XF出版物快报

2018年12

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Aging Research
Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress
Choi, S. J., Piao, S., Nagar, H., Jung, S. B., Kim, S., Lee, I., Kim, S. M., Song, H. J., Shin, N., Kim, D. W., Irani, K., Jeon, B. H., Park, J. W. and Kim, C. S.
Biochem Biophys Res Commun. 2018 Sep 10, 503 (3):1805-1811.

TLR4-mediated activation of the ERK pathway following UVA irradiation contributes to increased cytokine and MMP expression in senescent human dermal fibroblasts
Seo, S. W., Park, S. K., Oh, S. J. and Shin, O. S.
PLoS One. 2018 Aug 17, 13 (8):e0202323.

Cancer Research
TIMMDC1 Knockdown Inhibits Growth and Metastasis of Gastric Cancer Cells through Metabolic Inhibition and AKT/GSK3beta/beta-Catenin Signaling Pathway

Liu, Y., Huang, Y., Zhang, J., Pei, C., Hu, J., Lyu, J. and Shen, Y.
Int J Biol Sci. 2018 Jul 27, 14 (10):1256-1267.

LMW-PTP modulates glucose metabolism in cancer cells
Lori, G., Gamberi, T., Paoli, P., Caselli, A., Pranzini, E., Marzocchini, R., Modesti, A. and Raugei, G.
Biochim Biophys Acta Gen Subj. 2018 Dec 01, 1862 (12):2533-2544.

Effects of carnitine palmitoyltransferases on cancer cellular senescence
Guan, L., Chen, Y., Wang, Y., Zhang, H., Fan, S., Gao, Y., Jiao, T., Fu, K., Sun, J., Yu, A., Huang, M. and Bi, H.
J Cell Physiol. 2019 Feb 01, 234 (2):1707-1719.

Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia
Jalali, S., Price-Troska, T., Paludo, J., Villasboas, J., Kim, H. J., Yang, Z. Z., Novak, A. J. and Ansell, S. M.
Blood Adv. 2018 Aug 14, 2 (15):1985-1997.

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum
Steenbergen, R., Oti, M., Ter Horst, R., Tat, W., Neufeldt, C., Belovodskiy, A., Chua, T. T., Cho, W. J., Joyce, M., Dutilh, B. E. and Tyrrell, D. L.
Sci Rep. 2018 Aug 3, 8 (1):11685.

Systems analysis of intracellular pH vulnerabilities for cancer therapy
Persi, E., Duran-Frigola, M., Damaghi, M., Roush, W. R., Aloy, P., Cleveland, J. L., Gillies, R. J. and Ruppin, E.
Nat Commun. 2018 Jul 31, 9 (1):2997.

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R. I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J. D., Klaeyle, L., Langa, X., Beckmann, C. C. A., Wlodarski, M. W., Muller, P., Van Essen, D., Rambold, A., Kapp, F. G., Mione, M., Buescher, J. M., Pearce, E. L., Polyzos, A. and Trompouki, E.
Nat Commun. 2018 Aug 6, 9 (1):3090.

Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma
Reustle, A., Fisel, P., Renner, O., Buttner, F., Winter, S., Rausch, S., Kruck, S., Nies, A. T., Hennenlotter, J., Scharpf, M., Fend, F., Stenzl, A., Bedke, J., Schwab, M. and Schaeffeler, E.
Int J Cancer. 2018 Dec 15, 143 (12):3181-3193.

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism
Li, C., Zhang, Y., Cheng, X., Yuan, H., Zhu, S., Liu, J., Wen, Q., Xie, Y., Liu, J., Kroemer, G., Klionsky, D. J., Lotze, M. T., Zeh, H. J., Kang, R. and Tang, D.
Dev Cell. 2018 Aug 20, 46 (4):441-455 e8.

Tigecycline as a dual inhibitor of retinoblastoma and angiogenesis via inducing mitochondrial dysfunctions and oxidative damage
Xiong, Y., Liu, W., Huang, Q., Wang, J., Wang, Y., Li, H. and Fu, X.
Sci Rep. 2018 Aug 6, 8 (1):11747.

Na/K-ATPase Y260 Phosphorylation-mediated Src Regulation in Control of Aerobic Glycolysis and Tumor Growth
Banerjee, M., Cui, X., Li, Z., Yu, H., Cai, L., Jia, X., He, D., Wang, C., Gao, T. and Xie, Z.
Sci Rep. 2018 Aug 17, 8 (1):12322.

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
Suzuki, J., Yamada, T., Inoue, K., Nabe, S., Kuwahara, M., Takemori, N., Takemori, A., Matsuda, S., Kanoh, M., Imai, Y., Yasukawa, M. and Yamashita, M.
Nat Commun. 2018 Aug 17, 9 (1):3296.

KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc
Li, J., Liu, Q., Liu, Z., Xia, Q., Zhang, Z., Zhang, R., Gao, T., Gu, G., Wang, Y., Wang, D., Chen, X., Yang, Y., He, D. and Xin, T.
J Exp Clin Cancer Res. 2018 Aug 16, 37 (1):194.

MiR-139-5p is associated with poor prognosis and regulates glycolysis by repressing PKM2 in gallbladder carcinoma
Chen, J., Yu, Y., Chen, X., He, Y., Hu, Q., Li, H., Han, Q., Ren, F., Li, J., Li, C., Bao, J., Ren, Z., Duan, Z., Cui, G. and Sun, R.
Cell Prolif. 2018 Dec 01, 51 (6):e12510.

A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3
Tajan, M., Hock, A. K., Blagih, J., Robertson, N. A., Labuschagne, C. F., Kruiswijk, F., Humpton, T. J., Adams, P. D. and Vousden, K. H.
Cell Metab. 2018 Nov 6, 28 (5):721-736 e6.

Hexokinase 2 is dispensable for T cell-dependent immunity
Mehta, M. M., Weinberg, S. E., Steinert, E. M., Chhiba, K., Martinez, C. A., Gao, P., Perlman, H. R., Bryce, P., Hay, N. and Chandel, N. S.
Cancer Metab. 2018 Aug 17, 6:10.

ING5-mediated antineuroblastoma effects of suberoylanilide hydroxamic acid
Wu, J. C., Jiang, H. M., Yang, X. H. and Zheng, H. C.
Cancer Med. 2018 Sep 01, 7 (9):4554-4569.

The miR-15b-5p/PDK4 axis regulates osteosarcoma proliferation through modulation of the Warburg effect
Weng, Y., Shen, Y., He, Y., Pan, X., Xu, J., Jiang, Y., Zhang, Q., Wang, S., Kong, F., Zhao, S., Zhou, D. and Zhang, Y.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2749-2757.

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells
Manerba, M., Di Ianni, L., Govoni, M., Comparone, A. and Di Stefano, G.
PLoS One. 2018 Aug 23, 13 (8):e0202588.

n-3 Polyunsaturated fatty acids induce acute myeloid leukemia cell death associated with mitochondrial glycolytic switch and Nrf2 pathway activation
Picou, F., Debeissat, C., Bourgeais, J., Gallay, N., Ferrie, E., Foucault, A., Ravalet, N., Maciejewski, A., Vallet, N., Ducrocq, E., Haddaoui, L., Domenech, J., Herault, O. and Gyan, E.
Pharmacol Res. 2018 Oct 01, 136:45-55.

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis
Taparra, K., Wang, H., Malek, R., Lafargue, A., Barbhuiya, M. A., Wang, X., Simons, B. W., Ballew, M., Nugent, K., Groves, J., Williams, R. D., Shiraishi, T., Verdone, J., Yildirir, G., Henry, R., Zhang, B., Wong, J., Wang, K. K., Nelkin, B. D., Pienta, K. J., Felsher, D., Zachara, N. E. and Tran, P. T.
J Clin Invest. 2018 Nov 1, 128 (11):4924-4937.

Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance
Song, K. H., Kim, J. H., Lee, Y. H., Bae, H. C., Lee, H. J., Woo, S. R., Oh, S. J., Lee, K. M., Yee, C., Kim, B. W., Cho, H., Chung, E. J., Chung, J. Y., Hewitt, S. M., Chung, T. W., Ha, K. T., Bae, Y. K., Mao, C. P., Yang, A., Wu, T. C. and Kim, T. W.
J Clin Invest. 2018 Aug 31, 128 (9):4098-4114.

Low expression of ENC1 predicts a favorable prognosis in patients with ovarian cancer
Fan, S., Wang, Y., Sheng, N., Xie, Y., Lu, J., Zhang, Z., Shan, Q., Wu, D., Sun, C., Li, M., Hu, B. and Zheng, Y.
J Cell Biochem. 2019 Jan 01, 120 (1):861-871.

Impact of Mitochondrion-Targeting Group on the Reactivity and Cytostatic Pathway of Platinum(IV) Complexes
Jin, S., Hao, Y., Zhu, Z., Muhammad, N., Zhang, Z., Wang, K., Guo, Y., Guo, Z. and Wang, X.
Inorg Chem. 2018 Sep 4, 57 (17):11135-11145.

APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells
Jacobsen, K. M., Villadsen, N. L., Torring, T., Nielsen, C. B., Salomon, T., Nielsen, M. M., Tsakos, M., Sibbersen, C., Scavenius, C., Nielsen, R., Christensen, E. I., Guerra, P. F., Bross, P., Pedersen, J. S., Enghild, J. J., Johannsen, M., Frokiaer, J., Overgaard, J., Horsman, M. R., Busk, M. and Poulsen, T. B.
Cell Chem Biol. 2018 Nov 15, 25 (11):1337-1349 e12.

Metabolic reprogramming of stromal fibroblasts by melanoma exosome microRNA favours a pre-metastatic microenvironment
La Shu, S., Yang, Y., Allen, C. L., Maguire, O., Minderman, H., Sen, A., Ciesielski, M. J., Collins, K. A., Bush, P. J., Singh, P., Wang, X., Morgan, M., Qu, J., Bankert, R. B., Whiteside, T. L., Wu, Y. and Ernstoff, M. S.
Sci Rep. 2018 Aug 27, 8 (1):12905.

Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer
Lehman, J. M., Hoeksema, M. D., Staub, J., Qian, J., Harris, B., Callison, J. C., Miao, J., Shi, C., Eisenberg, R., Chen, H., Chen, S. C. and Massion, P. P.
Int J Cancer. 2018 Aug 28, [epub ahead of print]

Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells
Richter, S., D'Antongiovanni, V., Martinelli, S., Bechmann, N., Riverso, M., Poitz, D. M., Pacak, K., Eisenhofer, G., Mannelli, M. and Rapizzi, E.
Cell Tissue Res. 2018 Dec 01, 374 (3):473-485.

The NAD(+) Salvage Pathway Supports PHGDH-Driven Serine Biosynthesis
Murphy, J. P., Giacomantonio, M. A., Paulo, J. A., Everley, R. A., Kennedy, B. E., Pathak, G. P., Clements, D. R., Kim, Y., Dai, C., Sharif, T., Gygi, S. P. and Gujar, S.
Cell Rep. 2018 Aug 28, 24 (9):2381-2391 e5.

The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
Zhang, X., Pellegrini, P., Saei, A. A., Hillert, E. K., Mazurkiewicz, M., Olofsson, M. H., Zubarev, R. A., D'Arcy, P. and Linder, S.
Biochem Pharmacol. 2018 Oct 01, 156:291-301.

Cardiovascular Research
Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress
Choi, S. J., Piao, S., Nagar, H., Jung, S. B., Kim, S., Lee, I., Kim, S. M., Song, H. J., Shin, N., Kim, D. W., Irani, K., Jeon, B. H., Park, J. W. and Kim, C. S.
Biochem Biophys Res Commun. 2018 Sep 10, 503 (3):1805-1811.

Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry
Sowton, A. P., Millington-Burgess, S. L., Murray, A. J. and Harper, M. T.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2721-2727.

Macrophages from The Upper and Lower Human Respiratory Tract Are Metabolically Distinct
Lavrich, K. S., Speen, A. M., Ghio, A. J., Bromberg, P. A., Samet, J. M. and Alexis, N. E.
Am J Physiol Lung Cell Mol Physiol. 2018 Aug 9, [epub ahead of print]

Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart
Warren, J. S., Tracy, C. M., Miller, M. R., Makaju, A., Szulik, M. W., Oka, S. I., Yuzyuk, T. N., Cox, J. E., Kumar, A., Lozier, B. K., Wang, L., Llana, J. G., Sabry, A. D., Cawley, K. M., Barton, D. W., Han, Y. H., Boudina, S., Fiehn, O., Tucker, H. O., Zaitsev, A. V. and Franklin, S.
Proc Natl Acad Sci U S A. 2018 Aug 14, 115 (33):E7871-E7880.

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes
Ramachandra, C. J. A., Mehta, A., Wong, P., Ja, K., Fritsche-Danielson, R., Bhat, R. V., Hausenloy, D. J., Kovalik, J. P. and Shim, W.
Int J Cardiol. 2018 Dec 1, 272:288-297.

RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases
Tang, Y., He, Y., Li, C., Mu, W., Zou, Y., Liu, C., Qian, S., Zhang, F., Pan, J., Wang, Y., Huang, H., Pan, D., Yang, P., Mei, J., Zeng, R. and Tang, Q. Q.
Cell Discov. 2018 Aug 21, 4:52.

Glucose metabolism and metabolic flexibility in blood platelets
Aibibula, M., Naseem, K. M. and Sturmey, R. G.
J Thromb Haemost. 2018 Nov 01, 16 (11):2300-2314.

Quiescent Endothelial Cells Upregulate Fatty Acid beta-Oxidation for Vasculoprotection via Redox Homeostasis
Kalucka, J., Bierhansl, L., Conchinha, N. V., Missiaen, R., Elia, I., Bruning, U., Scheinok, S., Treps, L., Cantelmo, A. R., Dubois, C., de Zeeuw, P., Goveia, J., Zecchin, A., Taverna, F., Morales-Rodriguez, F., Brajic, A., Conradi, L. C., Schoors, S., Harjes, U., Vriens, K., Pilz, G. A., Chen, R., Cubbon, R., Thienpont, B., Cruys, B., Wong, B. W., Ghesquiere, B., Dewerchin, M., De Bock, K., Sagaert, X., Jessberger, S., Jones, E. A. V., Gallez, B., Lambrechts, D., Mazzone, M., Eelen, G., Li, X., Fendt, S. M. and Carmeliet, P.
Cell Metab. 2018 Dec 4, 28 (6):881-894 e13.

Cell Physiology Research
The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism
Hofherr, A., Seger, C., Fitzpatrick, F., Busch, T., Michel, E., Luan, J., Osterried, L., Linden, F., Kramer-Zucker, A., Wakimoto, B., Schutze, C., Wiedemann, N., Artati, A., Adamski, J., Walz, G., Kunji, E. R. S., Montell, C., Watnick, T. and Kottgen, M.
PLoS Biol. 2018 Aug 06, 16 (8):e2005651.

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency
Bocca, C., Kane, M. S., Veyrat-Durebex, C., Chupin, S., Alban, J., Kouassi Nzoughet, J., Le Mao, M., Chao de la Barca, J. M., Amati-Bonneau, P., Bonneau, D., Procaccio, V., Lenaers, G., Simard, G., Chevrollier, A. and Reynier, P.
Sci Rep. 2018 Aug 1, 8 (1):11528.

Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice
Hubbard, W. B., Harwood, C. L., Geisler, J. G., Vekaria, H. J. and Sullivan, P. G.
J Neurosci Res. 2018 Oct 01, 96 (10):1677-1688.

Functional Divergence of Mitochondria and Coevolution of Genomes: Cool Mitochondria in Hot Lizards
Haenel, G. J. and Del Gaizo Moore, V.
Physiol Biochem Zool. 2018 Sep 01, 91 (5):1068-1081

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling
Glass, H., Pal, A., Reinhardt, P., Sterneckert, J., Wegner, F., Storch, A. and Hermann, A.
Mol Cell Neurosci. 2018 Oct 01, 92:137-148.

Cannabinoid-1 receptor regulates mitochondrial dynamics and function in renal proximal tubular cells
Drori, A., Permyakova, A., Hadar, R., Udi, S., Nemirovski, A. and Tam, J.
Diabetes Obes Metab. 2019 Jan 01, 21 (1):146-159.

A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training
Lee, H., Kim, K., Kim, B., Shin, J., Rajan, S., Wu, J., Chen, X., Brown, M. D., Lee, S. and Park, J. Y.
J Physiol. 2018 Sep 01, 596 (18):4413-4426.

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
Kong, X., Yao, T., Zhou, P., Kazak, L., Tenen, D., Lyubetskaya, A., Dawes, B. A., Tsai, L., Kahn, B. B., Spiegelman, B. M., Liu, T. and Rosen, E. D.
Cell Metab. 2018 Oct 2, 28 (4):631-643 e3.

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
Nayak, M. K., Dhanesha, N., Doddapattar, P., Rodriguez, O., Sonkar, V. K., Dayal, S. and Chauhan, A. K.
Blood Adv. 2018 Aug 14, 2 (15):2029-2038.

Expansion capacity of human muscle progenitor cells differs by age, sex, and metabolic fuel preference
Riddle, E. S., Bender, E. L. and Thalacker-Mercer, A. E.
Am J Physiol Cell Physiol. 2018 Aug 15, [eub ahead od print]

Acute decompression following simulated dive conditions alters mitochondrial respiration and motility
Jang, D. H., Owiredu, S., Ranganathan, A. and Eckmann, D. M.
Am J Physiol Cell Physiol. 2018 Aug 15, [epub ahead of print]

Impact of Mitochondrion-Targeting Group on the Reactivity and Cytostatic Pathway of Platinum(IV) Complexes
Jin, S., Hao, Y., Zhu, Z., Muhammad, N., Zhang, Z., Wang, K., Guo, Y., Guo, Z. and Wang, X.
Inorg Chem. 2018 Sep 4, 57 (17):11135-11145.

Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite
Carballal, S., Valez, V., Alvarez-Paggi, D., Tovmasyan, A., Batinic-Haberle, I., Ferrer-Sueta, G., Murgida, D. H. and Radi, R.
Free Radic Biol Med. 2018 Oct 01, 126:379-392.

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
Shanmughapriya, S., Tomar, D., Dong, Z., Slovik, K. J., Nemani, N., Natarajaseenivasan, K., Carvalho, E., Lu, C., Corrigan, K., Garikipati, V. N. S., Ibetti, J., Rajan, S., Barrero, C., Chuprun, K., Kishore, R., Merali, S., Tian, Y., Yang, W. and Madesh, M.
Nat Commun. 2018 Aug 29, 9 (1):3449.

Tbx1 regulates inherited metabolic and myogenic abilities of progenitor cells derived from slow- and fast-type muscle
Motohashi, N., Uezumi, A., Asakura, A., Ikemoto-Uezumi, M., Mori, S., Mizunoe, Y., Takashima, R., Miyagoe-Suzuki, Y., Takeda, S. and Shigemoto, K.
Cell Death Differ. 2018 Aug 28, [epub ahead of print]

Drug Discovery
Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice
Hubbard, W. B., Harwood, C. L., Geisler, J. G., Vekaria, H. J. and Sullivan, P. G.
J Neurosci Res. 2018 Oct 01, 96 (10):1677-1688.

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
Battista, C., Yang, K., Stahl, S. H., Mettetal, J. T., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Toxicol Sci. 2018 Nov 1, 166 (1):123-130.

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., Williams, D. P., Kevin Park, B. and Chadwick, A. E.
Toxicol In Vitro. 2018 Dec 01, 53:136-147.

Impact of Mitochondrion-Targeting Group on the Reactivity and Cytostatic Pathway of Platinum(IV) Complexes
Jin, S., Hao, Y., Zhu, Z., Muhammad, N., Zhang, Z., Wang, K., Guo, Y., Guo, Z. and Wang, X.
Inorg Chem. 2018 Sep 4, 57 (17):11135-11145.

APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells
Jacobsen, K. M., Villadsen, N. L., Torring, T., Nielsen, C. B., Salomon, T., Nielsen, M. M., Tsakos, M., Sibbersen, C., Scavenius, C., Nielsen, R., Christensen, E. I., Guerra, P. F., Bross, P., Pedersen, J. S., Enghild, J. J., Johannsen, M., Frokiaer, J., Overgaard, J., Horsman, M. R., Busk, M. and Poulsen, T. B.
Cell Chem Biol. 2018 Nov 15, 25 (11):1337-1349 e12.

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
Sollberger, G., Choidas, A., Burn, G. L., Habenberger, P., Di Lucrezia, R., Kordes, S., Menninger, S., Eickhoff, J., Nussbaumer, P., Klebl, B., Kruger, R., Herzig, A. and Zychlinsky, A.
Sci Immunol. 2018 Aug 24, 3 (26).

Food and Nutritional Research
The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency
Bocca, C., Kane, M. S., Veyrat-Durebex, C., Chupin, S., Alban, J., Kouassi Nzoughet, J., Le Mao, M., Chao de la Barca, J. M., Amati-Bonneau, P., Bonneau, D., Procaccio, V., Lenaers, G., Simard, G., Chevrollier, A. and Reynier, P.
Sci Rep. 2018 Aug 1, 8 (1):11528.

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
Lee, M. S., Han, H. J., Han, S. Y., Kim, I. Y., Chae, S., Lee, C. S., Kim, S. E., Yoon, S. G., Park, J. W., Kim, J. H., Shin, S., Jeong, M., Ko, A., Lee, H. Y., Oh, K. J., Lee, Y. H., Bae, K. H., Koo, S. H., Kim, J. W., Seong, J. K., Hwang, D. and Song, J.
Nat Commun. 2018 Aug 24, 9 (1):3404.

Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans
Hibshman, J. D., Leuthner, T. C., Shoben, C., Mello, D. F., Sherwood, D. R., Meyer, J. N. and Baugh, L. R.
Am J Physiol Cell Physiol. 2018 Aug 22, [epub ahead of print]

Hepatobiology Research
Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
Battista, C., Yang, K., Stahl, S. H., Mettetal, J. T., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Toxicol Sci. 2018 Nov 1, 166 (1):123-130.

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., Williams, D. P., Kevin Park, B. and Chadwick, A. E.
Toxicol In Vitro. 2018 Dec 01, 53:136-147.

Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1
Li, A., Liu, Q., Li, Q., Liu, B., Yang, Y. and Zhang, N.
EBioMedicine. 2018 Aug 01, 34:243-255.

Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARgamma
Higgins, C. B., Zhang, Y., Mayer, A. L., Fujiwara, H., Stothard, A. I., Graham, M. J., Swarts, B. M. and DeBosch, B. J.
JCI Insight. 2018 Aug 23, 3 (16).

Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling
Cox, C. S., McKay, S. E., Holmbeck, M. A., Christian, B. E., Scortea, A. C., Tsay, A. J., Newman, L. E. and Shadel, G. S.
Cell Metab. 2018 Nov 6, 28 (5):776-786 e5.

Ethanol and C2 ceramide activate fatty acid oxidation in human hepatoma cells
Correnti, J. M., Gottshall, L., Lin, A., Williams, B., Oranu, A., Beck, J., Chen, J., Bennett, M. J. and Carr, R. M.
Sci Rep. 2018 Aug 27, 8 (1):12923.

Immunology Research
Cutting Edge: Glycolytic Metabolism and Mitochondrial Metabolism Are Uncoupled in Antigen-Activated CD8(+) Recent Thymic Emigrants
Cunningham, C. A., Hoppins, S. and Fink, P. J.
J Immunol. 2018 Sep 15, 201 (6):1627-1632.

AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47(phox) Phosphorylation by PP2A
Bhat, S. A., Sood, A., Shukla, R. and Hanif, K.
Mol Neurobiol. 2018 Aug 3, [epub ahead of print]

Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity
Liebmann, M., Hucke, S., Koch, K., Eschborn, M., Ghelman, J., Chasan, A. I., Glander, S., Schadlich, M., Kuhlencord, M., Daber, N. M., Eveslage, M., Beyer, M., Dietrich, M., Albrecht, P., Stoll, M., Busch, K. B., Wiendl, H., Roth, J., Kuhlmann, T. and Klotz, L.
Proc Natl Acad Sci U S A. 2018 Aug 21, 115 (34):E8017-E8026.

Inflammation stimulates hypoxia-inducible factor-1alpha regulatory activity in 3T3-L1 adipocytes with conditioned medium from lipopolysaccharide-activated RAW 264.7 macrophages
Lopez-Pascual, A., Lorente-Cebrian, S., Moreno-Aliaga, M. J., Martinez, J. A. and Gonzalez-Muniesa, P.
J Cell Physiol. 2018 Jan 01, 234 (1):550-560.

Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia
Jalali, S., Price-Troska, T., Paludo, J., Villasboas, J., Kim, H. J., Yang, Z. Z., Novak, A. J. and Ansell, S. M.
Blood Adv. 2018 Aug 14, 2 (15):1985-1997.

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways
Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R. I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J. D., Klaeyle, L., Langa, X., Beckmann, C. C. A., Wlodarski, M. W., Muller, P., Van Essen, D., Rambold, A., Kapp, F. G., Mione, M., Buescher, J. M., Pearce, E. L., Polyzos, A. and Trompouki, E.
Nat Commun. 2018 Aug 6, 9 (1):3090.

PINK1 and PARK2 Suppress Pancreatic Tumorigenesis through Control of Mitochondrial Iron-Mediated Immunometabolism
Li, C., Zhang, Y., Cheng, X., Yuan, H., Zhu, S., Liu, J., Wen, Q., Xie, Y., Liu, J., Kroemer, G., Klionsky, D. J., Lotze, M. T., Zeh, H. J., Kang, R. and Tang, D.
Dev Cell. 2018 Aug 20, 46 (4):441-455 e8.

Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry
Sowton, A. P., Millington-Burgess, S. L., Murray, A. J. and Harper, M. T.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2721-2727.

DUSP6 mediates T cell receptor-engaged glycolysis and restrains TFH cell differentiation
Hsu, W. C., Chen, M. Y., Hsu, S. C., Huang, L. R., Kao, C. Y., Cheng, W. H., Pan, C. H., Wu, M. S., Yu, G. Y., Hung, M. S., Leu, C. M., Tan, T. H. and Su, Y. W.
Proc Natl Acad Sci U S A. 2018 Aug 21, 115 (34):E8027-E8036.

BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation
Deason, K., Troutman, T. D., Jain, A., Challa, D. K., Mandraju, R., Brewer, T., Ward, E. S. and Pasare, C.
J Exp Med. 2018 Sep 3, 215 (9):2413-2428.

ARID5B regulates metabolic programming in human adaptive NK cells
Cichocki, F., Wu, C. Y., Zhang, B., Felices, M., Tesi, B., Tuininga, K., Dougherty, P., Taras, E., Hinderlie, P., Blazar, B. R., Bryceson, Y. T. and Miller, J. S.
J Exp Med. 2018 Sep 3, 215 (9):2379-2395.

Education-dependent activation of glycolysis promotes the cytolytic potency of licensed human natural killer cells
Schafer, J. R., Salzillo, T. C., Chakravarti, N., Kararoudi, M. N., Trikha, P., Foltz, J. A., Wang, R., Li, S. and Lee, D. A.
J Allergy Clin Immunol. 2018 Aug 7, [epub ahead of print]

Macrophages from The Upper and Lower Human Respiratory Tract Are Metabolically Distinct
Lavrich, K. S., Speen, A. M., Ghio, A. J., Bromberg, P. A., Samet, J. M. and Alexis, N. E.
Am J Physiol Lung Cell Mol Physiol. 2018 Aug 9, [epub ahead of print]

The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation
Suzuki, J., Yamada, T., Inoue, K., Nabe, S., Kuwahara, M., Takemori, N., Takemori, A., Matsuda, S., Kanoh, M., Imai, Y., Yasukawa, M. and Yamashita, M.
Nat Commun. 2018 Aug 17, 9 (1):3296.

KPNA2 promotes metabolic reprogramming in glioblastomas by regulation of c-myc
Li, J., Liu, Q., Liu, Z., Xia, Q., Zhang, Z., Zhang, R., Gao, T., Gu, G., Wang, Y., Wang, D., Chen, X., Yang, Y., He, D. and Xin, T.
J Exp Clin Cancer Res. 2018 Aug 16, 37 (1):194.

Hexokinase 2 is dispensable for T cell-dependent immunity
Mehta, M. M., Weinberg, S. E., Steinert, E. M., Chhiba, K., Martinez, C. A., Gao, P., Perlman, H. R., Bryce, P., Hay, N. and Chandel, N. S.
Cancer Metab. 2018 Aug 17, 6:10.

Dichloroacetate, an inhibitor of pyruvate dehydrogenase kinases, inhibits platelet aggregation and arterial thrombosis
Nayak, M. K., Dhanesha, N., Doddapattar, P., Rodriguez, O., Sonkar, V. K., Dayal, S. and Chauhan, A. K.
Blood Adv. 2018 Aug 14, 2 (15):2029-2038.

The vimentin intermediate filament network restrains regulatory T cell suppression of graft-versus-host disease
McDonald-Hyman, C., Muller, J. T., Loschi, M., Thangavelu, G., Saha, A., Kumari, S., Reichenbach, D. K., Smith, M. J., Zhang, G., Koehn, B. H., Lin, J., Mitchell, J. S., Fife, B. T., Panoskaltsis-Mortari, A., Feser, C. J., Kirchmeier, A. K., Osborn, M. J., Hippen, K. L., Kelekar, A., Serody, J. S., Turka, L. A., Munn, D. H., Chi, H., Neubert, T. A., Dustin, M. L. and Blazar, B. R.
J Clin Invest. 2018 Oct 1, 128 (10):4604-4621.

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function
Izquierdo, H. M., Brandi, P., Gomez, M. J., Conde-Garrosa, R., Priego, E., Enamorado, M., Martinez-Cano, S., Sanchez, I., Conejero, L., Jimenez-Carretero, D., Martin-Puig, S., Guilliams, M. and Sancho, D.
Cell Rep. 2018 Aug 14, 24 (7):1738-1746.

The activation of lactate dehydrogenase induced by mTOR drives neoplastic change in breast epithelial cells
Manerba, M., Di Ianni, L., Govoni, M., Comparone, A. and Di Stefano, G.
PLoS One. 2018 Aug 23, 13 (8):e0202588.

Mitochondrial reprogramming via ATP5H loss promotes multimodal cancer therapy resistance
Song, K. H., Kim, J. H., Lee, Y. H., Bae, H. C., Lee, H. J., Woo, S. R., Oh, S. J., Lee, K. M., Yee, C., Kim, B. W., Cho, H., Chung, E. J., Chung, J. Y., Hewitt, S. M., Chung, T. W., Ha, K. T., Bae, Y. K., Mao, C. P., Yang, A., Wu, T. C. and Kim, T. W.
J Clin Invest. 2018 Aug 31, 128 (9):4098-4114.

Effects of cobalt and chromium ions on oxidative stress and energy metabolism in macrophages in vitro
Salloum, Z., Lehoux, E. A., Harper, M. E. and Catelas, I.
J Orthop Res. 2018 Aug 25, [epub ahead of print]

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
Tilstra, J. S., Avery, L., Menk, A. V., Gordon, R. A., Smita, S., Kane, L. P., Chikina, M., Delgoffe, G. M. and Shlomchik, M. J.
J Clin Invest. 2018 Nov 1, 128 (11):4884-4897.

TMEM41B is a novel regulator of autophagy and lipid mobilization
Moretti, F., Bergman, P., Dodgson, S., Marcellin, D., Claerr, I., Goodwin, J. M., DeJesus, R., Kang, Z., Antczak, C., Begue, D., Bonenfant, D., Graff, A., Genoud, C., Reece-Hoyes, J. S., Russ, C., Yang, Z., Hoffman, G. R., Mueller, M., Murphy, L. O., Xavier, R. J. and Nyfeler, B.
EMBO Rep. 2018 Sep 01, 19 (9).

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
Koenis, D. S., Medzikovic, L., van Loenen, P. B., van Weeghel, M., Huveneers, S., Vos, M., Evers-van Gogh, I. J., Van den Bossche, J., Speijer, D., Kim, Y., Wessels, L., Zelcer, N., Zwart, W., Kalkhoven, E. and de Vries, C. J.
Cell Rep. 2018 Aug 21, 24 (8):2127-2140 e7.

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy
Xu, J., Potter, M., Tomas, C., Elson, J. L., Morten, K. J., Poulton, J., Wang, N., Jin, H., Hou, Z. and Huang, W. E.
Analyst. 2018 Sep 12, [epub ahead of print]

Glucose metabolism and metabolic flexibility in blood platelets
Aibibula, M., Naseem, K. M. and Sturmey, R. G.
J Thromb Haemost. 2018 Nov 01, 16 (11):2300-2314.

Gasdermin D plays a vital role in the generation of neutrophil extracellular traps
Sollberger, G., Choidas, A., Burn, G. L., Habenberger, P., Di Lucrezia, R., Kordes, S., Menninger, S., Eickhoff, J., Nussbaumer, P., Klebl, B., Kruger, R., Herzig, A. and Zychlinsky, A.
Sci Immunol. 2018 Aug 24, 3 (26).

PPARgamma Deficiency Suppresses the Release of IL-1beta and IL-1alpha in Macrophages via a Type 1 IFN-Dependent Mechanism
Weber, K. J., Sauer, M., He, L., Tycksen, E., Kalugotla, G., Razani, B. and Schilling, J. D.
J Immunol. 2018 Oct 1, 201 (7):2054-2069.

miR-143 Regulates Memory T Cell Differentiation by Reprogramming T Cell Metabolism
Zhang, T., Zhang, Z., Li, F., Ping, Y., Qin, G., Zhang, C. and Zhang, Y.
J Immunol. 2018 Oct 1, 201 (7):2165-2175.

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1
Yang, K., Huang, R., Fujihira, H., Suzuki, T. and Yan, N.
J Exp Med. 2018 Oct 1, 215 (10):2600-2616.

Metabolic control of regulatory T cell stability and function by TRAF3IP3 at the lysosome
Yu, X., Teng, X. L., Wang, F., Zheng, Y., Qu, G., Zhou, Y., Hu, Z., Wu, Z., Chang, Y., Chen, L., Li, H. B., Su, B., Lu, L., Liu, Z., Sun, S. C. and Zou, Q.
J Exp Med. 2018 Sep 3, 215 (9):2463-2476.

Absence of hexose-6-phosphate dehydrogenase results in reduced overall glucose consumption but does not prevent 11beta-hydroxysteroid dehydrogenase-1-dependent glucocorticoid activation
Marbet, P., Klusonova, P., Birk, J., Kratschmar, D. V. and Odermatt, A.
FEBS J. 2018 Nov 01, 285 (21):3993-4004.

Mitochondrial Disease Research
Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy
Pacheu-Grau, D., Callegari, S., Emperador, S., Thompson, K., Aich, A., Topol, S. E., Spencer, E. G., McFarland, R., Ruiz-Pesini, E., Torkamani, A., Taylor, R. W., Montoya, J. and Rehling, P.
Hum Mol Genet. 2018 Dec 1, 27 (23):4135-4144.

Overexpression of human mitochondrial alanyl-tRNA synthetase suppresses biochemical defects of the mt-tRNA(Ala) mutation in cybrids
Zhao, X., Han, J., Zhu, L., Xiao, Y., Wang, C., Hong, F., Jiang, P. and Guan, M. X.
Int J Biol Sci. 2018 Aug 06, 14 (11):1437-1444.

Model Organisms
The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism
Hofherr, A., Seger, C., Fitzpatrick, F., Busch, T., Michel, E., Luan, J., Osterried, L., Linden, F., Kramer-Zucker, A., Wakimoto, B., Schutze, C., Wiedemann, N., Artati, A., Adamski, J., Walz, G., Kunji, E. R. S., Montell, C., Watnick, T. and Kottgen, M.
PLoS Biol. 2018 Aug 06, 16 (8):e2005651.

Non-selective autophagy reduces mitochondrial content during starvation in Caenorhabditis elegans
Hibshman, J. D., Leuthner, T. C., Shoben, C., Mello, D. F., Sherwood, D. R., Meyer, J. N. and Baugh, L. R.
Am J Physiol Cell Physiol. 2018 Aug 22, [epub ahead of print]

Nephrology Research
Podocyte-Specific Loss of Kruppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease
Horne, S. J., Vasquez, J. M., Guo, Y., Ly, V., Piret, S. E., Leonardo, A. R., Ling, J., Revelo, M. P., Bogenhagen, D., Yang, V. W., He, J. C. and Mallipattu, S. K.
Diabetes. 2018 Nov 01, 67 (11):2420-2433.

Kidney-infiltrating T cells in murine lupus nephritis are metabolically and functionally exhausted
Tilstra, J. S., Avery, L., Menk, A. V., Gordon, R. A., Smita, S., Kane, L. P., Chikina, M., Delgoffe, G. M. and Shlomchik, M. J.
J Clin Invest. 2018 Nov 1, 128 (11):4884-4897.

Neurobiology Research
The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency
Bocca, C., Kane, M. S., Veyrat-Durebex, C., Chupin, S., Alban, J., Kouassi Nzoughet, J., Le Mao, M., Chao de la Barca, J. M., Amati-Bonneau, P., Bonneau, D., Procaccio, V., Lenaers, G., Simard, G., Chevrollier, A. and Reynier, P.
Sci Rep. 2018 Aug 1, 8 (1):11528.

Mitochondrial uncoupling prodrug improves tissue sparing, cognitive outcome, and mitochondrial bioenergetics after traumatic brain injury in male mice
Hubbard, W. B., Harwood, C. L., Geisler, J. G., Vekaria, H. J. and Sullivan, P. G.
J Neurosci Res. 2018 Oct 01, 96 (10):1677-1688.

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling
Glass, H., Pal, A., Reinhardt, P., Sterneckert, J., Wegner, F., Storch, A. and Hermann, A.
Mol Cell Neurosci. 2018 Oct 01, 92:137-148.

AT2R Activation Prevents Microglia Pro-inflammatory Activation in a NOX-Dependent Manner: Inhibition of PKC Activation and p47(phox) Phosphorylation by PP2A
Bhat, S. A., Sood, A., Shukla, R. and Hanif, K.
Mol Neurobiol. 2018 Aug 3, [epub ahead of print]

Deciphering OPA1 mutations pathogenicity by combined analysis of human, mouse and yeast cell models
Del Dotto, V., Fogazza, M., Musiani, F., Maresca, A., Aleo, S. J., Caporali, L., La Morgia, C., Nolli, C., Lodi, T., Goffrini, P., Chan, D., Carelli, V., Rugolo, M., Baruffini, E. and Zanna, C.
Biochim Biophys Acta Mol Basis Dis. 2018 Oct 01, 1864 (10):3496-3514.

Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease
Bermudez, M. L., Skelton, M. R. and Genter, M. B.
Mol Genet Metab. 2018 Nov 01, 125 (3):305-313.

AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission
Flippo, K. H., Gnanasekaran, A., Perkins, G. A., Ajmal, A., Merrill, R. A., Dickey, A. S., Taylor, S. S., McKnight, G. S., Chauhan, A. K., Usachev, Y. M. and Strack, S.
J Neurosci. 2018 Sep 19, 38 (38):8233-8242.

Nicotine and electronic cigarette (E-Cig) exposure decreases brain glucose utilization in ischemic stroke
Sifat, A. E., Vaidya, B., Kaisar, M. A., Cucullo, L. and Abbruscato, T. J.
J Neurochem. 2018 Oct 01, 147 (2):204-221.

Optineurin E50K triggers BDNF deficiency-mediated mitochondrial dysfunction in retinal photoreceptor cell line
Shim, M. S., Kim, K. Y., Noh, M., Ko, J. Y., Ahn, S., An, M. A., Iwata, T., Perkins, G. A., Weinreb, R. N. and Ju, W. K.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2690-2697.

ING5-mediated antineuroblastoma effects of suberoylanilide hydroxamic acid
Wu, J. C., Jiang, H. M., Yang, X. H. and Zheng, H. C.
Cancer Med. 2018 Sep 01, 7 (9):4554-4569.

Heptanoate is neuroprotective in vitro but triheptanoin post-treatment did not protect against middle cerebral artery occlusion in rats
Tan, K. N., Hood, R., Warren, K., Pepperall, D., Carrasco-Pozo, C., Manzanero, S., Borges, K. and Spratt, N. J.
Neurosci Lett. 2018 Sep 14, 683:207-214.

A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice
Sure, V. N., Sakamuri, S., Sperling, J. A., Evans, W. R., Merdzo, I., Mostany, R., Murfee, W. L., Busija, D. W. and Katakam, P. V. G.
Geroscience. 2018 Aug 01, 40 (4):365-375.

Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy
Pacheu-Grau, D., Callegari, S., Emperador, S., Thompson, K., Aich, A., Topol, S. E., Spencer, E. G., McFarland, R., Ruiz-Pesini, E., Torkamani, A., Taylor, R. W., Montoya, J. and Rehling, P.
Hum Mol Genet. 2018 Dec 1, 27 (23):4135-4144.

Monitoring of glutamate-induced excitotoxicity by mitochondrial oxygen consumption
Kumagai, A., Sasaki, T., Matsuoka, K., Abe, M., Tabata, T., Itoh, Y., Fuchino, H., Wugangerile, S., Suga, M., Yamaguchi, T., Kawahara, H., Nagaoka, Y., Kawabata, K., Furue, M. K. and Takemori, H.
Synapse. 2019 Jan 01, 73 (1):e22067.

Primary fibroblast co-culture stimulates growth and metabolism in Sdhb-impaired mouse pheochromocytoma MTT cells
Richter, S., D'Antongiovanni, V., Martinelli, S., Bechmann, N., Riverso, M., Poitz, D. M., Pacak, K., Eisenhofer, G., Mannelli, M. and Rapizzi, E.
Cell Tissue Res. 2018 Dec 01, 374 (3):473-485.

Obesity, Diabetes, & Metabolic Disorders
Berberine Reduces Pyruvate-driven Hepatic Glucose Production by Limiting Mitochondrial Import of Pyruvate through Mitochondrial Pyruvate Carrier 1
Li, A., Liu, Q., Li, Q., Liu, B., Yang, Y. and Zhang, N.
EBioMedicine. 2018 Aug 01, 34:243-255.

Inflammation stimulates hypoxia-inducible factor-1alpha regulatory activity in 3T3-L1 adipocytes with conditioned medium from lipopolysaccharide-activated RAW 264.7 macrophages
Lopez-Pascual, A., Lorente-Cebrian, S., Moreno-Aliaga, M. J., Martinez, J. A. and Gonzalez-Muniesa, P.
J Cell Physiol. 2018 Jan 01, 234 (1):550-560.

RBM4a modulates the impact of PRDM16 on development of brown adipocytes through an alternative splicing mechanism
Chi, Y. L. and Lin, J. C.
Biochim Biophys Acta Mol Cell Res. 2018 Nov, 1865 (11 Pt A):1515-1525

Seipin regulates lipid homeostasis by ensuring calcium-dependent mitochondrial metabolism
Ding, L., Yang, X., Tian, H., Liang, J., Zhang, F., Wang, G., Wang, Y., Ding, M., Shui, G. and Huang, X.
EMBO J. 2018 Sep 3, 37 (17) .

JMJD2B/KDM4B inactivation in adipose tissues accelerates obesity and systemic metabolic abnormalities
Kang, C., Saso, K., Ota, K., Kawazu, M., Ueda, T. and Okada, H.
Genes Cells. 2018 Sep 01, 23 (9):767-777.

Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin
Kong, X., Yao, T., Zhou, P., Kazak, L., Tenen, D., Lyubetskaya, A., Dawes, B. A., Tsai, L., Kahn, B. B., Spiegelman, B. M., Liu, T. and Rosen, E. D.
Cell Metab. 2018 Oct 2, 28 (4):631-643 e3.

Podocyte-Specific Loss of Kruppel-Like Factor 6 Increases Mitochondrial Injury in Diabetic Kidney Disease
Horne, S. J., Vasquez, J. M., Guo, Y., Ly, V., Piret, S. E., Leonardo, A. R., Ling, J., Revelo, M. P., Bogenhagen, D., Yang, V. W., He, J. C. and Mallipattu, S. K.
Diabetes. 2018 Nov 01, 67 (11):2420-2433.

RPS3A positively regulates the mitochondrial function of human periaortic adipose tissue and is associated with coronary artery diseases
Tang, Y., He, Y., Li, C., Mu, W., Zou, Y., Liu, C., Qian, S., Zhang, F., Pan, J., Wang, Y., Huang, H., Pan, D., Yang, P., Mei, J., Zeng, R. and Tang, Q. Q.
Cell Discov. 2018 Aug 21, 4:52.

Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation
Lee, M. S., Han, H. J., Han, S. Y., Kim, I. Y., Chae, S., Lee, C. S., Kim, S. E., Yoon, S. G., Park, J. W., Kim, J. H., Shin, S., Jeong, M., Ko, A., Lee, H. Y., Oh, K. J., Lee, Y. H., Bae, K. H., Koo, S. H., Kim, J. W., Seong, J. K., Hwang, D. and Song, J.
Nat Commun. 2018 Aug 24, 9 (1):3404.

Hepatocyte ALOXE3 is induced during adaptive fasting and enhances insulin sensitivity by activating hepatic PPARgamma
Higgins, C. B., Zhang, Y., Mayer, A. L., Fujiwara, H., Stothard, A. I., Graham, M. J., Swarts, B. M. and DeBosch, B. J.
JCI Insight. 2018 Aug 23, 3 (16).

PPARgamma Deficiency Suppresses the Release of IL-1beta and IL-1alpha in Macrophages via a Type 1 IFN-Dependent Mechanism
Weber, K. J., Sauer, M., He, L., Tycksen, E., Kalugotla, G., Razani, B. and Schilling, J. D.
J Immunol. 2018 Oct 1, 201 (7):2054-2069.

Berberine promotes glucose uptake and inhibits gluconeogenesis by inhibiting deacetylase SIRT3
Zhang, B., Pan, Y., Xu, L., Tang, D., Dorfman, R. G., Zhou, Q., Yin, Y., Li, Y., Zhou, L., Zhao, S., Zou, X., Wang, L. and Zhang, M.
Endocrine. 2018 Dec 01, 62 (3):576-587.

PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice
Song, N. J., Chang, S. H., Kim, S., Panic, V., Jang, B. H., Yun, U. J., Choi, J. H., Li, Z., Park, K. M., Yoon, J. H., Kim, S., Yoo, J. H., Ling, J., Thomas, K., Villanueva, C. J., Li, D. Y., Ahn, J. Y., Ku, J. M. and Park, K. W.
Cell Death Dis. 2018 Aug 29, 9 (9):876.

Stem Cell Biology
Isocitrate dehydrogenase 2 deficiency induces endothelial inflammation via p66sh-mediated mitochondrial oxidative stress
Choi, S. J., Piao, S., Nagar, H., Jung, S. B., Kim, S., Lee, I., Kim, S. M., Song, H. J., Shin, N., Kim, D. W., Irani, K., Jeon, B. H., Park, J. W. and Kim, C. S.
Biochem Biophys Res Commun. 2018 Sep 10, 503 (3):1805-1811.

The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism
Hofherr, A., Seger, C., Fitzpatrick, F., Busch, T., Michel, E., Luan, J., Osterried, L., Linden, F., Kramer-Zucker, A., Wakimoto, B., Schutze, C., Wiedemann, N., Artati, A., Adamski, J., Walz, G., Kunji, E. R. S., Montell, C., Watnick, T. and Kottgen, M.
PLoS Biol. 2018 Aug 06, 16 (8):e2005651.

The Metabolomic Bioenergetic Signature of Opa1-Disrupted Mouse Embryonic Fibroblasts Highlights Aspartate Deficiency
Bocca, C., Kane, M. S., Veyrat-Durebex, C., Chupin, S., Alban, J., Kouassi Nzoughet, J., Le Mao, M., Chao de la Barca, J. M., Amati-Bonneau, P., Bonneau, D., Procaccio, V., Lenaers, G., Simard, G., Chevrollier, A. and Reynier, P.
Sci Rep. 2018 Aug 1, 8 (1):11528.

Defective mitochondrial and lysosomal trafficking in chorea-acanthocytosis is independent of Src-kinase signaling
Glass, H., Pal, A., Reinhardt, P., Sterneckert, J., Wegner, F., Storch, A. and Hermann, A.
Mol Cell Neurosci. 2018 Oct 01, 92:137-148.

New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women
Min, Z., Gao, Q., Zhen, X., Fan, Y., Tan, T., Li, R., Zhao, Y. and Yu, Y.
Stem Cell Res Ther. 2018 Aug 9, 9 (1):210.

Expansion capacity of human muscle progenitor cells differs by age, sex, and metabolic fuel preference
Riddle, E. S., Bender, E. L. and Thalacker-Mercer, A. E.
Am J Physiol Cell Physiol. 2018 Aug 15, [eub ahead od print]

Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes
Ramachandra, C. J. A., Mehta, A., Wong, P., Ja, K., Fritsche-Danielson, R., Bhat, R. V., Hausenloy, D. J., Kovalik, J. P. and Shim, W.
Int J Cardiol. 2018 Dec 1, 272:288-297.

Mitohormesis in Mice via Sustained Basal Activation of Mitochondrial and Antioxidant Signaling
Cox, C. S., McKay, S. E., Holmbeck, M. A., Christian, B. E., Scortea, A. C., Tsay, A. J., Newman, L. E. and Shadel, G. S.
Cell Metab. 2018 Nov 6, 28 (5):776-786 e5.

Monitoring of glutamate-induced excitotoxicity by mitochondrial oxygen consumption
Kumagai, A., Sasaki, T., Matsuoka, K., Abe, M., Tabata, T., Itoh, Y., Fuchino, H., Wugangerile, S., Suga, M., Yamaguchi, T., Kawahara, H., Nagaoka, Y., Kawabata, K., Furue, M. K. and Takemori, H.
Synapse. 2019 Jan 01, 73 (1):e22067.

FOXD1-dependent MICU1 expression regulates mitochondrial activity and cell differentiation
Shanmughapriya, S., Tomar, D., Dong, Z., Slovik, K. J., Nemani, N., Natarajaseenivasan, K., Carvalho, E., Lu, C., Corrigan, K., Garikipati, V. N. S., Ibetti, J., Rajan, S., Barrero, C., Chuprun, K., Kishore, R., Merali, S., Tian, Y., Yang, W. and Madesh, M.
Nat Commun. 2018 Aug 29, 9 (1):3449.

Tbx1 regulates inherited metabolic and myogenic abilities of progenitor cells derived from slow- and fast-type muscle
Motohashi, N., Uezumi, A., Asakura, A., Ikemoto-Uezumi, M., Mori, S., Mizunoe, Y., Takashima, R., Miyagoe-Suzuki, Y., Takeda, S. and Shigemoto, K.
Cell Death Differ. 2018 Aug 28, [epub ahead of print]

Active mitochondria support osteogenic differentiation by stimulating beta-catenin acetylation
Shares, B. H., Busch, M., White, N., Shum, L. and Eliseev, R. A.
J Biol Chem. 2018 Oct 12, 293 (41):16019-16027.

The landscape of mitochondrial small non-coding RNAs in the PGCs of male mice, spermatogonia, gametes and in zygotes
Larriba, E., Rial, E. and Del Mazo, J.
BMC Genomics. 2018 Aug 28, 19 (1):634.

Techniques & Methods
The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., Williams, D. P., Kevin Park, B. and Chadwick, A. E.
Toxicol In Vitro. 2018 Dec 01, 53:136-147.

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum
Steenbergen, R., Oti, M., Ter Horst, R., Tat, W., Neufeldt, C., Belovodskiy, A., Chua, T. T., Cho, W. J., Joyce, M., Dutilh, B. E. and Tyrrell, D. L.
Sci Rep. 2018 Aug 3, 8 (1):11685.

Rapid kinetics of changes in oxygen consumption rate in thrombin-stimulated platelets measured by high-resolution respirometry
Sowton, A. P., Millington-Burgess, S. L., Murray, A. J. and Harper, M. T.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2721-2727.

A novel high-throughput assay for respiration in isolated brain microvessels reveals impaired mitochondrial function in the aged mice
Sure, V. N., Sakamuri, S., Sperling, J. A., Evans, W. R., Merdzo, I., Mostany, R., Murfee, W. L., Busija, D. W. and Katakam, P. V. G.
Geroscience. 2018 Aug 01, 40 (4):365-375.

A new approach to find biomarkers in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) by single-cell Raman micro-spectroscopy
Xu, J., Potter, M., Tomas, C., Elson, J. L., Morten, K. J., Poulton, J., Wang, N., Jin, H., Hou, Z. and Huang, W. E.
Analyst. 2018 Sep 12, [epub ahead of print]

Toxicology Research
Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
Battista, C., Yang, K., Stahl, S. H., Mettetal, J. T., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Toxicol Sci. 2018 Nov 1, 166 (1):123-130.

The utility of HepaRG cells for bioenergetic investigation and detection of drug-induced mitochondrial toxicity
Kamalian, L., Douglas, O., Jolly, C. E., Snoeys, J., Simic, D., Monshouwer, M., Williams, D. P., Kevin Park, B. and Chadwick, A. E.
Toxicol In Vitro. 2018 Dec 01, 53:136-147.

Nicotine and electronic cigarette (E-Cig) exposure decreases brain glucose utilization in ischemic stroke
Sifat, A. E., Vaidya, B., Kaisar, M. A., Cucullo, L. and Abbruscato, T. J.
J Neurochem. 2018 Oct 01, 147 (2):204-221.

Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines
Mastrangelopoulou, M., Grigalavicius, M., Berg, K., Menard, M. and Theodossiou, T. A.
Photochem Photobiol. 2018 Aug 14, [epub ahead of print]

Effects of cobalt and chromium ions on oxidative stress and energy metabolism in macrophages in vitro
Salloum, Z., Lehoux, E. A., Harper, M. E. and Catelas, I.
J Orthop Res. 2018 Aug 25, [epub ahead of print]

Cigarette Smoke Toxins-Induced Mitochondrial Dysfunction and Pancreatitis Involves Aryl Hydrocarbon Receptor Mediated Cyp1 Gene Expression: Protective Effects of Resveratrol
Ghosh, J., Chowdhury, A. R., Srinivasan, S., Chattopadhyay, M., Bose, M., Bhattacharya, S., Raza, H., Fuchs, S. Y., Rustgi, A. K., Gonzalez, F. J. and Avadhani, N. G.
Toxicol Sci. 2018 Dec 1, 166 (2):428-440.

Translational Research
Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
Battista, C., Yang, K., Stahl, S. H., Mettetal, J. T., Watkins, P. B., Siler, S. Q. and Howell, B. A.
Toxicol Sci. 2018 Nov 1, 166 (1):123-130.

Characterization of the breast cancer resistance protein (BCRP/ABCG2) in clear cell renal cell carcinoma
Reustle, A., Fisel, P., Renner, O., Buttner, F., Winter, S., Rausch, S., Kruck, S., Nies, A. T., Hennenlotter, J., Scharpf, M., Fend, F., Stenzl, A., Bedke, J., Schwab, M. and Schaeffeler, E.
Int J Cancer. 2018 Dec 15, 143 (12):3181-3193.

New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women
Min, Z., Gao, Q., Zhen, X., Fan, Y., Tan, T., Li, R., Zhao, Y. and Yu, Y.
Stem Cell Res Ther. 2018 Aug 9, 9 (1):210.

Mutations of the mitochondrial carrier translocase channel subunit TIM22 cause early-onset mitochondrial myopathy
Pacheu-Grau, D., Callegari, S., Emperador, S., Thompson, K., Aich, A., Topol, S. E., Spencer, E. G., McFarland, R., Ruiz-Pesini, E., Torkamani, A., Taylor, R. W., Montoya, J. and Rehling, P.
Hum Mol Genet. 2018 Dec 1, 27 (23):4135-4144.

For Research Use Only. Not for use in diagnostic procedures.