XF出版物快报 2019年1月

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Aging Research

Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10
Schniertshauer, D., Gebhard, D. and Bergemann, J.
J Aging Res. 2018 Sep 05, 2018:6354680.

Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity
Lim, Y. P., Go, M. K., Raida, M., Inoue, T., Wenk, M. R., Keasling, J. D., Chang, M. W. and Yew, W. S.
ACS Omega. 2018 Sep 30, 3 (9):11050-11061.

Quantitative Proteomic Analysis Reveals Caffeine-Perturbed Proteomic Profiles in Normal Bladder Epithelial Cells
Shahid, M., Kim, M., Yeon, A., Andres, A. M., You, S. and Kim, J.
Proteomics. 2018 Oct 01, 18 (20):e1800190.

Cancer Research

Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis
Curtis, M., Kenny, H. A., Ashcroft, B., Mukherjee, A., Johnson, A., Zhang, Y., Helou, Y., Batlle, R., Liu, X., Gutierrez, N., Gao, X., Yamada, S. D., Lastra, R., Montag, A., Ahsan, N., Locasale, J. W., Salomon, A. R., Nebreda, A. R. and Lengyel, E. Cell
Metab. 2018 Aug 28, [epub ahead of print]

Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer
Ma, W., Zhao, X., Wang, K., Liu, J. and Huang, G.
Cancer Biol Ther. 2018 Aug 01, [epub ahead of print]

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/beta1-integrin pathway
Urra, F. A., Munoz, F., Cordova-Delgado, M., Ramirez, M. P., Pena-Ahumada, B., Rios, M., Cruz, P., Ahumada-Castro, U., Bustos, G., Silva-Pavez, E., Pulgar, R., Morales, D., Varela, D., Millas-Vargas, J. P., Retamal, E., Ramirez-Rodriguez, O., Pessoa-Mahana, H., Pavani, M., Ferreira, J., Cardenas, C. and Araya-Maturana, R.
Sci Rep. 2018 Sep 4, 8 (1):13190.

Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells
Szwarc, M. M., Kommagani, R., Putluri, V., Dubrulle, J., Stossi, F., Mancini, M. A., Coarfa, C., Lanz, R. B., Putluri, N., DeMayo, F. J., Lydon, J. P. and O'Malley, B. W.
Sci Rep. 2018 Sep 3, 8 (1):13134.

Modulation of cellular bioenergetics by CO-releasing molecules and NO-donors inhibits the interaction of cancer cells with human lung microvascular endothelial cells
Stojak, M., Kaczara, P., Motterlini, R. and Chlopicki, S.
Pharmacol Res. 2018 Oct 10, 136:160-171.

A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer associated with clinical outcome
Stylianou, N., Lehman, M. L., Wang, C., Fard, A. T., Rockstroh, A., Fazli, L., Jovanovic, L., Ward, M., Sadowski, M. C., Kashyap, A. S., Buttyan, R., Gleave, M. E., Westbrook, T. F., Williams, E. D., Gunter, J. H., Nelson, C. C. and Hollier, B. G.
Oncogene. 2018 Sep 7, [epub ahead if print]

Mitochondrial dynamic alterations regulate melanoma cell progression
Dal Yontem, F., Kim, S. H., Ding, Z., Grimm, E., Ekmekcioglu, S. and Akcakaya, H.
J Cell Biochem. 2018 Sep 6, [epub ahead of print]

Double genetic disruption of lactate dehydrogenases A and B is required to ablate the "Warburg effect" restricting tumor growth to oxidative metabolism
Zdralevic, M., Brand, A., Di Ianni, L., Dettmer, K., Reinders, J., Singer, K., Peter, K., Schnell, A., Bruss, C., Decking, S. M., Koehl, G., Felipe-Abrio, B., Durivault, J., Bayer, P., Evangelista, M., O'Brien, T., Oefner, P. J., Renner, K., Pouyssegur, J. and Kreutz, M.
J Biol Chem. 2018 Oct 12, 293 (41):15947-15961.

Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation
Yang, P., Ding, G. B., Liu, W., Fu, R., Sajid, A. and Li, Z.
Food Funct. 2018 Nov 14, 9 (11):5547-5559.

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation
Johnson, T. I., Costa, A. S. H., Ferguson, A. N. and Frezza, C.
Cell Death Dis. 2018 Sep 6, 9 (9):913.

LncRNA CamK-A Regulates Ca(2+)-Signaling-Mediated Tumor Microenvironment Remodeling
Sang, L. J., Ju, H. Q., Liu, G. P., Tian, T., Ma, G. L., Lu, Y. X., Liu, Z. X., Pan, R. L., Li, R. H., Piao, H. L., Marks, J. R., Yang, L. J., Yan, Q., Wang, W., Shao, J., Zhou, Y., Zhou, T. and Lin, A.
Mol Cell. 2018 Oct 4, 72 (1):71-83 e7.

Inhibition of pyruvate dehydrogenase kinase 1 enhances the anti-cancer effect of EGFR tyrosine kinase inhibitors in non-small cell lung cancer
Yang, Z., Zhang, S. L., Hu, X. and Tam, K. Y.
Eur J Pharmacol. 2018 Nov 5, 838:41-52.

Targeting SLC25A10 alleviates improved antioxidant capacity and associated radioresistance of cancer cells induced by chronic-cycling hypoxia
Hlouschek, J., Ritter, V., Wirsdorfer, F., Klein, D., Jendrossek, V. and Matschke, J.
Cancer Lett. 2018 Dec 28, 439:24-38.

PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers
Gentric, G., Kieffer, Y., Mieulet, V., Goundiam, O., Bonneau, C., Nemati, F., Hurbain, I., Raposo, G., Popova, T., Stern, M. H., Lallemand-Breitenbach, V., Muller, S., Caneque, T., Rodriguez, R., Vincent-Salomon, A., de The, H., Rossignol, R. and Mechta-Grigoriou, F.
Cell Metab. 2019 Jan 8, 29 (1):156-173 e10.

2-deoxy-D-glucose augments photodynamic therapy induced mitochondrial caspase-independent apoptosis and energy-mediated autophagy
Feng, X., Shi, Y., Xie, L., Zhang, K., Wang, X., Liu, Q. and Wang, P.
Lasers Surg Med. 2018 Sep 17, [epub ahead of print]

Endothelial pyruvate kinase M2 maintains vascular integrity
Kim, B., Jang, C., Dharaneeswaran, H., Li, J., Bhide, M., Yang, S., Li, K. and Arany, Z.
J Clin Invest. 2018 Oct 1, 128 (10):4543-4556.

Tuberous sclerosis complex is required for tumor maintenance in MYC-driven Burkitt's lymphoma
Hartleben, G., Muller, C., Kramer, A., Schimmel, H., Zidek, L. M., Dornblut, C., Winkler, R., Eichwald, S., Kortman, G., Kosan, C., Kluiver, J., Petersen, I., van den Berg, A., Wang, Z. Q. and Calkhoven, C. F.
EMBO J. 2018 Nov 2, 37 (21).

Identification of DK419, a potent inhibitor of Wnt/beta-catenin signaling and colorectal cancer growth
Wang, J., Mook, R. A., Jr., Ren, X. R., Zhang, Q., Jing, G., Lu, M., Spasojevic, I., Lyerly, H. K., Hsu, D. and Chen, W.
Bioorg Med Chem. 2018 Nov 1, 26 (20):5435-5442.

Mitochondrial uncoupling reveals a novel therapeutic opportunity for p53-defective cancers
Kumar, R., Coronel, L., Somalanka, B., Raju, A., Aning, O. A., An, O., Ho, Y. S., Chen, S., Mak, S. Y., Hor, P. Y., Yang, H., Lakshmanan, M., Itoh, H., Tan, S. Y., Lim, Y. K., Wong, A. P. C., Chew, S. H., Huynh, T. H., Goh, B. C., Lim, C. Y., Tergaonkar, V. and Cheok, C. F.
Nat Commun. 2018 Sep 26, 9 (1):3931

Yes-associated protein (YAP) binds to HIF-1alpha and sustains HIF-1alpha protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
Zhang, X., Li, Y., Ma, Y., Yang, L., Wang, T., Meng, X., Zong, Z., Sun, X., Hua, X. and Li, H.
J Exp Clin Cancer Res. 2018 Sep 4, 37 (1):216.

Photodamaging of Mitochondrial DNA to Overcome Cisplatin Resistance by a Ru(II) -Pt(II) Bimetallic Complex
Zheng, Y., Zhang, D. Y., Zhang, H., Cao, J. J., Tan, C. P., Ji, L. N. and Mao, Z. W.
Chemistry. 2018 Dec 17, 24 (71):18971-18980.

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer
Zhong, X. Y., Yuan, X. M., Xu, Y. Y., Yin, M., Yan, W. W., Zou, S. W., Wei, L. M., Lu, H. J., Wang, Y. P. and Lei, Q. Y.
Cell Rep. 2018 Sep 18, 24 (12):3207-3223.

A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini, P., Serviss, J. T., Lundback, T., Bancaro, N., Mazurkiewicz, M., Kolosenko, I., Yu, D., Haraldsson, M., D'Arcy, P., Linder, S. and De Milito, A.
Cancer Cell Int. 2018 Sep 25, 18:147.

Platelet-mimicking nanoparticles co-loaded with W18O49 and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy
Zuo, H., Tao, J., Shi, H., He, J., Zhou, Z. and Zhang, C.
Acta Biomater. 2018 Oct 15, 80:296-307.

Cardiovascular Research

Atorvastatin, but not pravastatin, inhibits cardiac Akt/mTOR signaling and disturbs mitochondrial ultrastructure in cardiac myocytes
Godoy, J. C., Niesman, I. R., Busija, A. R., Kassan, A., Schilling, J. M., Schwarz, A., Alvarez, E. A., Dalton, N. D., Drummond, J. C., Roth, D. M., Kararigas, G., Patel, H. H. and Zemljic-Harpf, A. E.
FASEB J. 2019 Jan 01, 33 (1):1209-1225.

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis
Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., Chen, R., Huang, H., Vandekeere, S., Kalucka, J., Lange, C., Morales-Rodriguez, F., Cruys, B., Treps, L., Ramer, L., Vinckier, S., Brepoels, K., Wyns, S., Souffreau, J., Schoonjans, L., Lamers, W. H., Wu, Y., Haustraete, J., Hofkens, J., Liekens, S., Cubbon, R., Ghesquiere, B., Dewerchin, M., Gervasio, F. L., Li, X., van Buul, J. D., Wu, X. and Carmeliet, P.
Nature. 2018 Sep 01, 561 (7721):63-69.

G protein-coupled receptor kinase 2 contributes to impaired fatty acid metabolism in the failing heart
Pfleger, J., Gross, P., Johnson, J., Carter, R. L., Gao, E., Tilley, D. G., Houser, S. R. and Koch, W. J.
J Mol Cell Cardiol. 2018 Oct 01, 123:108-117.

Modulation of cellular bioenergetics by CO-releasing molecules and NO-donors inhibits the interaction of cancer cells with human lung microvascular endothelial cells
Stojak, M., Kaczara, P., Motterlini, R. and Chlopicki, S.
Pharmacol Res. 2018 Oct 10, 136:160-171.

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes
Cheung, J. Y., Gordon, J., Wang, J., Song, J., Zhang, X. Q., Prado, F. J., Shanmughapriya, S., Rajan, S., Tomar, D., Tahrir, F. G., Gupta, M. K., Knezevic, T., Merabova, N., Kontos, C. D., McClung, J. M., Klotman, P. E., Madesh, M., Khalili, K. and Feldman, A. M.
J Cell Physiol. 2019 Apr 01, 234 (4):4432-4444.

Endothelial pyruvate kinase M2 maintains vascular integrity
Kim, B., Jang, C., Dharaneeswaran, H., Li, J., Bhide, M., Yang, S., Li, K. and Arany, Z.
J Clin Invest. 2018 Oct 1, 128 (10):4543-4556.

An alternative renin isoform is cardioprotective by modulating mitochondrial metabolism
Wanka, H., Lutze, P., Staar, D., Grunow, B., Peters, B. S. and Peters, J.
J Cell Mol Med. 2018 Dec 01, 22 (12):5991-6001.

Cell Physiology Research

Role of glutamine synthetase in angiogenesis beyond glutamine synthesis
Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., Chen, R., Huang, H., Vandekeere, S., Kalucka, J., Lange, C., Morales-Rodriguez, F., Cruys, B., Treps, L., Ramer, L., Vinckier, S., Brepoels, K., Wyns, S., Souffreau, J., Schoonjans, L., Lamers, W. H., Wu, Y., Haustraete, J., Hofkens, J., Liekens, S., Cubbon, R., Ghesquiere, B., Dewerchin, M., Gervasio, F. L., Li, X., van Buul, J. D., Wu, X. and Carmeliet, P.
Nature. 2018 Sep 01, 561 (7721):63-69.

Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan
Saha, M., Reddy, H. M., Salih, M. A., Estrella, E., Jones, M. D., Mitsuhashi, S., Cho, K. A., Suzuki-Hatano, S., Rizzo, S. A., Hamad, M. H., Mukhtar, M. M., Hamed, A. A., Elseed, M. A., Lek, M., Valkanas, E., MacArthur, D. G., Kunkel, L. M., Pacak, C. A., Draper, I. and Kang, P. B.
Physiol Genomics. 2018 Nov 1, 50 (11):929-939.

RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1alpha signaling in nucleus pulposus cells
Pan, H., Strickland, A., Madhu, V., Johnson, Z. I., Chand, S. N., Brody, J. R., Fertala, A., Zheng, Z., Shapiro, I. M. and Risbud, M. V.
Matrix Biol. 2018 Aug 7, [epub ahead of print]

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
Seibler, P., Burbulla, L. F., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Munchau, A., Krainc, D. and Klein, C.
Brain. 2018 Oct 1, 141 (10):3052-3064.

Mitochondrial dynamic alterations regulate melanoma cell progression
Dal Yontem, F., Kim, S. H., Ding, Z., Grimm, E., Ekmekcioglu, S. and Akcakaya, H.
J Cell Biochem. 2018 Sep 6, [epub ahead of print]

Impairment of Fatty Acid Oxidation in Alveolar Epithelial Cells Mediates Acute Lung Injury
Cui, H., Xie, N., Banerjee, S., Ge, J., Guo, S. and Liu, G.
Am J Respir Cell Mol Biol. 2018 Sep 5, [epub ahead of print]

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
Sullivan, W. J., Mullen, P. J., Schmid, E. W., Flores, A., Momcilovic, M., Sharpley, M. S., Jelinek, D., Whiteley, A. E., Maxwell, M. B., Wilde, B. R., Banerjee, U., Coller, H. A., Shackelford, D. B., Braas, D., Ayer, D. E., de Aguiar Vallim, T. Q., Lowry, W. E. and Christofk, H. R.
Cell. 2018 Sep 20, 175 (1):117-132 e21.

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis
Yang, J. S., Hsu, J. W., Park, S. Y., Li, J., Oldham, W. M., Beznoussenko, G. V., Mironov, A. A., Loscalzo, J. and Hsu, V. W.
Nature. 2018 Sep 01, 561 (7722):263-267.

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Yakulov, T. A., Todkar, A. P., Slanchev, K., Wiegel, J., Bona, A., Gross, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T. B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A. and Walz, G.
Nat Commun. 2018 Sep 10, 9 (1):3660.

Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice
Liu, Z., Solesio, M. E., Schaffler, M. B., Frikha-Benayed, D., Rosen, C. J., Werner, H., Kopchick, J. J., Pavlov, E. V., Abramov, A. Y. and Yakar, S.
J Bone Miner Res. 2018 Sep 14, [epub ahead of print]

Sarcolipin Signaling Promotes Mitochondrial Biogenesis and Oxidative Metabolism in Skeletal Muscle
Maurya, S. K., Herrera, J. L., Sahoo, S. K., Reis, F. C. G., Vega, R. B., Kelly, D. P. and Periasamy, M.
Cell Rep. 2018 Sep 11, 24 (11):2919-2931.

Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity
Manczak, M., Kandimalla, R., Yin, X. and Reddy, P. H.
Hum Mol Genet. 2019 Jan 15, 28 (2):177-199.

Alpha-enolase regulates the malignant phenotype of pulmonary artery smooth muscle cells via the AMPK-Akt pathway
Dai, J., Zhou, Q., Chen, J., Rexius-Hall, M. L., Rehman, J. and Zhou, G.
Nat Commun. 2018 Sep 21, 9 (1):3850.

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations
Akbergenov, R., Duscha, S., Fritz, A. K., Juskeviciene, R., Oishi, N., Schmitt, K., Shcherbakov, D., Teo, Y., Boukari, H., Freihofer, P., Isnard-Petit, P., Oettinghaus, B., Frank, S., Thiam, K., Rehrauer, H., Westhof, E., Schacht, J., Eckert, A., Wolfer, D. and Bottger, E. C.
EMBO Rep. 2018 Nov 01, 19 (11).

Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics
Bao, F., Shi, H., Gao, M., Yang, L., Zhou, L., Zhao, Q., Wu, Y., Chen, K., Xiang, G., Long, Q., Guo, J., Zhang, J. and Liu, X.
Cell Death Dis. 2018 Sep 20, 9 (10):966.

Genome-wide screening of NEAT1 regulators reveals cross-regulation between paraspeckles and mitochondria
Wang, Y., Hu, S. B., Wang, M. R., Yao, R. W., Wu, D., Yang, L. and Chen, L. L.
Nat Cell Biol. 2018 Oct 01, 20 (10):1145-1158.

The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis
Gonzalez-Mariscal, I., Martin-Montalvo, A., Vazquez-Fonseca, L., Pomares-Viciana, T., Sanchez-Cuesta, A., Fernandez-Ayala, D. J., Navas, P. and Santos-Ocana, C.
Biochim Biophys Acta Bioenerg. 2018 Nov 01, 1859 (11):1235-1248.

Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4
Zhang, Y., Shan, P., Srivastava, A., Li, Z. and Lee, P. J.
Antioxid Redox Signal. 2018 Oct 25, [epub ahead of print]

Drug Discovery

Dichloroacetic acid (DCA) synergizes with the SIRT2 inhibitor Sirtinol and AGK2 to enhance anti-tumor efficacy in non-small cell lung cancer
Ma, W., Zhao, X., Wang, K., Liu, J. and Huang, G.
Cancer Biol Ther. 2018 Aug 01, [epub ahead of print]

Synthesis and antiproliferative activities of novel quartenary ammonium spinosyn derivatives
Ma, D. Y., Wang, L. L., Lai, Q., Peng, K. J., Li, X., Li, Z. X., Liu, L. J., Luo, Z. Y. and Liu, S. Y.
Bioorg Med Chem Lett. 2018 Nov 1, 28 (20):3346-3349.

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/beta1-integrin pathway
Urra, F. A., Munoz, F., Cordova-Delgado, M., Ramirez, M. P., Pena-Ahumada, B., Rios, M., Cruz, P., Ahumada-Castro, U., Bustos, G., Silva-Pavez, E., Pulgar, R., Morales, D., Varela, D., Millas-Vargas, J. P., Retamal, E., Ramirez-Rodriguez, O., Pessoa-Mahana, H., Pavani, M., Ferreira, J., Cardenas, C. and Araya-Maturana, R.
Sci Rep. 2018 Sep 4, 8 (1):13190.

Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity
Lim, Y. P., Go, M. K., Raida, M., Inoue, T., Wenk, M. R., Keasling, J. D., Chang, M. W. and Yew, W. S.
ACS Omega. 2018 Sep 30, 3 (9):11050-11061.

GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation
Drareni, K., Ballaire, R., Barilla, S., Mathew, M. J., Toubal, A., Fan, R., Liang, N., Chollet, C., Huang, Z., Kondili, M., Foufelle, F., Soprani, A., Roussel, R., Gautier, J. F., Alzaid, F., Treuter, E. and Venteclef, N.
Cell Rep. 2018 Sep 11, 24 (11):2957-2971 e6.

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity
Ikegami, R., Shimizu, I., Sato, T., Yoshida, Y., Hayashi, Y., Suda, M., Katsuumi, G., Li, J., Wakasugi, T., Minokoshi, Y., Okamoto, S., Hinoi, E., Nielsen, S., Jespersen, N. Z., Scheele, C., Soga, T. and Minamino, T.
Cell Rep. 2018 Sep 11, 24 (11):2827-2837 e5.

Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death
Rabenau, M., Unger, M., Drewe, J. and Culmsee, C.
Phytomedicine. 2019 Jan 01, 52:107-116.

Photodamaging of Mitochondrial DNA to Overcome Cisplatin Resistance by a Ru(II) -Pt(II) Bimetallic Complex
Zheng, Y., Zhang, D. Y., Zhang, H., Cao, J. J., Tan, C. P., Ji, L. N. and Mao, Z. W.
Chemistry. 2018 Dec 17, 24 (71):18971-18980.

A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini, P., Serviss, J. T., Lundback, T., Bancaro, N., Mazurkiewicz, M., Kolosenko, I., Yu, D., Haraldsson, M., D'Arcy, P., Linder, S. and De Milito, A.
Cancer Cell Int. 2018 Sep 25, 18:147.

Platelet-mimicking nanoparticles co-loaded with W18O49 and metformin alleviate tumor hypoxia for enhanced photodynamic therapy and photothermal therapy
Zuo, H., Tao, J., Shi, H., He, J., Zhou, Z. and Zhang, C.
Acta Biomater. 2018 Oct 15, 80:296-307.

Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes
David, J., O'Toole, E., O'Reilly, K., Thuery, G., Assmann, N., Finlay, D. and Harkin, A.
Neuroscience. 2018 Nov 10, 392:38-56.

Food & Nutritional Research

Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10
Schniertshauer, D., Gebhard, D. and Bergemann, J.
J Aging Res. 2018 Sep 05, 2018:6354680.

Tannic acid directly targets pyruvate kinase isoenzyme M2 to attenuate colon cancer cell proliferation
Yang, P., Ding, G. B., Liu, W., Fu, R., Sajid, A. and Li, Z.
Food Funct. 2018 Nov 14, 9 (11):5547-5559.

Synthetic Enzymology and the Fountain of Youth: Repurposing Biology for Longevity
Lim, Y. P., Go, M. K., Raida, M., Inoue, T., Wenk, M. R., Keasling, J. D., Chang, M. W. and Yew, W. S.
ACS Omega. 2018 Sep 30, 3 (9):11050-11061.

Common gut microbial metabolites of dietary flavonoids exert potent protective activities in beta-cells and skeletal muscle cells
Bitner, B. F., Ray, J. D., Kener, K. B., Herring, J. A., Tueller, J. A., Johnson, D. K., Tellez Freitas, C. M., Fausnacht, D. W., Allen, M. E., Thomson, A. H., Weber, K. S., McMillan, R. P., Hulver, M. W., Brown, D. A., Tessem, J. S. and Neilson, A. P.
J Nutr Biochem. 2018 Dec, 62:95-107.

Quantitative Proteomic Analysis Reveals Caffeine-Perturbed Proteomic Profiles in Normal Bladder Epithelial Cells
Shahid, M., Kim, M., Yeon, A., Andres, A. M., You, S. and Kim, J.
Proteomics. 2018 Oct 01, 18 (20):e1800190.

Hepatobiology Research

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Yakulov, T. A., Todkar, A. P., Slanchev, K., Wiegel, J., Bona, A., Gross, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T. B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A. and Walz, G.
Nat Commun. 2018 Sep 10, 9 (1):3660.

Deficiency in augmenter of liver regeneration accelerates liver fibrosis by promoting migration of hepatic stellate cell
Ai, W. L., Dong, L. Y., Wang, J., Li, Z. W., Wang, X., Gao, J., Wu, Y. and An, W.
Biochim Biophys Acta Mol Basis Dis. 2018 Nov 01, 1864 (11):3780-3791.

Yes-associated protein (YAP) binds to HIF-1alpha and sustains HIF-1alpha protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress
Zhang, X., Li, Y., Ma, Y., Yang, L., Wang, T., Meng, X., Zong, Z., Sun, X., Hua, X. and Li, H.
J Exp Clin Cancer Res. 2018 Sep 4, 37 (1):216.

CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer
Zhong, X. Y., Yuan, X. M., Xu, Y. Y., Yin, M., Yan, W. W., Zou, S. W., Wei, L. M., Lu, H. J., Wang, Y. P. and Lei, Q. Y.
Cell Rep. 2018 Sep 18, 24 (12):3207-3223.

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
Zhang, C., Seo, J., Murakami, K., Salem, E. S. B., Bernhard, E., Borra, V. J., Choi, K., Yuan, C. L., Chan, C. C., Chen, X., Huang, T., Weirauch, M. T., Divanovic, S., Qi, N. R., Thomas, H. E., Mercer, C. A., Siomi, H. and Nakamura, T.
Nat Commun. 2018 Sep 10, 9 (1):3658.

Deletion of the Mitochondrial Complex-IV Cofactor Heme A:Farnesyltransferase Causes Focal Segmental Glomerulosclerosis and Interferon Response
Baek, J. H., Gomez, I. G., Wada, Y., Roach, A., Mahad, D. and Duffield, J. S.
Am J Pathol. 2018 Dec 01, 188 (12):2745-2762.

Immunology Research

Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of beta-amyloid
Rubio-Araiz, A., Finucane, O. M., Keogh, S. and Lynch, M. A.
J Neuroinflammation. 2018 Aug 31, 15 (1):247.

Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 1: Enhancement of cellular viability, regulation of cellular apoptosis and improvement of mitochondrial functionality
Afrin, S., Gasparrini, M., Forbes-Hernandez, T. Y., Cianciosi, D., Reboredo-Rodriguez, P., Manna, P. P., Battino, M. and Giampieri, F.
Food Chem Toxicol. 2018 Nov 01, 121:203-213.

Autophagy Is a Tolerance-Avoidance Mechanism that Modulates TCR-Mediated Signaling and Cell Metabolism to Prevent Induction of T Cell Anergy
Mocholi, E., Dowling, S. D., Botbol, Y., Gruber, R. C., Ray, A. K., Vastert, S., Shafit-Zagardo, B., Coffer, P. J. and Macian, F.
Cell Rep. 2018 Jul 31, 24 (5):1136-1150.

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
Tsai, S., Clemente-Casares, X., Zhou, A. C., Lei, H., Ahn, J. J., Chan, Y. T., Choi, O., Luck, H., Woo, M., Dunn, S. E., Engleman, E. G., Watts, T. H., Winer, S. and Winer, D. A.
Cell Metab. 2018 Dec 4, 28 (6):922-934 e4.

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes
Cheung, J. Y., Gordon, J., Wang, J., Song, J., Zhang, X. Q., Prado, F. J., Shanmughapriya, S., Rajan, S., Tomar, D., Tahrir, F. G., Gupta, M. K., Knezevic, T., Merabova, N., Kontos, C. D., McClung, J. M., Klotman, P. E., Madesh, M., Khalili, K. and Feldman, A. M.
J Cell Physiol. 2019 Apr 01, 234 (4):4432-4444.

Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea
Abe, N., Choudhury, M. E., Watanabe, M., Kawasaki, S., Nishihara, T., Yano, H., Matsumoto, S., Kunieda, T., Kumon, Y., Yorozuya, T. and Tanaka, J.
Glia. 2018 Oct 01, 66 (10):2158-2173.

A Trypsin-Sensitive Proteoglycan from the Tapeworm Hymenolepis diminuta Inhibits Murine Neutrophil Chemotaxis in vitro by Suppressing p38 MAP Kinase Activation
Graves, N., Venu, V. P., Yipp, B. G., Petri, B., Hirota, S., Gilleard, J., McKay, D. M. and Lopes, F.
J Innate Immun. 2018 Sep 11, 1:1-14.

Cutting Edge: TGF-beta and Phosphatidylinositol 3-Kinase Signals Modulate Distinct Metabolism of Regulatory T Cell Subsets
Priyadharshini, B., Loschi, M., Newton, R. H., Zhang, J. W., Finn, K. K., Gerriets, V. A., Huynh, A., Rathmell, J. C., Blazar, B. R. and Turka, L. A.
J Immunol. 2018 Oct 15, 201 (8):2215-2219.

CD4(+) T cell activation, function, and metabolism are inhibited by low concentrations of DMSO
Holthaus, L., Lamp, D., Gavrisan, A., Sharma, V., Ziegler, A. G., Jastroch, M. and Bonifacio, E.
J Immunol Methods. 2018 Dec 01, 463:54-60.

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
Petrelli, A., Mijnheer, G., Hoytema van Konijnenburg, D. P., van der Wal, M. M., Giovannone, B., Mocholi, E., Vazirpanah, N., Broen, J. C., Hijnen, D., Oldenburg, B., Coffer, P. J., Vastert, S. J., Prakken, B. J., Spierings, E., Pandit, A., Mokry, M. and van Wijk, F.
J Clin Invest. 2018 Oct 1, 128 (10):4669-4681.

beta-Adrenergic signaling blocks murine CD8(+) T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress
Qiao, G., Bucsek, M. J., Winder, N. M., Chen, M., Giridharan, T., Olejniczak, S. H., Hylander, B. L. and Repasky, E. A.
Cancer Immunol Immunother. 2019 Jan 01, 68 (1):11-22.

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes
Howard, N. C., Marin, N. D., Ahmed, M., Rosa, B. A., Martin, J., Bambouskova, M., Sergushichev, A., Loginicheva, E., Kurepina, N., Rangel-Moreno, J., Chen, L., Kreiswirth, B. N., Klein, R. S., Balada-Llasat, J. M., Torrelles, J. B., Amarasinghe, G. K., Mitreva, M., Artyomov, M. N., Hsu, F. F., Mathema, B. and Khader, S. A.
Nat Microbiol. 2018 Oct 01, 3 (10):1099-1108.

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses
Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. and Caldwell, R. B.
Cell Death Dis. 2018 Sep 25, 9 (10):1001.

Cellular fatty acid level regulates the effect of tolylfluanid on mitochondrial dysfunction and insulin sensitivity in C2C12 skeletal myotubes
Davis, A. F., Thomas, A. A., Shorter, K. S., Brown, S. L. and Baumgarner, B. L.
Biochem Biophys Res Commun. 2018 Oct 28, 505 (2):392-398.

Infectious Disease Research

Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes
Cheung, J. Y., Gordon, J., Wang, J., Song, J., Zhang, X. Q., Prado, F. J., Shanmughapriya, S., Rajan, S., Tomar, D., Tahrir, F. G., Gupta, M. K., Knezevic, T., Merabova, N., Kontos, C. D., McClung, J. M., Klotman, P. E., Madesh, M., Khalili, K. and Feldman, A. M.
J Cell Physiol. 2019 Apr 01, 234 (4):4432-4444.

A Trypsin-Sensitive Proteoglycan from the Tapeworm Hymenolepis diminuta Inhibits Murine Neutrophil Chemotaxis in vitro by Suppressing p38 MAP Kinase Activation
Graves, N., Venu, V. P., Yipp, B. G., Petri, B., Hirota, S., Gilleard, J., McKay, D. M. and Lopes, F.
J Innate Immun. 2018 Sep 11, 1:1-14.

Identification of cryptic subunits from an apicomplexan ATP synthase
Huet, D., Rajendran, E., van Dooren, G. G. and Lourido, S.
Elife. 2018 Sep 11, 7.

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes
Howard, N. C., Marin, N. D., Ahmed, M., Rosa, B. A., Martin, J., Bambouskova, M., Sergushichev, A., Loginicheva, E., Kurepina, N., Rangel-Moreno, J., Chen, L., Kreiswirth, B. N., Klein, R. S., Balada-Llasat, J. M., Torrelles, J. B., Amarasinghe, G. K., Mitreva, M., Artyomov, M. N., Hsu, F. F., Mathema, B. and Khader, S. A.
Nat Microbiol. 2018 Oct 01, 3 (10):1099-1108.

Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major
Mukherjee, S., Xu, W., Hsu, F. F., Patel, J., Huang, J. and Zhang, K.
Mol Microbiol. 2018 Sep 27, [epub ahead of print]

Mitochondrial Disease Reseach

Mitochondrial DNA 3243A>T mutation in a patient with MELAS syndrome
Ikeda, T., Osaka, H., Shimbo, H., Tajika, M., Yamazaki, M., Ueda, A., Murayama, K. and Yamagata, T.
Hum Genome Var. 2018 Sep 04, 5:25.

Mutant MRPS5 affects mitoribosomal accuracy and confers stress-related behavioral alterations
Akbergenov, R., Duscha, S., Fritz, A. K., Juskeviciene, R., Oishi, N., Schmitt, K., Shcherbakov, D., Teo, Y., Boukari, H., Freihofer, P., Isnard-Petit, P., Oettinghaus, B., Frank, S., Thiam, K., Rehrauer, H., Westhof, E., Schacht, J., Eckert, A., Wolfer, D. and Bottger, E. C.
EMBO Rep. 2018 Nov 01, 19 (11).

Deep sequencing discovery of causal mtDNA mutations in a patient with unspecific neurological disease
Spangenberg, L., Grana, M., Mansilla, S., Martinez, J., Tapie, A., Greif, G., Montano, N., Vaglio, A., Guecaimburu, R., Robello, C., Castro, L., Quijano, C., Raggio, V. and Naya, H.
Mitochondrion. 2018 Sep 15, [epub ahead of print]

Deletion of the Mitochondrial Complex-IV Cofactor Heme A:Farnesyltransferase Causes Focal Segmental Glomerulosclerosis and Interferon Response
Baek, J. H., Gomez, I. G., Wada, Y., Roach, A., Mahad, D. and Duffield, J. S.
Am J Pathol. 2018 Dec 01, 188 (12):2745-2762.

Model Organisms

CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Yakulov, T. A., Todkar, A. P., Slanchev, K., Wiegel, J., Bona, A., Gross, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T. B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A. and Walz, G.
Nat Commun. 2018 Sep 10, 9 (1):3660.

Nephrology Research

Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-kappaB and improving mitochondrial function
Yu, X., Meng, X., Xu, M., Zhang, X., Zhang, Y., Ding, G., Huang, S., Zhang, A. and Jia, Z.
EBioMedicine. 2018 Oct 01, 36:266-280.

Neurobiology Research

Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan
Saha, M., Reddy, H. M., Salih, M. A., Estrella, E., Jones, M. D., Mitsuhashi, S., Cho, K. A., Suzuki-Hatano, S., Rizzo, S. A., Hamad, M. H., Mukhtar, M. M., Hamed, A. A., Elseed, M. A., Lek, M., Valkanas, E., MacArthur, D. G., Kunkel, L. M., Pacak, C. A., Draper, I. and Kang, P. B.
Physiol Genomics. 2018 Nov 1, 50 (11):929-939.

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
Seibler, P., Burbulla, L. F., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Munchau, A., Krainc, D. and Klein, C.
Brain. 2018 Oct 1, 141 (10):3052-3064.

Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease
Brose, R. D., Lehrmann, E., Zhang, Y., Reeves, R. H., Smith, K. D. and Mattson, M. P.
Neurobiol Aging. 2018 Dec 01, 72:121-133.

Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with Either Sporadic or Familial Alzheimer's Disease
Bell, S. M., Barnes, K., Clemmens, H., Al-Rafiah, A. R., Al-Ofi, E. A., Leech, V., Bandmann, O., Shaw, P. J., Blackburn, D. J., Ferraiuolo, L. and Mortiboys, H.
J Mol Biol. 2018 Oct 19, 430 (21):3942-3953.

Comparison of the detrimental features of microglia and infiltrated macrophages in traumatic brain injury: A study using a hypnotic bromovalerylurea
Abe, N., Choudhury, M. E., Watanabe, M., Kawasaki, S., Nishihara, T., Yano, H., Matsumoto, S., Kunieda, T., Kumon, Y., Yorozuya, T. and Tanaka, J.
Glia. 2018 Oct 01, 66 (10):2158-2173.

Pantothenate Rescues Iron Accumulation in Pantothenate Kinase-Associated Neurodegeneration Depending on the Type of Mutation
Alvarez-Cordoba, M., Fernandez Khoury, A., Villanueva-Paz, M., Gomez-Navarro, C., Villalon-Garcia, I., Suarez-Rivero, J. M., Povea-Cabello, S., de la Mata, M., Cotan, D., Talaveron-Rey, M., Perez-Pulido, A. J., Salas, J. J., Perez-Villegas, E. M., Diaz-Quintana, A., Armengol, J. A. and Sanchez-Alcazar, J. A.
Mol Neurobiol. 2018 Sep 1, [epub ahead of print]

Proteomic and functional data sets on synaptic mitochondria from rats with genetic ablation of Parkin
Villeneuve, L. M., Stauch, K. L., Purnell, P. S. and Fox, H. S.
Data Brief. 2018 Aug 28, 20:568-572.

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons
Chavarria, C., Rodriguez-Bottero, S., Quijano, C., Cassina, P. and Souza, J. M.
Biochem J. 2018 Oct 11, 475 (19):3153-3169.

Prokineticin-2 promotes chemotaxis and alternative A2 reactivity of astrocytes
Neal, M., Luo, J., Harischandra, D. S., Gordon, R., Sarkar, S., Jin, H., Anantharam, V., Desaubry, L., Kanthasamy, A. and Kanthasamy, A.
Glia. 2018 Oct 01, 66 (10):2137-2157.

Polybrene induces neural degeneration by bidirectional Ca(2+) influx-dependent mitochondrial and ER-mitochondrial dynamics
Bao, F., Shi, H., Gao, M., Yang, L., Zhou, L., Zhao, Q., Wu, Y., Chen, K., Xiang, G., Long, Q., Guo, J., Zhang, J. and Liu, X.
Cell Death Dis. 2018 Sep 20, 9 (10):966.

beta-Adrenergic signaling blocks murine CD8(+) T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress
Qiao, G., Bucsek, M. J., Winder, N. M., Chen, M., Giridharan, T., Olejniczak, S. H., Hylander, B. L. and Repasky, E. A.
Cancer Immunol Immunother. 2019 Jan 01, 68 (1):11-22.

Deep sequencing discovery of causal mtDNA mutations in a patient with unspecific neurological disease
Spangenberg, L., Grana, M., Mansilla, S., Martinez, J., Tapie, A., Greif, G., Montano, N., Vaglio, A., Guecaimburu, R., Robello, C., Castro, L., Quijano, C., Raggio, V. and Naya, H.
Mitochondrion. 2018 Sep 15, [epub ahead of print]

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy
Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. and Okano, H.
Sci Rep. 2018 Sep 21, 8 (1):14215.

Distinct multilevel misregulations of Parkin and PINK1 revealed in cell and animal models of TDP-43 proteinopathy
Sun, X., Duan, Y., Qin, C., Li, J. C., Duan, G., Deng, X., Ni, J., Cao, X., Xiang, K., Tian, K., Chen, C. H., Li, A. and Fang, Y.
Cell Death Dis. 2018 Sep 20, 9 (10):953.

Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes
David, J., O'Toole, E., O'Reilly, K., Thuery, G., Assmann, N., Finlay, D. and Harkin, A.
Neuroscience. 2018 Nov 10, 392:38-56.

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses
Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. and Caldwell, R. B.
Cell Death Dis. 2018 Sep 25, 9 (10):1001.

Synaptosomes
Murphy, K. M.
Springer Protocols. 2018 Dec 01, 141.

Centella asiatica attenuates hippocampal mitochondrial dysfunction and improves memory and executive function in beta-amyloid overexpressing mice
Gray, N. E., Zweig, J. A., Caruso, M., Zhu, J. Y., Wright, K. M., Quinn, J. F. and Soumyanath, A.
Mol Cell Neurosci. 2018 Dec 01, 93:1-9.

Concurrent AFG3L2 and SPG7 mutations associated with syndromic parkinsonism and optic atrophy with aberrant OPA1 processing and mitochondrial network fragmentation
Magri, S., Fracasso, V., Plumari, M., Alfei, E., Ghezzi, D., Gellera, C., Rusmini, P., Poletti, A., Di Bella, D., Elia, A. E., Pantaleoni, C. and Taroni, F.
Hum Mutat. 2018 Dec 01, 39 (12):2060-2071.

Obesity, Diabetes & Metabolic Diseases

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
Tsai, S., Clemente-Casares, X., Zhou, A. C., Lei, H., Ahn, J. J., Chan, Y. T., Choi, O., Luck, H., Woo, M., Dunn, S. E., Engleman, E. G., Watts, T. H., Winer, S. and Winer, D. A.
Cell Metab. 2018 Dec 4, 28 (6):922-934 e4.

N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes
Huber, K., Hofer, D. C., Trefely, S., Pelzmann, H. J., Madreiter-Sokolowski, C., Duta-Mare, M., Schlager, S., Trausinger, G., Stryeck, S., Graier, W. F., Kolb, D., Magnes, C., Snyder, N. W., Prokesch, A., Kratky, D., Madl, T., Wellen, K. E. and Bogner-Strauss, J. G.
Biochim Biophys Acta Mol Cell Res. 2019 Mar 01, 1866 (3):337-348.

The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus
Micakovic, T., Papagiannarou, S., Clark, E., Kuzay, Y., Abramovic, K., Peters, J., Sticht, C., Volk, N., Fleming, T., Nawroth, P., Hammes, H. P., Alenina, N., Grone, H. J. and Hoffmann, S. C.
Kidney Int. 2018 Nov 01, 94 (5):937-950.

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements
Fabbiano, S., Suarez-Zamorano, N., Chevalier, C., Lazarevic, V., Kieser, S., Rigo, D., Leo, S., Veyrat-Durebex, C., Gaia, N., Maresca, M., Merkler, D., Gomez de Aguero, M., Macpherson, A., Schrenzel, J. and Trajkovski, M.
Cell Metab. 2018 Dec 4, 28 (6):907-921 e7.

LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat
Schmidt, E., Dhaouadi, I., Gaziano, I., Oliverio, M., Klemm, P., Awazawa, M., Mitterer, G., Fernandez-Rebollo, E., Pradas-Juni, M., Wagner, W., Hammerschmidt, P., Loureiro, R., Kiefer, C., Hansmeier, N. R., Khani, S., Bergami, M., Heine, M., Ntini, E., Frommolt, P., Zentis, P., Orom, U. A., Heeren, J., Bluher, M., Bilban, M. and Kornfeld, J. W.
Nat Commun. 2018 Sep 6, 9 (1):3622.

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis
Peng, H. Y., Liang, Y. C., Tan, T. H., Chuang, H. C., Lin, Y. J. and Lin, J. C.
Int J Mol Sci. 2018 Sep 6, 19 (9).

GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation
Drareni, K., Ballaire, R., Barilla, S., Mathew, M. J., Toubal, A., Fan, R., Liang, N., Chollet, C., Huang, Z., Kondili, M., Foufelle, F., Soprani, A., Roussel, R., Gautier, J. F., Alzaid, F., Treuter, E. and Venteclef, N.
Cell Rep. 2018 Sep 11, 24 (11):2957-2971 e6.

Gamma-Aminobutyric Acid Signaling in Brown Adipose Tissue Promotes Systemic Metabolic Derangement in Obesity
Ikegami, R., Shimizu, I., Sato, T., Yoshida, Y., Hayashi, Y., Suda, M., Katsuumi, G., Li, J., Wakasugi, T., Minokoshi, Y., Okamoto, S., Hinoi, E., Nielsen, S., Jespersen, N. Z., Scheele, C., Soga, T. and Minamino, T.
Cell Rep. 2018 Sep 11, 24 (11):2827-2837 e5.

TGF-beta receptor 1 regulates progenitors that promote browning of white fat
Wankhade, U. D., Lee, J. H., Dagur, P. K., Yadav, H., Shen, M., Chen, W., Kulkarni, A. B., McCoy, J. P., Finkel, T., Cypess, A. M. and Rane, S. G.
Mol Metab. 2018 Oct 01, 16:160-171.

Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function
Comas, F., Lluch, A., Sabater, M., Latorre, J., Ortega, F., Ricart, W., Lopez, M., Fernandez-Real, J. M. and Moreno-Navarrete, J. M.
Int J Obes (Lond). 2018 Sep 11, [epub ahead of print]

Thyroid hormone (T3) stimulates brown adipose tissue activation via mitochondrial biogenesis and MTOR-mediated mitophagy
Yau, W. W., Singh, B. K., Lesmana, R., Zhou, J., Sinha, R. A., Wong, K. A., Wu, Y., Bay, B. H., Sugii, S., Sun, L. and Yen, P. M.
Autophagy. 2019 Jan 01, 15 (1):131-150.

Deficiency of Sphingosine-1-Phosphate Reduces the Expression of Prohibitin and Causes beta-Cell Impairment via Mitochondrial Dysregulation
Hong, S. W., Lee, J., Kwon, H., Park, S. E., Rhee, E. J., Park, C. Y., Oh, K. W., Park, S. W. and Lee, W. Y.
Endocrinol Metab (Seoul). 2018 Sep 01, 33 (3):403-412.

Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology
Zhang, C., Seo, J., Murakami, K., Salem, E. S. B., Bernhard, E., Borra, V. J., Choi, K., Yuan, C. L., Chan, C. C., Chen, X., Huang, T., Weirauch, M. T., Divanovic, S., Qi, N. R., Thomas, H. E., Mercer, C. A., Siomi, H. and Nakamura, T.
Nat Commun. 2018 Sep 10, 9 (1):3658.

Cellular fatty acid level regulates the effect of tolylfluanid on mitochondrial dysfunction and insulin sensitivity in C2C12 skeletal myotubes
Davis, A. F., Thomas, A. A., Shorter, K. S., Brown, S. L. and Baumgarner, B. L.
Biochem Biophys Res Commun. 2018 Oct 28, 505 (2):392-398.

GPER and ERalpha mediate estradiol enhancement of mitochondrial function in inflamed adipocytes through a PKA dependent mechanism
Bauza-Thorbrugge, M., Rodriguez-Cuenca, S., Vidal-Puig, A., Galmes-Pascual, B. M., Sbert-Roig, M., Gianotti, M., Llado, I. and Proenza, A. M.
J Steroid Biochem Mol Biol. 2019 Jan 01, 185:256-267.

Restoration of GLP-1 secretion by Berberine is associated with protection of colon enterocytes from mitochondrial overheating in diet-induced obese mice
Sun, Y., Jin, C., Zhang, X., Jia, W., Le, J. and Ye, J.
Nutr Diabetes. 2018 Sep 24, 8 (1):53.

Adipose mTORC1 Suppresses Prostaglandin Signaling and Beige Adipogenesis via the CRTC2-COX-2 Pathway
Zhang, X., Luo, Y., Wang, C., Ding, X., Yang, X., Wu, D., Silva, F., Yang, Z., Zhou, Q., Wang, L., Wang, X., Zhou, J., Boyd, N., Spafford, M., Burge, M., Yang, X. O. and Liu, M.
Cell Rep. 2018 Sep 18, 24 (12):3180-3193.

Activation of brown adipocytes by placental growth factor
Zhou, J., Wu, N. N., Yin, R. L., Ma, W., Yan, C., Feng, Y. M., Zhang, C. H. and Zhao, D.
Biochem Biophys Res Commun. 2018 Oct 2, 504 (2):470-477.

Stem Cell Biology

Iron overload is accompanied by mitochondrial and lysosomal dysfunction in WDR45 mutant cells
Seibler, P., Burbulla, L. F., Dulovic, M., Zittel, S., Heine, J., Schmidt, T., Rudolph, F., Westenberger, A., Rakovic, A., Munchau, A., Krainc, D. and Klein, C.
Brain. 2018 Oct 1, 141 (10):3052-3064.

The Long Noncoding RNA Lncenc1 Maintains Naive States of Mouse ESCs by Promoting the Glycolysis Pathway
Sun, Z., Zhu, M., Lv, P., Cheng, L., Wang, Q., Tian, P., Yan, Z. and Wen, B.
Stem Cell Reports. 2018 Sep 11, 11 (3):741-755.

The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells
Jeong, Y.-H., Oh, H., Lee, M., Kim, C. Y., Joo, C., Park, S.-J., Song, Y.-H., Kang, C., Chung, H.-M., Kang, S.-W., Huh, K. and Moon, S.-H.
Polymers. 2018 Jul 01, 10 (8):839.

The pathogenesis linked to coenzyme Q10 insufficiency in iPSC-derived neurons from patients with multiple-system atrophy
Nakamoto, F. K., Okamoto, S., Mitsui, J., Sone, T., Ishikawa, M., Yamamoto, Y., Kanegae, Y., Nakatake, Y., Imaizumi, K., Ishiura, H., Tsuji, S. and Okano, H.
Sci Rep. 2018 Sep 21, 8 (1):14215.

Revealing the metabolic characteristics of human embryonic stem cells by genome-scale metabolic modeling
He, Y., Wang, Y., Zhang, B., Li, Y., Diao, L., Lu, L., Yao, J., Liu, Z., Li, D. and He, F.
FEBS Lett. 2018 Nov 01, 592 (22):3670-3682.

Techniques & Methods

The Effect of Hexanoyl Glycol Chitosan on the Proliferation of Human Mesenchymal Stem Cells
Jeong, Y.-H., Oh, H., Lee, M., Kim, C. Y., Joo, C., Park, S.-J., Song, Y.-H., Kang, C., Chung, H.-M., Kang, S.-W., Huh, K. and Moon, S.-H.
Polymers. 2018 Jul 01, 10 (8):839.

CD4(+) T cell activation, function, and metabolism are inhibited by low concentrations of DMSO
Holthaus, L., Lamp, D., Gavrisan, A., Sharma, V., Ziegler, A. G., Jastroch, M. and Bonifacio, E.
J Immunol Methods. 2018 Dec 01, 463:54-60.

A drug screening assay on cancer cells chronically adapted to acidosis
Pellegrini, P., Serviss, J. T., Lundback, T., Bancaro, N., Mazurkiewicz, M., Kolosenko, I., Yu, D., Haraldsson, M., D'Arcy, P., Linder, S. and De Milito, A.
Cancer Cell Int. 2018 Sep 25, 18:147.

Synaptosomes
Murphy, K. M.
Springer Protocols. 2018 Dec 01, 141.

Toxicology Research

Fumarate hydratase loss promotes mitotic entry in the presence of DNA damage after ionising radiation
Johnson, T. I., Costa, A. S. H., Ferguson, A. N. and Frezza, C.
Cell Death Dis. 2018 Sep 6, 9 (9):913.

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons
Chavarria, C., Rodriguez-Bottero, S., Quijano, C., Cassina, P. and Souza, J. M.
Biochem J. 2018 Oct 11, 475 (19):3153-3169.

1,25-Dihydroxyvitamin D3 modulates the effects of sublethal BPA on mitochondrial function via activating PI3K-Akt pathway and 17beta-estradiol secretion in rat granulosa cells
Lee, C. T., Wang, J. Y., Chou, K. Y. and Hsu, M. I.
J Steroid Biochem Mol Biol. 2019 Jan 01, 185:200-211.

The role of formation of pyrrole-ATP synthase subunit beta adduct in pyrrolizidine alkaloid-induced hepatotoxicity
Lu, Y., Ma, J., Song, Z., Ye, Y., Fu, P. P. and Lin, G.
Arch Toxicol. 2018 Nov 01, 92 (11):3403-3414.

Celastrol ameliorates cisplatin nephrotoxicity by inhibiting NF-kappaB and improving mitochondrial function
Yu, X., Meng, X., Xu, M., Zhang, X., Zhang, Y., Ding, G., Huang, S., Zhang, A. and Jia, Z.
EBioMedicine. 2018 Oct 01, 36:266-280.

Air pollution-derived PM2.5 impairs mitochondrial function in healthy and chronic obstructive pulmonary diseased human bronchial epithelial cells
Leclercq, B., Kluza, J., Antherieu, S., Sotty, J., Alleman, L. Y., Perdrix, E., Loyens, A., Coddeville, P., Lo Guidice, J. M., Marchetti, P. and Garcon, G.
Environ Pollut. 2018 Dec 01, 243 (Pt B):1434-1449.

Translational Research

Impact of PYROXD1 deficiency on cellular respiration and correlations with genetic analyses of limb-girdle muscular dystrophy in Saudi Arabia and Sudan
Saha, M., Reddy, H. M., Salih, M. A., Estrella, E., Jones, M. D., Mitsuhashi, S., Cho, K. A., Suzuki-Hatano, S., Rizzo, S. A., Hamad, M. H., Mukhtar, M. M., Hamed, A. A., Elseed, M. A., Lek, M., Valkanas, E., MacArthur, D. G., Kunkel, L. M., Pacak, C. A., Draper, I. and Kang, P. B.
Physiol Genomics. 2018 Nov 1, 50 (11):929-939.

Mitochondrial DNA 3243A>T mutation in a patient with MELAS syndrome
Ikeda, T., Osaka, H., Shimbo, H., Tajika, M., Yamazaki, M., Ueda, A., Murayama, K. and Yamagata, T.
Hum Genome Var. 2018 Sep 04, 5:25.

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
Petrelli, A., Mijnheer, G., Hoytema van Konijnenburg, D. P., van der Wal, M. M., Giovannone, B., Mocholi, E., Vazirpanah, N., Broen, J. C., Hijnen, D., Oldenburg, B., Coffer, P. J., Vastert, S. J., Prakken, B. J., Spierings, E., Pandit, A., Mokry, M. and van Wijk, F.
J Clin Invest. 2018 Oct 1, 128 (10):4669-4681.

Adipose tissue TSH as a new modulator of human adipocyte mitochondrial function
Comas, F., Lluch, A., Sabater, M., Latorre, J., Ortega, F., Ricart, W., Lopez, M., Fernandez-Real, J. M. and Moreno-Navarrete, J. M.
Int J Obes (Lond). 2018 Sep 11, [epub ahead of print]

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