masters, G., Guarino, M., Lin, C., Nefedova, Y., Black, P., Kagan, V. E. and Gabrilovich, D. I.
Nature. 2019 May, 569(7754):73-78.

Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma
Chen, D. P., Ning, W. R., Jiang, Z. Z., Peng, Z. P., Zhu, L. Y., Zhuang, S. M., Kuang, D. M., Zheng, L. and Wu, Y.
J Hepatol. 2019 Aug, 71(2):333-343.

Phenformin, But Not Metformin, Delays Development of T Cell Acute Lymphoblastic Leukemia/Lymphoma via Cell-Autonomous AMPK Activation
Vara-Ciruelos, D., Dandapani, M., Russell, F. M., Grzes, K. M., Atrih, A., Foretz, M., Viollet, B., Lamont, D. J., Cantrell, D. A. and Hardie, D. G.
Cell Rep. 2019 Apr 16, 27(3):690-698 e4.

Mitochondrial autoimmunity and MNRR1 in breast carcinogenesis
Aras, S., Maroun, M. C., Song, Y., Bandyopadhyay, S., Stark, A., Yang, Z. Q., Long, M. P., Grossman, L. I. and Fernandez-Madrid, F.
BMC Cancer. 2019 May 2, 19(1):411.

Proinflammatory Effect of Endothelial Microparticles Is Mitochondria Mediated and Modulated Through MAPKAPK2 (MAPK-Activated Protein Kinase 2) Leading to Attenuation of Cardiac Hypertrophy
Tripathi, D., Biswas, B., Manhas, A., Singh, A., Goyal, D., Gaestel, M. and Jagavelu, K.
Arterioscler Thromb Vasc Biol. 2019 Jun, 39(6):1100-1112.

Cytochrome c oxidase dysfunction enhances phagocytic function and osteoclast formation in macrophages
Angireddy, R., Kazmi, H. R., Srinivasan, S., Sun, L., Iqbal, J., Fuchs, S. Y., Guha, M., Kijima, T., Yuen, T., Zaidi, M. and Avadhani, N. G.
FASEB J. 2019 Aug, 33(8):9167-9181.

Synthesis of novel andrographolide beckmann rearrangement derivatives and evaluation of their HK2-related anti-inflammatory activities
Wang, W., Wu, Y., Yang, K., Wu, C., Tang, R., Li, H. and Chen, L.
Eur J Med Chem. 2019 Jul 1, 173:282-293.

Infectious Disease Research

Immunometabolic phenotype of BV-2 microglia cells upon murine cytomegalovirus infection
Kucic, N., Racki, V., Jurdana, K., Marcelic, M. and Grabusic, K.
J Neurovirol. 2019 Apr 25, [epub ahead of print]

Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection
Li, Y., Jia, A., Wang, Y., Dong, L., Wang, Y., He, Y., Wang, S., Cao, Y., Yang, H., Bi, Y. and Liu, G.
J Cell Physiol. 2019 Nov 1, 234(11):20298-20309.

HIF1alpha-Induced Glycolysis in Macrophage Is Essential for the Protective Effect of Ouabain during Endotoxemia
Shao, C., Lin, S., Liu, S., Jin, P., Lu, W., Li, N., Zhang, Y., Bo, L. and Bian, J.
Oxid Med Cell Longev. 2019 Apr 28, 2019:7136585.

Microbial Research

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Ast, T., Meisel, J. D., Patra, S., Wang, H., Grange, R. M. H., Kim, S. H., Calvo, S. E., Orefice, L. L., Nagashima, F., Ichinose, F., Zapol, W. M., Ruvkun, G., Barondeau, D. P. and Mootha, V. K.
Cell. 2019 May 30, 177(6):1507-1521 e16.

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Kikuchi, K., Saigusa, D., Kanemitsu, Y., Matsumoto, Y., Thanai, P., Suzuki, N., Mise, K., Yamaguchi, H., Nakamura, T., Asaji, K., Mukawa, C., Tsukamoto, H., Sato, T., Oikawa, Y., Iwasaki, T., Oe, Y., Tsukimi, T., Fukuda, N. N., Ho, H. J., Nanto-Hara, F., Ogura, J., Saito, R., Nagao, S., Ohsaki, Y., Shimada, S., Suzuki, T., Toyohara, T., Mishima, E., Shima, H., Akiyama, Y., Akiyama, Y., Ichijo, M., Matsuhashi, T., Matsuo, A., Ogata, Y., Yang, C. C., Suzuki, C., Breeggemann, M. C., Heymann, J., Shimizu, M., Ogawa, S., Takahashi, N., Suzuki, T., Owada, Y., Kure, S., Mano, N., Soga, T., Wada, T., Kopp, J. B., Fukuda, S., Hozawa, A., Yamamoto, M., Ito, S., Wada, J., Tomioka, Y. and Abe, T.
Nat Commun. 2019 Apr 23, 10(1):1835.

Immune effects of glycolysis or oxidative phosphorylation metabolic pathway in protecting against bacterial infection
Li, Y., Jia, A., Wang, Y., Dong, L., Wang, Y., He, Y., Wang, S., Cao, Y., Yang, H., Bi, Y. and Liu, G.
J Cell Physiol. 2019 Nov 1, 234(11):20298-20309.

Mitochondrial Disease Research

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Ast, T., Meisel, J. D., Patra, S., Wang, H., Grange, R. M. H., Kim, S. H., Calvo, S. E., Orefice, L. L., Nagashima, F., Ichinose, F., Zapol, W. M., Ruvkun, G., Barondeau, D. P. and Mootha, V. K.
Cell. 2019 May 30, 177(6):1507-1521 e16.

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2alpha Axis
Balsa, E., Soustek, M. S., Thomas, A., Cogliati, S., Garcia-Poyatos, C., Martin-Garcia, E., Jedrychowski, M., Gygi, S. P., Enriquez, J. A. and Puigserver, P.
Mol Cell. 2019 Jun 6, 74(5):877-890 e6.

Mitochondrial oxidative phosphorylation capacity of cryopreserved cells
Lauridsen, P. E., Rasmussen, L. J. and Desler, C.
Mitochondrion. 2019 Jul 1, 47(47-53.

Model Organisms

Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis
Ast, T., Meisel, J. D., Patra, S., Wang, H., Grange, R. M. H., Kim, S. H., Calvo, S. E., Orefice, L. L., Nagashima, F., Ichinose, F., Zapol, W. M., Ruvkun, G., Barondeau, D. P. and Mootha, V. K.
Cell. 2019 May 30, 177(6):1507-1521 e16.

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model
Precazzini, F., Pancher, M., Gatto, P., Tushe, A., Adami, V., Anelli, V. and Mione, M. C.
Dev Biol. 2019 Apr 15, [epub ahead of print]

Acute exposure to triphenyl phosphate inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish embryos
Qi, Z., Chen, M., Song, Y., Wang, X., Li, B., Chen, Z. F., Tsang, S. Y. and Cai, Z.
J Cell Physiol. 2019 Nov, 234(11):21235-21248.

Nephrology Research

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy
Saxena, S., Mathur, A. and Kakkar, P.
J Cell Physiol. 2019 Nov, 234(11):19223-19236.

Neurobiology Research

Histaminergic transmission slows progression of amyotrophic lateral sclerosis
Apolloni, S., Amadio, S., Fabbrizio, P., Morello, G., Spampinato, A. G., Latagliata, E. C., Salvatori, I., Proietti, D., Ferri, A., Madaro, L., Puglisi-Allegra, S., Cavallaro, S. and Volonte, C.
J Cachexia Sarcopenia Muscle. 2019 Aug 1, 10(4):872-893.

Higher Reliance on Glycolysis Limits Glycolytic Responsiveness in Degenerating Glaucomatous Optic Nerve
Jassim, A. H., Coughlin, L., Harun-Or-Rashid, M., Kang, P. T., Chen, Y. R. and Inman, D. M.
Mol Neurobiol. 2019 Oct 1, 56(10):7097-7112.

The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-kappaB pathway
Han, C. J., Zheng, J. Y., Sun, L., Yang, H. C., Cao, Z. Q., Zhang, X. H., Zheng, L. T. and Zhen, X. C.
Acta Pharmacol Sin. 2019 Apr 23, [epub ahead of print]

mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders
Grace, H. E., Galdun, P., 3rd, Lesnefsky, E. J., West, F. D. and Iyer, S.
Stem Cells Dev. 2019 Jul 1, 28(13):846-859.

The Response to Stimulation in Neurons and Astrocytes
Juaristi, I., Contreras, L., Gonzalez-Sanchez, P., Perez-Liebana, I., Gonzalez-Moreno, L., Pardo, B., Del Arco, A. and Satrustegui, J.
Neurochem Res. 2019 Apr 23, [epub ahead of print]

Immunometabolic phenotype of BV-2 microglia cells upon murine cytomegalovirus infection
Kucic, N., Racki, V., Jurdana, K., Marcelic, M. and Grabusic, K.
J Neurovirol. 2019 Apr 25, [epub ahead of print]

Hyperhomocysteinemia-induced death of retinal ganglion cells: The role of Muller glial cells and NRF2
Navneet, S., Zhao, J., Wang, J., Mysona, B., Barwick, S., Ammal Kaidery, N., Saul, A., Kaddour-Djebbar, I., Bollag, W. B., Thomas, B., Bollinger, K. E. and Smith, S. B.
Redox Biol. 2019 Jun 1, 24:101199.

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function
Ni, P., Noh, H., Park, G. H., Shao, Z., Guan, Y., Park, J. M., Yu, S., Park, J. S., Coyle, J. T., Weinberger, D. R., Straub, R. E., Cohen, B. M., McPhie, D. L., Yin, C., Huang, W., Kim, H. Y. and Chung, S.
Mol Psychiatry. 2019 Apr 24, [epub ahead of print]

The S1P mimetic fingolimod phosphate regulates mitochondrial oxidative stress in neuronal cells
Martin-Montanez, E., Pavia, J., Valverde, N., Boraldi, F., Lara, E., Oliver, B., Hurtado-Guerrero, I., Fernandez, O. and Garcia-Fernandez, M.
Free Radic Biol Med. 2019 Jun 1, 137:116-130.

Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis
Lee, W., Cho, J. H., Lee, Y., Lee, S., Kim, D. H., Ha, S., Kondo, Y., Ishigami, A., Chung, H. Y. and Lee, J.
Food Chem Toxicol. 2019 Jul 1, 129:239-248.

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
Tarantini, S., Valcarcel-Ares, M. N., Toth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M., Ballabh, P., Sule, Z., Farkas, E., Baur, J. A., Sinclair, D. A., Csiszar, A. and Ungvari, Z.
Redox Biol. 2019 Jun 1, 24:101192.

Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis
Sundstrom, T., Prestegarden, L., Azuaje, F., Aasen, S. N., Rosland, G. V., Varughese, J. K., Bahador, M., Bernatz, S., Braun, Y., Harter, P. N., Skaftnesmo, K. O., Ingham, E. S., Mahakian, L. M., Tam, S., Tepper, C. G., Petersen, K., Ferrara, K. W., Tronstad, K. J., Lund-Johansen, M., Beschorner, R., Bjerkvig, R. and Thorsen, F.
Acta Neuropathol Commun. 2019 Apr 10, 7(1):55.

Mitochondrial Regulation of the Hippocampal Firing Rate Set Point and Seizure Susceptibility
Styr, B., Gonen, N., Zarhin, D., Ruggiero, A., Atsmon, R., Gazit, N., Braun, G., Frere, S., Vertkin, I., Shapira, I., Harel, M., Heim, L. R., Katsenelson, M., Rechnitz, O., Fadila, S., Derdikman, D., Rubinstein, M., Geiger, T., Ruppin, E. and Slutsky, I.
Neuron. 2019 Jun 5, 102(5):1009-1024 e8.

Metabolic constraints of swelling-activated glutamate release in astrocytes and their implication for ischemic tissue damage
Wilson, C. S., Bach, M. D., Ashkavand, Z., Norman, K. R., Martino, N., Adam, A. P. and Mongin, A. A.
J Neurochem. 2019 Apr 29, [epub ahead of print]

Somatic autophagy of axonal mitochondria in ischemic neurons
Zheng, Y., Zhang, X., Wu, X., Jiang, L., Ahsan, A., Ma, S., Xiao, Z., Han, F., Qin, Z. H., Hu, W. and Chen, Z.
J Cell Biol. 2019 Jun 3, 218(6):1891-1907.

Obesity, Diabetes & Metabolic Diseases

Identification of functional lipid metabolism biomarkers of brown adipose tissue aging
Gohlke, S., Zagoriy, V., Cuadros Inostroza, A., Meret, M., Mancini, C., Japtok, L., Schumacher, F., Kuhlow, D., Graja, A., Stephanowitz, H., Jahnert, M., Krause, E., Wernitz, A., Petzke, K. J., Schurmann, A., Kleuser, B. and Schulz, T. J.
Mol Metab. 2019 Jun 1, 24:1-17.

Metformin acutely lowers blood glucose levels by inhibition of intestinal glucose transport
Horakova, O., Kroupova, P., Bardova, K., Buresova, J., Janovska, P., Kopecky, J. and Rossmeisl, M.
Sci Rep. 2019 Apr 16, 9(1):6156.

Exploring the In Vivo Role of the Mitochondrial Calcium Uniporter in Brown Fat Bioenergetics
Flicker, D., Sancak, Y., Mick, E., Goldberger, O. and Mootha, V. K.
Cell Rep. 2019 Apr 30, 27(5):1364-1375 e5.

Endothelium-Derived Factors Influence Differentiation of Fat-Derived Stromal Cells Post-Exercise in Subjects with Prediabetes
Kundu, N., Domingues, C. C., Nylen, E. S., Paal, E., Kokkinos, P. and Sen, S.
Metab Syndr Relat Disord. 2019 Apr 24, [epub ahead of print]

Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease
Kikuchi, K., Saigusa, D., Kanemitsu, Y., Matsumoto, Y., Thanai, P., Suzuki, N., Mise, K., Yamaguchi, H., Nakamura, T., Asaji, K., Mukawa, C., Tsukamoto, H., Sato, T., Oikawa, Y., Iwasaki, T., Oe, Y., Tsukimi, T., Fukuda, N. N., Ho, H. J., Nanto-Hara, F., Ogura, J., Saito, R., Nagao, S., Ohsaki, Y., Shimada, S., Suzuki, T., Toyohara, T., Mishima, E., Shima, H., Akiyama, Y., Akiyama, Y., Ichijo, M., Matsuhashi, T., Matsuo, A., Ogata, Y., Yang, C. C., Suzuki, C., Breeggemann, M. C., Heymann, J., Shimizu, M., Ogawa, S., Takahashi, N., Suzuki, T., Owada, Y., Kure, S., Mano, N., Soga, T., Wada, T., Kopp, J. B., Fukuda, S., Hozawa, A., Yamamoto, M., Ito, S., Wada, J., Tomioka, Y. and Abe, T.
Nat Commun. 2019 Apr 23, 10(1):1835.

CXCL12-CXCR4 pathway activates brown adipocytes and induces insulin resistance in CXCR4-deficient mice under high-fat diet
Kurita, K., Ishikawa, K., Takeda, K., Fujimoto, M., Ono, H., Kumagai, J., Inoue, H., Yokoh, H. and Yokote, K.
Sci Rep. 2019 Apr 16, 9(1):6165.

Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions
Thapa, D., Zhang, M., Manning, J. R., Guimaraes, D. A., Stoner, M. W., Lai, Y. C., Shiva, S. and Scott, I.
Physiol Rep. 2019 Apr, 7(8):e14054.

Critical role of mitochondrial dysfunction and impaired mitophagy in diabetic nephropathy
Saxena, S., Mathur, A. and Kakkar, P.
J Cell Physiol. 2019 Nov, 234(11):19223-19236.

SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue
Shuai, L., Zhang, L. N., Li, B. H., Tang, C. L., Wu, L. Y., Li, J. and Li, J. Y.
Diabetes. 2019 Jul, 68(7):1449-1461.

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues
Raajendiran, A., Ooi, G., Bayliss, J., O'Brien, P. E., Schittenhelm, R. B., Clark, A. K., Taylor, R. A., Rodeheffer, M. S., Burton, P. R. and Watt, M. J.
Cell Rep. 2019 Apr 30, 27(5):1528-1540 e7.

Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation
Wang, G., Meyer, J. G., Cai, W., Softic, S., Li, M. E., Verdin, E., Newgard, C., Schilling, B. and Kahn, C. R.
Mol Cell. 2019 May 16, 74(4):844-857 e7.

Effects of AMPK on Apoptosis and Energy Metabolism of Gastric Smooth Muscle Cells in Rats with Diabetic Gastroparesis
Zhang, M. H., Fang, X. S., Guo, J. Y. and Jin, Z.
Cell Biochem Biophys. 2019 Jun, 77(2):165-177.

Review Paper

High-throughput extracellular pH monitoring and antibiotics screening by polymeric fluorescent sensor with LCST property
Pan, T., Yang, C., Li, J., Jiang, J., Wen, J., Wang, Z., Zhong, K., Tian, Y. and Chen, M.
Methods. 2019 Apr 30, [epub ahead of print]

Electron carriers and energy conservation in mitochondrial respiration
Ramsay, R. R.
ChemTexts. 2019 Apr 23, [epub ahead of print]

Stem Cell Biology

Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats
Dreschers, S., Ohl, K., Lehrke, M., Mollmann, J., Denecke, B., Costa, I., Vogl, T., Viemann, D., Roth, J., Orlikowsky, T. and Tenbrock, K.
Nat Commun. 2019 Apr 11, 10(1):1685.

YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells
Chen, F., Zhou, J., Li, Y., Zhao, Y., Yuan, J., Cao, Y., Wang, L., Zhang, Z., Zhang, B., Wang, C. C., Cheung, T. H., Wu, Z., Wong, C. C., Sun, H. and Wang, H.
EMBO J. 2019 May 15, 38(10).

Angiotensin II and TGF-beta1 Induce Alterations in Human Amniotic Fluid-Derived Mesenchymal Stem Cells Leading to Cardiomyogenic Differentiation Initiation
Gasiuniene, M., Petkus, G., Matuzevicius, D., Navakauskas, D. and Navakauskiene, R.
Int J Stem Cells. 2019 Jul 31, 12(2):251-264.

mRNA Reprogramming of T8993G Leigh's Syndrome Fibroblast Cells to Create Induced Pluripotent Stem Cell Models for Mitochondrial Disorders
Grace, H. E., Galdun, P., 3rd, Lesnefsky, E. J., West, F. D. and Iyer, S.
Stem Cells Dev. 2019 Jul 1, 28(13):846-859.

Loss of PKM2 in Lgr5(+) intestinal stem cells promotes colitis-associated colorectal cancer
Kim, Y., Lee, Y. S., Kang, S. W., Kim, S., Kim, T. Y., Lee, S. H., Hwang, S. W., Kim, J., Kim, E. N., Ju, J. S., Park, Y. Y. and Kweon, M. N.
Sci Rep. 2019 Apr 17, 9(1):6212.

Endothelium-Derived Factors Influence Differentiation of Fat-Derived Stromal Cells Post-Exercise in Subjects with Prediabetes
Kundu, N., Domingues, C. C., Nylen, E. S., Paal, E., Kokkinos, P. and Sen, S.
Metab Syndr Relat Disord. 2019 Apr 24, [epub ahead of print]

Immunometabolic phenotype of BV-2 microglia cells upon murine cytomegalovirus infection
Kucic, N., Racki, V., Jurdana, K., Marcelic, M. and Grabusic, K.
J Neurovirol. 2019 Apr 25, [epub ahead of print]

iPSC-derived homogeneous populations of developing schizophrenia cortical interneurons have compromised mitochondrial function
Ni, P., Noh, H., Park, G. H., Shao, Z., Guan, Y., Park, J. M., Yu, S., Park, J. S., Coyle, J. T., Weinberger, D. R., Straub, R. E., Cohen, B. M., McPhie, D. L., Yin, C., Huang, W., Kim, H. Y. and Chung, S.
Mol Psychiatry. 2019 Apr 24, [epub ahead of print]

Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis
Lee, W., Cho, J. H., Lee, Y., Lee, S., Kim, D. H., Ha, S., Kondo, Y., Ishigami, A., Chung, H. Y. and Lee, J.
Food Chem Toxicol. 2019 Jul 1, 129:239-248.

Iron regulatory protein 2 modulates the switch from aerobic glycolysis to oxidative phosphorylation in mouse embryonic fibroblasts
Li, H., Liu, Y., Shang, L., Cai, J., Wu, J., Zhang, W., Pu, X., Dong, W., Qiao, T. and Li, K.
Proc Natl Acad Sci U S A. 2019 May 14, 116(20):9871-9876.

Acute exposure to triphenyl phosphate inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish embryos
Qi, Z., Chen, M., Song, Y., Wang, X., Li, B., Chen, Z. F., Tsang, S. Y. and Cai, Z.
J Cell Physiol. 2019 Nov, 234(11):21235-21248.

Metformin Delays Satellite Cell Activation and Maintains Quiescence
Pavlidou, T., Marinkovic, M., Rosina, M., Fuoco, C., Vumbaca, S., Gargioli, C., Castagnoli, L. and Cesareni, G.
Stem Cells Int. 2019 Apr 24, 2019:5980465.

The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration
Sala, D., Cunningham, T. J., Stec, M. J., Etxaniz, U., Nicoletti, C., Dall'Agnese, A., Puri, P. L., Duester, G., Latella, L. and Sacco, A.
Nat Commun. 2019 Apr 17, 10(1):1796.

Identification of Metabolically Distinct Adipocyte Progenitor Cells in Human Adipose Tissues
Raajendiran, A., Ooi, G., Bayliss, J., O'Brien, P. E., Schittenhelm, R. B., Clark, A. K., Taylor, R. A., Rodeheffer, M. S., Burton, P. R. and Watt, M. J.
Cell Rep. 2019 Apr 30, 27(5):1528-1540 e7.

Metabolomic and Transcriptional Analyses Reveal Atmospheric Oxygen During Human Induced Pluripotent Stem Cell Generation Impairs Metabolic Reprogramming
Spyrou, J., Gardner, D. K. and Harvey, A. J.
Stem Cells. 2019 May 1, [epub ahead of print]

TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network
Seruggia, D., Oti, M., Tripathi, P., Canver, M. C., LeBlanc, L., Di Giammartino, D. C., Bullen, M. J., Nefzger, C. M., Sun, Y. B. Y., Farouni, R., Polo, J. M., Pinello, L., Apostolou, E., Kim, J., Orkin, S. H. and Das, P. P.
Mol Cell. 2019 Jun 20, 74(6):1148-1163 e7.

ATP turnover and glucose dependency in hematopoietic stem/progenitor cells are increased by proliferation and differentiation
Watanuki, S., Kobayashi, H., Sorimachi, Y., Yamamoto, M., Okamoto, S. and Takubo, K.
Biochem Biophys Res Commun. 2019 Jun 18, 514(1):287-294.

Techniques & Methods

Improvements in single-use bioreactor film material composition leads to robust and reliable Chinese hamster ovary cell performance
Kelly, P. S., Dorival-Garcia, N., Pare, S., Carillo, S., Ta, C., Alarcon Miguez, A., Coleman, O., Harper, E., Shannon, M., Henry, M., Connolly, L., Clynes, M., Meleady, P., Bones, J. and Barron, N.
Biotechnol Prog. 2019 Jul 1, 35(4):e2824.

An improved method for isolation of mitochondria from cell lines that enables reconstitution of calcium-dependent processes
Ishii, M., Beeson, G., Beeson, C. and Rohrer, B.
Anal Biochem. 2019 Jul 15, 577: 52-58.

Mitochondrial oxidative phosphorylation capacity of cryopreserved cells
Lauridsen, P. E., Rasmussen, L. J. and Desler, C.
Mitochondrion. 2019 Jul 1, 47(47-53.

High-throughput extracellular pH monitoring and antibiotics screening by polymeric fluorescent sensor with LCST property
Pan, T., Yang, C., Li, J., Jiang, J., Wen, J., Wang, Z., Zhong, K., Tian, Y. and Chen, M.
Methods. 2019 Apr 30, [epub ahead of print]

Toxicology Research

Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1
Chen, L., Lang, A. L., Poff, G. D., Ding, W. X. and Beier, J. I.
Redox Biol. 2019 Jun 1, 24:101205.

Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression
Breton, C. V., Song, A. Y., Xiao, J., Kim, S. J., Mehta, H. H., Wan, J., Yen, K., Sioutas, C., Lurmann, F., Xue, S., Morgan, T. E., Zhang, J. and Cohen, P.
Mitochondrion. 2019 May, 46:22-29.

Modelling changes in glutathione homeostasis as a function of quinone redox metabolism
Kelly, R. A., Leedale, J., Calleja, D., Enoch, S. J., Harrell, A., Chadwick, A. E. and Webb, S.
Sci Rep. 2019 Apr 19, 9(1):6333.

Organophosphorus Flame Retardants Impair Intracellular Lipid Metabolic Function in Human Hepatocellular Cells
Hao, Z., Zhang, Z., Lu, D., Ding, B., Shu, L., Zhang, Q. and Wang, C.
Chem Res Toxicol. 2019 Jun 17, 32(6):1250-1258.

Dibutyl phthalate impairs neural progenitor cell proliferation and hippocampal neurogenesis
Lee, W., Cho, J. H., Lee, Y., Lee, S., Kim, D. H., Ha, S., Kondo, Y., Ishigami, A., Chung, H. Y. and Lee, J.
Food Chem Toxicol. 2019 Jul 1, 129:239-248.

Acute exposure to triphenyl phosphate inhibits the proliferation and cardiac differentiation of mouse embryonic stem cells and zebrafish embryos
Qi, Z., Chen, M., Song, Y., Wang, X., Li, B., Chen, Z. F., Tsang, S. Y. and Cai, Z.
J Cell Physiol. 2019 Nov, 234(11):21235-21248.

Metabolomics reveals tepotinib-related mitochondrial dysfunction in MET-activating mutations-driven models
Poliakova, M., Felser, A., Pierzchala, K., Nuoffer, J. M., Aebersold, D. M., Zimmer, Y., Zamboni, N. and Medova, M.
FEBS J. 2019 Jul, 286(14):2692-2710.

Translational Research

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight
Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A., Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. and Turek, F. W.
Science. 2019 Apr 12, 364(6436).

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