XF出版物快报

2018年11

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Aging Research
Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy
Manzella, N., Santin, Y., Maggiorani, D., Martini, H., Douin-Echinard, V., Passos, J. F., Lezoualc'h, F., Binda, C., Parini, A. and Mialet-Perez, J.
Aging Cell. 2018 Oct 01, 17 (5):e12811.

Proteomics reveals Rictor as a noncanonical TGF-beta signaling target during aneurysm progression in Marfan mice
Parker, S. J., Stotland, A., MacFarlane, E., Wilson, N., Orosco, A., Venkatraman, V., Madrid, K., Gottlieb, R., Dietz, H. C. and Van Eyk, J. E.
Am J Physiol Heart Circ Physiol. 2018 Nov 1, 315 (5):H1112-H1126.

Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span
Sessions, A. O., Min, P., Cordes, T., Weickert, B. J., Divakaruni, A. S., Murphy, A. N., Metallo, C. M. and Engler, A. J.
APL Bioeng. 2018 Sep 01, 2 (3).

Cancer Research
Four Key Steps Control Glycolytic Flux in Mammalian Cells
Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E. and Rabinowitz, J. D.
Cell Syst. 2018 Jul 25, 7 (1):49-62 e8.

Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
Daemen, A., Liu, B., Song, K., Kwong, M., Gao, M., Hong, R., Nannini, M., Peterson, D., Liederer, B. M., de la Cruz, C., Sangaraju, D., Jaochico, A., Zhao, X., Sandoval, W., Hunsaker, T., Firestein, R., Latham, S., Sampath, D., Evangelista, M. and Hatzivassiliou, G.
Cell Metab. 2018 Sep 4, 28 (3):383-399 e9.

Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity
Carlisle, S. M., Trainor, P. J., Doll, M. A., Stepp, M. W., Klinge, C. M. and Hein, D. W.
Mol Carcinog. 2018 Nov 01, 57 (11):1458-1466.

ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells
Xu, Y., Gao, W., Zhang, Y., Wu, S., Liu, Y., Deng, X., Xie, L., Yang, J., Yu, H., Su, J. and Sun, L.
Int J Oncol. 2018 Sep 01, 53 (3):1055-1068.

Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI
Lam, W. W., Oakden, W., Murray, L., Klein, J., Iorio, C., Screaton, R. A., Koletar, M. M., Chu, W., Liu, S. K. and Stanisz, G. J.
Sci Rep. 2018 Jul 11, 8 (1):10447.

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
Xu, S., Catapang, A., Braas, D., Stiles, L., Doh, H. M., Lee, J. T., Graeber, T. G., Damoiseaux, R., Shirihai, O. and Herschman, H. R.
Cancer Metab. 2018 Jun 28, 6:7.

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
Wong, K. S., Mabanglo, M. F., Seraphim, T. V., Mollica, A., Mao, Y. Q., Rizzolo, K., Leung, E., Moutaoufik, M. T., Hoell, L., Phanse, S., Goodreid, J., Barbosa, L. R. S., Ramos, C. H. I., Babu, M., Mennella, V., Batey, R. A., Schimmer, A. D. and Houry, W. A.
Cell Chem Biol. 2018 Aug 16, 25 (8):1017-1030 e9.

A Caspase-3 Reporter for Fluorescence Lifetime Imaging of Single-Cell Apoptosis
Buschhaus, J., Humphries, B., Luker, K. and Luker, G.
Cells. 2018 Jun 01, 7 (6):57.

The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer
Fuhr, L., El-Athman, R., Scrima, R., Cela, O., Carbone, A., Knoop, H., Li, Y., Hoffmann, K., Laukkanen, M. O., Corcione, F., Steuer, R., Meyer, T. F., Mazzoccoli, G., Capitanio, N. and Relogio, A.
EBioMedicine. 2018 Jul 01, 33:105-121.

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
Onodera, Y., Nam, J. M., Horikawa, M., Shirato, H. and Sabe, H.
Nat Commun. 2018 Jul 11, 9 (1):2682.

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Bunse, L., Pusch, S., Bunse, T., Sahm, F., Sanghvi, K., Friedrich, M., Alansary, D., Sonner, J. K., Green, E., Deumelandt, K., Kilian, M., Neftel, C., Uhlig, S., Kessler, T., von Landenberg, A., Berghoff, A. S., Marsh, K., Steadman, M., Zhu, D., Nicolay, B., Wiestler, B., Breckwoldt, M. O., Al-Ali, R., Karcher-Bausch, S., Bozza, M., Oezen, I., Kramer, M., Meyer, J., Habel, A., Eisel, J., Poschet, G., Weller, M., Preusser, M., Nadji-Ohl, M., Thon, N., Burger, M. C., Harter, P. N., Ratliff, M., Harbottle, R., Benner, A., Schrimpf, D., Okun, J., Herold-Mende, C., Turcan, S., Kaulfuss, S., Hess-Stumpp, H., Bieback, K., Cahill, D. P., Plate, K. H., Hanggi, D., Dorsch, M., Suva, M. L., Niemeyer, B. A., von Deimling, A., Wick, W. and Platten, M.
Nat Med. 2018 Aug 01, 24 (8):1192-1203.

Effects of Tumor Microenvironmental Factors on DNA Methylation and Radiation Sensitivity in A549 Human Lung Adenocarcinoma
Oh, J.-M., Kim, Y.-E., Hong, B.-J., Bok, S., Jeon, S.-U., Lee, C.-J., Park, D.-Y., Kim, I. H., Kim, H. J. and Ahn, G. O.
Journal of Radiation Protection and Research. 2018 Nov 01, 43 (2):66-74

Targeting mitochondria by anthelmintic drug atovaquone sensitizes renal cell carcinoma to chemotherapy and immunotherapy
Chen, D., Sun, X., Zhang, X. and Cao, J.
J Biochem Mol Toxicol. 2018 Sep 01, 32 (9):e22195.

Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer
Eastlack, S. C., Dong, S., Ivan, C. and Alahari, S. K.
Mol Cancer. 2018 Jul 16, 17 (1):100.

Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia
Pin, F., Barreto, R., Kitase, Y., Mitra, S., Erne, C. E., Novinger, L. J., Zimmers, T. A., Couch, M. E., Bonewald, L. F. and Bonetto, A.
J Cachexia Sarcopenia Muscle. 2018 Aug 01, 9 (4):685-700.

Acetylation of PGC1alpha by histone deacetylase 1 downregulation is implicated in radiation-induced senescence of brain endothelial cells
Kim, S. B., Heo, J. I., Kim, H. and Kim, K. S.
J Gerontol A Biol Sci Med Sci. 2018 Jul 17, [epub ahead of print]

Wild-type IDH2 promotes the Warburg effect and tumor growth through HIF1alpha in lung cancer
Li, J., He, Y., Tan, Z., Lu, J., Li, L., Song, X., Shi, F., Xie, L., You, S., Luo, X., Li, N., Li, Y., Liu, X., Tang, M., Weng, X., Yi, W., Fan, J., Zhou, J., Qiang, G., Qiu, S., Wu, W., Bode, A. M. and Cao, Y.
Theranostics. 2018 Jul 16, 8 (15):4050-4061.

CPT1A-mediated fatty acid oxidation promotes colorectal cancer cell metastasis by inhibiting anoikis
Wang, Y. N., Zeng, Z. L., Lu, J., Wang, Y., Liu, Z. X., He, M. M., Zhao, Q., Wang, Z. X., Li, T., Lu, Y. X., Wu, Q. N., Yu, K., Wang, F., Pu, H. Y., Li, B., Jia, W. H., Shi, M., Xie, D., Kang, T. B., Huang, P., Ju, H. Q. and Xu, R. H.
Oncogene. 2018 Jul 11, [epub ahead of print]

Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells
Yang, K. M. and Kim, K.
J Cell Biochem. 2018 Nov 01, 119 (10):8501-8510.

Carnosine influences transcription via epigenetic regulation as demonstrated by enhanced histone acetylation of the pyruvate dehydrogenase kinase 4 promoter in glioblastoma cells
Oppermann, H., Alvanos, A., Seidel, C., Meixensberger, J. and Gaunitz, F.
Amino Acids. 2018 Jul 20, [epub ahead of print]

mTORC2 contributes to the metabolic reprogramming in EGFR tyrosine-kinase inhibitor resistant cells in non-small cell lung cancer
Chiang, C. T., Demetriou, A. N., Ung, N., Choudhury, N., Ghaffarian, K., Ruderman, D. L. and Mumenthaler, S. M.
Cancer Lett. 2018 Oct 10, 434:152-159.

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression
Cong, J., Wang, X., Zheng, X., Wang, D., Fu, B., Sun, R., Tian, Z. and Wei, H.
Cell Metab. 2018 Aug 7, 28 (2):243-255 e5.

Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability
Afrin, S., Giampieri, F., Forbes-Hernandez, T. Y., Gasparrini, M., Amici, A., Cianciosi, D., Quiles, J. L. and Battino, M.
Free Radic Biol Med. 2018 Oct 01, 126:41-54.

CAB39L elicited an anti-Warburg effect via a LKB1-AMPK-PGC1alpha axis to inhibit gastric tumorigenesis
Li, W., Wong, C. C., Zhang, X., Kang, W., Nakatsu, G., Zhao, Q., Chen, H., Go, M. Y. Y., Chiu, P. W. Y., Wang, X., Ji, J., Li, X., Cai, Z., Ng, E. K. W. and Yu, J.
Oncogene. 2018 Jul 27, [epub ahead of print]

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
Zhang, Y., Yu, G., Chu, H., Wang, X., Xiong, L., Cai, G., Liu, R., Gao, H., Tao, B., Li, W., Li, G., Liang, J. and Yang, W.
Mol Cell. 2018 Jul 19, 71 (2):201-215 e7.

Metabolic reprogramming in colon cancer reversed by DHTS through regulating PTEN/AKT/HIF1alpha mediated signal pathway
Wang, L., Yu, Z., Ren, S., Song, J., Wang, J. and Du, G.
Biochim Biophys Acta Gen Subj. 2018 Jul 20, 1862 (10):2281-2292.

Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors
Zhang, W., Hu, X., Zhou, W. and Tam, K. Y.
J Proteome Res. 2018 Sep 7, 17 (9):3012-3021.

Vnn1 pantetheinase limits the Warburg effect and sarcoma growth by rescuing mitochondrial activity
Giessner, C., Millet, V., Mostert, K. J., Gensollen, T., Vu Manh, T.-P., Garibal, M., Dieme, B., Attaf-Bouabdallah, N., Chasson, L., Brouilly, N., Laprie, C., Lesluyes, T., Blay, J. Y., Shintu, L., Martin, J. C., Strauss, E., Galland, F. and Naquet, P.
Life Science Alliance. 2018 Jul 23, [epub ahead of print]

Near-simultaneous quantification of glucose uptake, mitochondrial membrane potential, and vascular parameters in murine flank tumors using quantitative diffuse reflectance and fluorescence spectroscopy
Zhu, C., Martin, H. L., Crouch, B. T., Martinez, A. F., Li, M., Palmer, G. M., Dewhirst, M. W. and Ramanujam, N.
Biomed Opt Express. 2018 Jul 1, 9 (7):3399-3412.

Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines
Shimamura, M., Yamamoto, K., Kurashige, T. and Nagayama, Y.
Exp Cell Res. 2018 Sep 15, 370 (2):699-707.

HZ08 suppresses RelB-activated MnSOD expression and enhances Radiosensitivity of prostate Cancer cells
Zhang, Y., Xu, Z., Ding, J., Tan, C., Hu, W., Li, Y., Huang, W. and Xu, Y.
J Exp Clin Cancer Res. 2018 Jul 27, 37 (1):174

Glycemic Variability Promotes Both Local Invasion and Metastatic Colonization by Pancreatic Ductal Adenocarcinoma
Jian, Z., Cheng, T., Zhang, Z., Raulefs, S., Shi, K., Steiger, K., Maeritz, N., Kleigrewe, K., Hofmann, T., Benitz, S., Bruns, P., Lamp, D., Jastroch, M., Akkan, J., Jager, C., Huang, P., Nie, S., Shen, S., Zou, X., Ceyhan, G. O., Michalski, C. W., Friess, H., Kleeff, J. and Kong, B.
Cell Mol Gastroenterol Hepatol. 2018 Jul 26, 6 (4):429-449.

Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy
Brachtendorf, S., Wanger, R. A., Birod, K., Thomas, D., Trautmann, S., Wegner, M. S., Fuhrmann, D. C., Brune, B., Geisslinger, G. and Grosch, S.
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Oct 01, 1863 (10):1214-1227.

Cardiovascular Research
Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity
Alam, S., Abdullah, C. S., Aishwarya, R., Miriyala, S., Panchatcharam, M., Peretik, J. M., Orr, A. W., James, J., Robbins, J. and Bhuiyan, M. S.
J Am Heart Assoc. 2018 Jul 9, 7 (14).

Different roles of myocardial ROCK1 and ROCK2 in cardiac dysfunction and postcapillary pulmonary hypertension in mice
Sunamura, S., Satoh, K., Kurosawa, R., Ohtsuki, T., Kikuchi, N., Elias-Al-Mamun, M., Shimizu, T., Ikeda, S., Suzuki, K., Satoh, T., Omura, J., Nogi, M., Numano, K., Siddique, M. A. H., Miyata, S., Miura, M. and Shimokawa, H.
Proc Natl Acad Sci U S A. 2018 Jul 24, 115 (30):E7129-E7138.

Monoamine oxidase-A is a novel driver of stress-induced premature senescence through inhibition of parkin-mediated mitophagy
Manzella, N., Santin, Y., Maggiorani, D., Martini, H., Douin-Echinard, V., Passos, J. F., Lezoualc'h, F., Binda, C., Parini, A. and Mialet-Perez, J.
Aging Cell. 2018 Oct 01, 17 (5):e12811.

Proteomics reveals Rictor as a noncanonical TGF-beta signaling target during aneurysm progression in Marfan mice
Parker, S. J., Stotland, A., MacFarlane, E., Wilson, N., Orosco, A., Venkatraman, V., Madrid, K., Gottlieb, R., Dietz, H. C. and Van Eyk, J. E.
Am J Physiol Heart Circ Physiol. 2018 Nov 1, 315 (5):H1112-H1126.

Preserved cardiac function by vinculin enhances glucose oxidation and extends health- and life-span
Sessions, A. O., Min, P., Cordes, T., Weickert, B. J., Divakaruni, A. S., Murphy, A. N., Metallo, C. M. and Engler, A. J.
APL Bioeng. 2018 Sep 01, 2 (3).

Ubiquinol (Reduced Coenzyme Q10) and Cellular Oxygen Consumption in Patients Undergoing Coronary Artery Bypass Grafting
Holmberg, M. J., Uber, A., Stankovic, N., Chen, C. O., Grossestreuer, A. V., Donnino, M. W., Andersen, L. W. and Liu, X.
J Intensive Care Med. 2018 Jan 1, [epub ahead of print]

Evaluation of mitochondrial respiratory function in rat cardiomyocytes under different glucose conditions, using an extracellular flux analysis method
Tsubone, H. and Mutoh, T.
Clin Exp Pharmacol Physiol. 2018 Dec 01, 45 (12):1330-1333.

Cell Physiology Research
Role of Angptl4/Fiaf in exercise-induced skeletal muscle AMPK activation
Chang, H., Kwon, O., Shin, M. S., Kang, G. M., Leem, Y. H., Lee, C. H., Kim, S. J., Roh, E., Kim, H. K., Youn, B. S. and Kim, M. S.
J Appl Physiol (1985). 2018 Sep 1, 125 (3):715-722.

Metformin reverses established lung fibrosis in a bleomycin model
Rangarajan, S., Bone, N. B., Zmijewska, A. A., Jiang, S., Park, D. W., Bernard, K., Locy, M. L., Ravi, S., Deshane, J., Mannon, R. B., Abraham, E., Darley-Usmar, V., Thannickal, V. J. and Zmijewski, J. W.
Nat Med. 2018 Aug 01, 24 (8):1121-1127.

Excessive irisin increases oxidative stress and apoptosis in murine heart
Ho, M. Y., Wen, M. S., Yeh, J. K., Hsieh, I. C., Chen, C. C., Hsieh, M. J., Tsai, M. L., Yang, C. H., Wu, V. C., Hung, K. C., Wang, C. C. and Wang, C. Y.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2493-2498.

The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress
Kim, K. H., Son, J. M., Benayoun, B. A. and Lee, C.
Cell Metab. 2018 Sep 4, 28 (3):516-524 e7.

Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe
Onodera, Y., Nam, J. M., Horikawa, M., Shirato, H. and Sabe, H.
Nat Commun. 2018 Jul 11, 9 (1):2682.

Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity
Alam, S., Abdullah, C. S., Aishwarya, R., Miriyala, S., Panchatcharam, M., Peretik, J. M., Orr, A. W., James, J., Robbins, J. and Bhuiyan, M. S.
J Am Heart Assoc. 2018 Jul 9, 7 (14).

Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-gamma Coactivator-1 Signaling Pathway in Osteoarthritis Rats
Wang, L., Shan, H., Wang, B., Wang, N., Zhou, Z., Pan, C. and Wang, F.
Pharmacology. 2018 Jun 29, [epub ahead of print]

Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia
Pin, F., Barreto, R., Kitase, Y., Mitra, S., Erne, C. E., Novinger, L. J., Zimmers, T. A., Couch, M. E., Bonewald, L. F. and Bonetto, A.
J Cachexia Sarcopenia Muscle. 2018 Aug 01, 9 (4):685-700.

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity
Angelova, P. R., Vinogradova, D., Neganova, M. E., Serkova, T. P., Sokolov, V. V., Bachurin, S. O., Shevtsova, E. F. and Abramov, A. Y.
Mol Neurobiol. 2018 Jul 14, [epub ahead of print]

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
Vandekeere, S., Dubois, C., Kalucka, J., Sullivan, M. R., Garcia-Caballero, M., Goveia, J., Chen, R., Diehl, F. F., Bar-Lev, L., Souffreau, J., Pircher, A., Kumar, S., Vinckier, S., Hirabayashi, Y., Furuya, S., Schoonjans, L., Eelen, G., Ghesquiere, B., Keshet, E., Li, X., Vander Heiden, M. G., Dewerchin, M. and Carmeliet, P.
Cell Metab. 2018 Oct 2, 28 (4):573-587 e13.

Global Proteome Remodeling during ER Stress Involves Hac1-Driven Expression of Long Undecoded Transcript Isoforms
Van Dalfsen, K. M., Hodapp, S., Keskin, A., Otto, G. M., Berdan, C. A., Higdon, A., Cheunkarndee, T., Nomura, D. K., Jovanovic, M. and Brar, G. A.
Dev Cell. 2018 Jul 16, 46 (2):219-235 e8.

Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia
Wei, H. J., Gupta, A., Kao, W. M., Almudallal, O., Letterio, J. J. and Pareek, T. K.
J Autoimmun. 2018 Nov 01, 94:33-44.

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis
Pala, F., Di Girolamo, D., Mella, S., Yennek, S., Chatre, L., Ricchetti, M. and Tajbakhsh, S.
J Cell Sci. 2018 Jul 27, 131 (14).

Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice
Cole, L. K., Kim, J. H., Amoscato, A. A., Tyurina, Y. Y., Bay, R. H., Karimi, B., Siddiqui, T. J., Kagan, V. E., Hatch, G. M. and Kauppinen, T. M.
Biochim Biophys Acta Mol Basis Dis. 2018 Oct 01, 1864 (10):3353-3367.

Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants
Brasil, S., Leal, F., Vega, A., Navarrete, R., Ecay, M. J., Desviat, L. R., Riera, C., Padilla, N., de la Cruz, X., Couce, M. L., Martin-Hernandez, E., Morais, A., Pedron, C., Pena-Quintana, L., Rigoldi, M., Specola, N., de Almeida, I. T., Vives, I., Yahyaoui, R., Rodriguez-Pombo, P., Ugarte, M., Perez-Cerda, C., Merinero, B. and Perez, B.
Orphanet J Rare Dis. 2018 Jul 24, 13 (1):125.

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
Graham, D. B., Jasso, G. J., Mok, A., Goel, G., Ng, A. C. Y., Kolde, R., Varma, M., Doench, J. G., Root, D. E., Clish, C. B., Carr, S. A. and Xavier, R. J.
Cell Rep. 2018 Jul 24, 24 (4):838-850.

Drug Discovery
Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State
Daemen, A., Liu, B., Song, K., Kwong, M., Gao, M., Hong, R., Nannini, M., Peterson, D., Liederer, B. M., de la Cruz, C., Sangaraju, D., Jaochico, A., Zhao, X., Sandoval, W., Hunsaker, T., Firestein, R., Latham, S., Sampath, D., Evangelista, M. and Hatzivassiliou, G.
Cell Metab. 2018 Sep 4, 28 (3):383-399 e9.

Rubella Viruses Shift Cellular Bioenergetics to a More Oxidative and Glycolytic Phenotype with a Strain-Specific Requirement for Glutamine
Bilz, N. C., Jahn, K., Lorenz, M., Ludtke, A., Hubschen, J. M., Geyer, H., Mankertz, A., Hubner, D., Liebert, U. G. and Claus, C.
J Virol. 2018 Sep 1, 92 (17).

A precision therapeutic strategy for hexokinase 1-null, hexokinase 2-positive cancers
Xu, S., Catapang, A., Braas, D., Stiles, L., Doh, H. M., Lee, J. T., Graeber, T. G., Damoiseaux, R., Shirihai, O. and Herschman, H. R.
Cancer Metab. 2018 Jun 28, 6:7.

Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death
Wong, K. S., Mabanglo, M. F., Seraphim, T. V., Mollica, A., Mao, Y. Q., Rizzolo, K., Leung, E., Moutaoufik, M. T., Hoell, L., Phanse, S., Goodreid, J., Barbosa, L. R. S., Ramos, C. H. I., Babu, M., Mennella, V., Batey, R. A., Schimmer, A. D. and Houry, W. A.
Cell Chem Biol. 2018 Aug 16, 25 (8):1017-1030 e9.

Puerarin Attenuates Osteoarthritis via Upregulating AMP-Activated Protein Kinase/Proliferator-Activated Receptor-gamma Coactivator-1 Signaling Pathway in Osteoarthritis Rats
Wang, L., Shan, H., Wang, B., Wang, N., Zhou, Z., Pan, C. and Wang, F.
Pharmacology. 2018 Jun 29, [epub ahead of print]

Targeting mitochondria by anthelmintic drug atovaquone sensitizes renal cell carcinoma to chemotherapy and immunotherapy
Chen, D., Sun, X., Zhang, X. and Cao, J.
J Biochem Mol Toxicol. 2018 Sep 01, 32 (9):e22195.

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity
Angelova, P. R., Vinogradova, D., Neganova, M. E., Serkova, T. P., Sokolov, V. V., Bachurin, S. O., Shevtsova, E. F. and Abramov, A. Y.
Mol Neurobiol. 2018 Jul 14, [epub ahead of print]

Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration
Larsen, E. M., Chang, C. F., Sakata-Kato, T., Arico, J. W., Lombardo, V. M., Wirth, D. F. and Taylor, R. E.
Org Biomol Chem. 2018 Aug 1, 16 (30):5403-5406.

Liquid Chromatography-Tandem Mass Spectrometry Method Revealed that Lung Cancer Cells Exhibited Distinct Metabolite Profiles upon the Treatment with Different Pyruvate Dehydrogenase Kinase Inhibitors
Zhang, W., Hu, X., Zhou, W. and Tam, K. Y.
J Proteome Res. 2018 Sep 7, 17 (9):3012-3021.

Food and Nutritional Research
LETM1 couples mitochondrial DNA metabolism and nutrient preference
Durigon, R., Mitchell, A. L., Jones, A. W., Manole, A., Mennuni, M., Hirst, E. M., Houlden, H., Maragni, G., Lattante, S., Doronzio, P. N., Dalla Rosa, I., Zollino, M., Holt, I. J. and Spinazzola, A.
EMBO Mol Med. 2018 Sep 01, 10 (9).

Oxygen Consumption Rate Analysis of Mitochondrial Dysfunction Caused by Bacillus cereus Cereulide in Caco-2 and HepG2 Cells
Decleer, M., Jovanovic, J., Vakula, A., Udovicki, B., Agoua, R. E. K., Madder, A., De Saeger, S. and Rajkovic, A.
Toxins (Basel). 2018 Jul 2, 10 (7).

Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective?
Repp, B. M., Mastantuono, E., Alston, C. L., Schiff, M., Haack, T. B., Rotig, A., Ardissone, A., Lombes, A., Catarino, C. B., Diodato, D., Schottmann, G., Poulton, J., Burlina, A., Jonckheere, A., Munnich, A., Rolinski, B., Ghezzi, D., Rokicki, D., Wellesley, D., Martinelli, D., Wenhong, D., Lamantea, E., Ostergaard, E., Pronicka, E., Pierre, G., Smeets, H. J. M., Wittig, I., Scurr, I., de Coo, I. F. M., Moroni, I., Smet, J., Mayr, J. A., Dai, L., de Meirleir, L., Schuelke, M., Zeviani, M., Morscher, R. J., McFarland, R., Seneca, S., Klopstock, T., Meitinger, T., Wieland, T., Strom, T. M., Herberg, U., Ahting, U., Sperl, W., Nassogne, M. C., Ling, H., Fang, F., Freisinger, P., Van Coster, R., Strecker, V., Taylor, R. W., Haberle, J., Vockley, J., Prokisch, H. and Wortmann, S.
Orphanet J Rare Dis. 2018 Jul 19, 13 (1):120.

A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1alpha-SIRT3-UCP2 Axis
Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, L. J., Storm-Mathisen, J. and Bergersen, L. H.
Neurochem Res. 2018 Jul 19, [epub ahead of print]

Manuka honey synergistically enhances the chemopreventive effect of 5-fluorouracil on human colon cancer cells by inducing oxidative stress and apoptosis, altering metabolic phenotypes and suppressing metastasis ability
Afrin, S., Giampieri, F., Forbes-Hernandez, T. Y., Gasparrini, M., Amici, A., Cianciosi, D., Quiles, J. L. and Battino, M.
Free Radic Biol Med. 2018 Oct 01, 126:41-54.

Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants
Brasil, S., Leal, F., Vega, A., Navarrete, R., Ecay, M. J., Desviat, L. R., Riera, C., Padilla, N., de la Cruz, X., Couce, M. L., Martin-Hernandez, E., Morais, A., Pedron, C., Pena-Quintana, L., Rigoldi, M., Specola, N., de Almeida, I. T., Vives, I., Yahyaoui, R., Rodriguez-Pombo, P., Ugarte, M., Perez-Cerda, C., Merinero, B. and Perez, B.
Orphanet J Rare Dis. 2018 Jul 24, 13 (1):125.

Hepatobiology Research
Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions
Liu, J., Jiang, S., Zhao, Y., Sun, Q., Zhang, J., Shen, D., Wu, J., Shen, N., Fu, X., Sun, X., Yu, D., Chen, J., He, J., Shi, T., Ding, Y., Fang, L., Xue, B. and Li, C.
J Pathol. 2018 Nov 01, 246 (3):277-288.

Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis
Probert, P. M., Leitch, A. C., Dunn, M. P., Meyer, S. K., Palmer, J. M., Abdelghany, T. M., Lakey, A. F., Cooke, M. P., Talbot, H., Wills, C., McFarlane, W., Blake, L. I., Rosenmai, A. K., Oskarsson, A., Figueiredo, R., Wilson, C., Kass, G. E., Jones, D. E., Blain, P. G. and Wright, M. C.
J Hepatol. 2018 Nov 01, 69 (5):1123-1135.

Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole
Luckert, C., Braeuning, A., de Sousa, G., Durinck, S., Katsanou, E. S., Konstantinidou, P., Machera, K., Milani, E. S., Peijnenburg, A., Rahmani, R., Rajkovic, A., Rijkers, D., Spyropoulou, A., Stamou, M., Stoopen, G., Sturla, S., Wollscheid, B., Zucchini-Pascal, N. and Lampen, A.
Chem Res Toxicol. 2018 Aug 20, 31 (8):784-798.

CXC Motif Ligand 16 Promotes Nonalcoholic Fatty Liver Disease Progression via Hepatocyte-Stellate Cell Crosstalk
Jiang, L., Yang, M., Li, X., Wang, Y., Zhou, G. and Zhao, J.
J Clin Endocrinol Metab. 2018 Nov 1, 103 (11):3974-3985.

Enhanced glycolysis in the process of renal fibrosis aggravated the development of chronic kidney disease
Yin, X. N., Wang, J., Cui, L. F. and Fan, W. X.
Eur Rev Med Pharmacol Sci. 2018 Jul 01, 22 (13):4243-4251.

Immunology Research
Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation
Raud, B., Roy, D. G., Divakaruni, A. S., Tarasenko, T. N., Franke, R., Ma, E. H., Samborska, B., Hsieh, W. Y., Wong, A. H., Stuve, P., Arnold-Schrauf, C., Guderian, M., Lochner, M., Rampertaap, S., Romito, K., Monsale, J., Bronstrup, M., Bensinger, S. J., Murphy, A. N., McGuire, P. J., Jones, R. G., Sparwasser, T. and Berod, L.
Cell Metab. 2018 Sep 4, 28 (3):504-515 e7.

Reprogramming of Th1 cells into regulatory T cells through rewiring of the metabolic status
Kanamori, M., Nakatsukasa, H., Ito, M., Chikuma, S. and Yoshimura, A.
Int Immunol. 2018 Jul 24, 30 (8):357-373.

The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity
Castro, W., Chelbi, S. T., Niogret, C., Ramon-Barros, C., Welten, S. P. M., Osterheld, K., Wang, H., Rota, G., Morgado, L., Vivier, E., Raeber, M. E., Boyman, O., Delorenzi, M., Barras, D., Ho, P. C., Oxenius, A. and Guarda, G.
Nat Immunol. 2018 Aug 01, 19 (8):809-820.

Metabolic signaling directs the reciprocal lineage decisions of alphabeta and gammadelta T cells
Yang, K., Blanco, D. B., Chen, X., Dash, P., Neale, G., Rosencrance, C., Easton, J., Chen, W., Cheng, C., Dhungana, Y., Kc, A., Awad, W., Guo, X. J., Thomas, P. G. and Chi, H.
Sci Immunol. 2018 Jul 6, 3 (25).

Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation
Nguyen T, Staines D, Johnston S and Marshall-Gradisnik S
Asian Pacific Journal of Allergy and Immunology. 2018 Jul 08, [epub ahead of print]

The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis
Deng, W., Zhu, S., Zeng, L., Liu, J., Kang, R., Yang, M., Cao, L., Wang, H., Billiar, T. R., Jiang, J., Xie, M. and Tang, D.
Cell Rep. 2018 Jul 10, 24 (2):366-378.

Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
Torralba, D., Baixauli, F., Villarroya-Beltri, C., Fernandez-Delgado, I., Latorre-Pellicer, A., Acin-Perez, R., Martin-Cofreces, N. B., Jaso-Tamame, A. L., Iborra, S., Jorge, I., Gonzalez-Aseguinolaza, G., Garaude, J., Vicente-Manzanares, M., Enriquez, J. A., Mittelbrunn, M. and Sanchez-Madrid, F.
Nat Commun. 2018 Jul 9, 9 (1):2658.

Initial B Cell Activation Induces Metabolic Reprogramming and Mitochondrial Remodeling
Waters, L. R., Ahsan, F. M., Wolf, D. M., Shirihai, O. and Teitell, M. A.
iScience. 2018 Jul 27, 5:99-109.

Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Bunse, L., Pusch, S., Bunse, T., Sahm, F., Sanghvi, K., Friedrich, M., Alansary, D., Sonner, J. K., Green, E., Deumelandt, K., Kilian, M., Neftel, C., Uhlig, S., Kessler, T., von Landenberg, A., Berghoff, A. S., Marsh, K., Steadman, M., Zhu, D., Nicolay, B., Wiestler, B., Breckwoldt, M. O., Al-Ali, R., Karcher-Bausch, S., Bozza, M., Oezen, I., Kramer, M., Meyer, J., Habel, A., Eisel, J., Poschet, G., Weller, M., Preusser, M., Nadji-Ohl, M., Thon, N., Burger, M. C., Harter, P. N., Ratliff, M., Harbottle, R., Benner, A., Schrimpf, D., Okun, J., Herold-Mende, C., Turcan, S., Kaulfuss, S., Hess-Stumpp, H., Bieback, K., Cahill, D. P., Plate, K. H., Hanggi, D., Dorsch, M., Suva, M. L., Niemeyer, B. A., von Deimling, A., Wick, W. and Platten, M.
Nat Med. 2018 Aug 01, 24 (8):1192-1203.

Targeting mitochondria by anthelmintic drug atovaquone sensitizes renal cell carcinoma to chemotherapy and immunotherapy
Chen, D., Sun, X., Zhang, X. and Cao, J.
J Biochem Mol Toxicol. 2018 Sep 01, 32 (9):e22195.

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity
Pavlou, S., Lindsay, J., Ingram, R., Xu, H. and Chen, M.
BMC Immunol. 2018 Jul 11, 19 (1):24.

2B4 Mediates Inhibition of CD8(+) T Cell Responses via Attenuation of Glycolysis and Cell Division
Laurie, S. J., Liu, D., Wagener, M. E., Stark, P. C., Terhorst, C. and Ford, M. L.
J Immunol. 2018 Sep 1, 201 (5):1536-1548.

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression
Cong, J., Wang, X., Zheng, X., Wang, D., Fu, B., Sun, R., Tian, Z. and Wei, H.
Cell Metab. 2018 Aug 7, 28 (2):243-255 e5.

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells
Vandekeere, S., Dubois, C., Kalucka, J., Sullivan, M. R., Garcia-Caballero, M., Goveia, J., Chen, R., Diehl, F. F., Bar-Lev, L., Souffreau, J., Pircher, A., Kumar, S., Vinckier, S., Hirabayashi, Y., Furuya, S., Schoonjans, L., Eelen, G., Ghesquiere, B., Keshet, E., Li, X., Vander Heiden, M. G., Dewerchin, M. and Carmeliet, P.
Cell Metab. 2018 Oct 2, 28 (4):573-587 e13.

Nrf2-mediated metabolic reprogramming of tolerogenic dendritic cells is protective against aplastic anemia
Wei, H. J., Gupta, A., Kao, W. M., Almudallal, O., Letterio, J. J. and Pareek, T. K.
J Autoimmun. 2018 Nov 01, 94:33-44.

Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium
Lee, Y., Chakraborty, S., Meininger, C. J. and Muthuchamy, M.
Microcirculation. 2018 Oct 01, 25 (7):e12492.

Macrophage-Associated PGK1 Phosphorylation Promotes Aerobic Glycolysis and Tumorigenesis
Zhang, Y., Yu, G., Chu, H., Wang, X., Xiong, L., Cai, G., Liu, R., Gao, H., Tao, B., Li, W., Li, G., Liang, J. and Yang, W.
Mol Cell. 2018 Jul 19, 71 (2):201-215 e7.

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
Graham, D. B., Jasso, G. J., Mok, A., Goel, G., Ng, A. C. Y., Kolde, R., Varma, M., Doench, J. G., Root, D. E., Clish, C. B., Carr, S. A. and Xavier, R. J.
Cell Rep. 2018 Jul 24, 24 (4):838-850.

Neutrophil extracellular trap formation requires OPA1-dependent glycolytic ATP production
Amini, P., Stojkov, D., Felser, A., Jackson, C. B., Courage, C., Schaller, A., Gelman, L., Soriano, M. E., Nuoffer, J. M., Scorrano, L., Benarafa, C., Yousefi, S. and Simon, H. U.
Nat Commun. 2018 Jul 27, 9 (1):2958.

Early effector maturation of naive human CD8(+) T cells requires mitochondrial biogenesis
Fischer, M., Bantug, G. R., Dimeloe, S., Gubser, P. M., Burgener, A. V., Grahlert, J., Balmer, M. L., Develioglu, L., Steiner, R., Unterstab, G., Sauder, U., Hoenger, G. and Hess, C.
Eur J Immunol. 2018 Oct 01, 48 (10):1632-1643.

Infectious Disease Research
Rubella Viruses Shift Cellular Bioenergetics to a More Oxidative and Glycolytic Phenotype with a Strain-Specific Requirement for Glutamine
Bilz, N. C., Jahn, K., Lorenz, M., Ludtke, A., Hubschen, J. M., Geyer, H., Mankertz, A., Hubner, D., Liebert, U. G. and Claus, C.
J Virol. 2018 Sep 1, 92 (17).

Conformation-guided analogue design identifies potential antimalarial compounds through inhibition of mitochondrial respiration
Larsen, E. M., Chang, C. F., Sakata-Kato, T., Arico, J. W., Lombardo, V. M., Wirth, D. F. and Taylor, R. E.
Org Biomol Chem. 2018 Aug 1, 16 (30):5403-5406.

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity
Pavlou, S., Lindsay, J., Ingram, R., Xu, H. and Chen, M.
BMC Immunol. 2018 Jul 11, 19 (1):24.

Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes
Graham, D. B., Jasso, G. J., Mok, A., Goel, G., Ng, A. C. Y., Kolde, R., Varma, M., Doench, J. G., Root, D. E., Clish, C. B., Carr, S. A. and Xavier, R. J.
Cell Rep. 2018 Jul 24, 24 (4):838-850.

The invasive cell coat at the microsporidian Trachipleistophora hominis-host cell interface contains secreted hexokinases
Ferguson, S. and Lucocq, J.
Microbiologyopen. 2018 Jul 27, [epub ahead of print]

Mitochondrial Disease Research
LETM1 couples mitochondrial DNA metabolism and nutrient preference
Durigon, R., Mitchell, A. L., Jones, A. W., Manole, A., Mennuni, M., Hirst, E. M., Houlden, H., Maragni, G., Lattante, S., Doronzio, P. N., Dalla Rosa, I., Zollino, M., Holt, I. J. and Spinazzola, A.
EMBO Mol Med. 2018 Sep 01, 10 (9).

mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
Pereira, C. V., Bacman, S. R., Arguello, T., Zekonyte, U., Williams, S. L., Edgell, D. R. and Moraes, C. T.
EMBO Mol Med. 2018 Sep 01, 10 (9).

PNPase knockout results in mtDNA loss and an altered metabolic gene expression program
Shimada, E., Ahsan, F. M., Nili, M., Huang, D., Atamdede, S., TeSlaa, T., Case, D., Yu, X., Gregory, B. D., Perrin, B. J., Koehler, C. M. and Teitell, M. A.
PLoS One. 2018 Jul 19, 13 (7):e0200925.

Model Organisms
Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae
Wang, X. H., Zheng, S. S., Huang, T., Su, L. M., Zhao, Y. H., Souders, C. L., 2nd and Martyniuk, C. J.
Chemosphere. 2018 Nov 01, 210:633-644.

Neurobiology Research
Activity of translation regulator eukaryotic elongation factor-2 kinase is increased in Parkinson disease brain and its inhibition reduces alpha synuclein toxicity
Jan, A., Jansonius, B., Delaidelli, A., Bhanshali, F., An, Y. A., Ferreira, N., Smits, L. M., Negri, G. L., Schwamborn, J. C., Jensen, P. H., Mackenzie, I. R., Taubert, S. and Sorensen, P. H.
Acta Neuropathol Commun. 2018 Jul 2, [epub ahead of print]

Nrf2 activation attenuates the early suppression of mitochondrial respiration due to the alpha-synuclein overexpression
Fu, M. H., Wu, C. W., Lee, Y. C., Hung, C. Y., Chen, I. C. and Wu, K. L. H.
Biomed J. 2018 Jun 01, 41 (3):169-183.

R106C TFG variant causes infantile neuroaxonal dystrophy "plus" syndrome
Catania, A., Battini, R., Pippucci, T., Pasquariello, R., Chiapparini, M. L., Seri, M., Garavaglia, B., Zorzi, G., Nardocci, N., Ghezzi, D. and Tiranti, V.
Neurogenetics. 2018 Aug 01, 19 (3):179-187.

Reduced glycolytic reserve in isolated natural killer cells from Myalgic encephalomyelitis/chronic fatigue syndrome patients: A preliminary investigation
Nguyen T, Staines D, Johnston S and Marshall-Gradisnik S
Asian Pacific Journal of Allergy and Immunology. 2018 Jul 08, [epub ahead of print]

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention
Wu, L., Zhang, X. and Zhao, L.
J Neurosci. 2018 Jul 25, 38 (30):6665-6681.

Acetylation of PGC1alpha by histone deacetylase 1 downregulation is implicated in radiation-induced senescence of brain endothelial cells
Kim, S. B., Heo, J. I., Kim, H. and Kim, K. S.
J Gerontol A Biol Sci Med Sci. 2018 Jul 17, [epub ahead of print]

Pharmacological Sequestration of Mitochondrial Calcium Uptake Protects Neurons Against Glutamate Excitotoxicity
Angelova, P. R., Vinogradova, D., Neganova, M. E., Serkova, T. P., Sokolov, V. V., Bachurin, S. O., Shevtsova, E. F. and Abramov, A. Y.
Mol Neurobiol. 2018 Jul 14, [epub ahead of print]

Chronic benzodiazepine suppresses translocator protein and elevates amyloid beta in mice
Tan, S., Metzger, D. B. and Jung, M. E.
Pharmacol Biochem Behav. 2018 Sep 01, 172:59-67.

Abnormal RNA stability in amyotrophic lateral sclerosis
Tank, E. M., Figueroa-Romero, C., Hinder, L. M., Bedi, K., Archbold, H. C., Li, X., Weskamp, K., Safren, N., Paez-Colasante, X., Pacut, C., Thumma, S., Paulsen, M. T., Guo, K., Hur, J., Ljungman, M., Feldman, E. L. and Barmada, S. J.
Nat Commun. 2018 Jul 20, 9 (1):2845.

Aberrant cardiolipin metabolism is associated with cognitive deficiency and hippocampal alteration in tafazzin knockdown mice
Cole, L. K., Kim, J. H., Amoscato, A. A., Tyurina, Y. Y., Bay, R. H., Karimi, B., Siddiqui, T. J., Kagan, V. E., Hatch, G. M. and Kauppinen, T. M.
Biochim Biophys Acta Mol Basis Dis. 2018 Oct 01, 1864 (10):3353-3367.

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease
Milanese, C., Cerri, S., Ulusoy, A., Gornati, S. V., Plat, A., Gabriels, S., Blandini, F., Di Monte, D. A., Hoeijmakers, J. H. and Mastroberardino, P. G.
Cell Death Dis. 2018 Jul 26, 9 (8):818.

Clinical and Molecular Characteristics of Mitochondrial Dysfunction in Autism Spectrum Disorder
Rose, S., Niyazov, D. M., Rossignol, D. A., Goldenthal, M., Kahler, S. G. and Frye, R. E.
Mol Diagn Ther. 2018 Oct 01, 22 (5):571-593.

Butyrate regulates inflammatory cytokine expression without affecting oxidative respiration in primary astrocytes from spontaneously hypertensive rats
Yang, T., Rodriguez, V., Malphurs, W. L., Schmidt, J. T., Ahmari, N., Sumners, C., Martyniuk, C. J. and Zubcevic, J.
Physiol Rep. 2018 Jul 01, 6 (14):e13732.

Obesity, Diabetes, & Metabolic Disorders
Excessive irisin increases oxidative stress and apoptosis in murine heart
Ho, M. Y., Wen, M. S., Yeh, J. K., Hsieh, I. C., Chen, C. C., Hsieh, M. J., Tsai, M. L., Yang, C. H., Wu, V. C., Hung, K. C., Wang, C. C. and Wang, C. Y.
Biochem Biophys Res Commun. 2018 Sep 18, 503 (4):2493-2498.

Programming and Regulation of Metabolic Homeostasis by HDAC11
Sun, L., Marin de Evsikova, C., Bian, K., Achille, A., Telles, E., Pei, H. and Seto, E.
EBioMedicine. 2018 Jul 01, 33:157-168.

Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors
Bayindir-Buchhalter, I., Wolff, G., Lerch, S., Sijmonsma, T., Schuster, M., Gronych, J., Billeter, A. T., Babaei, R., Krunic, D., Ketscher, L., Spielmann, N., Hrabe de Angelis, M., Ruas, J. L., Muller-Stich, B. P., Heikenwalder, M., Lichter, P., Herzig, S. and Vegiopoulos, A.
EMBO Mol Med. 2018 Aug 01, 10 (8).

Oleoylethanolamide modulates glucagon-like peptide-1 receptor agonist signaling and enhances exendin-4-mediated weight loss in obese mice
Brown, J. D., McAnally, D., Ayala, J. E., Burmeister, M. A., Morfa, C., Smith, L. and Ayala, J. E.
Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1, 315 (4):R595-R608.

Adipogenesis in Primary Cell Culture
Larsen, T. J., Jespersen, N. Z. and Scheele, C.
Handb Exp Pharmacol. 2018 Jul 7, [epub ahead of print]

Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions
Liu, J., Jiang, S., Zhao, Y., Sun, Q., Zhang, J., Shen, D., Wu, J., Shen, N., Fu, X., Sun, X., Yu, D., Chen, J., He, J., Shi, T., Ding, Y., Fang, L., Xue, B. and Li, C.
J Pathol. 2018 Nov 01, 246 (3):277-288.

TRPC1 regulates brown adipose tissue activity in a PPARgamma-dependent manner
Wolfrum, C., Kiehlmann, E. and Pelczar, P.
Am J Physiol Endocrinol Metab. 2018 Jul 10, [epub ahead of print]

p38alpha blocks brown adipose tissue thermogenesis through p38delta inhibition
Matesanz, N., Nikolic, I., Leiva, M., Pulgarin-Alfaro, M., Santamans, A. M., Bernardo, E., Mora, A., Herrera-Melle, L., Rodriguez, E., Beiroa, D., Caballero, A., Martin-Garcia, E., Acin-Perez, R., Hernandez-Cosido, L., Leiva-Vega, L., Torres, J. L., Centeno, F., Nebreda, A. R., Enriquez, J. A., Nogueiras, R., Marcos, M. and Sabio, G.
PLoS Biol. 2018 Jul 06, 16 (7):e2004455.

Cold-induced epigenetic programming of the sperm enhances brown adipose tissue activity in the offspring
Sun, W., Dong, H., Becker, A. S., Dapito, D. H., Modica, S., Grandl, G., Opitz, L., Efthymiou, V., Straub, L. G., Sarker, G., Balaz, M., Balazova, L., Perdikari, A., Kiehlmann, E., Bacanovic, S., Zellweger, C., Peleg-Raibstein, D., Pelczar, P., Reik, W., Burger, I. A., von Meyenn, F. and Wolfrum, C.
Nat Med. 2018 Sep 01, 24 (9):1372-1383.

Sustained high glucose exposure sensitizes macrophage responses to cytokine stimuli but reduces their phagocytic activity
Pavlou, S., Lindsay, J., Ingram, R., Xu, H. and Chen, M.
BMC Immunol. 2018 Jul 11, 19 (1):24.

miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity
Koh, E. H., Chernis, N., Saha, P. K., Xiao, L., Bader, D. A., Zhu, B., Rajapakshe, K., Hamilton, M. P., Liu, X., Perera, D., Chen, X., York, B., Trauner, M., Coarfa, C., Bajaj, M., Moore, D. D., Deng, T., McGuire, S. E. and Hartig, S. M.
Diabetes. 2018 Jul 12, [epub ahead of print]

Enhancing enterocyte fatty acid oxidation in mice affects glycemic control depending on dietary fat
Ramachandran, D., Clara, R., Fedele, S., Michel, L., Burkard, J., Kaufman, S., Diaz, A. A., Weissfeld, N., De Bock, K., Prip-Buus, C., Langhans, W. and Mansouri, A.
Sci Rep. 2018 Jul 17, 8 (1):10818.

A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1alpha-SIRT3-UCP2 Axis
Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, L. J., Storm-Mathisen, J. and Bergersen, L. H.
Neurochem Res. 2018 Jul 19, [epub ahead of print]

Insulin resistance disrupts cell integrity, mitochondrial function, and inflammatory signaling in lymphatic endothelium
Lee, Y., Chakraborty, S., Meininger, C. J. and Muthuchamy, M.
Microcirculation. 2018 Oct 01, 25 (7):e12492.

The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation
Yang, C., Wong, C.-M., Wei, J., Chung, A. C. K. and Cai, Z.
Science of The Total Environment. 2018 Dec 10, 644:1312-1322.

Olfactomedin 4 Deletion Improves Male Mouse Glucose Intolerance and Insulin Resistance Induced by a High-Fat Diet
Liu, W., Aerbajinai, W., Li, H., Liu, Y., Gavrilova, O., Jain, S. and Rodgers, G. P.
Endocrinology. 2018 Sep 1, 159 (9):3235-3244.

Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARalpha Pathway in Adipocytes
Zhou, L., Yu, M., Arshad, M., Wang, W., Lu, Y., Gong, J., Gu, Y., Li, P. and Xu, L.
Diabetes. 2018 Oct 01, 67 (10):1935-1948.

Effects of visfatin on brown adipose tissue energy regulation using T37i cells
Dimitriadis, G. K., Adya, R., Tan, B. K., Jones, T. A., Menon, V. S., Ramanjaneya, M., Kaltsas, G., Miras, A. D. and Randeva, H. S.
Cytokine. 2018 Jul 27, [epub ahead of print]

Browning of Pig White Preadipocytes by Co-Overexpressing Pig PGC-1alpha and Mice UCP1
Hou, L., Xie, M., Cao, L., Shi, J., Xu, G., Hu, C. and Wang, C.
Cell Physiol Biochem. 2018 Jul 18, [epub ahead of print]

Stem Cell Biology
Method for measuring extracellular flux from intact polarized epithelial monolayers
Calton, M. A., Beaulieu, M. O., Benchorin, G. and Vollrath, D.
Mol Vis. 2018 Jun 25, 24:425-433.

PNPase knockout results in mtDNA loss and an altered metabolic gene expression program
Shimada, E., Ahsan, F. M., Nili, M., Huang, D., Atamdede, S., TeSlaa, T., Case, D., Yu, X., Gregory, B. D., Perrin, B. J., Koehler, C. M. and Teitell, M. A.
PLoS One. 2018 Jul 19, 13 (7):e0200925.

Intracellular redox status controls spherogenicity, an in vitro cancer stem cell marker, in thyroid cancer cell lines
Shimamura, M., Yamamoto, K., Kurashige, T. and Nagayama, Y.
Exp Cell Res. 2018 Sep 15, 370 (2):699-707.

Distinct metabolic states govern skeletal muscle stem cell fates during prenatal and postnatal myogenesis
Pala, F., Di Girolamo, D., Mella, S., Yennek, S., Chatre, L., Ricchetti, M. and Tajbakhsh, S.
J Cell Sci. 2018 Jul 27, 131 (14).

Techniques & Methods
Adipogenesis in Primary Cell Culture
Larsen, T. J., Jespersen, N. Z. and Scheele, C.
Handb Exp Pharmacol. 2018 Jul 7, [epub ahead of print]

Method for measuring extracellular flux from intact polarized epithelial monolayers
Calton, M. A., Beaulieu, M. O., Benchorin, G. and Vollrath, D.
Mol Vis. 2018 Jun 25, 24:425-433.

Differentiation of Normal and Radioresistant Prostate Cancer Xenografts Using Magnetization Transfer-Prepared MRI
Lam, W. W., Oakden, W., Murray, L., Klein, J., Iorio, C., Screaton, R. A., Koletar, M. M., Chu, W., Liu, S. K. and Stanisz, G. J.
Sci Rep. 2018 Jul 11, 8 (1):10447.

A Caspase-3 Reporter for Fluorescence Lifetime Imaging of Single-Cell Apoptosis
Buschhaus, J., Humphries, B., Luker, K. and Luker, G.
Cells. 2018 Jun 01, 7 (6):57.

Near-simultaneous quantification of glucose uptake, mitochondrial membrane potential, and vascular parameters in murine flank tumors using quantitative diffuse reflectance and fluorescence spectroscopy
Zhu, C., Martin, H. L., Crouch, B. T., Martinez, A. F., Li, M., Palmer, G. M., Dewhirst, M. W. and Ramanujam, N.
Biomed Opt Express. 2018 Jul 1, 9 (7):3399-3412.

Toxicology Research
Identification of a xenobiotic as a potential environmental trigger in primary biliary cholangitis
Probert, P. M., Leitch, A. C., Dunn, M. P., Meyer, S. K., Palmer, J. M., Abdelghany, T. M., Lakey, A. F., Cooke, M. P., Talbot, H., Wills, C., McFarlane, W., Blake, L. I., Rosenmai, A. K., Oskarsson, A., Figueiredo, R., Wilson, C., Kass, G. E., Jones, D. E., Blain, P. G. and Wright, M. C.
J Hepatol. 2018 Nov 01, 69 (5):1123-1135.

Oxygen Consumption Rate Analysis of Mitochondrial Dysfunction Caused by Bacillus cereus Cereulide in Caco-2 and HepG2 Cells
Decleer, M., Jovanovic, J., Vakula, A., Udovicki, B., Agoua, R. E. K., Madder, A., De Saeger, S. and Rajkovic, A.
Toxins (Basel). 2018 Jul 2, 10 (7).

Adverse Outcome Pathway-Driven Analysis of Liver Steatosis in Vitro: A Case Study with Cyproconazole
Luckert, C., Braeuning, A., de Sousa, G., Durinck, S., Katsanou, E. S., Konstantinidou, P., Machera, K., Milani, E. S., Peijnenburg, A., Rahmani, R., Rajkovic, A., Rijkers, D., Spyropoulou, A., Stamou, M., Stoopen, G., Sturla, S., Wollscheid, B., Zucchini-Pascal, N. and Lampen, A.
Chem Res Toxicol. 2018 Aug 20, 31 (8):784-798.

Fluazinam impairs oxidative phosphorylation and induces hyper/hypo-activity in a dose specific manner in zebrafish larvae
Wang, X. H., Zheng, S. S., Huang, T., Su, L. M., Zhao, Y. H., Souders, C. L., 2nd and Martyniuk, C. J.
Chemosphere. 2018 Nov 01, 210:633-644.

The brominated flame retardant BDE 47 upregulates purine metabolism and mitochondrial respiration to promote adipocyte differentiation
Yang, C., Wong, C.-M., Wei, J., Chung, A. C. K. and Cai, Z.
Science of The Total Environment. 2018 Dec 10, 644:1312-1322.

Translational Research
R106C TFG variant causes infantile neuroaxonal dystrophy "plus" syndrome
Catania, A., Battini, R., Pippucci, T., Pasquariello, R., Chiapparini, M. L., Seri, M., Garavaglia, B., Zorzi, G., Nardocci, N., Ghezzi, D. and Tiranti, V.
Neurogenetics. 2018 Aug 01, 19 (3):179-187.

Ubiquinol (Reduced Coenzyme Q10) and Cellular Oxygen Consumption in Patients Undergoing Coronary Artery Bypass Grafting
Holmberg, M. J., Uber, A., Stankovic, N., Chen, C. O., Grossestreuer, A. V., Donnino, M. W., Andersen, L. W. and Liu, X.
J Intensive Care Med. 2018 Jan 1, [epub ahead of print]

Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective?
Repp, B. M., Mastantuono, E., Alston, C. L., Schiff, M., Haack, T. B., Rotig, A., Ardissone, A., Lombes, A., Catarino, C. B., Diodato, D., Schottmann, G., Poulton, J., Burlina, A., Jonckheere, A., Munnich, A., Rolinski, B., Ghezzi, D., Rokicki, D., Wellesley, D., Martinelli, D., Wenhong, D., Lamantea, E., Ostergaard, E., Pronicka, E., Pierre, G., Smeets, H. J. M., Wittig, I., Scurr, I., de Coo, I. F. M., Moroni, I., Smet, J., Mayr, J. A., Dai, L., de Meirleir, L., Schuelke, M., Zeviani, M., Morscher, R. J., McFarland, R., Seneca, S., Klopstock, T., Meitinger, T., Wieland, T., Strom, T. M., Herberg, U., Ahting, U., Sperl, W., Nassogne, M. C., Ling, H., Fang, F., Freisinger, P., Van Coster, R., Strecker, V., Taylor, R. W., Haberle, J., Vockley, J., Prokisch, H. and Wortmann, S.
Orphanet J Rare Dis. 2018 Jul 19, 13 (1):120.

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