XF出版物快报 2019年8月

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Aging Research

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression
Sramkova, V., Koc, M., Krauzova, E., Kracmerova, J., Siklova, M., Elkalaf, M., Langin, D., Stich, V. and Rossmeislova, L.
J Physiol Biochem. 2019 Mar 25, [epub ahead of print]

Cellular energetics and mitochondrial uncoupling in canine aging
Nicholatos, J. W., Robinette, T. M., Tata, S. V. P., Yordy, J. D., Francisco, A. B., Platov, M., Yeh, T. K., Ilkayeva, O. R., Huynh, F. K., Dokukin, M., Volkov, D., Weinstein, M. A., Boyko, A. R., Miller, R. A., Sokolov, I., Hirschey, M. D. and Libert, S.
Geroscience. 2019 Apr 1, 41(2):229-242.

FASN activity is important for the initial stages of the induction of senescence
Fafian-Labora, J., Carpintero-Fernandez, P., Jordan, S. J. D., Shikh-Bahaei, T., Abdullah, S. M., Mahenthiran, M., Rodriguez-Navarro, J. A., Niklison-Chirou, M. V. and O'Loghlen, A.
Cell Death Dis. 2019 Apr 8, 10(4):318.

Cancer Research

Methods in Molecular Biology: Cancer Metabolism Methods and Protocols
Haznadar, M.
Springer Protocols. 2019 July 1, 1928.

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. and Rodriguez, P. C.
Nat Commun. 2019 Mar 20, 10(1):1280.

Extracellular vesicle-packaged HIF-1alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
Chen, F., Chen, J., Yang, L., Liu, J., Zhang, X., Zhang, Y., Tu, Q., Yin, D., Lin, D., Wong, P. P., Huang, D., Xing, Y., Zhao, J., Li, M., Liu, Q., Su, F., Su, S. and Song, E.
Nat Cell Biol. 2019 Apr 1, 21(4):498-510.

High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity
Hai, P., Imai, T., Xu, S., Zhang, R., Aft, R. L., Zou, J. and Wang, L. V.
Nat Biomed Eng. 2019 May 1, 3(5):381-391.

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
Elkholi, R., Abraham-Enachescu, I., Trotta, A. P., Rubio-Patino, C., Mohammed, J. N., Luna-Vargas, M. P. A., Gelles, J. D., Kaminetsky, J. R., Serasinghe, M. N., Zou, C., Ali, S., McStay, G. P., Pfleger, C. M. and Chipuk, J. E.
Mol Cell. 2019 May 2, 74(3):452-465 e7.

Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis
Hong, S. M., Lee, Y. K., Park, I., Kwon, S. M., Min, S. and Yoon, G.
J Biol Chem. 2019 May 10, 294(19):7810-7820.

A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers
de Matos, M. R., Posa, I., Carvalho, F. S., Morais, V. A., Grosso, A. R. and de Almeida, S. F.
Cancers (Basel). 2019 Mar 20, 11(3).

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells
Fabian, A., Stegner, S., Miarka, L., Zimmermann, J., Lenk, L., Rahn, S., Buttlar, J., Viol, F., Knaack, H., Esser, D., Schauble, S., Grossmann, P., Marinos, G., Hasler, R., Mikulits, W., Saur, D., Kaleta, C., Schafer, H. and Sebens, S.
Cancer Lett. 2019 Jul 1, 453: 95-106.

PKM2 coordinates glycolysis with mitochondrial fusion and oxidative phosphorylation
Li, T., Han, J., Jia, L., Hu, X., Chen, L. and Wang, Y.
Protein Cell. 2019 Aug 1, 10(8):583-594.

Dietary palmitate cooperates with Src kinase to promote prostate tumor progression
Kim, S., Yang, X., Yin, A., Zha, J., Beharry, Z., Bai, A., Bielawska, A., Bartlett, M. G., Yin, H. and Cai, H.
Prostate. 2019 Jun 1, 79(8):896-908.

Lycopene Inhibits Reactive Oxygen Species-Mediated NF-kappaB Signaling and Induces Apoptosis in Pancreatic Cancer Cells
Jeong, Y., Lim, J. W. and Kim, H.
Nutrients. 2019 Apr 1, 11(4).

Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Liu, P., Zhao, L., Pol, J., Levesque, S., Petrazzuolo, A., Pfirschke, C., Engblom, C., Rickelt, S., Yamazaki, T., Iribarren, K., Senovilla, L., Bezu, L., Vacchelli, E., Sica, V., Melis, A., Martin, T., Xia, L., Yang, H., Li, Q., Chen, J., Durand, S., Aprahamian, F., Lefevre, D., Broutin, S., Paci, A., Bongers, A., Minard-Colin, V., Tartour, E., Zitvogel, L., Apetoh, L., Ma, Y., Pittet, M. J., Kepp, O. and Kroemer, G.
Nat Commun. 2019 Apr 2, 10(1):1486.

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia
Pin, F., Novinger, L. J., Huot, J. R., Harris, R. A., Couch, M. E., O'Connell, T. M. and Bonetto, A.
FASEB J. 2019 Jun 1, 33(6):7778-7790.

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer
Kitani, T., Ong, S. G., Lam, C. K., Rhee, J. W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., Witteles, R. M., Sharma, A., Sayed, N. and Wu, J. C.
Circulation. 2019 May 21, 139(21):2451-2465.

UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer
Hu, Q., Qin, Y., Ji, S., Xu, W., Liu, W., Sun, Q., Zhang, Z., Liu, M., Ni, Q., Yu, X. and Xu, X.
Cancer Lett. 2019 Jun 28, 452:226-236.

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma
Qie, S., Yoshida, A., Parnham, S., Oleinik, N., Beeson, G. C., Beeson, C. C., Ogretmen, B., Bass, A. J., Wong, K. K., Rustgi, A. K. and Diehl, J. A.
Nat Commun. 2019 Mar 21, 10(1):1296.

Bound polyphenol from foxtail millet bran exhibits an antiproliferative activity in HT-29 cells by reprogramming miR-149-mediated aerobic glycolysis
Shi, J., Shan, S., Zhou, G., Li, H., Song, G., Li, Z. and Yang, D.
Journal of Functional Foods. 2019 May 1, 56:246-254.

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis
Santofimia-Castano, P., Xia, Y., Lan, W., Zhou, Z., Huang, C., Peng, L., Soubeyran, P., Velazquez-Campoy, A., Abian, O., Rizzuti, B., Neira, J. L. and Iovanna, J. J Clin Invest. 2019 Mar 28, 129(6):2500-2513.

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition
Subedi, A., Muroi, M., Futamura, Y., Kawamura, T., Aono, H., Nishi, M., Ryo, A., Watanabe, N. and Osada, H.
FEBS Lett. 2019 Apr 1, 593(8):763-776.

The Mitochondrial Transacylase, Tafazzin, Regulates for AML Stemness by Modulating Intracellular Levels of Phospholipids
Seneviratne, A. K., Xu, M., Henao, J. J. A., Fajardo, V. A., Hao, Z., Voisin, V., Xu, G. W., Hurren, R., Kim, S., MacLean, N., Wang, X., Gronda, M., Jeyaraju, D., Jitkova, Y., Ketela, T., Mullokandov, M., Sharon, D., Thomas, G., Chouinard-Watkins, R., Hawley, J. R., Schafer, C., Yau, H. L., Khuchua, Z., Aman, A., Al-Awar, R., Gross, A., Claypool, S. M., Bazinet, R. P., Lupien, M., Chan, S., De Carvalho, D. D., Minden, M. D., Bader, G. D., Stark, K. D., LeBlanc, P. and Schimmer, A. D.
Cell Stem Cell. 2019 Apr 4, 24(4):621-636 e16.

Homeodomain-interacting protein kinase 2 suppresses proliferation and aerobic glycolysis via ERK/cMyc axis in pancreatic cancer
Qin, Y., Hu, Q., Ji, S., Xu, J., Dai, W., Liu, W., Xu, W., Sun, Q., Zhang, Z., Ni, Q., Yu, X., Zhang, B. and Xu, X.
Cell Prolif. 2019 May 1, 52(3):e12603.

PRMT5 enhances tumorigenicity and glycolysis in pancreatic cancer via the FBW7/cMyc axis
Qin, Y., Hu, Q., Xu, J., Ji, S., Dai, W., Liu, W., Xu, W., Sun, Q., Zhang, Z., Ni, Q., Zhang, B., Yu, X. and Xu, X.
Cell Commun Signal. 2019 Mar 29, 17(1):30. 

Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1alpha-dependent pathway
Sacca, C. D., Gorini, F., Ambrosio, S., Amente, S., Faicchia, D., Matarese, G., Lania, L. and Majello, B.
Biochim Biophys Acta Gene Regul Mech. 2019 May 1, 1862(5):535-546.

Mitochondria-Accumulating Rhenium(I) Tricarbonyl Complexes Induce Cell Death via Irreversible Oxidative Stress and Glutathione Metabolism Disturbance
Wang, F. X., Liang, J. H., Zhang, H., Wang, Z. H., Wan, Q., Tan, C. P., Ji, L. N. and Mao, Z. W.
ACS Appl Mater Interfaces. 2019 Apr 10, 11(14):13123-13133.

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. and Jordan, C. T.
Cell Rep. 2019 Apr 2, 27(1):238-254 e6.

HIF-1alpha Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Miska, J., Lee-Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. S. and Lesniak, M. S.
Cell Rep. 2019 Apr 2, 27(1):226-237 e4.

Monomethyltransferase SET8 facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis
Chen, X., Ding, X., Wu, Q., Qi, J., Zhu, M. and Miao, C.
Cell Death Dis. 2019 Apr 5, 10(4):312.

Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance
Kulkoyluoglu-Cotul, E., Smith, B. P., Wrobel, K., Zhao, Y. C., Chen, K. L. A., Hieronymi, K., Imir, O. B., Duong, K., O'Callaghan, C., Mehta, A., Sahoo, S., Haley, B., Chang, H., Landesman, Y. and Madak-Erdogan, Z.
Cancers (Basel). 2019 Apr 4, 11(4).

The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming
Xu, L., Wang, L., Zhou, L., Dorfman, R. G., Pan, Y., Tang, D., Wang, Y., Yin, Y., Jiang, C., Zou, X., Wu, J. and Zhang, M.
Neoplasia. 2019 May 1, 21(5):429-441.

Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells
Wei, Z., Jia, J., Heng, G., Xu, H., Shan, J., Wang, G., Liu, C., Xia, J., Zhou, H., Wu, M., Yang, Z., Wang, M., Xiong, Z., Huang, H., Liu, L. and Qian, C.
Hepatology. 2019 Mar 22, [epub ahead of print]

A Targeting Membrane Injury Strategy via Calcification for the Inhibition of Leukemia Cells
Zhu, L., Wang, G., Ma, X., Yang, H., Guo, Y. and Yang, L.
ChemistrySelect. 2019 Apr 1, 4(13):3642-3645.

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation
Varum, S., Baggiolini, A., Zurkirchen, L., Atak, Z. K., Cantu, C., Marzorati, E., Bossart, R., Wouters, J., Hausel, J., Tuncer, E., Zingg, D., Veen, D., John, N., Balz, M., Levesque, M. P., Basler, K., Aerts, S., Zamboni, N., Dummer, R. and Sommer, L.
Cell Stem Cell. 2019 Apr 4, 24(4):637-653 e9.

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity
Wang, Y., Du, X., Wei, J., Long, L., Tan, H., Guy, C., Dhungana, Y., Qian, C., Neale, G., Fu, Y. X., Yu, J., Peng, J. and Chi, H. Cell Res. 2019 May 1, 29(5):391-405. 

Low levels of pyruvate induced by a positive feedback loop protects cholangiocarcinoma cells from apoptosis
Zhang, M., Pan, Y., Tang, D., Dorfman, R. G., Xu, L., Zhou, Q., Zhou, L., Wang, Y., Li, Y., Yin, Y., Kong, B., Friess, H., Zhao, S., Wu, J. L., Wang, L. and Zou, X.
Cell Commun Signal. 2019 Mar 12, 17(1):23.

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
Zhang, X., Selvaraju, K., Saei, A. A., D'Arcy, P., Zubarev, R. A., Arner, E. S. and Linder, S.
Biochimie. 2019 Jul 1, 162:46-54.

Cardiovascular Research

Mitochondria-associated lactate dehydrogenase is not a biologically significant contributor to bioenergetic function in murine striated muscle
Fulghum, K. L., Rood, B. R., Shang, V. O., McNally, L. A., Riggs, D. W., Zheng, Y. T. and Hill, B. G.
Redox Biol. 2019 Jun 1, 24:101177.

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer
Kitani, T., Ong, S. G., Lam, C. K., Rhee, J. W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., Witteles, R. M., Sharma, A., Sayed, N. and Wu, J. C.
Circulation. 2019 May 21, 139(21):2451-2465.

Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages
Hu, X., Cai, X., Ma, R., Fu, W., Zhang, C. and Du, X.
J Cell Physiol. 2019 Aug 1, 234(10):18792-18800.

Punicalagin attenuates endothelial dysfunction by activating FoxO1, a pivotal regulating switch of mitochondrial biogenesis
Liu, X., Cao, K., Lv, W., Feng, Z., Liu, J., Gao, J., Li, H., Zang, W. and Liu, J.
Free Radic Biol Med. 2019 May 1, 135:251-260.

Down-regulation of MEIS1 promotes the maturation of oxidative phosphorylation in perinatal cardiomyocytes
Lindgren, I. M., Drake, R. R., Chattergoon, N. N. and Thornburg, K. L.
FASEB J. 2019 Jun 1, 33(6):7417-7426.

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation
Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C. and MacDonald, A. S.
Nat Immunol. 2019 May 1, 20(5):571-580.

Mitochondrial dynamics modulation as a critical contribution for Shenmai injection in attenuating hypoxia/reoxygenation injury
Yu, J., Li, Y., Liu, X., Ma, Z., Michael, S., Orgah, J. O., Fan, G. and Zhu, Y.
J Ethnopharmacol. 2019 Jun 12, 237:9-19.

CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis
Zhang, H., Watanabe, R., Berry, G. J., Nadler, S. G., Goronzy, J. J. and Weyand, C. M.
J Am Coll Cardiol. 2019 Apr 16, 73(14):1811-1823.

Mitochondrial dysfunction-mediated decline in angiogenic capacity of endothelial progenitor cells is associated with capillary rarefaction in patients with hypertension via downregulation of CXCR4/JAK2/SIRT5 signaling
Yu, B. B., Zhi, H., Zhang, X. Y., Liang, J. W., He, J., Su, C., Xia, W. H., Zhang, G. X. and Tao, J.
EBioMedicine. 2019 Apr 1, 42:64-75.

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles
Zhang, J. Z., Termglinchan, V., Shao, N. Y., Itzhaki, I., Liu, C., Ma, N., Tian, L., Wang, V. Y., Chang, A. C. Y., Guo, H., Kitani, T., Wu, H., Lam, C. K., Kodo, K., Sayed, N., Blau, H. M. and Wu, J. C.
Cell Stem Cell. 2019 May 2, 24(5):802-811 e5.

Cell Physiology Research

Mitochondria-associated lactate dehydrogenase is not a biologically significant contributor to bioenergetic function in murine striated muscle
Fulghum, K. L., Rood, B. R., Shang, V. O., McNally, L. A., Riggs, D. W., Zheng, Y. T. and Hill, B. G.
Redox Biol. 2019 Jun 1, 24:101177.

Mitochondria and oxidative stress in ovarian endometriosis
Chen, C., Zhou, Y., Hu, C., Wang, Y., Yan, Z., Li, Z. and Wu, R.
Free Radic Biol Med. 2019 May 20, 136:22-34.

Transcriptomic Analysis of Single Isolated Myofibers Identifies miR-27a-3p and miR-142-3p as Regulators of Metabolism in Skeletal Muscle
Chemello, F., Grespi, F., Zulian, A., Cancellara, P., Hebert-Chatelain, E., Martini, P., Bean, C., Alessio, E., Buson, L., Bazzega, M., Armani, A., Sandri, M., Ferrazza, R., Laveder, P., Guella, G., Reggiani, C., Romualdi, C., Bernardi, P., Scorrano, L., Cagnin, S. and Lanfranchi, G.
Cell Rep. 2019 Mar 26, 26(13):3784-3797 e8.

The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10
Cai, T., Hua, B., Luo, D., Xu, L., Cheng, Q., Yuan, G., Yan, Z., Sun, N., Hua, L. and Lu, C.
Biochim Biophys Acta Mol Cell Res. 2019 Aug 1, 1866(8):1310-1321.

PDK4 drives metabolic alterations and muscle atrophy in cancer cachexia
Pin, F., Novinger, L. J., Huot, J. R., Harris, R. A., Couch, M. E., O'Connell, T. M. and Bonetto, A.
FASEB J. 2019 Jun 1, 33(6):7778-7790.

Does cellular metabolism from primary fibroblasts and oxidative stress in blood differ between mammals and birds? The (lack-thereof) scaling of oxidative stress
Jimenez, A. G., O'Connor, E. S., Tobin, K. J., Anderson, K. N., Winward, J. D., Fleming, A., Winner, C., Chinchilli, E., Amy, M., Carlson, K. and Downs, C. J.
Integr Comp Biol. 2019 Mar 29, [epub ahead of print]

The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts
Pal, S., Maurya, S. K., Chattopadhyay, S., Pal China, S., Porwal, K., Kulkarni, C., Sanyal, S., Sinha, R. A. and Chattopadhyay, N.
Biochem Pharmacol. 2019 Jun 1, 164:34-44.

IMP2 Increases Mouse Skeletal Muscle Mass and Voluntary Activity by Enhancing Autocrine Insulin-Like Growth Factor 2 Production and Optimizing Muscle Metabolism
Regue, L., Ji, F., Flicker, D., Kramer, D., Pierce, W., Davidoff, T., Widrick, J. J., Houstis, N., Minichiello, L., Dai, N. and Avruch, J.
Mol Cell Biol. 2019 Mar 19, 39(7).

Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium
Summer, R., Shaghaghi, H., Schriner, D., Roque, W., Sales, D., Cuevas-Mora, K., Desai, V., Bhushan, A., Ramirez, M. I. and Romero, F.
Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1, 316(6):L1049-L1060.

Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle
Li, Y., Pan, H., Zhang, X., Wang, H., Liu, S., Zhang, H., Qian, H., Wang, L. and Ying, H.
J Agric Food Chem. 2019 Apr 24, 67(16):4483-4492.

Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome
Cai, X. B., Wu, K. C., Zhang, X., Lv, J. N., Jin, G. H., Xiang, L., Chen, J., Huang, X. F., Pan, D., Lu, B., Lu, F., Qu, J. and Jin, Z. B.
Clin Genet. 2019 Jul 1, 96(1):61-71.

Mitochondrial dynamics modulation as a critical contribution for Shenmai injection in attenuating hypoxia/reoxygenation injury
Yu, J., Li, Y., Liu, X., Ma, Z., Michael, S., Orgah, J. O., Fan, G. and Zhu, Y.
J Ethnopharmacol. 2019 Jun 12, 237:9-19.

Mitochondrial carrier protein overloading and misfolding induce aggresomes and proteostatic adaptations in the cytosol
Liu, Y., Wang, X., Coyne, L. P., Yang, Y., Qi, Y., Middleton, F. A. and Chen, X. J.
Mol Biol Cell. 2019 May 15, 30(11):1272-1284.

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts
Zhou, X., Luethi, D., Sanvee, G. M., Bouitbir, J., Liechti, M. E. and Krahenbuhl, S.
Int J Mol Sci. 2019 Mar 28, 20(7).

MicroRNA-181a/b-1 over-expression enhances osteogenesis by modulating PTEN/PI3K/AKT signaling and mitochondrial metabolism
Zheng, H., Liu, J., Tycksen, E., Nunley, R. and McAlinden, A.
Bone. 2019 Jun 1, 123:92-102.

ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells
Wang, X., Wang, Q. C., Sun, Z., Li, T., Yang, K., An, C., Guo, C. and Tang, T. S.
Biochem Biophys Res Commun. 2019 May 14, 512(4):914-920.

Acute increases in O-GlcNAc indirectly impair mitochondrial bioenergetics through dysregulation of LonP1-mediated mitochondrial protein complex turnover
Wright, J. N., Benavides, G. A., Johnson, M. S., Wani, W., Ouyang, X., Zou, L., Collins, H. E., Zhang, J., Darley-Usmar, V. and Chatham, J. C.
Am J Physiol Cell Physiol. 2019 Jun 1, 316(6):C862-C875.

Drug Discovery

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. and Rodriguez, P. C.
Nat Commun. 2019 Mar 20, 10(1):1280.

Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Liu, P., Zhao, L., Pol, J., Levesque, S., Petrazzuolo, A., Pfirschke, C., Engblom, C., Rickelt, S., Yamazaki, T., Iribarren, K., Senovilla, L., Bezu, L., Vacchelli, E., Sica, V., Melis, A., Martin, T., Xia, L., Yang, H., Li, Q., Chen, J., Durand, S., Aprahamian, F., Lefevre, D., Broutin, S., Paci, A., Bongers, A., Minard-Colin, V., Tartour, E., Zitvogel, L., Apetoh, L., Ma, Y., Pittet, M. J., Kepp, O. and Kroemer, G.
Nat Commun. 2019 Apr 2, 10(1):1486.

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer
Kitani, T., Ong, S. G., Lam, C. K., Rhee, J. W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., Witteles, R. M., Sharma, A., Sayed, N. and Wu, J. C.
Circulation. 2019 May 21, 139(21):2451-2465.

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice
Palacios-Gonzalez, B., Vargas-Castillo, A., Velazquez-Villegas, L. A., Vasquez-Reyes, S., Lopez, P., Noriega, L. G., Aleman, G., Tovar-Palacio, C., Torre-Villalvazo, I., Yang, L. J., Zarain-Herzberg, A., Torres, N. and Tovar, A. R.
J Nutr Biochem. 2019 Jun 1, 68:59-68.

Bound polyphenol from foxtail millet bran exhibits an antiproliferative activity in HT-29 cells by reprogramming miR-149-mediated aerobic glycolysis
Shi, J., Shan, S., Zhou, G., Li, H., Song, G., Li, Z. and Yang, D.
Journal of Functional Foods. 2019 May 1, 56:246-254.

Combined Targeting of Estrogen Receptor Alpha and XPO1 Prevent Akt Activation, Remodel Metabolic Pathways and Induce Autophagy to Overcome Tamoxifen Resistance
Kulkoyluoglu-Cotul, E., Smith, B. P., Wrobel, K., Zhao, Y. C., Chen, K. L. A., Hieronymi, K., Imir, O. B., Duong, K., O'Callaghan, C., Mehta, A., Sahoo, S., Haley, B., Chang, H., Landesman, Y. and Madak-Erdogan, Z.
Cancers (Basel). 2019 Apr 4, 11(4).

Tranexamic acid suppresses the release of mitochondrial DNA, protects the endothelial monolayer and enhances oxidative phosphorylation
Prudovsky, I., Carter, D., Kacer, D., Palmeri, M., Soul, T., Kumpel, C., Pyburn, K., Barrett, K., DeMambro, V., Alexandrov, I., Brandina, I., Kramer, R. and Rappold, J.
J Cell Physiol. 2019 Nov 1, 234(11):19121-19129.

Repurposing of auranofin: Thioredoxin reductase remains a primary target of the drug
Zhang, X., Selvaraju, K., Saei, A. A., D'Arcy, P., Zubarev, R. A., Arner, E. S. and Linder, S.
Biochimie. 2019 Jul 1, 162:46-54.

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts
Zhou, X., Luethi, D., Sanvee, G. M., Bouitbir, J., Liechti, M. E. and Krahenbuhl, S.
Int J Mol Sci. 2019 Mar 28, 20(7).

Food & Nutritional Research

Dietary palmitate cooperates with Src kinase to promote prostate tumor progression
Kim, S., Yang, X., Yin, A., Zha, J., Beharry, Z., Bai, A., Bielawska, A., Bartlett, M. G., Yin, H. and Cai, H.
Prostate. 2019 Jun 1, 79(8):896-908.

Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages
Hu, X., Cai, X., Ma, R., Fu, W., Zhang, C. and Du, X.
J Cell Physiol. 2019 Aug 1, 234(10):18792-18800.

Geniposide Improves Glucose Homeostasis via Regulating FoxO1/PDK4 in Skeletal Muscle
Li, Y., Pan, H., Zhang, X., Wang, H., Liu, S., Zhang, H., Qian, H., Wang, L. and Ying, H.
J Agric Food Chem. 2019 Apr 24, 67(16):4483-4492.

Hepatobiology Research

Lactic acidosis caused by repressed lactate dehydrogenase subunit B expression down-regulates mitochondrial oxidative phosphorylation via the pyruvate dehydrogenase (PDH)-PDH kinase axis
Hong, S. M., Lee, Y. K., Park, I., Kwon, S. M., Min, S. and Yoon, G.
J Biol Chem. 2019 May 10, 294(19):7810-7820.

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells
Fabian, A., Stegner, S., Miarka, L., Zimmermann, J., Lenk, L., Rahn, S., Buttlar, J., Viol, F., Knaack, H., Esser, D., Schauble, S., Grossmann, P., Marinos, G., Hasler, R., Mikulits, W., Saur, D., Kaleta, C., Schafer, H. and Sebens, S.
Cancer Lett. 2019 Jul 1, 453: 95-106.

The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10
Cai, T., Hua, B., Luo, D., Xu, L., Cheng, Q., Yuan, G., Yan, Z., Sun, N., Hua, L. and Lu, C.
Biochim Biophys Acta Mol Cell Res. 2019 Aug 1, 1866(8):1310-1321.

Epigallocatechin Gallate Inhibits Hepatic Glucose Production in Primary Hepatocytes via Downregulating PKA Signaling Pathways and Transcriptional Factor FoxO1
Li, X., Chen, Y., Shen, J. Z., Pan, Q., Yang, W., Yan, H., Liu, H., Ai, W., Liao, W. and Guo, S.
J Agric Food Chem. 2019 Apr 3, 67(13):3651-3661.

Blockade of MCU-Mediated Ca(2+) Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation
Tomar, D., Jana, F., Dong, Z., Quinn, W. J., 3rd, Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D., Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. and Madesh, M.
Cell Rep. 2019 Mar 26, 26(13):3709-3725 e7.

Senescent Hepatocytes in Decompensated Liver Show Reduced UPR(MT) and Its Key Player, CLPP, Attenuates Senescence In Vitro
Sen, B., Rastogi, A., Nath, R., Shasthry, S. M., Pamecha, V., Pandey, S., Gupta, K. J., Sarin, S. K., Trehanpati, N. and Ramakrishna, G.
Cell Mol Gastroenterol Hepatol. 2019 August 1, 8(1):73-94.

FASN activity is important for the initial stages of the induction of senescence
Fafian-Labora, J., Carpintero-Fernandez, P., Jordan, S. J. D., Shikh-Bahaei, T., Abdullah, S. M., Mahenthiran, M., Rodriguez-Navarro, J. A., Niklison-Chirou, M. V. and O'Loghlen, A.
Cell Death Dis. 2019 Apr 8, 10(4):318.

Monomethyltransferase SET8 facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis
Chen, X., Ding, X., Wu, Q., Qi, J., Zhu, M. and Miao, C.
Cell Death Dis. 2019 Apr 5, 10(4):312.

An Improved Method for Preparation of Uniform and Functional Mitochondria from Fresh Liver
Farah, N. K., Liu, X., Wu, C. H. and Wu, G. Y.
J Clin Transl Hepatol. 2019 Mar 28, 7(1):46-50.

Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells
Wei, Z., Jia, J., Heng, G., Xu, H., Shan, J., Wang, G., Liu, C., Xia, J., Zhou, H., Wu, M., Yang, Z., Wang, M., Xiong, Z., Huang, H., Liu, L. and Qian, C.
Hepatology. 2019 Mar 22, [epub ahead of print]

Immunology Research

ER stress-induced mediator C/EBP homologous protein thwarts effector T cell activity in tumors through T-bet repression
Cao, Y., Trillo-Tinoco, J., Sierra, R. A., Anadon, C., Dai, W., Mohamed, E., Cen, L., Costich, T. L., Magliocco, A., Marchion, D., Klar, R., Michel, S., Jaschinski, F., Reich, R. R., Mehrotra, S., Cubillos-Ruiz, J. R., Munn, D. H., Conejo-Garcia, J. R. and Rodriguez, P. C.
Nat Commun. 2019 Mar 20, 10(1):1280.

Extracellular vesicle-packaged HIF-1alpha-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
Chen, F., Chen, J., Yang, L., Liu, J., Zhang, X., Zhang, Y., Tu, Q., Yin, D., Lin, D., Wong, P. P., Huang, D., Xing, Y., Zhao, J., Li, M., Liu, Q., Su, F., Su, S. and Song, E.
Nat Cell Biol. 2019 Apr 1, 21(4):498-510.

The NLRP3 inflammasome modulates glycolysis by increasing PFKFB3 in an IL-1beta-dependent manner in macrophages
Finucane, O. M., Sugrue, J., Rubio-Araiz, A., Guillot-Sestier, M. V. and Lynch, M. A.
Sci Rep. 2019 Mar 11, 9(1):4034.

Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells
Bader, S., Wolf, L., Milenkovic, V. M., Gruber, M., Nothdurfter, C., Rupprecht, R. and Wetzel, C. H.
Psychoneuroendocrinology. 2019 Aug 1, 106:65-76.

Distinct metabolic patterns during microglial remodeling by oleate and palmitate
Chausse, B., Kakimoto, P. A., Caldeira-da-Silva, C. C., Chaves-Filho, A. B., Yoshinaga, M. Y., da Silva, R. P., Miyamoto, S. and Kowaltowski, A. J.
Biosci Rep. 2019 Apr 30, 39(4).

Crizotinib-induced immunogenic cell death in non-small cell lung cancer
Liu, P., Zhao, L., Pol, J., Levesque, S., Petrazzuolo, A., Pfirschke, C., Engblom, C., Rickelt, S., Yamazaki, T., Iribarren, K., Senovilla, L., Bezu, L., Vacchelli, E., Sica, V., Melis, A., Martin, T., Xia, L., Yang, H., Li, Q., Chen, J., Durand, S., Aprahamian, F., Lefevre, D., Broutin, S., Paci, A., Bongers, A., Minard-Colin, V., Tartour, E., Zitvogel, L., Apetoh, L., Ma, Y., Pittet, M. J., Kepp, O. and Kroemer, G.
Nat Commun. 2019 Apr 2, 10(1):1486.

Iron-load exacerbates the severity of atherosclerosis via inducing inflammation and enhancing the glycolysis in macrophages
Hu, X., Cai, X., Ma, R., Fu, W., Zhang, C. and Du, X.
J Cell Physiol. 2019 Aug 1, 234(10):18792-18800.

Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function
Kumar, A., Pyaram, K., Yarosz, E. L., Hong, H., Lyssiotis, C. A., Giri, S. and Chang, C. H.
Proc Natl Acad Sci U S A. 2019 Apr 9, 116(15):7439-7448.

Shp-2 is critical for ERK and metabolic engagement downstream of IL-15 receptor in NK cells
Niogret, C., Miah, S. M. S., Rota, G., Fonta, N. P., Wang, H., Held, W., Birchmeier, W., Sexl, V., Yang, W., Vivier, E., Ho, P. C., Brossay, L. and Guarda, G.
Nat Commun. 2019 Mar 29, 10(1):1444.

The lung environment controls alveolar macrophage metabolism and responsiveness in type 2 inflammation
Svedberg, F. R., Brown, S. L., Krauss, M. Z., Campbell, L., Sharpe, C., Clausen, M., Howell, G. J., Clark, H., Madsen, J., Evans, C. M., Sutherland, T. E., Ivens, A. C., Thornton, D. J., Grencis, R. K., Hussell, T., Cunoosamy, D. M., Cook, P. C. and MacDonald, A. S.
Nat Immunol. 2019 May 1, 20(5):571-580.

HIF-1alpha Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Miska, J., Lee-Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. S. and Lesniak, M. S.
Cell Rep. 2019 Apr 2, 27(1):226-237 e4.

IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival
Majumder, S., Amatya, N., Revu, S., Jawale, C. V., Wu, D., Rittenhouse, N., Menk, A., Kupul, S., Du, F., Raphael, I., Bhattacharjee, A., Siebenlist, U., Hand, T. W., Delgoffe, G. M., Poholek, A. C., Gaffen, S. L., Biswas, P. S. and McGeachy, M. J.
Nat Immunol. 2019 May 1, 20(5):534-545.

Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4(+) T Cells
Previte, D. M., Martins, C. P., O'Connor, E. C., Marre, M. L., Coudriet, G. M., Beck, N. W., Menk, A. V., Wright, R. H., Tse, H. M., Delgoffe, G. M. and Piganelli, J. D.
Cell Rep. 2019 Apr 2, 27(1):129-141 e4.

LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity
Wang, Y., Du, X., Wei, J., Long, L., Tan, H., Guy, C., Dhungana, Y., Qian, C., Neale, G., Fu, Y. X., Yu, J., Peng, J. and Chi, H. Cell Res. 2019 May 1, 29(5):391-405. 

CD28 Signaling Controls Metabolic Fitness of Pathogenic T Cells in Medium and Large Vessel Vasculitis
Zhang, H., Watanabe, R., Berry, G. J., Nadler, S. G., Goronzy, J. J. and Weyand, C. M.
J Am Coll Cardiol. 2019 Apr 16, 73(14):1811-1823.

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts
Zhou, X., Luethi, D., Sanvee, G. M., Bouitbir, J., Liechti, M. E. and Krahenbuhl, S.
Int J Mol Sci. 2019 Mar 28, 20(7).

Influence of genetic copy number variants of the human GLUT3 glucose transporter gene SLC2A3 on protein expression, glycolysis and rheumatoid arthritis risk: A genetic replication study
Simpfendorfer, K. R., Li, W., Shih, A., Wen, H., Kothari, H. P., Einsidler, E. A., Wuster, A., Hunkapiller, J., Behrens, T. W., Graham, R. R., Townsend, M. J., Behar, D. M., Hu, R., Greenspan, E. and Gregersen, P. K.
Mol Genet Metab Rep. 2019 Apr 6, 19:100470.

miR-142 controls metabolic reprogramming that regulates dendritic cell activation
Sun, Y., Oravecz-Wilson, K., Bridges, S., McEachin, R., Wu, J., Kim, S. H., Taylor, A., Zajac, C., Fujiwara, H., Peltier, D. C., Saunders, T. and Reddy, P.
J Clin Invest. 2019 Apr 8, 129(5):2029-2042.

Mitochondrial Disease Research

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
Barriocanal-Casado, E., Hidalgo-Gutierrez, A., Raimundo, N., Gonzalez-Garcia, P., Acuna-Castroviejo, D., Escames, G. and Lopez, L. C.
EBioMedicine. 2019 Apr 1, 42:511-523.

Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy
Hytti, M., Korhonen, E., Hyttinen, J. M. T., Roehrich, H., Kaarniranta, K., Ferrington, D. A. and Kauppinen, A.
Oxid Med Cell Longev. 2019 Mar 17, 2019:1583656.

Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
Sarasija, S., Laboy, J. T., Ashkavand, Z., Bonner, J., Tang, Y. and Norman, K. R.
Elife. 2018 Jul 10, 7.

Tranexamic acid suppresses the release of mitochondrial DNA, protects the endothelial monolayer and enhances oxidative phosphorylation
Prudovsky, I., Carter, D., Kacer, D., Palmeri, M., Soul, T., Kumpel, C., Pyburn, K., Barrett, K., DeMambro, V., Alexandrov, I., Brandina, I., Kramer, R. and Rappold, J.
J Cell Physiol. 2019 Nov 1, 234(11):19121-19129.

Quantitative Variation in m.3243A > G Mutation Produce Discrete Changes in Energy Metabolism
McMillan, R. P., Stewart, S., Budnick, J. A., Caswell, C. C., Hulver, M. W., Mukherjee, K. and Srivastava, S.
Sci Rep. 2019 Apr 8, 9(1):5752.

G-quadruplex dynamics contribute to regulation of mitochondrial gene expression
Falabella, M., Kolesar, J. E., Wallace, C., de Jesus, D., Sun, L., Taguchi, Y. V., Wang, C., Wang, T., Xiang, I. M., Alder, J. K., Maheshan, R., Horne, W., Turek-Herman, J., Pagano, P. J., St Croix, C. M., Sondheimer, N., Yatsunyk, L. A., Johnson, F. B. and Kaufman, B. A.
Sci Rep. 2019 Apr 3, 9(1):5605.

PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease
Fleck, D., Phu, L., Verschueren, E., Hinkle, T., Reichelt, M., Bhangale, T., Haley, B., Wang, Y., Graham, R., Kirkpatrick, D. S., Sheng, M. and Bingol, B.
J Neurosci. 2019 Jun 12, 39(24):4636-4656.

Mitochondrial Targeting of Antioxidants Alters Pancreatic Acinar Cell Bioenergetics and Determines Cell Fate
Armstrong, J. A., Cash, N. J., Morton, J. C., Tepikin, A. V., Sutton, R. and Criddle, D. N.
Int J Mol Sci. 2019 Apr 5, 20(7).

Model Organisms

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
Elkholi, R., Abraham-Enachescu, I., Trotta, A. P., Rubio-Patino, C., Mohammed, J. N., Luna-Vargas, M. P. A., Gelles, J. D., Kaminetsky, J. R., Serasinghe, M. N., Zou, C., Ali, S., McStay, G. P., Pfleger, C. M. and Chipuk, J. E.
Mol Cell. 2019 May 2, 74(3):452-465 e7.

Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
Sarasija, S., Laboy, J. T., Ashkavand, Z., Bonner, J., Tang, Y. and Norman, K. R.
Elife. 2018 Jul 10, 7.

Neurobiology Research

Differential effects of TSPO ligands on mitochondrial function in mouse microglia cells
Bader, S., Wolf, L., Milenkovic, V. M., Gruber, M., Nothdurfter, C., Rupprecht, R. and Wetzel, C. H.
Psychoneuroendocrinology. 2019 Aug 1, 106:65-76.

Distinct metabolic patterns during microglial remodeling by oleate and palmitate
Chausse, B., Kakimoto, P. A., Caldeira-da-Silva, C. C., Chaves-Filho, A. B., Yoshinaga, M. Y., da Silva, R. P., Miyamoto, S. and Kowaltowski, A. J.
Biosci Rep. 2019 Apr 30, 39(4).

Rapamycin administration is not a valid therapeutic strategy for every case of mitochondrial disease
Barriocanal-Casado, E., Hidalgo-Gutierrez, A., Raimundo, N., Gonzalez-Garcia, P., Acuna-Castroviejo, D., Escames, G. and Lopez, L. C.
EBioMedicine. 2019 Apr 1, 42:511-523.

SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke
Bernstock, J. D., Peruzzotti-Jametti, L., Leonardi, T., Vicario, N., Ye, D., Lee, Y. J., Maric, D., Johnson, K. R., Mou, Y., Van Den Bosch, A., Winterbone, M., Friedman, G. K., Franklin, R. J. M., Hallenbeck, J. M. and Pluchino, S.
EBioMedicine. 2019 Apr 1, 42:214-224.

Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson's Disease
Cronin-Furman, E. N., Barber-Singh, J., Bergquist, K. E., Yagi, T. and Trimmer, P. A.
Biomolecules. 2019 Mar 27, 9(4).

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
Hu, D., Sun, X., Liao, X., Zhang, X., Zarabi, S., Schimmer, A., Hong, Y., Ford, C., Luo, Y. and Qi, X.
Acta Neuropathol. 2019 Jun 1, 137(6):939-960.

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice
Polyzos, A. A., Lee, D. Y., Datta, R., Hauser, M., Budworth, H., Holt, A., Mihalik, S., Goldschmidt, P., Frankel, K., Trego, K., Bennett, M. J., Vockley, J., Xu, K., Gratton, E. and McMurray, C. T.
Cell Metab. 2019 Jun 4, 29(6):1258-1273 e11.

Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
Sarasija, S., Laboy, J. T., Ashkavand, Z., Bonner, J., Tang, Y. and Norman, K. R.
Elife. 2018 Jul 10, 7.

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. and Yang, S. H.
J Neurosci Methods. 2019 May 15, 320:50-63.

Dual Properties of Lactate in Muller Cells: The Effect of GPR81 Activation
Vohra, R., Aldana, B. I., Waagepetersen, H., Bergersen, L. H. and Kolko, M.
Invest Ophthalmol Vis Sci. 2019 Mar 1, 60(4):999-1008.

Glutamine regulates mitochondrial uncoupling protein 2 to promote glutaminolysis in neuroblastoma cells
Rupprecht, A., Moldzio, R., Modl, B. and Pohl, E. E.
Biochim Biophys Acta Bioenerg. 2019 May 1, 1860(5):391-401.

HIF-1alpha Is a Metabolic Switch between Glycolytic-Driven Migration and Oxidative Phosphorylation-Driven Immunosuppression of Tregs in Glioblastoma
Miska, J., Lee-Chang, C., Rashidi, A., Muroski, M. E., Chang, A. L., Lopez-Rosas, A., Zhang, P., Panek, W. K., Cordero, A., Han, Y., Ahmed, A. U., Chandel, N. S. and Lesniak, M. S.
Cell Rep. 2019 Apr 2, 27(1):226-237 e4.

PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease
Fleck, D., Phu, L., Verschueren, E., Hinkle, T., Reichelt, M., Bhangale, T., Haley, B., Wang, Y., Graham, R., Kirkpatrick, D. S., Sheng, M. and Bingol, B.
J Neurosci. 2019 Jun 12, 39(24):4636-4656.

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation
Varum, S., Baggiolini, A., Zurkirchen, L., Atak, Z. K., Cantu, C., Marzorati, E., Bossart, R., Wouters, J., Hausel, J., Tuncer, E., Zingg, D., Veen, D., John, N., Balz, M., Levesque, M. P., Basler, K., Aerts, S., Zamboni, N., Dummer, R. and Sommer, L.
Cell Stem Cell. 2019 Apr 4, 24(4):637-653 e9.

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis
Weyemi, U., Paul, B. D., Bhattacharya, D., Malla, A. P., Boufraqech, M., Harraz, M. M., Bonner, W. M. and Snyder, S. H.
Proc Natl Acad Sci U S A. 2019 Apr 9, 116(15):7471-7476.

ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
Zhao, Y., Sun, X., Hu, D., Prosdocimo, D. A., Hoppel, C., Jain, M. K., Ramachandran, R. and Qi, X.
Nat Commun. 2019 Mar 26, 10(1):1371.

Obesity, Diabetes & Metabolic Diseases

Chronic fructose renders pancreatic beta-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling
Bartley, C., Brun, T., Oberhauser, L., Grimaldi, M., Molica, F., Kwak, B. R., Bosco, D., Chanson, M. and Maechler, P.
Am J Physiol Endocrinol Metab. 2019 Jul 1, 317(1):E25-E41.

The osteogenic effect of liraglutide involves enhanced mitochondrial biogenesis in osteoblasts
Pal, S., Maurya, S. K., Chattopadhyay, S., Pal China, S., Porwal, K., Kulkarni, C., Sanyal, S., Sinha, R. A. and Chattopadhyay, N.
Biochem Pharmacol. 2019 Jun 1, 164:34-44.

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice
Palacios-Gonzalez, B., Vargas-Castillo, A., Velazquez-Villegas, L. A., Vasquez-Reyes, S., Lopez, P., Noriega, L. G., Aleman, G., Tovar-Palacio, C., Torre-Villalvazo, I., Yang, L. J., Zarain-Herzberg, A., Torres, N. and Tovar, A. R.
J Nutr Biochem. 2019 Jun 1, 68:59-68.

Epigallocatechin Gallate Inhibits Hepatic Glucose Production in Primary Hepatocytes via Downregulating PKA Signaling Pathways and Transcriptional Factor FoxO1
Li, X., Chen, Y., Shen, J. Z., Pan, Q., Yang, W., Yan, H., Liu, H., Ai, W., Liao, W. and Guo, S.
J Agric Food Chem. 2019 Apr 3, 67(13):3651-3661.

Expression of lipogenic markers is decreased in subcutaneous adipose tissue and adipocytes of older women and is negatively linked to GDF15 expression
Sramkova, V., Koc, M., Krauzova, E., Kracmerova, J., Siklova, M., Elkalaf, M., Langin, D., Stich, V. and Rossmeislova, L.
J Physiol Biochem. 2019 Mar 25, [epub ahead of print]

Stem Cell Biology

MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network
Elkholi, R., Abraham-Enachescu, I., Trotta, A. P., Rubio-Patino, C., Mohammed, J. N., Luna-Vargas, M. P. A., Gelles, J. D., Kaminetsky, J. R., Serasinghe, M. N., Zou, C., Ali, S., McStay, G. P., Pfleger, C. M. and Chipuk, J. E.
Mol Cell. 2019 May 2, 74(3):452-465 e7.

Metastasis of pancreatic cancer: An uninflamed liver micromilieu controls cell growth and cancer stem cell properties by oxidative phosphorylation in pancreatic ductal epithelial cells
Fabian, A., Stegner, S., Miarka, L., Zimmermann, J., Lenk, L., Rahn, S., Buttlar, J., Viol, F., Knaack, H., Esser, D., Schauble, S., Grossmann, P., Marinos, G., Hasler, R., Mikulits, W., Saur, D., Kaleta, C., Schafer, H. and Sebens, S.
Cancer Lett. 2019 Jul 1, 453: 95-106.

The circadian protein CLOCK regulates cell metabolism via the mitochondrial carrier SLC25A10
Cai, T., Hua, B., Luo, D., Xu, L., Cheng, Q., Yuan, G., Yan, Z., Sun, N., Hua, L. and Lu, C.
Biochim Biophys Acta Mol Cell Res. 2019 Aug 1, 1866(8):1310-1321.

SUMOylation promotes survival and integration of neural stem cell grafts in ischemic stroke
Bernstock, J. D., Peruzzotti-Jametti, L., Leonardi, T., Vicario, N., Ye, D., Lee, Y. J., Maric, D., Johnson, K. R., Mou, Y., Van Den Bosch, A., Winterbone, M., Friedman, G. K., Franklin, R. J. M., Hallenbeck, J. M. and Pluchino, S.
EBioMedicine. 2019 Apr 1, 42:214-224.

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
Hu, D., Sun, X., Liao, X., Zhang, X., Zarabi, S., Schimmer, A., Hong, Y., Ford, C., Luo, Y. and Qi, X.
Acta Neuropathol. 2019 Jun 1, 137(6):939-960.

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer
Kitani, T., Ong, S. G., Lam, C. K., Rhee, J. W., Zhang, J. Z., Oikonomopoulos, A., Ma, N., Tian, L., Lee, J., Telli, M. L., Witteles, R. M., Sharma, A., Sayed, N. and Wu, J. C.
Circulation. 2019 May 21, 139(21):2451-2465.

NUPR1 acts as a pro-survival factor in human bone marrow-derived mesenchymal stem cells and is induced by the hypoxia mimetic reagent deferoxamine
Matsunaga, K., Fujisawa, K., Takami, T., Burganova, G., Sasai, N., Matsumoto, T., Yamamoto, N. and Sakaida, I.
J Clin Biochem Nutr. 2019 May 1, 64(3):209-216.

Metabolic switching in pluripotent stem cells reorganizes energy metabolism and subcellular organelles
O'Reilly, C., Cho, J. H., Qi, Q., Peters, J. L., Fukuda, Y., Frase, S., Peng, J., Schuetz, J. D., Cheng, Y., Yoon, S. O. and Han, M. J.
Exp Cell Res. 2019 Jun 1, 379(1):55-64.

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells
Adane, B., Ye, H., Khan, N., Pei, S., Minhajuddin, M., Stevens, B. M., Jones, C. L., D'Alessandro, A., Reisz, J. A., Zaberezhnyy, V., Gasparetto, M., Ho, T. C., Kelly, K. K., Myers, J. R., Ashton, J. M., Siegenthaler, J., Kume, T., Campbell, E. L., Pollyea, D. A., Becker, M. W. and Jordan, C. T.
Cell Rep. 2019 Apr 2, 27(1):238-254 e6.

Sirtuin-1/Mitochondrial Ribosomal Protein S5 Axis Enhances the Metabolic Flexibility of Liver Cancer Stem Cells
Wei, Z., Jia, J., Heng, G., Xu, H., Shan, J., Wang, G., Liu, C., Xia, J., Zhou, H., Wu, M., Yang, Z., Wang, M., Xiong, Z., Huang, H., Liu, L. and Qian, C.
Hepatology. 2019 Mar 22, [epub ahead of print]

A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles
Zhang, J. Z., Termglinchan, V., Shao, N. Y., Itzhaki, I., Liu, C., Ma, N., Tian, L., Wang, V. Y., Chang, A. C. Y., Guo, H., Kitani, T., Wu, H., Lam, C. K., Kodo, K., Sayed, N., Blau, H. M. and Wu, J. C.
Cell Stem Cell. 2019 May 2, 24(5):802-811 e5.

ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells
Wang, X., Wang, Q. C., Sun, Z., Li, T., Yang, K., An, C., Guo, C. and Tang, T. S.
Biochem Biophys Res Commun. 2019 May 14, 512(4):914-920.

Histone H2AX promotes neuronal health by controlling mitochondrial homeostasis
Weyemi, U., Paul, B. D., Bhattacharya, D., Malla, A. P., Boufraqech, M., Harraz, M. M., Bonner, W. M. and Snyder, S. H.
Proc Natl Acad Sci U S A. 2019 Apr 9, 116(15):7471-7476.

Techniques & Methods

Methods in Molecular Biology: Cancer Metabolism Methods and Protocols
Haznadar, M.
Springer Protocols. 2019 July 1, 1928.

High-throughput, label-free, single-cell photoacoustic microscopy of intratumoral metabolic heterogeneity
Hai, P., Imai, T., Xu, S., Zhang, R., Aft, R. L., Zou, J. and Wang, L. V.
Nat Biomed Eng. 2019 May 1, 3(5):381-391.

A novel serum free primary astrocyte culture method that mimic quiescent astrocyte phenotype
Prah, J., Winters, A., Chaudhari, K., Hersh, J., Liu, R. and Yang, S. H.
J Neurosci Methods. 2019 May 15, 320:50-63.

A New Efficient Method for Measuring Oxygen Consumption Rate Directly ex vivo in Human Epidermal Biopsies
Schniertshauer, D., Gebhard, D. and Bergemann, J.
Bio-Protocol. 2019 Mar 5, 9(5).

An Improved Method for Preparation of Uniform and Functional Mitochondria from Fresh Liver
Farah, N. K., Liu, X., Wu, C. H. and Wu, G. Y.
J Clin Transl Hepatol. 2019 Mar 28, 7(1):46-50.

Toxicology Research

Molecular Toxicological Mechanisms of Synthetic Cathinones on C2C12 Myoblasts
Zhou, X., Luethi, D., Sanvee, G. M., Bouitbir, J., Liechti, M. E. and Krahenbuhl, S.
Int J Mol Sci. 2019 Mar 28, 20(7).

Translational Research

Influence of genetic copy number variants of the human GLUT3 glucose transporter gene SLC2A3 on protein expression, glycolysis and rheumatoid arthritis risk: A genetic replication study
Simpfendorfer, K. R., Li, W., Shih, A., Wen, H., Kothari, H. P., Einsidler, E. A., Wuster, A., Hunkapiller, J., Behrens, T. W., Graham, R. R., Townsend, M. J., Behar, D. M., Hu, R., Greenspan, E. and Gregersen, P. K.
Mol Genet Metab Rep. 2019 Apr 6, 19:100470.

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