XF出版物快报 2019年3月

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Aging Research

Pharmaceutical Induction of PGC-1alpha Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage
Satish, S., Philipose, H., Rosales, M. A. B. and Saint-Geniez, M.
Oxid Med Cell Longev. 2018 Nov 05, 2018:9248640.

ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties
Nannelli, G., Terzuoli, E., Giorgio, V., Donnini, S., Lupetti, P., Giachetti, A., Bernardi, P. and Ziche, M.
Oxid Med Cell Longev. 2018 Nov 14, 2018:9765027.

Loss of PINK1 causes age-dependent decrease of dopamine release and mitochondrial dysfunction
Zhi, L., Qin, Q., Muqeem, T., Seifert, E. L., Liu, W., Zheng, S., Li, C. and Zhang, H.
Neurobiol Aging. 2019 Mar 01, 75:1-10.

Age-related declines in alpha-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Sahu, A., Mamiya, H., Shinde, S. N., Cheikhi, A., Winter, L. L., Vo, N. V., Stolz, D., Roginskaya, V., Tang, W. Y., St Croix, C., Sanders, L. H., Franti, M., Van Houten, B., Rando, T. A., Barchowsky, A. and Ambrosio, F.
Nat Commun. 2018 Nov 19, 9(1):4859.

Cancer Research

Evaluating the Metabolic Alterations in Pancreatic Cancer
Dasgupta, A.
Method in Molec Biol. 2018 Oct 31, 1882.

LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state
Furth, N., Pateras, I. S., Rotkopf, R., Vlachou, V., Rivkin, I., Schmitt, I., Bakaev, D., Gershoni, A., Ainbinder, E., Leshkowitz, D., Johnson, R. L., Gorgoulis, V. G., Oren, M. and Aylon, Y.
Life Sci Alliance. 2018 Oct 30, 1(5):e201800171.

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis
Rufener, R., Dick, L., D'Ascoli, L., Ritler, D., Hizem, A., Wells, T. N. C., Hemphill, A. and Lundstrom-Stadelmann, B.
Int J Parasitol Drugs Drug Resist. 2018 Dec 01, 8(3):440-450.

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., Kreslavsky, T., Kogler, M., Hoffmann, D., Ticevic, M., da Luz Scheffer, D., Tortola, L., Cikes, D., Jais, A., Rangachari, M., Rao, S., Paolino, M., Novatchkova, M., Aichinger, M., Barrett, L., Latremoliere, A., Wirnsberger, G., Lametschwandtner, G., Busslinger, M., Zicha, S., Latini, A., Robson, S. C., Waisman, A., Andrews, N., Costigan, M., Channon, K. M., Weiss, G., Kozlov, A. V., Tebbe, M., Johnsson, K., Woolf, C. J. and Penninger, J. M.
Nature. 2018 Nov 01, 563(7732):564-568.

Magmas inhibition as a potential treatment strategy in malignant glioma
Di, K., Lomeli, N., Bota, D. A. and Das, B. C.
J Neurooncol. 2019 Jan 01, 141(2):267-276.

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1
Hulse, M., Caruso, L. B., Madzo, J., Tan, Y., Johnson, S. and Tempera, I.
PLoS Pathog. 2018 Nov 05, 14(11):e1007394.

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Bohn, T., Rapp, S., Luther, N., Klein, M., Bruehl, T. J., Kojima, N., Aranda Lopez, P., Hahlbrock, J., Muth, S., Endo, S., Pektor, S., Brand, A., Renner, K., Popp, V., Gerlach, K., Vogel, D., Lueckel, C., Arnold-Schild, D., Pouyssegur, J., Kreutz, M., Huber, M., Koenig, J., Weigmann, B., Probst, H. C., von Stebut, E., Becker, C., Schild, H., Schmitt, E. and Bopp, T.
Nat Immunol. 2018 Dec 01, 19(12):1319-1329.

TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation
Li, L., Li, L., Li, W., Chen, T., Bin, Z., Zhao, L., Wang, H., Wang, X., Xu, L., Liu, X., Wang, D., Li, B., Mak, T. W., Du, W., Yang, X. and Jiang, P.
Nat Commun. 2018 Nov 8, 9(1):4683.

GABA, glutamine, glutamate oxidation and succinic semialdehyde dehydrogenase expression in human gliomas
Hujber, Z., Horvath, G., Petovari, G., Krencz, I., Danko, T., Meszaros, K., Rajnai, H., Szoboszlai, N., Leenders, W. P. J., Jeney, A., Tretter, L. and Sebestyen, A.
J Exp Clin Cancer Res. 2018 Nov 7, 37(1):271.

1-(5-Bromo-2-hydroxy-4-methoxyphenyl)ethanone [SE1] Inhibits MMP-9 Expression by Regulating NF-kappaB and MAPKs Signaling Pathways in HT1080 Human Fibrosarcoma Cells
Gong, F., Zhang, Y., Lin, J., Li, C., Zhou, C., Hong, P., Ryu, B. and Qian, Z. J.
Evid Based Complement Alternat Med. 2018 Nov 5, 2018:5639486.

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy
Lonetto, G., Koifman, G., Silberman, A., Attery, A., Solomon, H., Levin-Zaidman, S., Goldfinger, N., Porat, Z., Erez, A. and Rotter, V.
Cell Death Differ. 2018 Nov 9, [epub ahead of print]

Loss of TP53I11 Enhances the Extracellular Matrix-independent Survival by Promoting Activation of AMPK
Xiao, T., Xu, Z., Zhou, Y., Zhang, H., Geng, J., Liang, Y., Qiao, H. and Suo, G.
IUBMB Life. 2019 Feb 01, 71(2):183-191.

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells
Norden, E. and Heiss, E. H.
Carcinogenesis. 2019 Mar 12, 40(1):93-101.

Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming
Tan, Y., Lin, K., Zhao, Y., Wu, Q., Chen, D., Wang, J., Liang, Y., Li, J., Hu, J., Wang, H., Liu, Y., Zhang, S., He, W., Huang, Q., Hu, X., Yao, Z., Liang, B., Liao, W. and Shi, M.
Theranostics. 2018 Oct 29, 8(19):5452-5468.

ME1 promotes basal-like breast cancer progression and associates with poor prognosis
Liao, R., Ren, G., Liu, H., Chen, X., Cao, Q., Wu, X., Li, J. and Dong, C.
Sci Rep. 2018 Nov 13, 8(1):16743.

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
Pollyea, D. A., Stevens, B. M., Jones, C. L., Winters, A., Pei, S., Minhajuddin, M., D'Alessandro, A., Culp-Hill, R., Riemondy, K. A., Gillen, A. E., Hesselberth, J. R., Abbott, D., Schatz, D., Gutman, J. A., Purev, E., Smith, C. and Jordan, C. T.
Nat Med. 2018 Dec 01, 24(12):1859-1866.

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Michelet, X., Dyck, L., Hogan, A., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., O'Farrelly, C., Raverdeau, M., Vernon, A., Pettee, W., O'Shea, D., Nikolajczyk, B. S., Mills, K. H. G., Brenner, M. B., Finlay, D. and Lynch, L.
Nat Immunol. 2018 Dec 01, 19(12):1330-1340.

LAT2 regulates glutamine-dependent mTOR activation to promote glycolysis and chemoresistance in pancreatic cancer
Feng, M., Xiong, G., Cao, Z., Yang, G., Zheng, S., Qiu, J., You, L., Zheng, L., Zhang, T. and Zhao, Y.
J Exp Clin Cancer Res. 2018 Nov 12, 37(1):274.

Exosomes derived from acute myeloid leukemia cells promote chemoresistance by enhancing glycolysis-mediated vascular remodeling
Wang, B., Wang, X., Hou, D., Huang, Q., Zhan, W., Chen, C., Liu, J., You, R., Xie, J., Chen, P. and Huang, H.
J Cell Physiol. 2018 Nov 11, [epub ahead of print]

Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells
Wu, L., Liu, X., Cao, K. X., Ni, Z. H., Li, W. D. and Chen, Z. P.
J Cell Biochem. 2018 Oct 30, [epub ahead of print]

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
Jones, C. L., Stevens, B. M., D'Alessandro, A., Reisz, J. A., Culp-Hill, R., Nemkov, T., Pei, S., Khan, N., Adane, B., Ye, H., Krug, A., Reinhold, D., Smith, C., DeGregori, J., Pollyea, D. A. and Jordan, C. T.
Cancer Cell. 2018 Nov 12, 34(5):724-740 e4.

Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells
Bajzikova, M., Kovarova, J., Coelho, A. R., Boukalova, S., Oh, S., Rohlenova, K., Svec, D., Hubackova, S., Endaya, B., Judasova, K., Bezawork-Geleta, A., Kluckova, K., Chatre, L., Zobalova, R., Novakova, A., Vanova, K., Ezrova, Z., Maghzal, G. J., Magalhaes Novais, S., Olsinova, M., Krobova, L., An, Y. J., Davidova, E., Nahacka, Z., Sobol, M., Cunha-Oliveira, T., Sandoval-Acuna, C., Strnad, H., Zhang, T., Huynh, T., Serafim, T. L., Hozak, P., Sardao, V. A., Koopman, W. J. H., Ricchetti, M., Oliveira, P. J., Kolar, F., Kubista, M., Truksa, J., Dvorakova-Hortova, K., Pacak, K., Gurlich, R., Stocker, R., Zhou, Y., Berridge, M. V., Park, S., Dong, L., Rohlena, J. and Neuzil, J.
Cell Metab. 2019 Feb 5, 29(2):399-416 e10.

Metformin causes cancer cell death through downregulation of p53-dependent differentiated embryo chondrocyte 1
Hsieh Li, S. M., Liu, S. T., Chang, Y. L., Ho, C. L. and Huang, S. M.
J Biomed Sci. 2018 Nov 15, 25(1):81.

The transcription factor c-Myb regulates CD8(+) T cell stemness and antitumor immunity
Gautam, S., Fioravanti, J., Zhu, W., Le Gall, J. B., Brohawn, P., Lacey, N. E., Hu, J., Hocker, J. D., Hawk, N. V., Kapoor, V., Telford, W. G., Gurusamy, D., Yu, Z., Bhandoola, A., Xue, H. H., Roychoudhuri, R., Higgs, B. W., Restifo, N. P., Bender, T. P., Ji, Y. and Gattinoni, L.
Nat Immunol. 2019 Mar 01, 20(3):337-349.

Effects of tumor necrosis factor-alpha-induced exosomes on the endothelial cellular behavior, metabolism and bioenergetics
Li, B., Li, L., Zhang, Q., Zhang, H. and Xiu, R.
Microcirculation. 2019 Jan 01, 26(1):e12515.

Metabolic reprogramming of mitochondrial respiration in metastatic cancer
Herst, P. M., Grasso, C. and Berridge, M. V.
Cancer Metastasis Rev. 2018 Dec 01, 37(4):643-653.

Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma
Fang, E., Wang, J., Hong, M., Zheng, L. and Tong, Q.
Biochem Biophys Res Commun. 2019 Jan 1, 508(1):9-16.

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
Tabe, Y., Saitoh, K., Yang, H., Sekihara, K., Yamatani, K., Ruvolo, V., Taka, H., Kaga, N., Kikkawa, M., Arai, H., Miida, T., Andreeff, M., Spagnuolo, P. A. and Konopleva, M.
Sci Rep. 2018 Nov 15, 8(1):16837.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis Santofimia-Castano, P., Lan, W., Bintz, J., Gayet, O., Carrier, A., Lomberk, G., Neira, J. L., Gonzalez, A., Urrutia, R., Soubeyran, P. and Iovanna, J.
Sci Rep. 2018 Nov 19, 8(1):16999. 

CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-beta signaling Zhao, Z., Hao, D., Wang, L., Li, J., Meng, Y., Li, P., Wang, Y., Zhang, C., Zhou, H., Gardner, K. and Di, L. J.
Oncogene. 2018 Nov 15, [epub ahead of print]

Mitochondrial pyruvate import is a metabolic vulnerability in androgen receptor-driven prostate cancer
Bader, D. A., Hartig, S. M., Putluri, V., Foley, C., Hamilton, M. P., Smith, E. A., Saha, P. K., Panigrahi, A., Walker, C., Zong, L., Martini-Stoica, H., Chen, R., Rajapakshe, K., Coarfa, C., Sreekumar, A., Mitsiades, N., Bankson, J. A., Ittmann, M. M., O’Malley, B. W., Putluri, N. and McGuire, S. E.
Nature Metabolism. 2018 Nov 19, 1(1):70-85.

Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis
Santana-Codina, N., Roeth, A. A., Zhang, Y., Yang, A., Mashadova, O., Asara, J. M., Wang, X., Bronson, R. T., Lyssiotis, C. A., Ying, H. and Kimmelman, A. C.
Nat Commun. 2018 Nov 23, 9(1):4945.

BET inhibitors reduce cell size and induce reversible cell cycle arrest in AML
Zhang, S., Zhao, Y., Heaster, T. M., Fischer, M. A., Stengel, K. R., Zhou, X., Ramsey, H., Zhou, M. M., Savona, M. R., Skala, M. C. and Hiebert, S. W.
J Cell Biochem. 2018 Nov 11, [epub ahead of print]

Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway
Zhang, H., Zhu, L., Bai, M., Liu, Y., Zhan, Y., Deng, T., Yang, H., Sun, W., Wang, X., Zhu, K., Fan, Q., Li, J., Ying, G. and Ba, Y. Int J Cancer. 2018 Nov 9, [epub ahead of print]

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P. H., Yang, C., Sudderth, J., Rodriguez-Tirado, C., Girard, L., Minna, J. D., Mishra, P., DeBerardinis, R. J. and O'Donnell, K. A.
Cell Rep. 2018 Nov 20, 25(8):2223-2233 e6.

MUC16 mutation predicts a favorable clinical outcome and correlates decreased Warburg effect in gastric cancer
Zhao, H. and Zhang, L. Biochem
Biophys Res Commun. 2018 Dec 2, 506(4):780-786.
 

Cardiovascular Research

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy
Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Shanmughapriya, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. and Drosatos, K.
J Mol Cell Cardiol. 2019 Feb 01, 127(232-245.

Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
Qi, Z., Song, Y., Ding, Q., Liao, X., Li, R., Liu, G., Tsang, S. and Cai, Z.
Ecotoxicol Environ Saf. 2019 Jan 30, 168(378-387.

Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities
Paliwal, S., Chaudhuri, R., Agrawal, A. and Mohanty, S.
Stem Cell Res Ther. 2018 Nov 8, 9(1):298.

Serum Amyloid A3 is required for normal lung development and survival following influenza infection
Ather, J. L., Dienz, O., Boyson, J. E., Anathy, V., Amiel, E. and Poynter, M. E.
Sci Rep. 2018 Nov 8, 8(1):16571.

Exosomes derived from acute myeloid leukemia cells promote chemoresistance by enhancing glycolysis-mediated vascular remodeling
Wang, B., Wang, X., Hou, D., Huang, Q., Zhan, W., Chen, C., Liu, J., You, R., Xie, J., Chen, P. and Huang, H.
J Cell Physiol. 2018 Nov 11, [epub ahead of print]

Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest
Yang, L., Wang, J., Deng, Y., Gong, C., Li, Q., Chen, Q., Li, H., Jiang, C., Zhou, R., Hai, K., Wu, W. and Li, T.
PLoS One. 2018 Nov 06, 13(11):e0207098.

Doxorubicin-induced cardiotoxicity involves IFNgamma-mediated metabolic reprogramming in cardiomyocytes
Ni, C., Ma, P., Wang, R., Lou, X., Liu, X., Qin, Y., Xue, R., Blasig, I., Erben, U. and Qin, Z.
J Pathol. 2019 Mar 01, 247(3):320-332.

Transient Overexpression of VEGF-A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System
Zhao, Y., Li, X., Yang, L., Eckel-Mahan, K., Tong, Q., Gu, X., Kolonin, M. G. and Sun, K.
Mol Cell Biol. 2018 Aug 20, [epub ahead of print]

PRKAA1/AMPKalpha1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
Yang, Q., Xu, J., Ma, Q., Liu, Z., Sudhahar, V., Cao, Y., Wang, L., Zeng, X., Zhou, Y., Zhang, M., Xu, Y., Wang, Y., Weintraub, N. L., Zhang, C., Fukai, T., Wu, C., Huang, L., Han, Z., Wang, T., Fulton, D. J., Hong, M. and Huo, Y.
Nat Commun. 2018 Nov 7, 9(1):4667.

Cell Physiology Research

Redox regulation of EGFR steers migration of hypoxic mammary cells towards oxygen
Deygas, M., Gadet, R., Gillet, G., Rimokh, R., Gonzalo, P. and Mikaelian, I.
Nat Commun. 2018 Oct 31, 9(1):4545.

Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles
Jana, S., Strader, M. B., Meng, F., Hicks, W., Kassa, T., Tarandovskiy, I., De Paoli, S., Simak, J., Heaven, M. R., Belcher, J. D., Vercellotti, G. M. and Alayash, A. I.
JCI Insight. 2018 Nov 2, 3 (21).

Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants
Ryan, T. E., Yamaguchi, D. J., Schmidt, C. A., Zeczycki, T. N., Shaikh, S. R., Brophy, P., Green, T. D., Tarpey, M. D., Karnekar, R., Goldberg, E. J., Sparagna, G. C., Torres, M. J., Annex, B. H., Neufer, P. D., Spangenburg, E. E. and McClung, J. M.
JCI Insight. 2018 Nov 2, 3(21).

Oxidative stress alters mitochondrial bioenergetics and modifies pancreatic cell death independently of cyclophilin D, resulting in an apoptosis-to-necrosis shift
Armstrong, J. A., Cash, N. J., Ouyang, Y., Morton, J. C., Chvanov, M., Latawiec, D., Awais, M., Tepikin, A. V., Sutton, R. and Criddle, D. N.
J Biol Chem. 2018 May 25, 293(21):8032-8047. 

Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration
Liu, X., Qu, H., Zheng, Y., Liao, Q., Zhang, L., Liao, X., Xiong, X., Wang, Y., Zhang, R., Wang, H., Tong, Q., Liu, Z., Dong, H., Yang, G., Zhu, Z., Xu, J. and Zheng, H.
EMBO Mol Med. 2018 Dec 01, 10(12).

Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome
Koh, C. W. Q., Goh, Y. T., Toh, J. D. W., Neo, S. P., Ng, S. B., Gunaratne, J., Gao, Y. G., Quake, S. R., Burkholder, W. F. and Goh, W. S. S.
Nucleic Acids Res. 2018 Dec 14, 46(22):11659-11670.

Requirement of Pitx2 for skeletal muscle homeostasis
Chang, C. N., Singh, A. J., Gross, M. K. and Kioussi, C.
Dev Biol. 2019 Jan 1, 445(1):90-102.

Deficiency of the mitochondrial sulfide regulator ETHE1 disturbs cell growth, glutathione level and causes proteome alterations outside mitochondria
Sahebekhtiari, N., Fernandez-Guerra, P., Nochi, Z., Carlsen, J., Bross, P. and Palmfeldt, J.
Biochim Biophys Acta Mol Basis Dis. 2019 Jan 01, 1865(1):126-135.

Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury
Aubrecht, T. G., Faden, A. I., Sabirzhanov, B., Glaser, E. P., Roelofs, B. A., Polster, B. M., Makarevich, O. and Stoica, B. A.
Cell Death Dis. 2018 Nov 6, 9(11):1121.

Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells
Barlow, J. and Solomon, T. P. J.
Metabolism. 2019 Feb 01, 91:1-9.

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells
Dahlmans, D., Houzelle, A., Andreux, P., Wang, X., Jorgensen, J. A., Moullan, N., Daemen, S., Kersten, S., Auwerx, J. and Hoeks, J.
J Cell Physiol. 2019 May 01, 234(5):6601-6610.

FAM92A1 is a BAR domain protein required for mitochondrial ultrastructure and function
Wang, L., Yan, Z., Vihinen, H., Eriksson, O., Wang, W., Soliymani, R., Lu, Y., Xue, Y., Jokitalo, E., Li, J. and Zhao, H.
J Cell Biol. 2019 Jan 7, 218(1):97-111.

Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice
Wu, C. S., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., Lawler, J., Safe, S., Guo, S., Devaraj, S., Chen, Z. and Sun, Y.
J Gerontol A Biol Sci Med Sci. 2018 Nov 8, [epub ahead of print]

Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis
Yan, W. W., Liang, Y. L., Zhang, Q. X., Wang, D., Lei, M. Z., Qu, J., He, X. H., Lei, Q. Y. and Wang, Y. P.
EMBO Rep. 2018 Dec 01, 19(12).

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation
Nadeau, L., Patten, D. A., Caron, A., Garneau, L., Pinault-Masson, E., Foretz, M., Haddad, P., Anderson, B. G., Quinn, L. S., Jardine, K., McBurney, M. W., Pistilli, E. E., Harper, M. E. and Aguer, C.
Biochim Biophys Acta Gen Subj. 2019 Feb 01, 1863(2):395-407.

Age-related declines in alpha-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration
Sahu, A., Mamiya, H., Shinde, S. N., Cheikhi, A., Winter, L. L., Vo, N. V., Stolz, D., Roginskaya, V., Tang, W. Y., St Croix, C., Sanders, L. H., Franti, M., Van Houten, B., Rando, T. A., Barchowsky, A. and Ambrosio, F.
Nat Commun. 2018 Nov 19, 9(1):4859.

Smooth Muscle Contact Drives Endothelial Regeneration by BMPR2-Notch1-Mediated Metabolic and Epigenetic Changes
Miyagawa, K., Shi, M., Chen, P. I., Hennigs, J. K., Zhao, Z., Wang, M., Li, C. G., Saito, T., Taylor, S., Sa, S., Cao, A., Wang, L., Snyder, M. P. and Rabinovitch, M.
Circ Res. 2019 Jan 18, 124(2):211-224.

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
Morioka, S., Perry, J. S. A., Raymond, M. H., Medina, C. B., Zhu, Y., Zhao, L., Serbulea, V., Onengut-Gumuscu, S., Leitinger, N., Kucenas, S., Rathmell, J. C., Makowski, L. and Ravichandran, K. S.
Nature. 2018 Nov 01, 563(7733):714-718.

Drug Discovery

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis
Rufener, R., Dick, L., D'Ascoli, L., Ritler, D., Hizem, A., Wells, T. N. C., Hemphill, A. and Lundstrom-Stadelmann, B.
Int J Parasitol Drugs Drug Resist. 2018 Dec 01, 8(3):440-450.

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy
Kokkinaki, D., Hoffman, M., Kalliora, C., Kyriazis, I. D., Maning, J., Lucchese, A. M., Shanmughapriya, S., Tomar, D., Park, J. Y., Wang, H., Yang, X. F., Madesh, M., Lymperopoulos, A., Koch, W. J., Christofidou-Solomidou, M. and Drosatos, K.
J Mol Cell Cardiol. 2019 Feb 01, 127(232-245.

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease
Jeong, J. S., Piao, Y., Kang, S., Son, M., Kang, Y. C., Du, X. F., Ryu, J., Cho, Y. W., Jiang, H. H., Oh, M. S., Hong, S. P., Oh, Y. J. and Pak, Y. K.
Sci Rep. 2018 Oct 29, 8(1):15953.

Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility
Peng, S., Wang, Y., Zhou, Y., Ma, T., Wang, Y., Li, J., Huang, F., Kou, J., Qi, L., Liu, B. and Liu, K.
Phytomedicine. 2018 Nov 05, [epub ahead of print]

A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome
Jing, R., Corbett, J. L., Cai, J., Beeson, G. C., Beeson, C. C., Chan, S. S., Dimmock, D. P., Lazcares, L., Geurts, A. M., Lemasters, J. J. and Duncan, S. A.
Cell Rep. 2018 Nov 6, 25(6):1469-1484 e5.

Urolithin A gains in antiproliferative capacity by reducing the glycolytic potential via the p53/TIGAR axis in colon cancer cells
Norden, E. and Heiss, E. H.
Carcinogenesis. 2019 Mar 12, 40(1):93-101.

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
Pollyea, D. A., Stevens, B. M., Jones, C. L., Winters, A., Pei, S., Minhajuddin, M., D'Alessandro, A., Culp-Hill, R., Riemondy, K. A., Gillen, A. E., Hesselberth, J. R., Abbott, D., Schatz, D., Gutman, J. A., Purev, E., Smith, C. and Jordan, C. T.
Nat Med. 2018 Dec 01, 24(12):1859-1866.

Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells
Wu, L., Liu, X., Cao, K. X., Ni, Z. H., Li, W. D. and Chen, Z. P.
J Cell Biochem. 2018 Oct 30, [epub ahead of print]

Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest
Yang, L., Wang, J., Deng, Y., Gong, C., Li, Q., Chen, Q., Li, H., Jiang, C., Zhou, R., Hai, K., Wu, W. and Li, T.
PLoS One. 2018 Nov 06, 13(11):e0207098.

Doxorubicin-induced cardiotoxicity involves IFNgamma-mediated metabolic reprogramming in cardiomyocytes
Ni, C., Ma, P., Wang, R., Lou, X., Liu, X., Qin, Y., Xue, R., Blasig, I., Erben, U. and Qin, Z.
J Pathol. 2019 Mar 01, 247(3):320-332.

Eudragit((R))-based microcapsules of probucol with a gut-bacterial processed secondary bile acid
Mooranian, A., Zamani, N., Mikov, M., Golocorbin-Kon, S., Stojanovic, G., Arfuso, F. and Al-Salami, H.
Ther Deliv. 2018 Nov 01, 9(11):811-821.

Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma
Fang, E., Wang, J., Hong, M., Zheng, L. and Tong, Q.
Biochem Biophys Res Commun. 2019 Jan 1, 508(1):9-16.

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
Tabe, Y., Saitoh, K., Yang, H., Sekihara, K., Yamatani, K., Ruvolo, V., Taka, H., Kaga, N., Kikkawa, M., Arai, H., Miida, T., Andreeff, M., Spagnuolo, P. A. and Konopleva, M.
Sci Rep. 2018 Nov 15, 8(1):16837.

Food & Nutritional Research

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease
Jeong, J. S., Piao, Y., Kang, S., Son, M., Kang, Y. C., Du, X. F., Ryu, J., Cho, Y. W., Jiang, H. H., Oh, M. S., Hong, S. P., Oh, Y. J. and Pak, Y. K.
Sci Rep. 2018 Oct 29, 8(1):15953.

Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility
Peng, S., Wang, Y., Zhou, Y., Ma, T., Wang, Y., Li, J., Huang, F., Kou, J., Qi, L., Liu, B. and Liu, K.
Phytomedicine. 2018 Nov 05, [epub ahead of print]

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
Aw, W. C., Towarnicki, S. G., Melvin, R. G., Youngson, N. A., Garvin, M. R., Hu, Y., Nielsen, S., Thomas, T., Pickford, R., Bustamante, S., Vila-Sanjurjo, A., Smyth, G. K. and Ballard, J. W. O.
PLoS Genet. 2018 Nov 06, 14(11):e1007735.

Rapid detection of microbial contamination in UHT milk: practical application in dairy industry 
Kračmarová, M., Stiborová, H., Horáčková, Š. and Demnerová, K.
Czech Journal of Food Sciences. 2018 Dec 01, 36(No. 5):357-364.

Protective effects of ghrelin on fasting-induced muscle atrophy in aging mice
Wu, C. S., Wei, Q., Wang, H., Kim, D. M., Balderas, M., Wu, G., Lawler, J., Safe, S., Guo, S., Devaraj, S., Chen, Z. and Sun, Y.
J Gerontol A Biol Sci Med Sci. 2018 Nov 8, [epub ahead of print]

Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism
Vanherwegen, A. S., Eelen, G., Ferreira, G. B., Ghesquiere, B., Cook, D. P., Nikolic, T., Roep, B., Carmeliet, P., Telang, S., Mathieu, C. and Gysemans, C.
J Steroid Biochem Mol Biol. 2019 Mar 01, 187(134-145.

Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes
Schnell, D. M., Walton, R. G., Vekaria, H. J., Sullivan, P. G., Bollinger, L. M., Peterson, C. A. and Thomas, D. T.
J Nutr Biochem. 2019 Mar 01, 65(83-92.

Hepatobiology Research

A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome
Jing, R., Corbett, J. L., Cai, J., Beeson, G. C., Beeson, C. C., Chan, S. S., Dimmock, D. P., Lazcares, L., Geurts, A. M., Lemasters, J. J. and Duncan, S. A.
Cell Rep. 2018 Nov 6, 25(6):1469-1484 e5.

Synergistic antitumor effects of rhein and doxorubicin in hepatocellular carcinoma cells
Wu, L., Liu, X., Cao, K. X., Ni, Z. H., Li, W. D. and Chen, Z. P.
J Cell Biochem. 2018 Oct 30, [epub ahead of print]

Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction
Jeong, J. H., Kim, D. K., Lee, N. S., Jeong, Y. G., Kim, H. W., Kim, J. S. and Han, S. Y.
ASN Neuro. 2018 Jan-Dec, 10:1759091418810583.

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish
Sokol, A. M., Uszczynska-Ratajczak, B., Collins, M. M., Bazala, M., Topf, U., Lundegaard, P. R., Sugunan, S., Guenther, S., Kuenne, C., Graumann, J., Chan, S. S. L., Stainier, D. Y. R. and Chacinska, A.
PLoS Genet. 2018 Nov, 14(11):e1007743.

Immunology Research

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism
Johnson, M. O., Wolf, M. M., Madden, M. Z., Andrejeva, G., Sugiura, A., Contreras, D. C., Maseda, D., Liberti, M. V., Paz, K., Kishton, R. J., Johnson, M. E., de Cubas, A. A., Wu, P., Li, G., Zhang, Y., Newcomb, D. C., Wells, A. D., Restifo, N. P., Rathmell, W. K., Locasale, J. W., Davila, M. L., Blazar, B. R. and Rathmell, J. C.
Cell. 2018 Dec 13, 175(7):1780-1795 e19.

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs
Fan, M. Y., Low, J. S., Tanimine, N., Finn, K. K., Priyadharshini, B., Germana, S. K., Kaech, S. M. and Turka, L. A.
Cell Rep. 2018 Oct 30, 25(5):1204-1213 e4.

The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Cronin, S. J. F., Seehus, C., Weidinger, A., Talbot, S., Reissig, S., Seifert, M., Pierson, Y., McNeill, E., Longhi, M. S., Turnes, B. L., Kreslavsky, T., Kogler, M., Hoffmann, D., Ticevic, M., da Luz Scheffer, D., Tortola, L., Cikes, D., Jais, A., Rangachari, M., Rao, S., Paolino, M., Novatchkova, M., Aichinger, M., Barrett, L., Latremoliere, A., Wirnsberger, G., Lametschwandtner, G., Busslinger, M., Zicha, S., Latini, A., Robson, S. C., Waisman, A., Andrews, N., Costigan, M., Channon, K. M., Weiss, G., Kozlov, A. V., Tebbe, M., Johnsson, K., Woolf, C. J. and Penninger, J. M.
Nature. 2018 Nov 01, 563(7732):564-568.

Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1
Hulse, M., Caruso, L. B., Madzo, J., Tan, Y., Johnson, S. and Tempera, I.
PLoS Pathog. 2018 Nov 05, 14(11):e1007394.

Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages
Bohn, T., Rapp, S., Luther, N., Klein, M., Bruehl, T. J., Kojima, N., Aranda Lopez, P., Hahlbrock, J., Muth, S., Endo, S., Pektor, S., Brand, A., Renner, K., Popp, V., Gerlach, K., Vogel, D., Lueckel, C., Arnold-Schild, D., Pouyssegur, J., Kreutz, M., Huber, M., Koenig, J., Weigmann, B., Probst, H. C., von Stebut, E., Becker, C., Schild, H., Schmitt, E. and Bopp, T.
Nat Immunol. 2018 Dec 01, 19(12):1319-1329.

Serum Amyloid A3 is required for normal lung development and survival following influenza infection
Ather, J. L., Dienz, O., Boyson, J. E., Anathy, V., Amiel, E. and Poynter, M. E.
Sci Rep. 2018 Nov 8, 8(1):16571.

Rare ginsenosides ameliorate lipid overload-induced myocardial insulin resistance via modulating metabolic flexibility
Peng, S., Wang, Y., Zhou, Y., Ma, T., Wang, Y., Li, J., Huang, F., Kou, J., Qi, L., Liu, B. and Liu, K.
Phytomedicine. 2018 Nov 05, [epub ahead of print]

Targeting SHIP-1 in Myeloid Cells Enhances Trained Immunity and Boosts Response to Infection
Saz-Leal, P., Del Fresno, C., Brandi, P., Martinez-Cano, S., Dungan, O. M., Chisholm, J. D., Kerr, W. G. and Sancho, D.
Cell Rep. 2018 Oct 30, 25(5):1118-1126.

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Michelet, X., Dyck, L., Hogan, A., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., O'Farrelly, C., Raverdeau, M., Vernon, A., Pettee, W., O'Shea, D., Nikolajczyk, B. S., Mills, K. H. G., Brenner, M. B., Finlay, D. and Lynch, L.
Nat Immunol. 2018 Dec 01, 19(12):1330-1340.

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation
Gotoh, K., Morisaki, T., Setoyama, D., Sasaki, K., Yagi, M., Igami, K., Mizuguchi, S., Uchiumi, T., Fukui, Y. and Kang, D.
Cell Rep. 2018 Nov 13, 25(7):1800-1815 e4.

The transcription factor c-Myb regulates CD8(+) T cell stemness and antitumor immunity
Gautam, S., Fioravanti, J., Zhu, W., Le Gall, J. B., Brohawn, P., Lacey, N. E., Hu, J., Hocker, J. D., Hawk, N. V., Kapoor, V., Telford, W. G., Gurusamy, D., Yu, Z., Bhandoola, A., Xue, H. H., Roychoudhuri, R., Higgs, B. W., Restifo, N. P., Bender, T. P., Ji, Y. and Gattinoni, L.
Nat Immunol. 2019 Mar 01, 20(3):337-349.

Doxorubicin-induced cardiotoxicity involves IFNgamma-mediated metabolic reprogramming in cardiomyocytes
Ni, C., Ma, P., Wang, R., Lou, X., Liu, X., Qin, Y., Xue, R., Blasig, I., Erben, U. and Qin, Z.
J Pathol. 2019 Mar 01, 247(3):320-332.

IL-15 improves skeletal muscle oxidative metabolism and glucose uptake in association with increased respiratory chain supercomplex formation and AMPK pathway activation
Nadeau, L., Patten, D. A., Caron, A., Garneau, L., Pinault-Masson, E., Foretz, M., Haddad, P., Anderson, B. G., Quinn, L. S., Jardine, K., McBurney, M. W., Pistilli, E. E., Harper, M. E. and Aguer, C.
Biochim Biophys Acta Gen Subj. 2019 Feb 01, 1863(2):395-407.

Metabolic regulation of T cell development by Sin1-mTORC2 is mediated by pyruvate kinase M2
Ouyang, X., Han, Y., Qu, G., Li, M., Wu, N., Liu, H., Arojo, O., Sun, H., Liu, X., Liu, D., Chen, L., Zou, Q. and Su, B.
J Mol Cell Biol. 2019 Feb 1, 11(2):93-106.

Cellular metabolism constrains innate immune responses in early human ontogeny
Kan, B., Michalski, C., Fu, H., Au, H. H. T., Lee, K., Marchant, E. A., Cheng, M. F., Anderson-Baucum, E., Aharoni-Simon, M., Tilley, P., Mirmira, R. G., Ross, C. J., Luciani, D. S., Jan, E. and Lavoie, P. M.
Nat Commun. 2018 Nov 16, 9(1):4822.

Substrate fluxes in brown adipocytes upon adrenergic stimulation and uncoupling protein 1 ablation
Schweizer, S., Oeckl, J., Klingenspor, M. and Fromme, T.
Life Sci Alliance. 2018 Nov 14, 1(6):e201800136.

The Length Distribution and Multiple Specificity of Naturally Presented HLA-I Ligands
Gfeller, D., Guillaume, P., Michaux, J., Pak, H. S., Daniel, R. T., Racle, J., Coukos, G. and Bassani-Sternberg, M.
J Immunol. 2018 Dec 15, 201(12):3705-3716.

Attenuation of PKCdelta enhances metabolic activity and promotes expansion of blood progenitors
Rao, T. N., Gupta, M. K., Softic, S., Wang, L. D., Jang, Y. C., Thomou, T., Bezy, O., Kulkarni, R. N., Kahn, C. R. and Wagers, A. J.
EMBO J. 2018 Dec 14, 37(24).

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
Tabe, Y., Saitoh, K., Yang, H., Sekihara, K., Yamatani, K., Ruvolo, V., Taka, H., Kaga, N., Kikkawa, M., Arai, H., Miida, T., Andreeff, M., Spagnuolo, P. A. and Konopleva, M.
Sci Rep. 2018 Nov 15, 8(1):16837.

PRKAA1/AMPKalpha1-driven glycolysis in endothelial cells exposed to disturbed flow protects against atherosclerosis
Yang, Q., Xu, J., Ma, Q., Liu, Z., Sudhahar, V., Cao, Y., Wang, L., Zeng, X., Zhou, Y., Zhang, M., Xu, Y., Wang, Y., Weintraub, N. L., Zhang, C., Fukai, T., Wu, C., Huang, L., Han, Z., Wang, T., Fulton, D. J., Hong, M. and Huo, Y.
Nat Commun. 2018 Nov 7, 9(1):4667.

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release
Morioka, S., Perry, J. S. A., Raymond, M. H., Medina, C. B., Zhu, Y., Zhao, L., Serbulea, V., Onengut-Gumuscu, S., Leitinger, N., Kucenas, S., Rathmell, J. C., Makowski, L. and Ravichandran, K. S.
Nature. 2018 Nov 01, 563(7733):714-718.

Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism
Vanherwegen, A. S., Eelen, G., Ferreira, G. B., Ghesquiere, B., Cook, D. P., Nikolic, T., Roep, B., Carmeliet, P., Telang, S., Mathieu, C. and Gysemans, C.
J Steroid Biochem Mol Biol. 2019 Mar 01, 187(134-145.

Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes
Schnell, D. M., Walton, R. G., Vekaria, H. J., Sullivan, P. G., Bollinger, L. M., Peterson, C. A. and Thomas, D. T.
J Nutr Biochem. 2019 Mar 01, 65(83-92.

The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination
Turpaev, K., Krizhanovskii, C., Wang, X., Sargsyan, E., Bergsten, P. and Welsh, N.
FASEB J. 2019 Mar 01, 33(3):3510-3522.

The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation
Zhang, W., Li, Q., Li, D., Li, J., Aki, D. and Liu, Y. C.
J Exp Med. 2018 Dec 3, 215(12):3180-3193.

Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response
Basit, F., Mathan, T., Sancho, D. and de Vries, I. J. M.
Front Immunol. 2018 Nov 01, 9:2489.

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia
Baardman, J., Verberk, S. G. S., Prange, K. H. M., van Weeghel, M., van der Velden, S., Ryan, D. G., Wust, R. C. I., Neele, A. E., Speijer, D., Denis, S. W., Witte, M. E., Houtkooper, R. H., O'Neill L, A., Knatko, E. V., Dinkova-Kostova, A. T., Lutgens, E., de Winther, M. P. J. and Van den Bossche, J.
Cell Rep. 2018 Nov 20, 25(8):2044-2052 e5.

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia
Sekar, P., Huang, D. Y., Hsieh, S. L., Chang, S. F. and Lin, W. W.
Cell Commun Signal. 2018 Nov 20, 16(1):83.

Infectious Disease Research

Serum Amyloid A3 is required for normal lung development and survival following influenza infection
Ather, J. L., Dienz, O., Boyson, J. E., Anathy, V., Amiel, E. and Poynter, M. E.
Sci Rep. 2018 Nov 8, 8(1):16571.

Cellular metabolism constrains innate immune responses in early human ontogeny
Kan, B., Michalski, C., Fu, H., Au, H. H. T., Lee, K., Marchant, E. A., Cheng, M. F., Anderson-Baucum, E., Aharoni-Simon, M., Tilley, P., Mirmira, R. G., Ross, C. J., Luciani, D. S., Jan, E. and Lavoie, P. M.
Nat Commun. 2018 Nov 16, 9(1):4822.

Microbial Research

Rapid detection of microbial contamination in UHT milk: practical application in dairy industry 
Kračmarová, M., Stiborová, H., Horáčková, Š. and Demnerová, K.
Czech Journal of Food Sciences. 2018 Dec 01, 36(No. 5):357-364.

Mitochondrial Disease Research

Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers
Seminotti, B., Leipnitz, G., Karunanidhi, A., Kochersperger, C., Roginskaya, V. Y., Basu, S., Wang, Y., Wipf, P., Van Houten, B., Mohsen, A. W. and Vockley, J.
Hum Mol Genet. 2018 Nov 16, [epub ahead of print]

Model Organisms

Repurposing of an old drug: In vitro and in vivo efficacies of buparvaquone against Echinococcus multilocularis
Rufener, R., Dick, L., D'Ascoli, L., Ritler, D., Hizem, A., Wells, T. N. C., Hemphill, A. and Lundstrom-Stadelmann, B.
Int J Parasitol Drugs Drug Resist. 2018 Dec 01, 8(3):440-450.

Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio)
Liang, X., Adamovsky, O., Souders, C. L., 2nd and Martyniuk, C. J.
Environ Pollut. 2019 Feb 01, 245(272-281.

Genotype to phenotype: Diet-by-mitochondrial DNA haplotype interactions drive metabolic flexibility and organismal fitness
Aw, W. C., Towarnicki, S. G., Melvin, R. G., Youngson, N. A., Garvin, M. R., Hu, Y., Nielsen, S., Thomas, T., Pickford, R., Bustamante, S., Vila-Sanjurjo, A., Smyth, G. K. and Ballard, J. W. O.
PLoS Genet. 2018 Nov 06, 14(11):e1007735.

Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish
Sokol, A. M., Uszczynska-Ratajczak, B., Collins, M. M., Bazala, M., Topf, U., Lundegaard, P. R., Sugunan, S., Guenther, S., Kuenne, C., Graumann, J., Chan, S. S. L., Stainier, D. Y. R. and Chacinska, A.
PLoS Genet. 2018 Nov, 14(11):e1007743.

Nephrology Research

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R
Okamoto, K., Rausch, J. W., Wakashin, H., Fu, Y., Chung, J. Y., Dummer, P. D., Shin, M. K., Chandra, P., Suzuki, K., Shrivastav, S., Rosenberg, A. Z., Hewitt, S. M., Ray, P. E., Noiri, E., Le Grice, S. F. J., Hoek, M., Han, Z., Winkler, C. A. and Kopp, J. B.
Commun Biol. 2018 Nov 07, 1:188.

Dissection of metabolic reprogramming in polycystic kidney disease reveals coordinated rewiring of bioenergetic pathways
Podrini, C., Rowe, I., Pagliarini, R., Costa, A. S. H., Chiaravalli, M., Di Meo, I., Kim, H., Distefano, G., Tiranti, V., Qian, F., di Bernardo, D., Frezza, C. and Boletta, A.
Commun Biol. 2018 Nov 16, 1:194.

Neurobiology Research

Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease
Jeong, J. S., Piao, Y., Kang, S., Son, M., Kang, Y. C., Du, X. F., Ryu, J., Cho, Y. W., Jiang, H. H., Oh, M. S., Hong, S. P., Oh, Y. J. and Pak, Y. K.
Sci Rep. 2018 Oct 29, 8(1):15953.

May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells
Borlongan, C. V., Nguyen, H., Lippert, T., Russo, E., Tuazon, J., Xu, K., Lee, J. Y., Sanberg, P. R., Kaneko, Y. and Napoli, E.
J Cereb Blood Flow Metab. 2019 Feb 01, 39(2):367-370.

Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation
Liu, B., Li, Y., Stackpole, E. E., Novak, A., Gao, Y., Zhao, Y., Zhao, X. and Richter, J. D.
Proc Natl Acad Sci U S A. 2018 Nov 27, 115(48):E11397-E11405.

Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury
Aubrecht, T. G., Faden, A. I., Sabirzhanov, B., Glaser, E. P., Roelofs, B. A., Polster, B. M., Makarevich, O. and Stoica, B. A.
Cell Death Dis. 2018 Nov 6, 9(11):1121.

Melatonin improves neurological outcomes and preserves hippocampal mitochondrial function in a rat model of cardiac arrest
Yang, L., Wang, J., Deng, Y., Gong, C., Li, Q., Chen, Q., Li, H., Jiang, C., Zhou, R., Hai, K., Wu, W. and Li, T.
PLoS One. 2018 Nov 06, 13(11):e0207098.

Novel mutations in the mitochondrial complex I assembly gene NDUFAF5 reveal heterogeneous phenotypes
Simon, M. T., Eftekharian, S. S., Stover, A. E., Osborne, A. F., Braffman, B. H., Chang, R. C., Wang, R. Y., Steenari, M. R., Tang, S., Hwu, P. W., Taft, R. J., Benke, P. J. and Abdenur, J. E.
Mol Genet Metab. 2019 Jan, 126(1):53-63.

Neuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction
Jeong, J. H., Kim, D. K., Lee, N. S., Jeong, Y. G., Kim, H. W., Kim, J. S. and Han, S. Y.
ASN Neuro. 2018 Jan-Dec, 10:1759091418810583.

Mutated SUCLG1 causes mislocalization of SUCLG2 protein, morphological alterations of mitochondria and an early-onset severe neurometabolic disorder
Chinopoulos, C., Batzios, S., van den Heuvel, L. P., Rodenburg, R., Smeets, R., Waterham, H. R., Turkenburg, M., Ruiter, J. P., Wanders, R. J. A., Doczi, J., Horvath, G., Dobolyi, A., Vargiami, E., Wevers, R. A. and Zafeiriou, D.
Mol Genet Metab. 2019 Jan 01, 126(1):43-52.

Valproic acid suppresses Warburg effect and tumor progression in neuroblastoma
Fang, E., Wang, J., Hong, M., Zheng, L. and Tong, Q.
Biochem Biophys Res Commun. 2019 Jan 1, 508(1):9-16.

Transient Overexpression of VEGF-A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System
Zhao, Y., Li, X., Yang, L., Eckel-Mahan, K., Tong, Q., Gu, X., Kolonin, M. G. and Sun, K.
Mol Cell Biol. 2018 Aug 20, [epub ahead of print]

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia
Sekar, P., Huang, D. Y., Hsieh, S. L., Chang, S. F. and Lin, W. W.
Cell Commun Signal. 2018 Nov 20, 16(1):83.

Modulation of mitochondrial respiration underpins neuronal differentiation enhanced by lutein
Xie, K., Ngo, S., Rong, J. and Sheppard, A.
Neural Regen Res. 2019 Jan, 14(1):87-99.

PPARbeta/delta-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1DeltaE9 astrocytes
Konttinen, H., Gureviciene, I., Oksanen, M., Grubman, A., Loppi, S., Huuskonen, M. T., Korhonen, P., Lampinen, R., Keuters, M., Belaya, I., Tanila, H., Kanninen, K. M., Goldsteins, G., Landreth, G., Koistinaho, J. and Malm, T.
Glia. 2019 Jan 01, 67(1):146-159.

p66Shc activation promotes increased oxidative phosphorylation and renders CNS cells more vulnerable to amyloid beta toxicity
Lone, A., Harris, R. A., Singh, O., Betts, D. H. and Cumming, R. C.
Sci Rep. 2018 Nov 20, 8(1):17081.

Obesity, Diabetes & Metabolic Diseases

Mitochondrial glycerol 3-phosphate dehydrogenase promotes skeletal muscle regeneration
Liu, X., Qu, H., Zheng, Y., Liao, Q., Zhang, L., Liao, X., Xiong, X., Wang, Y., Zhang, R., Wang, H., Tong, Q., Liu, Z., Dong, H., Yang, G., Zhu, Z., Xu, J. and Zheng, H.
EMBO Mol Med. 2018 Dec 01, 10(12).

Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity
Loffler, M. C., Mayer, A. E., Trujillo Viera, J., Loza Valdes, A., El-Merahbi, R., Ade, C. P., Karwen, T., Schmitz, W., Slotta, A., Erk, M., Janaki-Raman, S., Matesanz, N., Torres, J. L., Marcos, M., Sabio, G., Eilers, M., Schulze, A. and Sumara, G.
EMBO J. 2018 Nov 15, 37(22).

Adipocytes fuel gastric cancer omental metastasis via PITPNC1-mediated fatty acid metabolic reprogramming
Tan, Y., Lin, K., Zhao, Y., Wu, Q., Chen, D., Wang, J., Liang, Y., Li, J., Hu, J., Wang, H., Liu, Y., Zhang, S., He, W., Huang, Q., Hu, X., Yao, Z., Liang, B., Liao, W. and Shi, M.
Theranostics. 2018 Oct 29, 8(19):5452-5468.

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
Michelet, X., Dyck, L., Hogan, A., Loftus, R. M., Duquette, D., Wei, K., Beyaz, S., Tavakkoli, A., Foley, C., Donnelly, R., O'Farrelly, C., Raverdeau, M., Vernon, A., Pettee, W., O'Shea, D., Nikolajczyk, B. S., Mills, K. H. G., Brenner, M. B., Finlay, D. and Lynch, L.
Nat Immunol. 2018 Dec 01, 19(12):1330-1340.

Conditioned media from contracting skeletal muscle potentiates insulin secretion and enhances mitochondrial energy metabolism of pancreatic beta-cells
Barlow, J. and Solomon, T. P. J.
Metabolism. 2019 Feb 01, 91:1-9.

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation
Li, Y., Schnabl, K., Gabler, S. M., Willershauser, M., Reber, J., Karlas, A., Laurila, S., Lahesmaa, M., M, U. D., Bast-Habersbrunner, A., Virtanen, K. A., Fromme, T., Bolze, F., O'Farrell, L. S., Alsina-Fernandez, J., Coskun, T., Ntziachristos, V., Nuutila, P. and Klingenspor, M.
Cell. 2018 Nov 29, 175(6):1561-1574 e12.

Carbon monoxide-induced metabolic switch in adipocytes improves insulin resistance in obese mice
Braud, L., Pini, M., Muchova, L., Manin, S., Kitagishi, H., Sawaki, D., Czibik, G., Ternacle, J., Derumeaux, G., Foresti, R. and Motterlini, R.
JCI Insight. 2018 Nov 15, 3(22).

Inhibition of FAO in AML co-cultured with BM adipocytes: mechanisms of survival and chemosensitization to cytarabine
Tabe, Y., Saitoh, K., Yang, H., Sekihara, K., Yamatani, K., Ruvolo, V., Taka, H., Kaga, N., Kikkawa, M., Arai, H., Miida, T., Andreeff, M., Spagnuolo, P. A. and Konopleva, M.
Sci Rep. 2018 Nov 15, 8(1):16837.

Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway
Zhang, H., Zhu, L., Bai, M., Liu, Y., Zhan, Y., Deng, T., Yang, H., Sun, W., Wang, X., Zhu, K., Fan, Q., Li, J., Ying, G. and Ba, Y. Int J Cancer. 2018 Nov 9, [epub ahead of print]

Transient Overexpression of VEGF-A in Adipose Tissue Promotes Energy Expenditure via Activation of the Sympathetic Nervous System
Zhao, Y., Li, X., Yang, L., Eckel-Mahan, K., Tong, Q., Gu, X., Kolonin, M. G. and Sun, K.
Mol Cell Biol. 2018 Aug 20, [epub ahead of print]

The protein synthesis inhibitor brusatol normalizes high-fat diet-induced glucose intolerance in male C57BL/6 mice: role of translation factor eIF5A hypusination
Turpaev, K., Krizhanovskii, C., Wang, X., Sargsyan, E., Bergsten, P. and Welsh, N.
FASEB J. 2019 Mar 01, 33(3):3510-3522.

Embryonic cell migratory capacity is impaired upon exposure to glucose in vivo and in vitro
Herion, N. J., Kruger, C., Staszkiewicz, J., Kappen, C. and Salbaum, J. M.
Birth Defects Res. 2018 Nov 19, [epub ahead of print]

Oxygen transporter for the hypoxic transplantation site
Komatsu, H., Cook, C. A., Gonzalez, N., Medrano, L., Salgado, M., Sui, F., Li, J., Kandeel, F., Mullen, Y. and Tai, Y. C.
Biofabrication. 2018 Dec 7, 11(1):015011.

Review Paper

Metabolic reprogramming of mitochondrial respiration in metastatic cancer
Herst, P. M., Grasso, C. and Berridge, M. V.
Cancer Metastasis Rev. 2018 Dec 01, 37(4):643-653.

Stem Cell Biology

Human tissue-specific MSCs demonstrate differential mitochondria transfer abilities that may determine their regenerative abilities
Paliwal, S., Chaudhuri, R., Agrawal, A. and Mohanty, S.
Stem Cell Res Ther. 2018 Nov 8, 9(1):298.

Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio)
Liang, X., Adamovsky, O., Souders, C. L., 2nd and Martyniuk, C. J.
Environ Pollut. 2019 Feb 01, 245(272-281.

May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells
Borlongan, C. V., Nguyen, H., Lippert, T., Russo, E., Tuazon, J., Xu, K., Lee, J. Y., Sanberg, P. R., Kaneko, Y. and Napoli, E.
J Cereb Blood Flow Metab. 2019 Feb 01, 39(2):367-370.

Regulatory discrimination of mRNAs by FMRP controls mouse adult neural stem cell differentiation
Liu, B., Li, Y., Stackpole, E. E., Novak, A., Gao, Y., Zhao, Y., Zhao, X. and Richter, J. D.
Proc Natl Acad Sci U S A. 2018 Nov 27, 115(48):E11397-E11405.

Mutant p53-dependent mitochondrial metabolic alterations in a mesenchymal stem cell-based model of progressive malignancy
Lonetto, G., Koifman, G., Silberman, A., Attery, A., Solomon, H., Levin-Zaidman, S., Goldfinger, N., Porat, Z., Erez, A. and Rotter, V.
Cell Death Differ. 2018 Nov 9, [epub ahead of print]

A Screen Using iPSC-Derived Hepatocytes Reveals NAD(+) as a Potential Treatment for mtDNA Depletion Syndrome
Jing, R., Corbett, J. L., Cai, J., Beeson, G. C., Beeson, C. C., Chan, S. S., Dimmock, D. P., Lazcares, L., Geurts, A. M., Lemasters, J. J. and Duncan, S. A.
Cell Rep. 2018 Nov 6, 25(6):1469-1484 e5.

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia
Pollyea, D. A., Stevens, B. M., Jones, C. L., Winters, A., Pei, S., Minhajuddin, M., D'Alessandro, A., Culp-Hill, R., Riemondy, K. A., Gillen, A. E., Hesselberth, J. R., Abbott, D., Schatz, D., Gutman, J. A., Purev, E., Smith, C. and Jordan, C. T.
Nat Med. 2018 Dec 01, 24(12):1859-1866.

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
Jones, C. L., Stevens, B. M., D'Alessandro, A., Reisz, J. A., Culp-Hill, R., Nemkov, T., Pei, S., Khan, N., Adane, B., Ye, H., Krug, A., Reinhold, D., Smith, C., DeGregori, J., Pollyea, D. A. and Jordan, C. T.
Cancer Cell. 2018 Nov 12, 34(5):724-740 e4.

Thrombopoietin Metabolically Primes Hematopoietic Stem Cells to Megakaryocyte-Lineage Differentiation
Nakamura-Ishizu, A., Matsumura, T., Stumpf, P. S., Umemoto, T., Takizawa, H., Takihara, Y., O'Neil, A., Majeed, A., MacArthur, B. D. and Suda, T.
Cell Rep. 2018 Nov 13, 25(7):1772-1785 e6.

Attenuation of PKCdelta enhances metabolic activity and promotes expansion of blood progenitors
Rao, T. N., Gupta, M. K., Softic, S., Wang, L. D., Jang, Y. C., Thomou, T., Bezy, O., Kulkarni, R. N., Kahn, C. R. and Wagers, A. J.
EMBO J. 2018 Dec 14, 37(24).

PPARbeta/delta-agonist GW0742 ameliorates dysfunction in fatty acid oxidation in PSEN1DeltaE9 astrocytes
Konttinen, H., Gureviciene, I., Oksanen, M., Grubman, A., Loppi, S., Huuskonen, M. T., Korhonen, P., Lampinen, R., Keuters, M., Belaya, I., Tanila, H., Kanninen, K. M., Goldsteins, G., Landreth, G., Koistinaho, J. and Malm, T.
Glia. 2019 Jan 01, 67(1):146-159.

Embryonic cell migratory capacity is impaired upon exposure to glucose in vivo and in vitro
Herion, N. J., Kruger, C., Staszkiewicz, J., Kappen, C. and Salbaum, J. M.
Birth Defects Res. 2018 Nov 19, [epub ahead of print]

MYC Induces a Hybrid Energetics Program Early in Cell Reprogramming
Prieto, J., Seo, A. Y., Leon, M., Santacatterina, F., Torresano, L., Palomino-Schatzlein, M., Gimenez, K., Vallet-Sanchez, A., Ponsoda, X., Pineda-Lucena, A., Cuezva, J. M., Lippincott-Schwartz, J. and Torres, J.
Stem Cell Reports. 2018 Dec 11, 11(6):1479-1492.

BICD1 mediates HIF1alpha nuclear translocation in mesenchymal stem cells during hypoxia adaptation
Lee, H. J., Jung, Y. H., Oh, J. Y., Choi, G. E., Chae, C. W., Kim, J. S., Lim, J. R., Kim, S. Y., Lee, S. J., Seong, J. K. and Han, H. J.
Cell Death Differ. 2018 Nov 21, [epub ahead of print]

Techniques & Methods

Evaluating the Metabolic Alterations in Pancreatic Cancer
Dasgupta, A.
Method in Molec Biol. 2018 Oct 31, 1882.

Rapid detection of microbial contamination in UHT milk: practical application in dairy industry 
Kračmarová, M., Stiborová, H., Horáčková, Š. and Demnerová, K.
Czech Journal of Food Sciences. 2018 Dec 01, 36(No. 5):357-364.

Eudragit((R))-based microcapsules of probucol with a gut-bacterial processed secondary bile acid
Mooranian, A., Zamani, N., Mikov, M., Golocorbin-Kon, S., Stojanovic, G., Arfuso, F. and Al-Salami, H.
Ther Deliv. 2018 Nov 01, 9(11):811-821.

Oxygen transporter for the hypoxic transplantation site
Komatsu, H., Cook, C. A., Gonzalez, N., Medrano, L., Salgado, M., Sui, F., Li, J., Kandeel, F., Mullen, Y. and Tai, Y. C.
Biofabrication. 2018 Dec 7, 11(1):015011.

Toxicology Research

Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro
Qi, Z., Song, Y., Ding, Q., Liao, X., Li, R., Liu, G., Tsang, S. and Cai, Z.
Ecotoxicol Environ Saf. 2019 Jan 30, 168(378-387.

Biological effects of the benzotriazole ultraviolet stabilizers UV-234 and UV-320 in early-staged zebrafish (Danio rerio)
Liang, X., Adamovsky, O., Souders, C. L., 2nd and Martyniuk, C. J.
Environ Pollut. 2019 Feb 01, 245(272-281.

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R
Okamoto, K., Rausch, J. W., Wakashin, H., Fu, Y., Chung, J. Y., Dummer, P. D., Shin, M. K., Chandra, P., Suzuki, K., Shrivastav, S., Rosenberg, A. Z., Hewitt, S. M., Ray, P. E., Noiri, E., Le Grice, S. F. J., Hoek, M., Han, Z., Winkler, C. A. and Kopp, J. B.
Commun Biol. 2018 Nov 07, 1:188.

Doxorubicin-induced cardiotoxicity involves IFNgamma-mediated metabolic reprogramming in cardiomyocytes
Ni, C., Ma, P., Wang, R., Lou, X., Liu, X., Qin, Y., Xue, R., Blasig, I., Erben, U. and Qin, Z.
J Pathol. 2019 Mar 01, 247(3):320-332.

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