Regulating oxygen metabolism can radiosensitize solid tumors.

Solid tumors often have regions of low oxygen tension, or hypoxia. Hypoxic tumor cells are 2-3 times more difficult to kill with radiation than well oxygenated cells. Because oxygen tension is a function of supply and demand, we have identified FDA-approved drugs that can lower oxygen consumption and bring the supply and demand back into balance. We now report that papaverine has an “off target effect” that inhibits mitochondrial complex 1. In model tumors, we find that papaverine increases oxygenation and enhances radiation response through its mitochondrial activity. Importantly, we do not see increased radiation damage in well oxygenated normal tissue.

What you will learn during the eSeminar:

  • Identification of papaverine’s activity that inhibits complex 1.
  • Papaverine’s ability to  increase tumor oxygenation.
  • Tumor-specific radiosensitization through papaverine’s activity at the mitochondria.

For Research Use Only.  Not for use in diagnostic procedures.

Thursday, November 29, 2018
8:00 PDT (Los Angeles)
11:00 EDT (New York)
16:00 BST (London)

Available On Demand after November 29
All registrants will be notified when available

Presented by:

Nicholas Denko, Ph.D
Associate Professor
Radiation Oncology Department
College of Medicine
The Ohio State University

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