XF Publications Alert - June 2019

The Publications Alert gathers and compiles a list of all the most recent peer-reviewed publications containing Seahorse XF and Soluble Sensor data, based solely on user-generated content.

Aging Research

New drugs for pharmacological extension of replicative life span in normal and progeroid cells
Vatolin, S., Radivoyevitch, T. and Maciejewski, J. P.
NPJ Aging Mech Dis. 2019 Jan 16, 5:2.

Plant-derived mitochondria-targeting cysteine-rich peptide modulates cellular bioenergetics
Kam, A., Loo, S., Dutta, B., Sze, S. K. and Tam, J. P.
J Biol Chem. 2019 Mar 15, 294(11):4000-4011.

Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults
Pence, B. D. and Yarbro, J. R.
Immun Ageing. 2019 Jan 26, 16:3.

Repurposing old carbon monoxide-releasing molecules towards the anti-angiogenic therapy of triple-negative breast cancer
Kourti, M., Westwell, A., Jiang, W. and Cai, J.
Oncotarget. 2019 Feb 1, 10(10):1132-1148.

Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle
Kitaoka, Y., Tamura, Y., Takahashi, K., Takeda, K., Takemasa, T. and Hatta, H.
Physiol Rep. 2019 Feb 1, 7(3):e13998.

Assays under Hypoxia

O2 Economizer for Inhibiting Cell Respiration To Combat the Hypoxia Obstacle in Tumor Treatments
Yu, W., Liu, T., Zhang, M., Wang, Z., Ye, J., Li, C. X., Liu, W., Li, R., Feng, J. and Zhang, X. Z.
ACS Nano. 2019 Feb 26, 13(2):1784-1794.

Cancer Research

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8(+) T cells
Gemta, L. F., Siska, P. J., Nelson, M. E., Gao, X., Liu, X., Locasale, J. W., Yagita, H., Slingluff, C. L., Jr., Hoehn, K. L., Rathmell, J. C. and Bullock, T. N. J.
Sci Immunol. 2019 Jan 25, 4(31).

Mitochondrial metabolism promotes adaptation to proteotoxic stress
Tsvetkov, P., Detappe, A., Cai, K., Keys, H. R., Brune, Z., Ying, W., Thiru, P., Reidy, M., Kugener, G., Rossen, J., Kocak, M., Kory, N., Tsherniak, A., Santagata, S., Whitesell, L., Ghobrial, I. M., Markley, J. L., Lindquist, S. and Golub, T. R.
Nat Chem Biol. 2019 May 27, [epub ahead of print]

Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation
Lee, J. S., Lee, H., Lee, S., Kang, J. H., Lee, S. H., Kim, S. G., Cho, E. S., Kim, N. H., Yook, J. I. and Kim, S. Y.
EBioMedicine. 2019 Feb 1, 40:184-197.

The mitochondrial retrograde signaling regulates Wnt signaling to promote tumorigenesis in colon cancer
Wen, Y. A., Xiong, X., Scott, T., Li, A. T., Wang, C., Weiss, H. L., Tan, L., Bradford, E., Fan, T. W. M., Chandel, N. S., Barrett, T. A. and Gao, T.
Cell Death Differ. 2019 Jan 18, [epub ahead of print]

Betulinic acid suppresses breast cancer aerobic glycolysis via caveolin-1/NF-kappaB/c-Myc pathway
Jiao, L., Wang, S., Zheng, Y., Wang, N., Yang, B., Wang, D., Yang, D., Mei, W., Zhao, Z. and Wang, Z.
Biochem Pharmacol. 2019 Mar 1, 161:149-162.

Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia
Mitchell, S. R., Larkin, K., Grieselhuber, N. R., Lai, T. H., Cannon, M., Orwick, S., Sharma, P., Asemelash, Y., Zhang, P., Goettl, V. M., Beaver, L., Mims, A., Puduvalli, V. K., Blachly, J. S., Lehman, A., Harrington, B., Henderson, S., Breitbach, J. T., Williams, K. E., Dong, S., Baloglu, E., Senapedis, W., Kirschner, K., Sampath, D., Lapalombella, R. and Byrd, J. C.
Blood Adv. 2019 Feb 12, 3(3):242-255.

A Code of Mono-phosphorylation Modulates the Function of RB
Sanidas, I., Morris, R., Fella, K. A., Rumde, P. H., Boukhali, M., Tai, E. C., Ting, D. T., Lawrence, M. S., Haas, W. and Dyson, N. J.
Mol Cell. 2019 Mar 7, 73(5):985-1000 e6.

Vitamin D and testosterone co-ordinately modulate intracellular zinc levels and energy metabolism in prostate cancer cells
Zhang, P., Schatz, A., Adeyemi, B., Kozminski, D., Welsh, J., Tenniswood, M. and Wang, W. W.
J Steroid Biochem Mol Biol. 2019 May 1, 189:248-258.

Exploration of the chondrosarcoma metabolome; the mTOR pathway as an important pro-survival pathway
Addie, R. D., de Jong, Y., Alberti, G., Kruisselbrink, A. B., Que, I., Baelde, H. and Bovee, J.
J Bone Oncol. 2019 Jan 29, 15:100222.

Deep motif deconvolution of HLA-II peptidomes for robust class II epitope predictions
Racle, J., Michaux, J., Rockinger, G. A., Arnaud, M., Bobisse, S., Chong, C., Guillaume, P., Coukos, G., Harari, A., Jandus, C., Bassani-Sternberg, M. and Gfeller, D.
bioRxiv. 2019 Feb 3, [epub ahead of print]

Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells
Clementino, M., Kim, D. and Zhang, Z.
Toxicol Sci. 2019 May 1, 169(1):224-234.

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression
Kalainayakan, S. P., Ghosh, P., Dey, S., Fitzgerald, K. E., Sohoni, S., Konduri, P. C., Garrossian, M., Liu, L. and Zhang, L.
Sci Rep. 2019 Feb 5, 9(1):1405.

Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors
Kovacs, T., Miko, E., Vida, A., Sebo, E., Toth, J., Csonka, T., Boratko, A., Ujlaki, G., Lente, G., Kovacs, P., Toth, D., Arkosy, P., Kiss, B., Mehes, G., Goedert, J. J. and Bai, P.
Sci Rep. 2019 Feb 4, 9(1):1300.

Plasminogen Activator Inhibitor 1 (PAI1) Promotes Actin Cytoskeleton Reorganization and Glycolytic Metabolism in Triple-Negative Breast Cancer
Humphries, B. A., Buschhaus, J. M., Chen, Y. C., Haley, H. R., Qyli, T., Chiang, B., Shen, N., Rajendran, S., Cutter, A., Cheng, Y. H., Chen, Y. T., Cong, J., Spinosa, P. C., Yoon, E., Luker, K. E. and Luker, G. D.
Mol Cancer Res. 2019 May 1, 17(5):1142-1154.

Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma
Yang, C., Wang, S., Ruan, H., Li, B., Cheng, Z., He, J., Zuo, Q., Yu, C., Wang, H., Lv, Y., Gu, D., Jin, G., Yao, M., Qin, W. and Jin, H.
J Cancer. 2019 Jan 29, 10(4):918-926.

O2 Economizer for Inhibiting Cell Respiration To Combat the Hypoxia Obstacle in Tumor Treatments
Yu, W., Liu, T., Zhang, M., Wang, Z., Ye, J., Li, C. X., Liu, W., Li, R., Feng, J. and Zhang, X. Z.
ACS Nano. 2019 Feb 26, 13(2):1784-1794.

Cancer Metabolism Methods and Protocols
Hazanadar, M.
Methods in Molecular Biology - Springer Protocols. 2019 Jun 1, 1928.

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways
Jia, D., Lu, M., Jung, K. H., Park, J. H., Yu, L., Onuchic, J. N., Kaipparettu, B. A. and Levine, H.
Proc Natl Acad Sci U S A. 2019 Feb 26, 116(9):3909-3918.

Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
Zhang, X., Wang, S., Wang, H., Cao, J., Huang, X., Chen, Z., Xu, P., Sun, G., Xu, J., Lv, J. and Xu, Z.
Mol Cancer. 2019 Feb 4, 18(1):20.

Inhibiting neddylation modification alters mitochondrial morphology and reprograms energy metabolism in cancer cells
Zhou, Q., Li, H., Li, Y., Tan, M., Fan, S., Cao, C., Meng, F., Zhu, L., Zhao, L., Guan, M. X., Jin, H. and Sun, Y.
JCI Insight. 2019 Feb 21, 4(4).

Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment
Huang, K., Jiang, L., Liang, R., Li, H., Ruan, X., Shan, C., Ye, D. and Zhou, L.
Eur J Med Chem. 2019 Apr 15, 168:45-57.

Tumor Suppressor miRNA-204-5p Regulates Growth, Metastasis, and Immune Microenvironment Remodeling in Breast Cancer
Hong, B. S., Ryu, H. S., Kim, N., Kim, J., Lee, E., Moon, H., Kim, K. H., Jin, M. S., Kwon, N. H., Kim, S., Kim, D., Chung, D. H., Jeong, K., Kim, K., Kim, K. Y., Lee, H. B., Han, W., Yun, J., Kim, J. I., Noh, D. Y. and Moon, H. G.
Cancer Res. 2019 Apr 1, 79(7):1520-1534.

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer
Zhuang, Y., Ly, R. C., Frazier, C. V., Yu, J., Qin, S., Fan, X. Y., Goetz, M. P., Boughey, J. C., Weinshilboum, R. and Wang, L.
Cancer Metab. 2019 Jan 24, 7:1.

Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis
Chen, C., Bai, L., Cao, F., Wang, S., He, H., Song, M., Chen, H., Liu, Y., Guo, J., Si, Q., Pan, Y., Zhu, R., Chuang, T. H., Xiang, R. and Luo, Y.
Oncogene. 2019 Jun 1, 38(23):4527-4539.

gamma-Tocotrienol inhibits oxidative phosphorylation and triggers apoptosis by inhibiting mitochondrial complex I subunit NDUFB8 and complex II subunit SDHB
Wang, H., Luo, J., Tian, W., Yan, W., Ge, S., Zhang, Y. and Sun, W.
Toxicology. 2019 Apr 1, 417:42-53.

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration
Abdullah, C. S., Alam, S., Aishwarya, R., Miriyala, S., Bhuiyan, M. A. N., Panchatcharam, M., Pattillo, C. B., Orr, A. W., Sadoshima, J., Hill, J. A. and Bhuiyan, M. S.
Sci Rep. 2019 Feb 14, 9(1):2002.

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
Luu, M., Pautz, S., Kohl, V., Singh, R., Romero, R., Lucas, S., Hofmann, J., Raifer, H., Vachharajani, N., Carrascosa, L. C., Lamp, B., Nist, A., Stiewe, T., Shaul, Y., Adhikary, T., Zaiss, M. M., Lauth, M., Steinhoff, U. and Visekruna, A.
Nat Commun. 2019 Feb 15, 10(1):760.

LCAL1 enhances lung cancer survival via inhibiting AMPK-related antitumor functions
Li, J. Y. and Luo, Z. Q.
Mol Cell Biochem. 2019 Jul 1, 457(1-2):11-20.

SSRP1 promotes colorectal cancer progression and is negatively regulated by miR-28-5p
Wu, W., He, K., Guo, Q., Chen, J., Zhang, M., Huang, K., Yang, D., Wu, L., Deng, Y., Luo, X., Yu, H., Ding, Q. and Xiang, G.
J Cell Mol Med. 2019 May 1, 23(5):3118-3129.

Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARgamma activation exerting cancer growth suppression
Hua, T. N. M., Kim, M. K., Vo, V. T. A., Choi, J. W., Choi, J. H., Kim, H. W., Cha, S. K., Park, K. S. and Jeong, Y.
EBioMedicine. 2019 Mar 1, 41(134-145.

Ligand-binding Domain-activating Mutations of ESR1 Rewire Cellular Metabolism of Breast Cancer Cells
Zinger, L., Merenbakh-Lamin, K., Klein, A., Elazar, A., Journo, S., Boldes, T., Pasmanik-Chor, M., Spitzer, A., Rubinek, T. and Wolf, I.
Clin Cancer Res. 2019 May 1, 25(9):2900-2914.

Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8(+) T-cell Response against Immunosuppressive Tumors
Viitala, M., Virtakoivu, R., Tadayon, S., Rannikko, J., Jalkanen, S. and Hollmen, M.
Clin Cancer Res. 2019 Jun 1, 25(11):3289-3303.

Systematic Dissection of the Metabolic-Apoptotic Interface in AML Reveals Heme Biosynthesis to Be a Regulator of Drug Sensitivity
Lin, K. H., Xie, A., Rutter, J. C., Ahn, Y. R., Lloyd-Cowden, J. M., Nichols, A. G., Soderquist, R. S., Koves, T. R., Muoio, D. M., MacIver, N. J., Lamba, J. K., Pardee, T. S., McCall, C. M., Rizzieri, D. A. and Wood, K. C.
Cell Metab. 2019 May 7, 29(5):1217-1231 e7.

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer
Kumar, R., Bhat, T. A., Walsh, E. M., Chaudhary, A. K., O'Malley, J., Rhim, J. S., Wang, J., Morrison, C. D., Attwood, K., Bshara, W., Mohler, J. L., Yadav, N. and Chandra, D.
Cancer Res. 2019 Apr 1, 79(7):1353-1368.

Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop
Ma, F., Liu, X., Zhou, S., Li, W., Liu, C., Chadwick, M. and Qian, C.
Cancer Lett. 2019 May 28, 450:63-75.

Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of beta-catenin pathway
Datta, S., Choudhury, D., Das, A., Mukherjee, D. D., Dasgupta, M., Bandopadhyay, S. and Chakrabarti, G.
Apoptosis. 2019 Jun 1, 24(5-6):414-433.

Cardiovascular Research

Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury
Cui, H., Banerjee, S., Guo, S., Xie, N., Ge, J., Jiang, D., Zornig, M., Thannickal, V. J. and Liu, G.
JCI Insight. 2019 Feb 21, 4(4).

PTX3: an inflammatory protein modulating ultrastructure and bioenergetics of human endothelial cells
Carrizzo, A., Procaccini, C., Lenzi, P., Fusco, C., Villa, F., Migliarino, S., De Lucia, M., Fornai, F., Matarese, G., Puca, A. A. and Vecchione, C.
Immun Ageing. 2019 Feb 2, 16:4.

MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells
Zhang, C., Ma, C., Zhang, L., Zhang, L., Zhang, F., Ma, M., Zheng, X., Mao, M., Shen, T. and Zhu, D.
J Mol Med (Berl). 2019 Mar 1, 97(3):409-422.

Glycogen Synthase Kinase-3alpha Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy
Nakamura, M., Liu, T., Husain, S., Zhai, P., Warren, J. S., Hsu, C. P., Matsuda, T., Phiel, C. J., Cox, J. E., Tian, B., Li, H. and Sadoshima, J.
Cell Metab. 2019 May 7, 29(5):1119-1134 e12.

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration
Abdullah, C. S., Alam, S., Aishwarya, R., Miriyala, S., Bhuiyan, M. A. N., Panchatcharam, M., Pattillo, C. B., Orr, A. W., Sadoshima, J., Hill, J. A. and Bhuiyan, M. S.
Sci Rep. 2019 Feb 14, 9(1):2002.

LCAL1 enhances lung cancer survival via inhibiting AMPK-related antitumor functions
Li, J. Y. and Luo, Z. Q.
Mol Cell Biochem. 2019 Jul 1, 457(1-2):11-20.

Proteomic Analysis Reveals Temporal Changes in Protein Expression in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes In Vitro
Hellen, N., Pinto Ricardo, C., Vauchez, K., Whiting, G., Wheeler, J. X. and Harding, S. E.
Stem Cells Dev. 2019 May 1, 28(9):565-578.

Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance
Gorski, D. J., Petz, A., Reichert, C., Twarock, S., Grandoch, M. and Fischer, J. W.
Sci Rep. 2019 Feb 12, 9(1):1827.

Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury
Manning, J. R., Thapa, D., Zhang, M., Stoner, M. W., Traba, J., McTiernan, C. F., Corey, C., Shiva, S., Sack, M. N. and Scott, I.
J Mol Cell Cardiol. 2019 Apr 1, 129(69-78.

Altered mitochondrial quality control in Atg7-deficient VSMCs promotes enhanced apoptosis and is linked to unstable atherosclerotic plaque phenotype
Nahapetyan, H., Moulis, M., Grousset, E., Faccini, J., Grazide, M. H., Mucher, E., Elbaz, M., Martinet, W. and Vindis, C.
Cell Death Dis. 2019 Feb 11, 10(2):119.

Cell Physiology Research

Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury
Cui, H., Banerjee, S., Guo, S., Xie, N., Ge, J., Jiang, D., Zornig, M., Thannickal, V. J. and Liu, G.
JCI Insight. 2019 Feb 21, 4(4).

Calcium Signalling Methods & Protocols
Raffaello, A. and Reane, D. V.
Methods in Molecular Biology. 2019 Jan 1, 1925.

HIF-1alpha metabolically controls collagen synthesis and modification in chondrocytes
Stegen, S., Laperre, K., Eelen, G., Rinaldi, G., Fraisl, P., Torrekens, S., Van Looveren, R., Loopmans, S., Bultynck, G., Vinckier, S., Meersman, F., Maxwell, P. H., Rai, J., Weis, M., Eyre, D. R., Ghesquiere, B., Fendt, S. M., Carmeliet, P. and Carmeliet, G.
Nature. 2019 Jan 1, 565(7740):511-515.

The nuclear background influences the penetrance of the near-homoplasmic m.1630 A>G MELAS variant in a symptomatic proband and asymptomatic mother
Uittenbogaard, M., Wang, H., Zhang, V. W., Wong, L. J., Brantner, C. A., Gropman, A. and Chiaramello, A.
Mol Genet Metab. 2019 Apr 1, 126(4):429-438.

Carnosic Acid Improves Outcome after Repetitive Mild Traumatic Brain Injury
Maynard, M. E., Underwood, E. L., Redell, J. B., Zhao, J., Kobori, N., Hood, K. N., Moore, A. N. and Dash, P. K.
J Neurotrauma. 2019 Mar 26, [epub ahead of print]

Mitochondrial translocation of estrogen receptor beta affords resistance to oxidative insult-induced apoptosis and contributes to the pathogenesis of endometriosis
Liao, T. L., Lee, Y. C., Tzeng, C. R., Wang, Y. P., Chang, H. Y., Lin, Y. F. and Kao, S. H.
Free Radic Biol Med. 2019 Jan 24, 134:359-373.

Feasibility of cellular bioenergetics as a biomarker in porphyria patients
Chacko, B., Culp, M. L., Bloomer, J., Phillips, J., Kuo, Y. F., Darley-Usmar, V. and Singal, A. K.
Mol Genet Metab Rep. 2019 Jun 29, 19:100451.

Mitochondrial fusion supports increased oxidative phosphorylation during cell proliferation
Yao, C. H., Wang, R., Wang, Y., Kung, C. P., Weber, J. D. and Patti, G. J.
Elife. 2019 Jan 29, 8.

Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number
Serrage, H. J., Joanisse, S., Cooper, P. R., Palin, W., Hadis, M., Darch, O., Philp, A. and Milward, M. R.
J Biophotonics. 2019 Jun 1, 12(6):e201800411.

Leucine, Palmitate, or Leucine/Palmitate Cotreatment Enhances Myotube Lipid Content and Oxidative Preference
Johnson, M. A., Gannon, N. P., Schnuck, J. K., Lyon, E. S., Sunderland, K. L. and Vaughan, R. A.
Lipids. 2018 Nov 1, 53(11-12):1043-1057.

MiR-449a-5p mediates mitochondrial dysfunction and phenotypic transition by targeting Myc in pulmonary arterial smooth muscle cells
Zhang, C., Ma, C., Zhang, L., Zhang, L., Zhang, F., Ma, M., Zheng, X., Mao, M., Shen, T. and Zhu, D.
J Mol Med (Berl). 2019 Mar 1, 97(3):409-422.

Metabolic regulation of dermal fibroblasts contributes to skin extracellular matrix homeostasis and fibrosis Zhao, X., Psarianos, P., Ghoraie, L. S., Yip, K., Goldstein, D., Gilbert, R., Witterick, I., Pang, H., Hussain, A., Lee, J. H., Williams, J., Bratman, S. V., Ailles, L., Haibe-Kains, B. and Liu, F.-F. Nature Metabolism. 2019 Jan 7, 1(1):147-157.

MELAS syndrome with m.4450 G>A mutation in mitochondrial tRNA(Met) gene
Kuwajima, M., Goto, M., Kurane, K., Shimbo, H., Omika, N., Jimbo, E. F., Muramatsu, K., Tajika, M., Shimura, M., Murayama, K., Kurosawa, K., Yamagata, T. and Osaka, H.
Brain Dev. 2019 May 1, 41(5):465-469.

Effects of Nrf2 deficiency on mitochondrial oxidative stress in aged skeletal muscle
Kitaoka, Y., Tamura, Y., Takahashi, K., Takeda, K., Takemasa, T. and Hatta, H.
Physiol Rep. 2019 Feb 1, 7(3):e13998.

Cardiac-specific deletion of GCN5L1 restricts recovery from ischemia-reperfusion injury
Manning, J. R., Thapa, D., Zhang, M., Stoner, M. W., Traba, J., McTiernan, C. F., Corey, C., Shiva, S., Sack, M. N. and Scott, I.
J Mol Cell Cardiol. 2019 Apr 1, 129(69-78.

TGF-beta2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism
Takahashi, H., Alves, C. R. R., Stanford, K. I., Middelbeek, R. J. W., Pasquale, N., Ryan, R. E., Xue, R., Sakaguchi, M., Lynes, M. D., So, K., Mul, J. D., Lee, M. Y., Balan, E., Pan, H., Dreyfuss, J. M., Hirshman, M. F., Azhar, M., Hannukainen, J. C., Nuutila, P., Kalliokoski, K. K., Nielsen, S., Pedersen, B. K., Kahn, C. R., Tseng, Y. H. and Goodyear, L. J.
Nat Metab. 2019 Feb 1, 1(2):291-303.

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function
Kaufmann, U., Kahlfuss, S., Yang, J., Ivanova, E., Koralov, S. B. and Feske, S.
Cell Metab. 2019 May 7, 29(5):1104-1118 e6.

Drug Discovery

New drugs for pharmacological extension of replicative life span in normal and progeroid cells
Vatolin, S., Radivoyevitch, T. and Maciejewski, J. P.
NPJ Aging Mech Dis. 2019 Jan 16, 5:2.

Selective targeting of NAMPT by KPT-9274 in acute myeloid leukemia
Mitchell, S. R., Larkin, K., Grieselhuber, N. R., Lai, T. H., Cannon, M., Orwick, S., Sharma, P., Asemelash, Y., Zhang, P., Goettl, V. M., Beaver, L., Mims, A., Puduvalli, V. K., Blachly, J. S., Lehman, A., Harrington, B., Henderson, S., Breitbach, J. T., Williams, K. E., Dong, S., Baloglu, E., Senapedis, W., Kirschner, K., Sampath, D., Lapalombella, R. and Byrd, J. C.
Blood Adv. 2019 Feb 12, 3(3):242-255.

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease
Zhang, L., Zhao, P., Yue, C., Jin, Z., Liu, Q., Du, X. and He, Q.
Biomaterials. 2019 Mar 1, 197:393-404.

Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression
Kalainayakan, S. P., Ghosh, P., Dey, S., Fitzgerald, K. E., Sohoni, S., Konduri, P. C., Garrossian, M., Liu, L. and Zhang, L.
Sci Rep. 2019 Feb 5, 9(1):1405.

Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment
Huang, K., Jiang, L., Liang, R., Li, H., Ruan, X., Shan, C., Ye, D. and Zhou, L.
Eur J Med Chem. 2019 Apr 15, 168:45-57.

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
Woodhead, J. L., Yang, K., Oldach, D., MacLauchlin, C., Fernandes, P., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Pharm Res. 2019 Feb 7, 36(3):48.

Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation
Zhao, S., Chu, Y., Zhang, Y., Zhou, Y., Jiang, Z., Wang, Z., Mao, L., Li, K., Sun, W., Li, P., Jia, S., Wang, C., Xu, A., Loomes, K., Tang, S., Wu, D., Hui, X. and Nie, T.
Life Sci. 2019 Apr 1, 222:117-124.

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer
Zhuang, Y., Ly, R. C., Frazier, C. V., Yu, J., Qin, S., Fan, X. Y., Goetz, M. P., Boughey, J. C., Weinshilboum, R. and Wang, L.
Cancer Metab. 2019 Jan 24, 7:1.

Repurposing old carbon monoxide-releasing molecules towards the anti-angiogenic therapy of triple-negative breast cancer
Kourti, M., Westwell, A., Jiang, W. and Cai, J.
Oncotarget. 2019 Feb 1, 10(10):1132-1148.

gamma-Tocotrienol inhibits oxidative phosphorylation and triggers apoptosis by inhibiting mitochondrial complex I subunit NDUFB8 and complex II subunit SDHB
Wang, H., Luo, J., Tian, W., Yan, W., Ge, S., Zhang, Y. and Sun, W.
Toxicology. 2019 Apr 1, 417:42-53.

Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration
Abdullah, C. S., Alam, S., Aishwarya, R., Miriyala, S., Bhuiyan, M. A. N., Panchatcharam, M., Pattillo, C. B., Orr, A. W., Sadoshima, J., Hill, J. A. and Bhuiyan, M. S.
Sci Rep. 2019 Feb 14, 9(1):2002.

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function
Kaufmann, U., Kahlfuss, S., Yang, J., Ivanova, E., Koralov, S. B. and Feske, S.
Cell Metab. 2019 May 7, 29(5):1104-1118 e6.

Modulation of autophagy by the novel mitochondrial complex I inhibitor Authipyrin
Kaiser, N., Corkery, D., Wu, Y., Laraia, L. and Waldmann, H.
Bioorg Med Chem. 2019 Jun 15, 27(12):2444-2448.

Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of beta-catenin pathway
Datta, S., Choudhury, D., Das, A., Mukherjee, D. D., Dasgupta, M., Bandopadhyay, S. and Chakrabarti, G.
Apoptosis. 2019 Jun 1, 24(5-6):414-433.

Food & Nutritional Research

Adverse effects of fluorescent carbon dots from canned yellow croaker on cellular respiration and glycolysis
Li, D., Na, X., Zhou, W., Wang, C., Li, Y., Zhu, B. W. and Tan, M.
Food Funct. 2019 Feb 20, 10(2):1123-1131.

Vitamin D and testosterone co-ordinately modulate intracellular zinc levels and energy metabolism in prostate cancer cells
Zhang, P., Schatz, A., Adeyemi, B., Kozminski, D., Welsh, J., Tenniswood, M. and Wang, W. W.
J Steroid Biochem Mol Biol. 2019 May 1, 189:248-258.

Cytotoxicity and mitochondrial dysfunction caused by the dietary supplement l-norvaline
Samardzic, K. and Rodgers, K. J.
Toxicol In Vitro. 2019 Apr 1, 56:163-171.

Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer
Kumar, R., Bhat, T. A., Walsh, E. M., Chaudhary, A. K., O'Malley, J., Rhim, J. S., Wang, J., Morrison, C. D., Attwood, K., Bshara, W., Mohler, J. L., Yadav, N. and Chandra, D.
Cancer Res. 2019 Apr 1, 79(7):1353-1368.

Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages
Walter, K. R., Lin, X., Jacobi, S. K., Kaser, T., Esposito, D. and Odle, J.
J Anim Sci Biotechnol. 2019 Feb 15, 10:13.

Hepatobiology Research

Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma
Yang, C., Wang, S., Ruan, H., Li, B., Cheng, Z., He, J., Zuo, Q., Yu, C., Wang, H., Lv, Y., Gu, D., Jin, G., Yao, M., Qin, W. and Jin, H.
J Cancer. 2019 Jan 29, 10(4):918-926.

Glial Cell Line-Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity
Mwangi, S. M., Li, G., Ye, L., Liu, Y., Reichardt, F., Yeligar, S. M., Hart, C. M., Czaja, M. J. and Srinivasan, S.
Hepatology. 2019 Jun 1, 69(6):2455-2470.

Activation of SIRT1 by L-serine increases fatty acid oxidation and reverses insulin resistance in C2C12 myotubes (L-serine activates SIRT1 in C2C12 myotubes)
Sim, W. C., Kim, D. G., Lee, W., Sim, H., Choi, Y. J. and Lee, B. H.
Cell Biol Toxicol. 2019 Feb 5, [epub ahead of print]

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
Woodhead, J. L., Yang, K., Oldach, D., MacLauchlin, C., Fernandes, P., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Pharm Res. 2019 Feb 7, 36(3):48.

Immunology Research

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8(+) T cells
Gemta, L. F., Siska, P. J., Nelson, M. E., Gao, X., Liu, X., Locasale, J. W., Yagita, H., Slingluff, C. L., Jr., Hoehn, K. L., Rathmell, J. C. and Bullock, T. N. J.
Sci Immunol. 2019 Jan 25, 4(31).

Long noncoding RNA Malat1 regulates differential activation of macrophages and response to lung injury
Cui, H., Banerjee, S., Guo, S., Xie, N., Ge, J., Jiang, D., Zornig, M., Thannickal, V. J. and Liu, G.
JCI Insight. 2019 Feb 21, 4(4).

Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice
Wang, A., Pope, S. D., Weinstein, J. S., Yu, S., Zhang, C., Booth, C. J. and Medzhitov, R.
Proc Natl Acad Sci U S A. 2019 Feb 5, 116(6):2200-2209.

Loss of intestinal sympathetic innervation elicits an innate immune driven colitis
Willemze, R. A., Welting, O., van Hamersveld, P., Verseijden, C., Nijhuis, L. E., Hilbers, F. W., Meijer, S. L., Heesters, B. A., Folgering, J. H. A., Darwinkel, H., Blancou, P., Vervoordeldonk, M. J., Seppen, J., Heinsbroek, S. E. M. and de Jonge, W. J.
Mol Med. 2019 Jan 7, 25(1):1.

Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation
Jitschin, R., Bottcher, M., Saul, D., Lukassen, S., Bruns, H., Loschinski, R., Ekici, A. B., Reis, A., Mackensen, A. and Mougiakakos, D.
Leukemia. 2019 Jan 24, [epub ahead of print]

Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets
Winnica, D., Corey, C., Mullett, S., Reynolds, M., Hill, G., Wendell, S., Que, L., Holguin, F. and Shiva, S.
Antioxid Redox Signal. 2019 Mar 6, [epub ahead of print]

Classical monocytes maintain ex vivo glycolytic metabolism and early but not later inflammatory responses in older adults
Pence, B. D. and Yarbro, J. R.
Immun Ageing. 2019 Jan 26, 16:3.

Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells
Almutairi, S. M., Ali, A. K., He, W., Yang, D. S., Ghorbani, P., Wang, L., Fullerton, M. D. and Lee, S. H.
J Biol Chem. 2019 Mar 22, 294(12):4644-4655.

IFNbeta enhances mesenchymal stromal (Stem) cells immunomodulatory function through STAT1-3 activation and mTOR-associated promotion of glucose metabolism
Vigo, T., La Rocca, C., Faicchia, D., Procaccini, C., Ruggieri, M., Salvetti, M., Centonze, D., Matarese, G., Uccelli, A. and Network, M.
Cell Death Dis. 2019 Jan 28, 10(2):85.

Deep motif deconvolution of HLA-II peptidomes for robust class II epitope predictions
Racle, J., Michaux, J., Rockinger, G. A., Arnaud, M., Bobisse, S., Chong, C., Guillaume, P., Coukos, G., Harari, A., Jandus, C., Bassani-Sternberg, M. and Gfeller, D.
bioRxiv. 2019 Feb 3, [epub ahead of print]

Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number
Serrage, H. J., Joanisse, S., Cooper, P. R., Palin, W., Hadis, M., Darch, O., Philp, A. and Milward, M. R.
J Biophotonics. 2019 Jun 1, 12(6):e201800411.

Leucine, Palmitate, or Leucine/Palmitate Cotreatment Enhances Myotube Lipid Content and Oxidative Preference
Johnson, M. A., Gannon, N. P., Schnuck, J. K., Lyon, E. S., Sunderland, K. L. and Vaughan, R. A.
Lipids. 2018 Nov 1, 53(11-12):1043-1057.

Dissection of the cellular function of the ZBED6 transcription factor in mouse myoblast cells using gene editing, RNAseq and proteomics
Younis, S., Naboulsi, R., Wang, X., Cao, X., Larsson, M., Sargsyan, E., Bergsten, P., Welsh, N. and Andersson, L.
bioRxiv. 2019 Feb 5, [epub ahead of print]

Label-free Method for Classification of T cell Activation
Walsh, A., Mueller, K., Jones, I., Walsh, C. M., Piscopo, N., Niemi, N. N., Pagliarini, D. J., Saha, K. and Skala, M. C.
bioRxiv. 2019 Jan 31, [epub ahead of print]

Guggulsterone Activates Adipocyte Beiging through Direct Effects on 3T3-L1 Adipocytes and Indirect Effects Mediated through RAW264.7 Macrophages
Miller, C. N., Samuels, J. S., Azhar, Y., Parmar, A., Shashidharamurthy, R. and Rayalam, S.
Medicines (Basel). 2019 Jan 31, 6(1).

Placental extracts regulate melanin synthesis in normal human melanocytes with alterations of mitochondrial respiration
Yoshimoto, S., Ohagi, Y., Yoshida, M., Yanagi, H., Hibino, S., Ichihashi, M. and Ando, H.
Exp Dermatol. 2019 Feb 1, 28 Suppl 1:50-54.

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc
Li, M., Lazorchak, A. S., Ouyang, X., Zhang, H., Liu, H., Arojo, O. A., Yan, L., Jin, J., Han, Y., Qu, G., Fu, Y., Xu, X., Liu, X., Zhang, W., Yang, Z., Ruan, C., Wang, Q., Liu, D., Huang, C., Lu, L., Jiang, S., Li, F. and Su, B. Cell
Mol Immunol. 2019 Jan 31, [epub ahead of print]

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery of Antigen and Improve Vaccine Efficacy while Inducing Low Inflammation
Senapati, S., Darling, R. J., Loh, D., Schneider, I. C., Wannemuehler, M. J., Narasimhan, B. and Mallapragada, S. K.
ACS Biomaterials Science & Engineering. 2019 Feb 5, 5(3):1332-1342.

Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells
Cross, E. W., Blain, T. J., Mathew, D. and Kedl, R. M.
PLoS One. 2019 Feb 8, 14(2):e0211446.

IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
Du, L., Lin, L., Li, Q., Liu, K., Huang, Y., Wang, X., Cao, K., Chen, X., Cao, W., Li, F., Shao, C., Wang, Y. and Shi, Y.
Cell Metab. 2019 Jun 4, 29(6):1363-1375 e8.

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes
Luu, M., Pautz, S., Kohl, V., Singh, R., Romero, R., Lucas, S., Hofmann, J., Raifer, H., Vachharajani, N., Carrascosa, L. C., Lamp, B., Nist, A., Stiewe, T., Shaul, Y., Adhikary, T., Zaiss, M. M., Lauth, M., Steinhoff, U. and Visekruna, A.
Nat Commun. 2019 Feb 15, 10(1):760.

Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8(+) T-cell Response against Immunosuppressive Tumors
Viitala, M., Virtakoivu, R., Tadayon, S., Rannikko, J., Jalkanen, S. and Hollmen, M.
Clin Cancer Res. 2019 Jun 1, 25(11):3289-3303.

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function
Kaufmann, U., Kahlfuss, S., Yang, J., Ivanova, E., Koralov, S. B. and Feske, S.
Cell Metab. 2019 May 7, 29(5):1104-1118 e6.

Glucose Metabolism is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes Mellitus
Fidler, T. P., Marti, A., Gerth, K., Middleton, E. A., Campbell, R. A., Rondina, M. T., Weyrich, A. S. and Abel, E. D.
Diabetes. 2019 Feb 7, [epub ahead of print]

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease
Runtsch, M. C., Nelson, M. C., Lee, S. H., Voth, W., Alexander, M., Hu, R., Wallace, J., Petersen, C., Panic, V., Villanueva, C. J., Evason, K. J., Bauer, K. M., Mosbruger, T., Boudina, S., Bronner, M., Round, J. L., Drummond, M. J. and O'Connell, R. M.
PLoS Genet. 2019 Feb 15, 15(2):e1007970.

Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program
Noh, J. H., Kim, K. M., Pandey, P. R., Noren Hooten, N., Munk, R., Kundu, G., De, S., Martindale, J. L., Yang, X., Evans, M. K., Abdelmohsen, K. and Gorospe, M.
Nucleic Acids Res. 2019 Mar 18, 47(5):2472-2486.

Dietary arachidonate in milk replacer triggers dual benefits of PGE2 signaling in LPS-challenged piglet alveolar macrophages
Walter, K. R., Lin, X., Jacobi, S. K., Kaser, T., Esposito, D. and Odle, J.
J Anim Sci Biotechnol. 2019 Feb 15, 10:13.

Serine Metabolism Supports Macrophage IL-1beta Production
Rodriguez, A. E., Ducker, G. S., Billingham, L. K., Martinez, C. A., Mainolfi, N., Suri, V., Friedman, A., Manfredi, M. G., Weinberg, S. E., Rabinowitz, J. D. and Chandel, N. S.
Cell Metab. 2019 Apr 2, 29(4):1003-1011 e4.

Infectious Disease Research

Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice
Wang, A., Pope, S. D., Weinstein, J. S., Yu, S., Zhang, C., Booth, C. J. and Medzhitov, R.
Proc Natl Acad Sci U S A. 2019 Feb 5, 116(6):2200-2209.

Legionella Methods & Protocols Second Edition
Buchrieser, C. and Hilbi, H.
Methods in Molecular Biology. 2019 Jun 1, 1921.

Phosphatidic acid as a limiting host metabolite for the proliferation of the microsporidium Tubulinosema ratisbonensis in Drosophila flies
Franchet, A., Niehus, S., Caravello, G. and Ferrandon, D.
Nat Microbiol. 2019 Apr 1, 4(4):645-655.

Pentablock Copolymer Micelle Nanoadjuvants Enhance Cytosolic Delivery of Antigen and Improve Vaccine Efficacy while Inducing Low Inflammation
Senapati, S., Darling, R. J., Loh, D., Schneider, I. C., Wannemuehler, M. J., Narasimhan, B. and Mallapragada, S. K.
ACS Biomaterials Science & Engineering. 2019 Feb 5, 5(3):1332-1342.

Microbial Research

Legionella Methods & Protocols Second Edition
Buchrieser, C. and Hilbi, H.
Methods in Molecular Biology. 2019 Jun 1, 1921.

Phosphatidic acid as a limiting host metabolite for the proliferation of the microsporidium Tubulinosema ratisbonensis in Drosophila flies
Franchet, A., Niehus, S., Caravello, G. and Ferrandon, D.
Nat Microbiol. 2019 Apr 1, 4(4):645-655.

Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors
Kovacs, T., Miko, E., Vida, A., Sebo, E., Toth, J., Csonka, T., Boratko, A., Ujlaki, G., Lente, G., Kovacs, P., Toth, D., Arkosy, P., Kiss, B., Mehes, G., Goedert, J. J. and Bai, P.
Sci Rep. 2019 Feb 4, 9(1):1300.

Mitochondrial Disease Research

ETF-QO Mutants Uncoupled Fatty Acid beta-Oxidation and Mitochondrial Bioenergetics Leading to Lipid Pathology
Chokchaiwong, S., Kuo, Y. T., Hsu, S. P., Hsu, Y. C., Lin, S. H., Zhong, W. B., Lin, Y. F. and Kao, S. H.
Cells. 2019 Jan 31, 8(2).

MELAS syndrome with m.4450 G>A mutation in mitochondrial tRNA(Met) gene
Kuwajima, M., Goto, M., Kurane, K., Shimbo, H., Omika, N., Jimbo, E. F., Muramatsu, K., Tajika, M., Shimura, M., Murayama, K., Kurosawa, K., Yamagata, T. and Osaka, H.
Brain Dev. 2019 May 1, 41(5):465-469.

Nephrology Research

Proximal Tubular Cell-Specific Ablation of Carnitine Acetyltransferase Causes Tubular Disease and Secondary Glomerulosclerosis
Kruger, C., Nguyen, T. T., Breaux, C., Guillory, A., Mangelli, M., Fridianto, K. T., Kovalik, J. P., Burk, D. H., Noland, R. C., Mynatt, R. and Stadler, K.
Diabetes. 2019 Apr 1, 68(4):819-831.

Neurobiology Research

Carnosic Acid Improves Outcome after Repetitive Mild Traumatic Brain Injury
Maynard, M. E., Underwood, E. L., Redell, J. B., Zhao, J., Kobori, N., Hood, K. N., Moore, A. N. and Dash, P. K.
J Neurotrauma. 2019 Mar 26, [epub ahead of print]

Distinct differences in rates of oxygen consumption and ATP synthesis of regionally isolated non-synaptic mouse brain mitochondria
Andersen, J. V., Jakobsen, E., Waagepetersen, H. S. and Aldana, B. I.
J Neurosci Res. 2019 Jan 24, [epub ahead of print]

Sustained release of bioactive hydrogen by Pd hydride nanoparticles overcomes Alzheimer's disease
Zhang, L., Zhao, P., Yue, C., Jin, Z., Liu, Q., Du, X. and He, Q.
Biomaterials. 2019 Mar 1, 197:393-404.

IFNbeta enhances mesenchymal stromal (Stem) cells immunomodulatory function through STAT1-3 activation and mTOR-associated promotion of glucose metabolism
Vigo, T., La Rocca, C., Faicchia, D., Procaccini, C., Ruggieri, M., Salvetti, M., Centonze, D., Matarese, G., Uccelli, A. and Network, M.
Cell Death Dis. 2019 Jan 28, 10(2):85.

Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming
Wolfe, H., Mela, V., Minogue, A. M., Miller, A. M., McGuigan, C., Williams, L., Lohan, D., Lawlor, B. A. and Lynch, M. A.
Neurosci Res. 2019 Jan 12, [epub ahead of print]

Oxygen consumption rate for evaluation of COQ2 variants associated with multiple system atrophy
Yasuda, T., Matsukawa, T., Mitsui, J. and Tsuji, S.
Neurogenetics. 2019 Mar 1, 20(1):51-52.

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease
Ward, J. M., Stoyas, C. A., Switonski, P. M., Ichou, F., Fan, W., Collins, B., Wall, C. E., Adanyeguh, I., Niu, C., Sopher, B. L., Kinoshita, C., Morrison, R. S., Durr, A., Muotri, A. R., Evans, R. M., Mochel, F. and La Spada, A. R.
Cell Rep. 2019 Jan 29, 26(5):1189-1202 e6.

Glial Cell Line-Derived Neurotrophic Factor Enhances Autophagic Flux in Mouse and Rat Hepatocytes and Protects Against Palmitate Lipotoxicity
Mwangi, S. M., Li, G., Ye, L., Liu, Y., Reichardt, F., Yeligar, S. M., Hart, C. M., Czaja, M. J. and Srinivasan, S.
Hepatology. 2019 Jun 1, 69(6):2455-2470.

Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathology
Chuang, C. Y., Yang, C. C., Soong, B. W., Yu, C. Y., Chen, S. H., Huang, H. P. and Kuo, H. C.
Sci Rep. 2019 Feb 4, 9(1):1166.

MELAS syndrome with m.4450 G>A mutation in mitochondrial tRNA(Met) gene
Kuwajima, M., Goto, M., Kurane, K., Shimbo, H., Omika, N., Jimbo, E. F., Muramatsu, K., Tajika, M., Shimura, M., Murayama, K., Kurosawa, K., Yamagata, T. and Osaka, H.
Brain Dev. 2019 May 1, 41(5):465-469.

Clinical and neuroimaging features of the m.10197G>A mtDNA mutation: New case reports and expansion of the phenotype variability
Tolomeo, D., Rubegni, A., Severino, M., Pochiero, F., Bruno, C., Cassandrini, D., Madeo, A., Doccini, S., Pedemonte, M., Rossi, A., D'Amore, F., Donati, M. A., Di Rocco, M., Santorelli, F. M. and Nesti, C.
J Neurol Sci. 2019 Apr 15, 399:69-75.

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina
Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Imamura Kawasawa, Y., Salzberg, A. C., Kimball, S. R., Jefferson, L. S. and Dennis, M. D.
J Biol Chem. 2019 Apr 5, 294(14):5508-5520.

Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells
Zheng, J., Croteau, D. L., Bohr, V. A. and Akbari, M.
Nucleic Acids Res. 2019 Feb 14, [epub ahead of print]

Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktaschel, P., Croteau, D. L., Akbari, M., Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. and Bohr, V. A.
Nat Neurosci. 2019 Mar 1, 22(3):401-412.

Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites
Kedaigle, A. J., Fraenkel, E., Atwal, R. S., Wu, M., Gusella, J. F., MacDonald, M. E., Kaye, J. A., Finkbeiner, S., Mattis, V. B., Tom, C. M., Svendsen, C., King, A. R., Chen, Y., Stocksdale, J. T., Lim, R. G., Casale, M., Wang, P. H., Thompson, L. M., Akimov, S. S., Ratovitski, T., Arbez, N. and Ross, C. A.
Hum Mol Genet. 2019 Feb 15, [epub ahead of print]

Obesity, Diabetes & Metabolic Diseases

Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets
Winnica, D., Corey, C., Mullett, S., Reynolds, M., Hill, G., Wendell, S., Que, L., Holguin, F. and Shiva, S.
Antioxid Redox Signal. 2019 Mar 6, [epub ahead of print]

Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue
Song, W., Luo, Q., Zhang, Y., Zhou, L., Liu, Y., Ma, Z., Guo, J., Huang, Y., Cheng, L., Meng, Z., Li, Z., Zhang, B., Li, S., Yee, S. W., Fan, H., Li, P., Giacomini, K. M. and Chen, L.
PLoS Biol. 2019 Jan, 17(1):e2006571.

Mitochondrial uncoupling has no effect on microvascular complications in type 2 diabetes
Hinder, L. M., Sas, K. M., O'Brien, P. D., Backus, C., Kayampilly, P., Hayes, J. M., Lin, C. M., Zhang, H., Shanmugam, S., Rumora, A. E., Abcouwer, S. F., Brosius, F. C., 3rd, Pennathur, S. and Feldman, E. L.
Sci Rep. 2019 Jan 29, 9(1):881.

FOXK1 and FOXK2 regulate aerobic glycolysis
Sukonina, V., Ma, H., Zhang, W., Bartesaghi, S., Subhash, S., Heglind, M., Foyn, H., Betz, M. J., Nilsson, D., Lidell, M. E., Naumann, J., Haufs-Brusberg, S., Palmgren, H., Mondal, T., Beg, M., Jedrychowski, M. P., Tasken, K., Pfeifer, A., Peng, X. R., Kanduri, C. and Enerback, S.
Nature. 2019 Feb 1, 566(7743):279-283.

Silver nanoparticles inhibit beige fat function and promote adiposity
Yue, L., Zhao, W., Wang, D., Meng, M., Zheng, Y., Li, Y., Qiu, J., Yu, J., Yan, Y., Lu, P., Sun, Y., Fu, J., Wang, J., Zhang, Q., Xu, L. and Ma, X.
Mol Metab. 2019 Apr 1, 22:1-11.

Regulation of microbiota GLP1 axis by sennoside A in diet-induced obese mice
Le, J., Zhang, X., Jia, W., Zhang, Y., Luo, J., Sun, Y. and Ye, J.
Acta Pharmaceutica Sinica B. 2019 Jan 29, [epub ahead of print]

Leucine, Palmitate, or Leucine/Palmitate Cotreatment Enhances Myotube Lipid Content and Oxidative Preference
Johnson, M. A., Gannon, N. P., Schnuck, J. K., Lyon, E. S., Sunderland, K. L. and Vaughan, R. A.
Lipids. 2018 Nov 1, 53(11-12):1043-1057.

Guggulsterone Activates Adipocyte Beiging through Direct Effects on 3T3-L1 Adipocytes and Indirect Effects Mediated through RAW264.7 Macrophages
Miller, C. N., Samuels, J. S., Azhar, Y., Parmar, A., Shashidharamurthy, R. and Rayalam, S.
Medicines (Basel). 2019 Jan 31, 6(1).

Glycogen Synthase Kinase-3alpha Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy
Nakamura, M., Liu, T., Husain, S., Zhai, P., Warren, J. S., Hsu, C. P., Matsuda, T., Phiel, C. J., Cox, J. E., Tian, B., Li, H. and Sadoshima, J.
Cell Metab. 2019 May 7, 29(5):1119-1134 e12.

Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation
Zhao, S., Chu, Y., Zhang, Y., Zhou, Y., Jiang, Z., Wang, Z., Mao, L., Li, K., Sun, W., Li, P., Jia, S., Wang, C., Xu, A., Loomes, K., Tang, S., Wu, D., Hui, X. and Nie, T.
Life Sci. 2019 Apr 1, 222:117-124.

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina
Dierschke, S. K., Miller, W. P., Favate, J. S., Shah, P., Imamura Kawasawa, Y., Salzberg, A. C., Kimball, S. R., Jefferson, L. S. and Dennis, M. D.
J Biol Chem. 2019 Apr 5, 294(14):5508-5520.

The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to beta-cell function
Zhang, Y., Zhou, F., Bai, M., Liu, Y., Zhang, L., Zhu, Q., Bi, Y., Ning, G., Zhou, L. and Wang, X.
Cell Death Dis. 2019 Jan 25, 10(2):66.

Cardiac fibroblast activation and hyaluronan synthesis in response to hyperglycemia and diet-induced insulin resistance
Gorski, D. J., Petz, A., Reichert, C., Twarock, S., Grandoch, M. and Fischer, J. W.
Sci Rep. 2019 Feb 12, 9(1):1827.

Glucose Metabolism is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes Mellitus
Fidler, T. P., Marti, A., Gerth, K., Middleton, E. A., Campbell, R. A., Rondina, M. T., Weyrich, A. S. and Abel, E. D.
Diabetes. 2019 Feb 7, [epub ahead of print]

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease
Runtsch, M. C., Nelson, M. C., Lee, S. H., Voth, W., Alexander, M., Hu, R., Wallace, J., Petersen, C., Panic, V., Villanueva, C. J., Evason, K. J., Bauer, K. M., Mosbruger, T., Boudina, S., Bronner, M., Round, J. L., Drummond, M. J. and O'Connell, R. M.
PLoS Genet. 2019 Feb 15, 15(2):e1007970.

Stem Cell Biology

Inflammation-induced glycolytic switch controls suppressivity of mesenchymal stem cells via STAT1 glycosylation
Jitschin, R., Bottcher, M., Saul, D., Lukassen, S., Bruns, H., Loschinski, R., Ekici, A. B., Reis, A., Mackensen, A. and Mougiakakos, D.
Leukemia. 2019 Jan 24, [epub ahead of print]

IFNbeta enhances mesenchymal stromal (Stem) cells immunomodulatory function through STAT1-3 activation and mTOR-associated promotion of glucose metabolism
Vigo, T., La Rocca, C., Faicchia, D., Procaccini, C., Ruggieri, M., Salvetti, M., Centonze, D., Matarese, G., Uccelli, A. and Network, M.
Cell Death Dis. 2019 Jan 28, 10(2):85.

Monocytes exposed to plasma from patients with Alzheimer's disease undergo metabolic reprogramming
Wolfe, H., Mela, V., Minogue, A. M., Miller, A. M., McGuigan, C., Williams, L., Lohan, D., Lawlor, B. A. and Lynch, M. A.
Neurosci Res. 2019 Jan 12, [epub ahead of print]

Oxygen consumption rate for evaluation of COQ2 variants associated with multiple system atrophy
Yasuda, T., Matsukawa, T., Mitsui, J. and Tsuji, S.
Neurogenetics. 2019 Mar 1, 20(1):51-52.

Metabolic and Organelle Morphology Defects in Mice and Human Patients Define Spinocerebellar Ataxia Type 7 as a Mitochondrial Disease
Ward, J. M., Stoyas, C. A., Switonski, P. M., Ichou, F., Fan, W., Collins, B., Wall, C. E., Adanyeguh, I., Niu, C., Sopher, B. L., Kinoshita, C., Morrison, R. S., Durr, A., Muotri, A. R., Evans, R. M., Mochel, F. and La Spada, A. R.
Cell Rep. 2019 Jan 29, 26(5):1189-1202 e6.

Placental extracts regulate melanin synthesis in normal human melanocytes with alterations of mitochondrial respiration
Yoshimoto, S., Ohagi, Y., Yoshida, M., Yanagi, H., Hibino, S., Ichihashi, M. and Ando, H.
Exp Dermatol. 2019 Feb 1, 28 Suppl 1:50-54.

Modeling spinocerebellar ataxias 2 and 3 with iPSCs reveals a role for glutamate in disease pathology
Chuang, C. Y., Yang, C. C., Soong, B. W., Yu, C. Y., Chen, S. H., Huang, H. P. and Kuo, H. C.
Sci Rep. 2019 Feb 4, 9(1):1166.

Senescence-associated metabolomic phenotype in primary and iPSC-derived mesenchymal stromal cells
Fernandez-Rebollo, E., Franzen, J., Hollmann, J., Ostrowska, A., Oliverio, M., Sieben, T., Rath, B., Kornfeld, J.-W. and Wagner, W.
bioRxiv. 2019 Feb 6, [epub ahead of print]

Targeting LIN28B reprograms tumor glucose metabolism and acidic microenvironment to suppress cancer stemness and metastasis
Chen, C., Bai, L., Cao, F., Wang, S., He, H., Song, M., Chen, H., Liu, Y., Guo, J., Si, Q., Pan, Y., Zhu, R., Chuang, T. H., Xiang, R. and Luo, Y.
Oncogene. 2019 Jun 1, 38(23):4527-4539.

Long non-coding RNA FGF13-AS1 inhibits glycolysis and stemness properties of breast cancer cells through FGF13-AS1/IGF2BPs/Myc feedback loop
Ma, F., Liu, X., Zhou, S., Li, W., Liu, C., Chadwick, M. and Qian, C.
Cancer Lett. 2019 May 28, 450:63-75.

Proteomic Analysis Reveals Temporal Changes in Protein Expression in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes In Vitro
Hellen, N., Pinto Ricardo, C., Vauchez, K., Whiting, G., Wheeler, J. X. and Harding, S. E.
Stem Cells Dev. 2019 May 1, 28(9):565-578.

Mitophagy inhibits amyloid-beta and tau pathology and reverses cognitive deficits in models of Alzheimer's disease
Fang, E. F., Hou, Y., Palikaras, K., Adriaanse, B. A., Kerr, J. S., Yang, B., Lautrup, S., Hasan-Olive, M. M., Caponio, D., Dan, X., Rocktaschel, P., Croteau, D. L., Akbari, M., Greig, N. H., Fladby, T., Nilsen, H., Cader, M. Z., Mattson, M. P., Tavernarakis, N. and Bohr, V. A.
Nat Neurosci. 2019 Mar 1, 22(3):401-412.

Bioenergetic deficits in Huntington's disease iPSC-derived neural cells and rescue with glycolytic metabolites
Kedaigle, A. J., Fraenkel, E., Atwal, R. S., Wu, M., Gusella, J. F., MacDonald, M. E., Kaye, J. A., Finkbeiner, S., Mattis, V. B., Tom, C. M., Svendsen, C., King, A. R., Chen, Y., Stocksdale, J. T., Lim, R. G., Casale, M., Wang, P. H., Thompson, L. M., Akimov, S. S., Ratovitski, T., Arbez, N. and Ross, C. A.
Hum Mol Genet. 2019 Feb 15, [epub ahead of print]

Techniques & Methods

Calcium Signalling Methods & Protocols
Raffaello, A. and Reane, D. V.
Methods in Molecular Biology. 2019 Jan 1, 1925.

Feasibility of cellular bioenergetics as a biomarker in porphyria patients
Chacko, B., Culp, M. L., Bloomer, J., Phillips, J., Kuo, Y. F., Darley-Usmar, V. and Singal, A. K.
Mol Genet Metab Rep. 2019 Jun 29, 19:100451.

Legionella Methods & Protocols Second Edition
Buchrieser, C. and Hilbi, H.
Methods in Molecular Biology. 2019 Jun 1, 1921.

Silver nanoparticles inhibit beige fat function and promote adiposity
Yue, L., Zhao, W., Wang, D., Meng, M., Zheng, Y., Li, Y., Qiu, J., Yu, J., Yan, Y., Lu, P., Sun, Y., Fu, J., Wang, J., Zhang, Q., Xu, L. and Ma, X.
Mol Metab. 2019 Apr 1, 22:1-11.

O2 Economizer for Inhibiting Cell Respiration To Combat the Hypoxia Obstacle in Tumor Treatments
Yu, W., Liu, T., Zhang, M., Wang, Z., Ye, J., Li, C. X., Liu, W., Li, R., Feng, J. and Zhang, X. Z.
ACS Nano. 2019 Feb 26, 13(2):1784-1794.

Label-free Method for Classification of T cell Activation
Walsh, A., Mueller, K., Jones, I., Walsh, C. M., Piscopo, N., Niemi, N. N., Pagliarini, D. J., Saha, K. and Skala, M. C.
bioRxiv. 2019 Jan 31, [epub ahead of print]

Cancer Metabolism Methods and Protocols
Hazanadar, M.
Methods in Molecular Biology - Springer Protocols. 2019 Jun 1, 1928.

Toxicology Research

Adverse effects of fluorescent carbon dots from canned yellow croaker on cellular respiration and glycolysis
Li, D., Na, X., Zhou, W., Wang, C., Li, Y., Zhu, B. W. and Tan, M.
Food Funct. 2019 Feb 20, 10(2):1123-1131.

Cytotoxicity and mitochondrial dysfunction caused by the dietary supplement l-norvaline
Samardzic, K. and Rodgers, K. J.
Toxicol In Vitro. 2019 Apr 1, 56:163-171.

Constitutive Activation of NAD-Dependent Sirtuin 3 Plays an Important Role in Tumorigenesis of Chromium(VI)-Transformed Cells
Clementino, M., Kim, D. and Zhang, Z.
Toxicol Sci. 2019 May 1, 169(1):224-234.

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
Woodhead, J. L., Yang, K., Oldach, D., MacLauchlin, C., Fernandes, P., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Pharm Res. 2019 Feb 7, 36(3):48.

IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette
Sohal, S. S., Eapen, M. S., Naidu, V. G. M. and Sharma, P.
ERJ Open Res. 2019 Feb 1, 5(1).

Translational Research

The nuclear background influences the penetrance of the near-homoplasmic m.1630 A>G MELAS variant in a symptomatic proband and asymptomatic mother
Uittenbogaard, M., Wang, H., Zhang, V. W., Wong, L. J., Brantner, C. A., Gropman, A. and Chiaramello, A.
Mol Genet Metab. 2019 Apr 1, 126(4):429-438.

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