XF出版物快报 2019年5月

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Aging Research

The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro
Cao, P., Zhang, J., Huang, Y., Fang, Y., Lyu, J. and Shen, Y.
Exp Gerontol. 2019 Apr 01, 118:9-18.

Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo
Aryal, N. K., Pant, V., Wasylishen, A. R., Parker-Thornburg, J., Baseler, L., El-Naggar, A. K., Liu, B., Kalia, A., Lozano, G. and Arur, S.
Proc Natl Acad Sci U S A. 2019 Jan 15, 116(3):960-969.

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
D'Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., Schneider, B. L. and Auwerx, J.
Mol Cell. 2019 Feb 21, 73(4):775-787 e10.

Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease
Lin, D. S., Huang, Y. W., Ho, C. S., Hung, P. L., Hsu, M. H., Wang, T. J., Wu, T. Y., Lee, T. H., Huang, Z. D., Chang, P. C. and Chiang, M. F.
Cells. 2019 Jan 17, 8(1).

Assays under Hypoxia

Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit(+) Cardiac Progenitor Cells
Korski, K. I., Kubli, D. A., Wang, B. J., Khalafalla, F. G., Monsanto, M. M., Firouzi, F., Echeagaray, O. H., Kim, T., Adamson, R. M., Dembitsky, W. P., Gustafsson, A. B. and Sussman, M. A.
Stem Cells. 2019 Apr 1, 37(4):555-567.

Cancer Research

IDH3α regulates one-carbon metabolism in glioblastoma
May, J. L., Kouri, F. M., Hurley, L. A., Liu, J., Tommasini-Ghelfi, S., Ji, Y., Gao, P., Calvert, A. E., Lee, A., Chandel, N. S., Davuluri, R. V., Horbinski, C. M., Locasale, J. W. and Stegh, A. H.
Science Advances. 2019 Jan 2, 5(1):eaat0456.

GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump
Schneditz, G., Elias, J. E., Pagano, E., Zaeem Cader, M., Saveljeva, S., Long, K., Mukhopadhyay, S., Arasteh, M., Lawley, T. D., Dougan, G., Bassett, A., Karlsen, T. H., Kaser, A. and Kaneider, N. C.
Sci Signal. 2019 Jan 1, 12(562).

Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress
Laurent, V., Toulet, A., Attane, C., Milhas, D., Dauvillier, S., Zaidi, F., Clement, E., Cinato, M., Le Gonidec, S., Guerard, A., Lehuede, C., Garandeau, D., Nieto, L., Renaud-Gabardos, E., Prats, A. C., Valet, P., Malavaud, B. and Muller, C.
Mol Cancer Res. 2019 Mar 1, 17(3):821-835.

Cyclin G2 Inhibits the Warburg Effect and Tumour Progression by Suppressing LDHA Phosphorylation in Glioma
Li, S., Gao, J., Zhuang, X., Zhao, C., Hou, X., Xing, X., Chen, C., Liu, Q., Liu, S. and Luo, Y.
Int J Biol Sci. 2019 Jan 1, 15(3):544-555.

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation
Lee, S. R., Kwon, S. W., Lee, Y. H., Kaya, P., Kim, J. M., Ahn, C., Jung, E. M., Lee, G. S., An, B. S., Jeung, E. B., Park, B. K. and Hong, E. J.
BMC Cancer. 2019 Jan 3, 19(1):6.

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity
Massalha, W., Markovits, M., Pichinuk, E., Feinstein-Rotkopf, Y., Tarshish, M., Mishra, K., Llado, V., Weil, M., Escriba, P. V. and Kakhlon, O.
Biosci Rep. 2019 Jan 31, 39(1).

Study of diffusive- and convective-transport mediated microtumor growth in a controlled microchamber
Hsu, Y. H., Liu, W. W., Wu, T. H., Lee, C. J., Chen, Y. H. and Li, P. C.
Biomed Microdevices. 2019 Jan 3, 21(1):7.

Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem/progenitor cell bioenergetics through binding to F0F1-ATP synthase complex
Fang, J. D., Tung, H. H. and Lee, S. L.
FASEB J. 2019 Mar 1, 33(3):4327-4340.

High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity
Wu, D. M., Wang, Y. J., Fan, S. H., Zhang, Z. F., Shan, Q., Lu, J., Chen, G. Q. and Zheng, Y. L.
Eur J Med Chem. 2019 Feb 15, 164(252-262.

Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles
Young, C. K. J. and Young, M. J.
Cell Cycle. 2019 Feb 1, 18(4):476-499.

Inhibition of mitochondrial translation as a therapeutic strategy for human ovarian cancer to overcome chemoresistance
Hu, B. and Guo, Y.
Biochem Biophys Res Commun. 2019 Feb 5, 509(2):373-378.

Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme
Desai, V., Jain, A., Shaghaghi, H., Summer, R., Lai, J. C. K. and Bhushan, A.
Anticancer Res. 2019 Jan 1, 39(1):57-66.

Altered energy metabolism and metabolic gene expression associated with increased metastatic capacity identified in MDA-MB-231 cell line variants
Tu, Y., Johnstone, C. N., Ryall, J. G., López-Campos, G. H., Keenan, C. R. and Stewart, A. G.
Journal of Cancer Metastasis and Treatment. 2018  Dec 24, 4:58.

CHCHD4 regulates a proliferation-EMT switch in tumour cells, through respiratory complex I mediated metabolism
Thomas, L. W., Esposito, C., Stephen, J. M., Costa, A. S., Frezza, C., Blacker, T. S., Szabadkai, G. and Ashcroft, M.
bioRxiv. 2019 Jan 7, [epub ahead of print]

The mitochondrial type IB topoisomerase drives mitochondrial translation and carcinogenesis
Baechler, S. A., Factor, V. M., Dalla Rosa, I., Ravji, A., Becker, D., Khiati, S., Miller Jenkins, L. M., Lang, M., Sourbier, C., Michaels, S. A., Neckers, L. M., Zhang, H. L., Spinazzola, A., Huang, S. N., Marquardt, J. U. and Pommier, Y.
Nat Commun. 2019 Jan 8, 10(1):83.

Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer
Wang, S. Q., Yang, X. Y., Cui, S. X., Gao, Z. H. and Qu, X. J.
Free Radic Biol Med. 2019 Jan 3, 134:87-98.

Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation
Sun, Y., Bandi, M., Lofton, T., Smith, M., Bristow, C. A., Carugo, A., Rogers, N., Leonard, P., Chang, Q., Mullinax, R., Han, J., Shi, X., Seth, S., Meyers, B. A., Miller, M., Miao, L., Ma, X., Feng, N., Giuliani, V., Geck Do, M., Czako, B., Palmer, W. S., Mseeh, F., Asara, J. M., Jiang, Y., Morlacchi, P., Zhao, S., Peoples, M., Tieu, T. N., Warmoes, M. O., Lorenzi, P. L., Muller, F. L., DePinho, R. A., Draetta, G. F., Toniatti, C., Jones, P., Heffernan, T. P. and Marszalek, J. R.
Cell Rep. 2019 Jan 8, 26(2):469-482 e5.

Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D
Hu, P., Li, S., Tian, N., Wu, F., Hu, Y., Li, D., Qi, Y., Wei, Z., Wei, Q., Li, Y., Yin, B., Jiang, T., Yuan, J., Qiang, B., Han, W. and Peng, X.
Cell Death Dis. 2019 Jan 10, 10(1):25.

Tafazzin-dependent cardiolipin composition in C6 glioma cells correlates with changes in mitochondrial and cellular functions, and cellular proliferation
Gurtler, S., Wolke, C., Otto, O., Heise, N., Scholz, F., Laporte, A., Elsner, M., Jorns, A., Weinert, S., Doring, M., Jansing, S., Gardemann, A., Lendeckel, U. and Schild, L.
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Apr, 1864(4):452-465.

NK cells specifically TCR-dressed to kill cancer cells
Mensali, N., Dillard, P., Hebeisen, M., Lorenz, S., Theodossiou, T., Myhre, M. R., Fane, A., Gaudernack, G., Kvalheim, G., Myklebust, J. H., Inderberg, E. M. and Walchli, S.
EBioMedicine. 2019 Feb 1, 40:106-117.

Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits
Norheim, F., Hasin-Brumshtein, Y., Vergnes, L., Chella Krishnan, K., Pan, C., Seldin, M. M., Hui, S. T., Mehrabian, M., Zhou, Z., Gupta, S., Parks, B. W., Walch, A., Reue, K., Hofmann, S. M., Arnold, A. P. and Lusis, A. J.
Cell Metab. 2019 Apr 2, 29(4):932-949 e4.

Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma
Buckley, A. M., Dunne, M. R., Lynam-Lennon, N., Kennedy, S. A., Cannon, A., Reynolds, A. L., Maher, S. G., Reynolds, J. V., Kennedy, B. N. and O'Sullivan, J.
Cancer Lett. 2019 Apr 10, 447:115-129.

Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis
Ishay-Ronen, D., Diepenbruck, M., Kalathur, R. K. R., Sugiyama, N., Tiede, S., Ivanek, R., Bantug, G., Morini, M. F., Wang, J., Hess, C. and Christofori, G.
Cancer Cell. 2019 Jan 14, 35(1):17-32 e6.

HPV, tumour metabolism and novel target identification in head and neck squamous cell carcinoma
Fleming, J. C., Woo, J., Moutasim, K., Mellone, M., Frampton, S. J., Mead, A., Ahmed, W., Wood, O., Robinson, H., Ward, M., Woelk, C. H., Ottensmeier, C. H., King, E., Kim, D., Blaydes, J. P. and Thomas, G. J.
Br J Cancer. 2019 Feb 1, 120(3):356-367.

The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma
Li, Z., Mbah, N. E., Overmeyer, J. H., Sarver, J. G., George, S., Trabbic, C. J., Erhardt, P. W. and Maltese, W. A.
BMC Cancer. 2019 Jan 16, 19(1):77.

Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer
Li, C., He, C., Xu, Y., Xu, H., Tang, Y., Chavan, H., Duan, S., Artigues, A., Forrest, M. L., Krishnamurthy, P., Han, S., Holzbeierlein, J. M. and Li, B.
Prostate. 2019 May 1, 79(6):628-639.

Metformin-activated AMPK regulates beta-catenin to reduce cell proliferation in colon carcinoma RKO cells
Park, S. Y., Kim, D. and Kee, S. H.
Oncol Lett. 2019 Mar 1, 17(3):2695-2702.

p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer
Chang, H. W., Kim, M. R., Lee, H. J., Lee, H. M., Kim, G. C., Lee, Y. S., Nam, H. Y., Lee, M., Jang, H. J., Lee, K. E., Lee, J. C., Byun, Y., Kim, S. W. and Kim, S. Y.
Oncogene. 2019 Jan 21, [epub ahead of print]

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal
Liu, M., O'Connor, R. S., Trefely, S., Graham, K., Snyder, N. W. and Beatty, G. L.
Nat Immunol. 2019 Jan 21, 20(3):265-275.

Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer
Chang, J. C., Chang, H. S., Wu, Y. C., Cheng, W. L., Lin, T. T., Chang, H. J., Kuo, S. J., Chen, S. T. and Liu, C. S.
J Exp Clin Cancer Res. 2019 Jan 23, 38(1):30.

Splicing factor ESRP1 controls ER-positive breast cancer by altering metabolic pathways
Gokmen-Polar, Y., Neelamraju, Y., Goswami, C. P., Gu, Y., Gu, X., Nallamothu, G., Vieth, E., Janga, S. C., Ryan, M. and Badve, S. S.
EMBO Rep. 2019 Feb 1, 20(2).

Assessment of zero-valent iron-based nanotherapeutics for ferroptosis induction and resensitization strategy in cancer cells
Huang, K. J., Wei, Y. H., Chiu, Y. C., Wu, S. R. and Shieh, D. B.
Biomater Sci. 2019 Mar 26, 7(4):1311-1322.

Modulation of Intracellular Oxygen Pressure by Dual-Drug Nanoparticles to Enhance Photodynamic Therapy
Fan, Y.-T., Zhou, T.-J., Cui, P.-F., He, Y.-J., Chang, X., Xing, L. and Jiang, H.-L.
Advanced Functional Materials. 2019 Jan 21, 29(10):1806708.

Cardiovascular Research

Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells
Likhite, N., Yadav, V., Milliman, E. J., Sopariwala, D. H., Lorca, S., Narayana, N. P., Sheth, M., Reineke, E. L., Giguere, V. and Narkar, V.
Mol Cell Biol. 2019 Feb 15, 39(5).

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
Liu, K., Guo, L., Zhou, Z., Pan, M. and Yan, C.
Microvasc Res. 2019 May 1, 123:74-80.

A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling
Dai, Q., Likes, C. E., 3rd, Luz, A. L., Mao, L., Yeh, J. S., Wei, Z., Kuchibhatla, M., Ilkayeva, O. R., Koves, T. R. and Price, T. M.
J Endocr Soc. 2019 Jan 3, 3(2):446-467.

Cardiomyopathy in children with mitochondrial disease: Prognosis and genetic background
Imai-Okazaki, A., Kishita, Y., Kohda, M., Mizuno, Y., Fushimi, T., Matsunaga, A., Yatsuka, Y., Hirata, T., Harashima, H., Takeda, A., Nakaya, A., Sakata, Y., Kogaki, S., Ohtake, A., Murayama, K. and Okazaki, Y.
Int J Cardiol. 2019 Mar 15, 279:115-121.

LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion
Chi, C., Leonard, A., Knight, W. E., Beussman, K. M., Zhao, Y., Cao, Y., Londono, P., Aune, E., Trembley, M. A., Small, E. M., Jeong, M. Y., Walker, L. A., Xu, H., Sniadecki, N. J., Taylor, M. R., Buttrick, P. M. and Song, K.
Proc Natl Acad Sci U S A. 2019 Jan 8, 116(2):556-565.

Cardiomyocyte-specific loss of RMP causes myocardial dysfunction and heart failure
Zhang, J., Sheng, J., Dong, L., Xu, Y., Yu, L., Liu, Y., Huang, X., Wan, S., Lan, H. Y. and Wang, H.
Cardiovasc Res. 2018 Dec 24, [epub ahead of print]

Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function
Clapp, P. W., Lavrich, K. S., van Heusden, C. A., Lazarowski, E. R., Carson, J. L. and Jaspers, I.
Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1, 316(3):L470-L486.

STAT3 Regulates the Onset of Oxidant-Induced Senescence in Lung Fibroblasts
Waters, D. W., Blokland, K. E. C., Pathinayake, P. S., Wei, L., Schuliga, M., Jaffar, J., Westall, G. P., Hansbro, P. M., Prele, C. M., Mutsaers, S. E., Bartlett, N. W., Burgess, J. K., Grainge, C. L. and Knight, D. A.
Am J Respir Cell Mol Biol. 2019 Jan 4, [epub ahead of print]

Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit(+) Cardiac Progenitor Cells
Korski, K. I., Kubli, D. A., Wang, B. J., Khalafalla, F. G., Monsanto, M. M., Firouzi, F., Echeagaray, O. H., Kim, T., Adamson, R. M., Dembitsky, W. P., Gustafsson, A. B. and Sussman, M. A.
Stem Cells. 2019 Apr 1, 37(4):555-567.

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury
Kurundkar, D., Kurundkar, A. R., Bone, N. B., Becker, E. J., Jr., Liu, W., Chacko, B., Darley-Usmar, V., Zmijewski, J. W. and Thannickal, V. J.
JCI Insight. 2019 Jan 10, 4(1).

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo
Venkatesh, S., Li, M., Saito, T., Tong, M., Rashed, E., Mareedu, S., Zhai, P., Barcena, C., Lopez-Otin, C., Yehia, G., Sadoshima, J. and Suzuki, C. K.
J Mol Cell Cardiol. 2019 Mar 1, 128:38-50.

Early-life undernutrition reprograms CD4(+) T-cell glycolysis and epigenetics to facilitate asthma
Chen, X., Lin, H., Yang, D., Xu, W., Liu, G., Liu, X., Sheng, J. and Huang, H.
J Allergy Clin Immunol. 2019 Jan 15, [epub ahead of print]

MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity
Lefranc, C., Friederich-Persson, M., Braud, L., Palacios-Ramirez, R., Karlsson, S., Boujardine, N., Motterlini, R., Jaisser, F. and Nguyen Dinh Cat, A.
Hypertension. 2019 Feb 1, 73(2):458-468.

EGFR (Epidermal Growth Factor Receptor) Signaling and the Mitochondria Regulate sFlt-1 (Soluble FMS-Like Tyrosine Kinase-1) Secretion
Hastie, R., Brownfoot, F. C., Pritchard, N., Hannan, N. J., Cannon, P., Nguyen, V., Palmer, K., Beard, S., Tong, S. and Kaitu'u-Lino, T. J.
Hypertension. 2019 Mar 1, 73(3):659-670.

Mesenchymal stromal cell-derived exosomes improve mitochondrial health in pulmonary arterial hypertension
Hogan, S. E., Rodriguez Salazar, M. P., Cheadle, J., Glenn, R., Medrano, C., Petersen, T. H. and Ilagan, R. M.
Am J Physiol Lung Cell Mol Physiol. 2019 May 1, 316(5):L723-L737.

miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells
Nasci, V. L., Chuppa, S., Griswold, L., Goodreau, K. A., Dash, R. K. and Kriegel, A. J.
Am J Physiol Heart Circ Physiol. 2019 Mar 1, 316(3):H710-H721.

Cell Physiology Research

Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue
Lehnig, A. C., Dewal, R. S., Baer, L. A., Kitching, K. M., Munoz, V. R., Arts, P. J., Sindeldecker, D. A., May, F. J., Lauritzen, H., Goodyear, L. J. and Stanford, K. I.
iScience. 2019 Jan 25, 11:425-439.

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance
Turpin-Nolan, S. M., Hammerschmidt, P., Chen, W., Jais, A., Timper, K., Awazawa, M., Brodesser, S. and Bruning, J. C.
Cell Rep. 2019 Jan 2, 26(1):1-10 e7.

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle
Nakazawa, H., Ikeda, K., Shinozaki, S., Yasuhara, S., Yu, Y. M., Martyn, J. A. J., Tompkins, R. G., Yorozu, T., Inoue, S. and Kaneki, M.
FEBS Open Bio. 2019 Jan 19, 9(2):348-363.

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury
Kurundkar, D., Kurundkar, A. R., Bone, N. B., Becker, E. J., Jr., Liu, W., Chacko, B., Darley-Usmar, V., Zmijewski, J. W. and Thannickal, V. J.
JCI Insight. 2019 Jan 10, 4(1).

Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo
Venkatesh, S., Li, M., Saito, T., Tong, M., Rashed, E., Mareedu, S., Zhai, P., Barcena, C., Lopez-Otin, C., Yehia, G., Sadoshima, J. and Suzuki, C. K.
J Mol Cell Cardiol. 2019 Mar 1, 128:38-50.

Post-stroke fatigue as an indicator of underlying bioenergetics alterations
Klinedinst, N. J., Schuh, R., Kittner, S. J., Regenold, W. T., Kehs, G., Hoch, C., Hackney, A. and Fiskum, G.
J Bioenerg Biomembr. 2019 Apr 1, 51(2):165-174.

Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis
Rosario, F. J., Gupta, M. B., Myatt, L., Powell, T. L., Glenn, J. P., Cox, L. and Jansson, T.
Sci Rep. 2019 Jan 22, 9(1):246.

Thermal stress induces glycolytic beige fat formation via a myogenic state
Chen, Y., Ikeda, K., Yoneshiro, T., Scaramozza, A., Tajima, K., Wang, Q., Kim, K., Shinoda, K., Sponton, C. H., Brown, Z., Brack, A. and Kajimura, S.
Nature. 2019 Jan 1, 565(7738):180-185.

TREM-1 regulates neutrophil chemotaxis by promoting NOX-dependent superoxide production
Baruah, S., Murthy, S., Keck, K., Galvan, I., Prichard, A., Allen, L. H., Farrelly, M. and Klesney-Tait, J.
J Leukoc Biol. 2019 Jan 22, [epub ahead of print]

Loss of Nmp4 optimizes osteogenic metabolism and secretion to enhance bone quality
Shao, Y., Wichern, E., Childress, P. J., Adaway, M., Misra, J., Klunk, A., Burr, D. B., Wek, R. C., Mosley, A. L., Liu, Y., Robling, A. G., Brustovetsky, N., Hamilton, J., Jacobs, K., Vashishth, D., Stayrook, K. R., Allen, M. R., Wallace, J. M. and Bidwell, J. P.
Am J Physiol Endocrinol Metab. 2019 May 1, 316(5):E749-E772.

Drug Discovery

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity
Massalha, W., Markovits, M., Pichinuk, E., Feinstein-Rotkopf, Y., Tarshish, M., Mishra, K., Llado, V., Weil, M., Escriba, P. V. and Kakhlon, O.
Biosci Rep. 2019 Jan 31, 39(1).

High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity
Wu, D. M., Wang, Y. J., Fan, S. H., Zhang, Z. F., Shan, Q., Lu, J., Chen, G. Q. and Zheng, Y. L.
Eur J Med Chem. 2019 Feb 15, 164(252-262.

Inhibition of mitochondrial translation as a therapeutic strategy for human ovarian cancer to overcome chemoresistance
Hu, B. and Guo, Y.
Biochem Biophys Res Commun. 2019 Feb 5, 509(2):373-378.

Combination of Biochanin A and Temozolomide Impairs Tumor Growth by Modulating Cell Metabolism in Glioblastoma Multiforme
Desai, V., Jain, A., Shaghaghi, H., Summer, R., Lai, J. C. K. and Bhushan, A.
Anticancer Res. 2019 Jan 1, 39(1):57-66.

Different influences on mitochondrial function, oxidative stress and cytotoxicity of antibiotics on primary human neuron and cell lines
Xiao, Y., Xiong, T., Meng, X., Yu, D., Xiao, Z. and Song, L.
J Biochem Mol Toxicol. 2019 Apr 1, 33(4):e22277.

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
Balaz, M., Becker, A. S., Balazova, L., Straub, L., Muller, J., Gashi, G., Maushart, C. I., Sun, W., Dong, H., Moser, C., Horvath, C., Efthymiou, V., Rachamin, Y., Modica, S., Zellweger, C., Bacanovic, S., Stefanicka, P., Varga, L., Ukropcova, B., Profant, M., Opitz, L., Amri, E. Z., Akula, M. K., Bergo, M., Ukropec, J., Falk, C., Zamboni, N., Betz, M. J., Burger, I. A. and Wolfrum, C.
Cell Metab. 2019 Apr 2, 29(4):901-916 e8.

Pyrazinib (P3), [(E)-2-(2-Pyrazin-2-yl-vinyl)-phenol], a small molecule pyrazine compound enhances radiosensitivity in oesophageal adenocarcinoma
Buckley, A. M., Dunne, M. R., Lynam-Lennon, N., Kennedy, S. A., Cannon, A., Reynolds, A. L., Maher, S. G., Reynolds, J. V., Kennedy, B. N. and O'Sullivan, J.
Cancer Lett. 2019 Apr 10, 447:115-129.

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify Emerging Metabolic Health Threats
Kim, S., Reed, E., Monti, S. and Schlezinger, J.
bioRxiv. 2019 Jan 13, [epub ahead of print]

Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway
Li, X., Xie, X., Zhang, L., Meng, Y., Li, N., Wang, M., Zhai, C., Liu, Z., Di, T., Zhang, L. and Li, P.
Life Sci. 2019 Feb 15, 219:311-321.

Alternol eliminates excessive ATP production by disturbing Krebs cycle in prostate cancer
Li, C., He, C., Xu, Y., Xu, H., Tang, Y., Chavan, H., Duan, S., Artigues, A., Forrest, M. L., Krishnamurthy, P., Han, S., Holzbeierlein, J. M. and Li, B.
Prostate. 2019 May 1, 79(6):628-639.

Food & Nutritional Research

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation
Lee, S. R., Kwon, S. W., Lee, Y. H., Kaya, P., Kim, J. M., Ahn, C., Jung, E. M., Lee, G. S., An, B. S., Jeung, E. B., Park, B. K. and Hong, E. J.
BMC Cancer. 2019 Jan 3, 19(1):6.

Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure
Fromme, T., Huttinger, K., Maurer, S., Li, Y., Gantert, T., Fiamoncini, J., Daniel, H., Westphal, S. and Klingenspor, M.
Sci Rep. 2019 Jan 15, 9(1):131.

Hepatobiology Research

Dietary intake of genistein suppresses hepatocellular carcinoma through AMPK-mediated apoptosis and anti-inflammation
Lee, S. R., Kwon, S. W., Lee, Y. H., Kaya, P., Kim, J. M., Ahn, C., Jung, E. M., Lee, G. S., An, B. S., Jeung, E. B., Park, B. K. and Hong, E. J.
BMC Cancer. 2019 Jan 3, 19(1):6.

Comparison of HepaRG cells following growth in proliferative and differentiated culture conditions reveals distinct bioenergetic profiles
Young, C. K. J. and Young, M. J.
Cell Cycle. 2019 Feb 1, 18(4):476-499.

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M. G., Lin, T., Shokhirev, M. N., Pinto, A. F. M., Ross, D. S., Saghatelian, A., Panda, S., Dow, L. E., Metallo, C. M. and Shaw, R. J.
Cell Rep. 2019 Jan 2, 26(1):192-208 e6.

The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis
Zhou, J., Wang, X., Wang, M., Chang, Y., Zhang, F., Ban, Z., Tang, R., Gan, Q., Wu, S., Guo, Y., Zhang, Q., Wang, F., Zhao, L., Jing, Y., Qian, W., Wang, G., Guo, W. and Yang, C.
J Cell Biol. 2019 Feb 4, 218(2):580-597.

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway
Li, Y., Yang, P., Zhao, L., Chen, Y., Zhang, X., Zeng, S., Wei, L., Varghese, Z., Moorhead, J. F., Chen, Y. and Ruan, X. Z.
J Lipid Res. 2019 Apr 1, 60(4):844-855.

Immunology Research

Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition
Thi Tran, U. and Kitami, T.
Commun Biol. 2019 Jan 3, 2:2.

ENaC-mediated sodium influx drives NLRP3 inflammasome-dependent autoinflammation in cystic fibrosis
Scambler, T., Jarosz-Griffiths, H. H., Lara-Reyna, S., Pathak, S., Wong, C., Holbrook, J., Martinon, F., Savic, S., Peckham, D. and McDermott, M. F.
bioRxiv. 2018 Nov 6, [epub ahead of print]

BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism
Kuhtreiber, W. M. and Faustman, D. L.
Trends Endocrinol Metab. 2019 Feb 1, 30(2):80-92.

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair
Zhang, S., Weinberg, S., DeBerge, M., Gainullina, A., Schipma, M., Kinchen, J. M., Ben-Sahra, I., Gius, D. R., Yvan-Charvet, L., Chandel, N. S., Schumacker, P. T. and Thorp, E. B.
Cell Metab. 2019 Feb 5, 29(2):443-456 e5.

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase
Seidi, A., Muellner-Wong, L. S., Rajendran, E., Tjhin, E. T., Dagley, L. F., Aw, V. Y., Faou, P., Webb, A. I., Tonkin, C. J. and van Dooren, G. G.
Elife. 2018 Sep 11, 7.

Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer
Wang, S. Q., Yang, X. Y., Cui, S. X., Gao, Z. H. and Qu, X. J.
Free Radic Biol Med. 2019 Jan 3, 134:87-98.

SIRT3 diminishes inflammation and mitigates endotoxin-induced acute lung injury
Kurundkar, D., Kurundkar, A. R., Bone, N. B., Becker, E. J., Jr., Liu, W., Chacko, B., Darley-Usmar, V., Zmijewski, J. W. and Thannickal, V. J.
JCI Insight. 2019 Jan 10, 4(1).

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A. and Kanthasamy, A. G.
Sci Signal. 2019 Jan 8, 12(563).

Mitochondrial complex III is essential for suppressive function of regulatory T cells
Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M. M., Martinez-Reyes, I., Gao, P., Helmin, K. A., Abdala-Valencia, H., Sena, L. A., Schumacker, P. T., Turka, L. A. and Chandel, N. S.
Nature. 2019 Jan 1, 565(7740):495-499.

Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System
Nieman, D. C., Lila, M. A. and Gillitt, N. D.
Annu Rev Food Sci Technol. 2019 Mar 25, 10:341-363.

NK cells specifically TCR-dressed to kill cancer cells
Mensali, N., Dillard, P., Hebeisen, M., Lorenz, S., Theodossiou, T., Myhre, M. R., Fane, A., Gaudernack, G., Kvalheim, G., Myklebust, J. H., Inderberg, E. M. and Walchli, S.
EBioMedicine. 2019 Feb 1, 40:106-117.

Early-life undernutrition reprograms CD4(+) T-cell glycolysis and epigenetics to facilitate asthma
Chen, X., Lin, H., Yang, D., Xu, W., Liu, G., Liu, X., Sheng, J. and Huang, H.
J Allergy Clin Immunol. 2019 Jan 15, [epub ahead of print]

Hesperidin inhibits keratinocyte proliferation and imiquimod-induced psoriasis-like dermatitis via the IRS-1/ERK1/2 pathway
Li, X., Xie, X., Zhang, L., Meng, Y., Li, N., Wang, M., Zhai, C., Liu, Z., Di, T., Zhang, L. and Li, P.
Life Sci. 2019 Feb 15, 219:311-321.

ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis
Endo, Y., Onodera, A., Obata-Ninomiya, K., Koyama-Nasu, R., Asou, H. K., Ito, T., Yamamoto, T., Kanno, T., Nakajima, T., Ishiwata, K., Kanuka, H., Tumes, D. J. and Nakayama, T.
Nature Metabolism. 2019 Jan 14, 1(2):261-275.

Extracellular vesicles can act as a potent immunomodulators of human microglial cells
Jonavice, U., Tunaitis, V., Kriauciunaite, K., Jarmalaviciute, A. and Pivoriunas, A.
J Tissue Eng Regen Med. 2019 Feb 1, 13(2):309-318.

Lipopolysaccharide-induced alteration of mitochondrial morphology induces a metabolic shift in microglia modulating the inflammatory response in vitro and in vivo
Nair, S., Sobotka, K. S., Joshi, P., Gressens, P., Fleiss, B., Thornton, C., Mallard, C. and Hagberg, H.
Glia. 2019 Jun 1, 67(6):1047-1061.

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics
Abdollahi Govar, A., Toro, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. and Modis, K.
Br J Pharmacol. 2019 Jan 14, [epub ahead of print]

A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes
Genders, A. J., Martin, S. D., McGee, S. L. and Bishop, D. J.
Am J Physiol Cell Physiol. 2019 Mar 1, 316(3):C404-C414.

Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal
Liu, M., O'Connor, R. S., Trefely, S., Graham, K., Snyder, N. W. and Beatty, G. L.
Nat Immunol. 2019 Jan 21, 20(3):265-275.

TREM-1 regulates neutrophil chemotaxis by promoting NOX-dependent superoxide production
Baruah, S., Murthy, S., Keck, K., Galvan, I., Prichard, A., Allen, L. H., Farrelly, M. and Klesney-Tait, J.
J Leukoc Biol. 2019 Jan 22, [epub ahead of print]

Immune Checkpoint Blockade - Methods and Protocols
Pico de Coaña, Y.
Methods in Molecular Biology. 2019 Jan 1, 1913.

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field
Sanz-Ortega, L., Rojas, J. M., Marcos, A., Portilla, Y., Stein, J. V. and Barber, D. F.
J Nanobiotechnology. 2019 Jan 22, 17(1):14.

The Autoimmune Susceptibility Gene C5orf30 Regulates Macrophage-Mediated Resolution of Inflammation
Dorris, E. R., Tazzyman, S. J., Moylett, J., Ramamoorthi, N., Hackney, J., Townsend, M., Muthana, M., Lewis, M. J., Pitzalis, C. and Wilson, A. G.
J Immunol. 2019 Feb 15, 202(4):1069-1078.

A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation and Function
De Vries, L. C. S., Duarte, J. M., De Krijger, M., Welting, O., Van Hamersveld, P. H. P., Van Leeuwen-Hilbers, F. W. M., Moerland, P. D., Jongejan, A., D'Haens, G. R., De Jonge, W. J. and Wildenberg, M. E.
Inflamm Bowel Dis. 2019 Mar 14, 25(4):647-660.

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
Schulthess, J., Pandey, S., Capitani, M., Rue-Albrecht, K. C., Arnold, I., Franchini, F., Chomka, A., Ilott, N. E., Johnston, D. G. W., Pires, E., McCullagh, J., Sansom, S. N., Arancibia-Carcamo, C. V., Uhlig, H. H. and Powrie, F.
Immunity. 2019 Feb 19, 50(2):432-445 e7.

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
McIntosh, A., Mela, V., Harty, C., Minogue, A. M., Costello, D. A., Kerskens, C. and Lynch, M. A.
Brain Pathol. 2019 Jan 20, [epub ahead of print]

Infectious Disease Research

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase

Seidi, A., Muellner-Wong, L. S., Rajendran, E., Tjhin, E. T., Dagley, L. F., Aw, V. Y., Faou, P., Webb, A. I., Tonkin, C. J. and van Dooren, G. G.
Elife. 2018 Sep 11, 7.

Microbial Research

Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presence of a divergent cytochrome c oxidase
Seidi, A., Muellner-Wong, L. S., Rajendran, E., Tjhin, E. T., Dagley, L. F., Aw, V. Y., Faou, P., Webb, A. I., Tonkin, C. J. and van Dooren, G. G.
Elife. 2018 Sep 11, 7.

A physiological drop in pH decreases mitochondrial respiration, and HDAC and Akt signaling, in L6 myocytes
Genders, A. J., Martin, S. D., McGee, S. L. and Bishop, D. J.
Am J Physiol Cell Physiol. 2019 Mar 1, 316(3):C404-C414.

The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
Schulthess, J., Pandey, S., Capitani, M., Rue-Albrecht, K. C., Arnold, I., Franchini, F., Chomka, A., Ilott, N. E., Johnston, D. G. W., Pires, E., McCullagh, J., Sansom, S. N., Arancibia-Carcamo, C. V., Uhlig, H. H. and Powrie, F.
Immunity. 2019 Feb 19, 50(2):432-445 e7.

Model Organisms

The RNA-Binding Protein PUM2 Impairs Mitochondrial Dynamics and Mitophagy During Aging
D'Amico, D., Mottis, A., Potenza, F., Sorrentino, V., Li, H., Romani, M., Lemos, V., Schoonjans, K., Zamboni, N., Knott, G., Schneider, B. L. and Auwerx, J.
Mol Cell. 2019 Feb 21, 73(4):775-787 e10.

Nephrology Research

miR-21-5p regulates mitochondrial respiration and lipid content in H9C2 cells
Nasci, V. L., Chuppa, S., Griswold, L., Goodreau, K. A., Dash, R. K. and Kriegel, A. J.
Am J Physiol Heart Circ Physiol. 2019 Mar 1, 316(3):H710-H721.

Neurobiology Research

The age-related changes and differences in energy metabolism and glutamate-glutamine recycling in the d-gal-induced and naturally occurring senescent astrocytes in vitro
Cao, P., Zhang, J., Huang, Y., Fang, Y., Lyu, J. and Shen, Y.
Exp Gerontol. 2019 Apr 01, 118:9-18.

Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem/progenitor cell bioenergetics through binding to F0F1-ATP synthase complex
Fang, J. D., Tung, H. H. and Lee, S. L.
FASEB J. 2019 Mar 1, 33(3):4327-4340.

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
Liu, K., Guo, L., Zhou, Z., Pan, M. and Yan, C.
Microvasc Res. 2019 May 1, 123:74-80.

Different influences on mitochondrial function, oxidative stress and cytotoxicity of antibiotics on primary human neuron and cell lines
Xiao, Y., Xiong, T., Meng, X., Yu, D., Xiao, Z. and Song, L.
J Biochem Mol Toxicol. 2019 Apr 1, 33(4):e22277.

Mitochondrial ribosomal protein PTCD3 mutations cause oxidative phosphorylation defects with Leigh syndrome
Borna, N. N., Kishita, Y., Kohda, M., Lim, S. C., Shimura, M., Wu, Y., Mogushi, K., Yatsuka, Y., Harashima, H., Hisatomi, Y., Fushimi, T., Ichimoto, K., Murayama, K., Ohtake, A. and Okazaki, Y.
Neurogenetics. 2019 Mar 1, 20(1):9-25.

Contribution of mitochondrial ND1 3394T>C mutation to the phenotypic manifestation of Leber's hereditary optic neuropathy
Ji, Y., Zhang, J., Yu, J., Wang, Y., Lu, Y., Liang, M., Li, Q., Jin, X., Wei, Y., Meng, F., Gao, Y., Cang, X., Tong, Y., Liu, X., Zhang, M., Jiang, P., Zhu, T., Mo, J. Q., Huang, T., Jiang, P. and Guan, M. X.
Hum Mol Genet. 2019 May 1, 28(9):1515-1529.

Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder
Chen, C. W., Wang, H. L., Huang, C. W., Huang, C. Y., Lim, W. K., Tu, I. C., Koorapati, A., Hsieh, S. T., Kan, H. W., Tzeng, S. R., Liao, J. C., Chong, W. M., Naroditzky, I., Kidron, D., Eran, A., Nijim, Y., Sela, E., Feldman, H. B., Kalfon, L., Raveh-Barak, H., Falik-Zaccai, T. C., Elpeleg, O., Mandel, H. and Chang, Z. F.
Proc Natl Acad Sci U S A. 2019 Jan 8, 116(2):566-574.

Post-stroke fatigue as an indicator of underlying bioenergetics alterations
Klinedinst, N. J., Schuh, R., Kittner, S. J., Regenold, W. T., Kehs, G., Hoch, C., Hackney, A. and Fiskum, G.
J Bioenerg Biomembr. 2019 Apr 1, 51(2):165-174.

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A. and Kanthasamy, A. G.
Sci Signal. 2019 Jan 8, 12(563).

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain
Wardelmann, K., Blumel, S., Rath, M., Alfine, E., Chudoba, C., Schell, M., Cai, W., Hauffe, R., Warnke, K., Flore, T., Ritter, K., Weiss, J., Kahn, C. R. and Kleinridders, A.
Mol Metab. 2019 Mar 1, 21:68-81.

MFN2 mutations in Charcot-Marie-Tooth disease alter mitochondria-associated ER membrane function but do not impair bioenergetics
Larrea, D., Pera, M., Gonelli, A., Cabrera, R. Q., Akman, H. O., Guardia-Laguarta, C., Velasco, K. R., Area-Gomez, E., Dal Bello, F., De Stefani, D., Horvath, R., Shy, M. E., Schon, E. A. and Giacomello, M.
Hum Mol Genet. 2019 Jan 11, [epub ahead of print]

Extracellular ATP and glutamate drive pyruvate production and energy demand to regulate mitochondrial respiration in astrocytes
Juaristi, I., Llorente-Folch, I., Satrustegui, J. and Del Arco, A.
Glia. 2019 Apr 1, 67(4):759-774.

Extracellular vesicles can act as a potent immunomodulators of human microglial cells
Jonavice, U., Tunaitis, V., Kriauciunaite, K., Jarmalaviciute, A. and Pivoriunas, A.
J Tissue Eng Regen Med. 2019 Feb 1, 13(2):309-318.

Neural Stem Cells - Methods and Protocols
Daadi, M. M.
Methods in Molecular Biology. 2019 Jan 1, 1919.

Iron accumulation in microglia triggers a cascade of events that leads to altered metabolism and compromised function in APP/PS1 mice
McIntosh, A., Mela, V., Harty, C., Minogue, A. M., Costello, D. A., Kerskens, C. and Lynch, M. A.
Brain Pathol. 2019 Jan 20, [epub ahead of print]

Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms
Kanthasamy, A., Jin, H., Charli, A., Vellareddy, A. and Kanthasamy, A.
Pharmacol Ther. 2019 Jan 22, [epub ahead of print]

Inhibition of bioenergetics provides novel insights into recruitment of PINK1-dependent neuronal mitophagy
Shin, Y. S., Ryall, J. G., Britto, J. M., Lau, C. L., Devenish, R. J., Nagley, P. and Beart, P. M.
J Neurochem. 2019 Apr 1, 149(2):269-283.

TGF-beta1 modifies histone acetylation and acetyl-coenzyme A metabolism in renal myofibroblasts
Smith, E. R., Wigg, B., Holt, S. and Hewitson, T. D.
Am J Physiol Renal Physiol. 2019 Jan 9, [epub ahead of print]

Obesity, Diabetes & Metabolic Diseases

Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress
Laurent, V., Toulet, A., Attane, C., Milhas, D., Dauvillier, S., Zaidi, F., Clement, E., Cinato, M., Le Gonidec, S., Guerard, A., Lehuede, C., Garandeau, D., Nieto, L., Renaud-Gabardos, E., Prats, A. C., Valet, P., Malavaud, B. and Muller, C.
Mol Cancer Res. 2019 Mar 1, 17(3):821-835.

Exercise Training Induces Depot-Specific Adaptations to White and Brown Adipose Tissue
Lehnig, A. C., Dewal, R. S., Baer, L. A., Kitching, K. M., Munoz, V. R., Arts, P. J., Sindeldecker, D. A., May, F. J., Lauritzen, H., Goodyear, L. J. and Stanford, K. I.
iScience. 2019 Jan 25, 11:425-439.

CerS1-Derived C18:0 Ceramide in Skeletal Muscle Promotes Obesity-Induced Insulin Resistance
Turpin-Nolan, S. M., Hammerschmidt, P., Chen, W., Jais, A., Timper, K., Awazawa, M., Brodesser, S. and Bruning, J. C.
Cell Rep. 2019 Jan 2, 26(1):1-10 e7.

Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle
Nakazawa, H., Ikeda, K., Shinozaki, S., Yasuhara, S., Yu, Y. M., Martyn, J. A. J., Tompkins, R. G., Yorozu, T., Inoue, S. and Kaneki, M.
FEBS Open Bio. 2019 Jan 19, 9(2):348-363.

Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation
Balaz, M., Becker, A. S., Balazova, L., Straub, L., Muller, J., Gashi, G., Maushart, C. I., Sun, W., Dong, H., Moser, C., Horvath, C., Efthymiou, V., Rachamin, Y., Modica, S., Zellweger, C., Bacanovic, S., Stefanicka, P., Varga, L., Ukropcova, B., Profant, M., Opitz, L., Amri, E. Z., Akula, M. K., Bergo, M., Ukropec, J., Falk, C., Zamboni, N., Betz, M. J., Burger, I. A. and Wolfrum, C.
Cell Metab. 2019 Apr 2, 29(4):901-916 e8.

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD
Garcia, D., Hellberg, K., Chaix, A., Wallace, M., Herzig, S., Badur, M. G., Lin, T., Shokhirev, M. N., Pinto, A. F. M., Ross, D. S., Saghatelian, A., Panda, S., Dow, L. E., Metallo, C. M. and Shaw, R. J.
Cell Rep. 2019 Jan 2, 26(1):192-208 e6.

BCG Therapy for Type 1 Diabetes: Restoration of Balanced Immunity and Metabolism
Kuhtreiber, W. M. and Faustman, D. L.
Trends Endocrinol Metab. 2019 Feb 1, 30(2):80-92.

Mitochondrial lysine deacetylation promotes energy metabolism and calcium signaling in insulin-secreting cells
De Marchi, U., Galindo, A. N., Thevenet, J., Hermant, A., Bermont, F., Lassueur, S., Domingo, J. S., Kussmann, M., Dayon, L. and Wiederkehr, A.
FASEB J. 2019 Apr 1, 33(4):4660-4674.

miRNA-451a regulates RPE function through promoting mitochondrial function in proliferative diabetic retinopathy
Shao, Y., Dong, L. J., Takahashi, Y., Chen, J., Liu, X., Chen, Q., Ma, J. X. and Li, X. R.
Am J Physiol Endocrinol Metab. 2019 Mar 1, 316(3):E443-E452.

Immunometabolism: A Multi-Omics Approach to Interpreting the Influence of Exercise and Diet on the Immune System
Nieman, D. C., Lila, M. A. and Gillitt, N. D.
Annu Rev Food Sci Technol. 2019 Mar 25, 10:341-363.

Insulin action in the brain regulates mitochondrial stress responses and reduces diet-induced weight gain
Wardelmann, K., Blumel, S., Rath, M., Alfine, E., Chudoba, C., Schell, M., Cai, W., Hauffe, R., Warnke, K., Flore, T., Ritter, K., Weiss, J., Kahn, C. R. and Kleinridders, A.
Mol Metab. 2019 Mar 1, 21:68-81.

Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
West, M. D., Chang, C. F., Larocca, D., Li, J., Jiang, J., Sim, P., Labat, I., Chapman, K. B., Wong, K. E., Nicoll, J., Van Kanegan, M. J., de Grey, A., Nasonkin, I. O., Stahl, A. and Sternberg, H.
Stem Cell Res Ther. 2019 Jan 8, 10(1):7.

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response
Hu, W., Jiang, C., Guan, D., Dierickx, P., Zhang, R., Moscati, A., Nadkarni, G. N., Steger, D. J., Loos, R. J. F., Hu, C., Jia, W., Soccio, R. E. and Lazar, M. A.
Cell Stem Cell. 2019 Feb 7, 24(2):299-308 e6.

Gain Fat-Lose Metastasis: Converting Invasive Breast Cancer Cells into Adipocytes Inhibits Cancer Metastasis
Ishay-Ronen, D., Diepenbruck, M., Kalathur, R. K. R., Sugiyama, N., Tiede, S., Ivanek, R., Bantug, G., Morini, M. F., Wang, J., Hess, C. and Christofori, G.
Cancer Cell. 2019 Jan 14, 35(1):17-32 e6.

MR (Mineralocorticoid Receptor) Induces Adipose Tissue Senescence and Mitochondrial Dysfunction Leading to Vascular Dysfunction in Obesity
Lefranc, C., Friederich-Persson, M., Braud, L., Palacios-Ramirez, R., Karlsson, S., Boujardine, N., Motterlini, R., Jaisser, F. and Nguyen Dinh Cat, A.
Hypertension. 2019 Feb 1, 73(2):458-468.

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify Emerging Metabolic Health Threats
Kim, S., Reed, E., Monti, S. and Schlezinger, J.
bioRxiv. 2019 Jan 13, [epub ahead of print]

Bile acid supplementation decreases body mass gain in C57BL/6J but not 129S6/SvEvTac mice without increasing energy expenditure
Fromme, T., Huttinger, K., Maurer, S., Li, Y., Gantert, T., Fiamoncini, J., Daniel, H., Westphal, S. and Klingenspor, M.
Sci Rep. 2019 Jan 15, 9(1):131.

Thermal stress induces glycolytic beige fat formation via a myogenic state
Chen, Y., Ikeda, K., Yoneshiro, T., Scaramozza, A., Tajima, K., Wang, Q., Kim, K., Shinoda, K., Sponton, C. H., Brown, Z., Brack, A. and Kajimura, S.
Nature. 2019 Jan 1, 565(7738):180-185.

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity
Shih, D. M., Meng, Y., Sallam, T., Vergnes, L., Shu, M. L., Reue, K., Tontonoz, P., Fogelman, A. M., Lusis, A. J. and Reddy, S. T.
Antioxidants (Basel). 2019 Jan 11, 8(1).

Stem Cell Biology

Mitochondrial localization of St14-encoding transmembrane serine protease is involved in neural stem/progenitor cell bioenergetics through binding to F0F1-ATP synthase complex
Fang, J. D., Tung, H. H. and Lee, S. L.
FASEB J. 2019 Mar 1, 33(3):4327-4340.

Loss of Estrogen-Related Receptor Alpha Facilitates Angiogenesis in Endothelial Cells
Likhite, N., Yadav, V., Milliman, E. J., Sopariwala, D. H., Lorca, S., Narayana, N. P., Sheth, M., Reineke, E. L., Giguere, V. and Narkar, V.
Mol Cell Biol. 2019 Feb 15, 39(5).

Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke
Liu, K., Guo, L., Zhou, Z., Pan, M. and Yan, C.
Microvasc Res. 2019 May 1, 123:74-80.

LAMP-2B regulates human cardiomyocyte function by mediating autophagosome-lysosome fusion
Chi, C., Leonard, A., Knight, W. E., Beussman, K. M., Zhao, Y., Cao, Y., Londono, P., Aune, E., Trembley, M. A., Small, E. M., Jeong, M. Y., Walker, L. A., Xu, H., Sniadecki, N. J., Taylor, M. R., Buttrick, P. M. and Song, K.
Proc Natl Acad Sci U S A. 2019 Jan 8, 116(2):556-565.

Bioenergetic Changes Underline Plasticity of Murine Embryonic Stem Cells
Vlaski-Lafarge, M., Loncaric, D., Perez, L., Labat, V., Debeissat, C., Brunet de la Grange, P., Rossignol, R., Ivanovic, Z. and Boeuf, H.
Stem Cells. 2019 Apr 1, 37(4):463-475.

Hypoxia Prevents Mitochondrial Dysfunction and Senescence in Human c-Kit(+) Cardiac Progenitor Cells
Korski, K. I., Kubli, D. A., Wang, B. J., Khalafalla, F. G., Monsanto, M. M., Firouzi, F., Echeagaray, O. H., Kim, T., Adamson, R. M., Dembitsky, W. P., Gustafsson, A. B. and Sussman, M. A.
Stem Cells. 2019 Apr 1, 37(4):555-567.

Clonal derivation of white and brown adipocyte progenitor cell lines from human pluripotent stem cells
West, M. D., Chang, C. F., Larocca, D., Li, J., Jiang, J., Sim, P., Labat, I., Chapman, K. B., Wong, K. E., Nicoll, J., Van Kanegan, M. J., de Grey, A., Nasonkin, I. O., Stahl, A. and Sternberg, H.
Stem Cell Res Ther. 2019 Jan 8, 10(1):7.

Patient Adipose Stem Cell-Derived Adipocytes Reveal Genetic Variation that Predicts Antidiabetic Drug Response
Hu, W., Jiang, C., Guan, D., Dierickx, P., Zhang, R., Moscati, A., Nadkarni, G. N., Steger, D. J., Loos, R. J. F., Hu, C., Jia, W., Soccio, R. E. and Lazar, M. A.
Cell Stem Cell. 2019 Feb 7, 24(2):299-308 e6.

Mitochondrial complex III is necessary for endothelial cell proliferation during angiogenesis
Diebold, L. P., Gil, H. J., Gao, P., Martinez, C. A., Weinberg, S. E. and Chandel, N. S.
Nature Metabolism. 2019 Jan 7, 1(1):158-171.

Oxidative Insults and Mitochondrial DNA Mutation Promote Enhanced Autophagy and Mitophagy Compromising Cell Viability in Pluripotent Cell Model of Mitochondrial Disease
Lin, D. S., Huang, Y. W., Ho, C. S., Hung, P. L., Hsu, M. H., Wang, T. J., Wu, T. Y., Lee, T. H., Huang, Z. D., Chang, P. C. and Chiang, M. F.
Cells. 2019 Jan 17, 8(1).

Extracellular vesicles can act as a potent immunomodulators of human microglial cells
Jonavice, U., Tunaitis, V., Kriauciunaite, K., Jarmalaviciute, A. and Pivoriunas, A.
J Tissue Eng Regen Med. 2019 Feb 1, 13(2):309-318.

3-Mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics
Abdollahi Govar, A., Toro, G., Szaniszlo, P., Pavlidou, A., Bibli, S. I., Thanki, K., Resto, V. A., Chao, C., Hellmich, M. R., Szabo, C., Papapetropoulos, A. and Modis, K.
Br J Pharmacol. 2019 Jan 14, [epub ahead of print]

Mesenchymal stromal cell-derived exosomes improve mitochondrial health in pulmonary arterial hypertension
Hogan, S. E., Rodriguez Salazar, M. P., Cheadle, J., Glenn, R., Medrano, C., Petersen, T. H. and Ilagan, R. M.
Am J Physiol Lung Cell Mol Physiol. 2019 May 1, 316(5):L723-L737.

Mechanistic Target of Rapamycin Complex 1 Promotes the Expression of Genes Encoding Electron Transport Chain Proteins and Stimulates Oxidative Phosphorylation in Primary Human Trophoblast Cells by Regulating Mitochondrial Biogenesis
Rosario, F. J., Gupta, M. B., Myatt, L., Powell, T. L., Glenn, J. P., Cox, L. and Jansson, T.
Sci Rep. 2019 Jan 22, 9(1):246.

Techniques & Methods

Immune Checkpoint Blockade - Methods and Protocols
Pico de Coaña, Y.
Methods in Molecular Biology. 2019 Jan 1, 1913.

T cells loaded with magnetic nanoparticles are retained in peripheral lymph nodes by the application of a magnetic field
Sanz-Ortega, L., Rojas, J. M., Marcos, A., Portilla, Y., Stein, J. V. and Barber, D. F.
J Nanobiotechnology. 2019 Jan 22, 17(1):14.

Modulation of Intracellular Oxygen Pressure by Dual-Drug Nanoparticles to Enhance Photodynamic Therapy
Fan, Y.-T., Zhou, T.-J., Cui, P.-F., He, Y.-J., Chang, X., Xing, L. and Jiang, H.-L.
Advanced Functional Materials. 2019 Jan 21, 29(10):1806708.

Toxicology Research

Minerval (2-hydroxyoleic acid) causes cancer cell selective toxicity by uncoupling oxidative phosphorylation and compromising bioenergetic compensation capacity
Massalha, W., Markovits, M., Pichinuk, E., Feinstein-Rotkopf, Y., Tarshish, M., Mishra, K., Llado, V., Weil, M., Escriba, P. V. and Kakhlon, O.
Biosci Rep. 2019 Jan 31, 39(1).

Different influences on mitochondrial function, oxidative stress and cytotoxicity of antibiotics on primary human neuron and cell lines
Xiao, Y., Xiong, T., Meng, X., Yu, D., Xiao, Z. and Song, L.
J Biochem Mol Toxicol. 2019 Apr 1, 33(4):e22277.

Cinnamaldehyde in flavored e-cigarette liquids temporarily suppresses bronchial epithelial cell ciliary motility by dysregulation of mitochondrial function
Clapp, P. W., Lavrich, K. S., van Heusden, C. A., Lazarowski, E. R., Carson, J. L. and Jaspers, I.
Am J Physiol Lung Cell Mol Physiol. 2019 Mar 1, 316(3):L470-L486.

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A. and Kanthasamy, A. G.
Sci Signal. 2019 Jan 8, 12(563).

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify Emerging Metabolic Health Threats
Kim, S., Reed, E., Monti, S. and Schlezinger, J.
bioRxiv. 2019 Jan 13, [epub ahead of print]

p53/BNIP3-dependent mitophagy limits glycolytic shift in radioresistant cancer
Chang, H. W., Kim, M. R., Lee, H. J., Lee, H. M., Kim, G. C., Lee, Y. S., Nam, H. Y., Lee, M., Jang, H. J., Lee, K. E., Lee, J. C., Byun, Y., Kim, S. W. and Kim, S. Y.
Oncogene. 2019 Jan 21, [epub ahead of print]

Environmental neurotoxicant-induced dopaminergic neurodegeneration: a potential link to impaired neuroinflammatory mechanisms
Kanthasamy, A., Jin, H., Charli, A., Vellareddy, A. and Kanthasamy, A.
Pharmacol Ther. 2019 Jan 22, [epub ahead of print]

Translational Research

Cardiomyopathy in children with mitochondrial disease: Prognosis and genetic background
Imai-Okazaki, A., Kishita, Y., Kohda, M., Mizuno, Y., Fushimi, T., Matsunaga, A., Yatsuka, Y., Hirata, T., Harashima, H., Takeda, A., Nakaya, A., Sakata, Y., Kogaki, S., Ohtake, A., Murayama, K. and Okazaki, Y.
Int J Cardiol. 2019 Mar 15, 279:115-121.

Mitochondrial ribosomal protein PTCD3 mutations cause oxidative phosphorylation defects with Leigh syndrome
Borna, N. N., Kishita, Y., Kohda, M., Lim, S. C., Shimura, M., Wu, Y., Mogushi, K., Yatsuka, Y., Harashima, H., Hisatomi, Y., Fushimi, T., Ichimoto, K., Murayama, K., Ohtake, A. and Okazaki, Y.
Neurogenetics. 2019 Mar 1, 20(1):9-25.

Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder
Chen, C. W., Wang, H. L., Huang, C. W., Huang, C. Y., Lim, W. K., Tu, I. C., Koorapati, A., Hsieh, S. T., Kan, H. W., Tzeng, S. R., Liao, J. C., Chong, W. M., Naroditzky, I., Kidron, D., Eran, A., Nijim, Y., Sela, E., Feldman, H. B., Kalfon, L., Raveh-Barak, H., Falik-Zaccai, T. C., Elpeleg, O., Mandel, H. and Chang, Z. F.
Proc Natl Acad Sci U S A. 2019 Jan 8, 116(2):566-574.

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