XF出版物快报

2018年10

欢迎访问2018年10月最新版安捷伦Seahorse XF出版物快报。本期发行列出了包含Seahorse XF数据的最新发表文章精选。需要更多信息吗?请访问我们更新的细胞参考数据库,通过作者、研究领域、或细胞类型来搜索发表的文章。 来自中国的科研人员和院所发表的文章已用粗体突出显示。

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Aging Research
Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research
Sakamuri, S., Sperling, J. A., Sure, V. N., Dholakia, M. H., Peterson, N. R., Rutkai, I., Mahalingam, P. S., Satou, R. and Katakam, P. V. G.
Geroscience. 2018 Jun 02, 40 (3):347-356.

Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging
Lin, J. B., Sene, A., Santeford, A., Fujiwara, H., Sidhu, R., Ligon, M. M., Shankar, V. A., Ban, N., Mysorekar, I. U., Ory, D. S. and Apte, R. S.
EBioMedicine. 2018 Jun 01, 32:9-20.

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells
Kuosmanen, S. M., Sihvola, V., Kansanen, E., Kaikkonen, M. U. and Levonen, A. L.
Redox Biol. 2018 Sep 01, 18:77-83.

Cancer Research
The role of glycosyltransferase enzyme GCNT3 in colon and ovarian cancer prognosis and chemoresistance
Fernandez, L. P., Sanchez-Martinez, R., Vargas, T., Herranz, J., Martin-Hernandez, R., Mendiola, M., Hardisson, D., Reglero, G., Feliu, J., Redondo, A. and Ramirez de Molina, A.
Sci Rep. 2018 May 31, 8 (1):8485.

Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer
Fujioka, R., Mochizuki, N., Ikeda, M., Sato, A., Nomura, S., Owada, S., Yomoda, S., Tsuchihara, K., Kishino, S. and Esumi, H.
PLoS One. 2018 Jun 01, 13 (6):e0198219.

Metabolite profiling identifies a signature of tumorigenicity in hepatocellular carcinoma
Cassim, S., Raymond, V. A., Lacoste, B., Lapierre, P. and Bilodeau, M.
Oncotarget. 2018 Jun 1, 9 (42):26868-26883.

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose
Lucantoni, F., Dussmann, H., Llorente-Folch, I. and Prehn, J. H. M.
Oncotarget. 2018 May 25, 9 (40):26046-26063.

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma
Miess, H., Dankworth, B., Gouw, A. M., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, D. W., Peck, B. and Schulze, A.
Oncogene. 2018 Jun 5, [epub ahead of print]

Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition
Gu, R., Zhang, M., Meng, H., Xu, D. and Xie, Y.
Biomed Pharmacother. 2018 Sep 01, 105:491-497.

Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms
Futamura, Y., Muroi, M., Aono, H., Kawatani, M., Hayashida, M., Sekine, T., Nogawa, T. and Osada, H.
Biochim Biophys Acta Proteins Proteom. 2018 Jun 6,  [epub ahead of print]

Beta-hydroxybutyrate (3-OHB) can influence the energetic phenotype of breast cancer cells, but does not impact their proliferation and the response to chemotherapy or radiation
Bartmann, C., Janaki Raman, S. R., Floter, J., Schulze, A., Bahlke, K., Willingstorfer, J., Strunz, M., Wockel, A., Klement, R. J., Kapp, M., Djuzenova, C. S., Otto, C. and Kammerer, U.
Cancer Metab. 2018 Jun 11, 6:8.

Rational design of mitochondria-targeted pyruvate dehydrogenase kinase 1 inhibitors with improved selectivity and antiproliferative activity
Xu, B., Yu, Z., Xiang, S., Li, Y., Zhang, S. L. and He, Y.
Eur J Med Chem. 2018 Jul 15, 155:275-284.

Evaluation of Rhodiola crenulata on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line
Wong, K. E., Mora, M. C., Sultana, N., Moriarty, K. P., Arenas, R. B., Yadava, N., Schneider, S. S. and Tirabassi, M. V.
Tumour Biol. 2018 Jun 01, 40 (6):1010428318779515.

IDH1-mutant cancer cells are sensitive to cisplatin and an IDH1-mutant inhibitor counteracts this sensitivity
Khurshed, M., Aarnoudse, N., Hulsbos, R., Hira, V. V. V., van Laarhoven, H. W. M., Wilmink, J. W., Molenaar, R. J. and van Noorden, C. J. F.
FASEB J. 2018 Jun 7, [epub ahead of print]

Deferoxamine suppresses esophageal squamous cell carcinoma cell growth via ERK1/2 mediated mitochondrial dysfunction
Lan, L., Wei, W., Zheng, Y., Niu, L., Chen, X., Huang, D., Gao, Y., Mo, S., Lu, J., Guo, M., Liu, Y. and Lu, B.
Cancer Lett. 2018 Sep 28, 432:132-143.

FGF9-induced ovarian cancer cell invasion involves VEGF-A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming
Bhattacharya, R., Ray Chaudhuri, S. and Roy, S. S.
J Cell Biochem. 2018 Jun 15, [epub ahead of print]

Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1alpha axis
Li, Q., Li, Y., Liang, L., Li, J., Luo, D., Liu, Q., Cai, S. and Li, X.
Cell Commun Signal. 2018 Jun 8, 16 (1):26.

AAED1 modulates proliferation and glycolysis in gastric cancer
Zhang, B., Wu, J., Cai, Y., Luo, M., Wang, B. and Gu, Y.
Oncol Rep. 2018 Aug 01, 40 (2):1156-1164.

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer
Lissanu Deribe, Y., Sun, Y., Terranova, C., Khan, F., Martinez-Ledesma, J., Gay, J., Gao, G., Mullinax, R. A., Khor, T., Feng, N., Lin, Y. H., Wu, C. C., Reyes, C., Peng, Q., Robinson, F., Inoue, A., Kochat, V., Liu, C. G., Asara, J. M., Moran, C., Muller, F., Wang, J., Fang, B., Papadimitrakopoulou, V., Wistuba, II, Rai, K., Marszalek, J. and Futreal, P. A.
Nat Med. 2018 Jul 01, 24 (7):1047-1057.

An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B., Deem, A., Daver, N., de Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., DePinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. and Marszalek, J. R.
Nat Med. 2018 Jul 01, 24 (7):1036-1046.

A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro
Lee, D. E., Alhallak, K., Jenkins, S. V., Vargas, I., Greene, N. P., Quinn, K. P., Griffin, R. J., Dings, R. P. M. and Rajaram, N.
Sci Rep. 2018 Jun 11, 8 (1):8815.

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation
Centini, R., Tsang, M., Iwata, T., Park, H., Delrow, J., Margineantu, D., Iritani, B. M., Gu, H., Liggitt, H. D., Kang, J., Kang, L., Hockenbery, D. M., Raftery, D. and Iritani, B. M.
PLoS One. 2018 Jun 13, 13 (6):e0197973.

SIRT2 Promotes the Migration and Invasion of Gastric Cancer through RAS/ERK/JNK/MMP-9 Pathway by Increasing PEPCK1-Related Metabolism
Li, Y., Zhang, M., Dorfman, R. G., Pan, Y., Tang, D., Xu, L., Zhao, Z., Zhou, Q., Zhou, L., Wang, Y., Yin, Y., Shen, S., Kong, B., Friess, H., Zhao, S., Wang, L. and Zou, X.
Neoplasia. 2018 Jul 01, 20 (7):745-756.

AMP kinase promotes glioblastoma bioenergetics and tumour growth
Chhipa, R. R., Fan, Q., Anderson, J., Muraleedharan, R., Huang, Y., Ciraolo, G., Chen, X., Waclaw, R., Chow, L. M., Khuchua, Z., Kofron, M., Weirauch, M. T., Kendler, A., McPherson, C., Ratner, N., Nakano, I., Dasgupta, N., Komurov, K. and Dasgupta, B.
Nat Cell Biol. 2018 Jul 01, 20 (7):823-835.

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
Fraszczak, J., Vadnais, C., Rashkovan, M., Ross, J., Beauchemin, H., Chen, R., Grapton, D., Khandanpour, C. and Moroy, T.
Leukemia. 2018 Jun 20, [epub ahead of print]

Energy Metabolism Rewiring Precedes UVB-Induced Primary Skin Tumor Formation
Hosseini, M., Dousset, L., Mahfouf, W., Serrano-Sanchez, M., Redonnet-Vernhet, I., Mesli, S., Kasraian, Z., Obre, E., Bonneu, M., Claverol, S., Vlaski, M., Ivanovic, Z., Rachidi, W., Douki, T., Taieb, A., Bouzier-Sore, A. K., Rossignol, R. and Rezvani, H. R.
Cell Rep. 2018 Jun 19, 23 (12):3621-3634.

The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition
Ke, F., Yu, J., Chen, W., Si, X., Li, X., Yang, F., Liao, Y. and Zuo, Z.
Biochem Biophys Res Commun. 2018 Oct 2, 504 (2):374-379.

Identification of Compounds That Decrease Glioblastoma Growth and Glucose Uptake in Vitro
Libby, C. J., Zhang, S., Benavides, G. A., Scott, S. E., Li, Y., Redmann, M., Tran, A. N., Otamias, A., Darley-Usmar, V., Napierala, M., Zhang, J., Augelli-Szafran, C. E., Zhang, W. and Hjelmeland, A. B.
ACS Chem Biol. 2018 Aug 17, 13 (8):2048-2057.

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
Pacella, I., Procaccini, C., Focaccetti, C., Miacci, S., Timperi, E., Faicchia, D., Severa, M., Rizzo, F., Coccia, E. M., Bonacina, F., Mitro, N., Norata, G. D., Rossetti, G., Ranzani, V., Pagani, M., Giorda, E., Wei, Y., Matarese, G., Barnaba, V. and Piconese, S.
Proc Natl Acad Sci U S A. 2018 Jul 10, 115 (28):E6546-E6555.

Codon-specific translation reprogramming promotes resistance to targeted therapy
Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Ghesquiere, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., Rorive, A., Jerusalem, G., Leucci, E., Dewaele, M., Vooijs, M., Leidel, S. A., Georges, M., Voz, M., Peers, B., Buttner, R., Marine, J. C., Chariot, A. and Close, P.
Nature. 2018 Jun 01, 558 (7711):605-609.

Aspartate is a limiting metabolite for cancer cell proliferation under hypoxia and in tumours
Garcia-Bermudez, J., Baudrier, L., La, K., Zhu, X. G., Fidelin, J., Sviderskiy, V. O., Papagiannakopoulos, T., Molina, H., Snuderl, M., Lewis, C. A., Possemato, R. L. and Birsoy, K.
Nat Cell Biol. 2018 Jul 01, 20 (7):775-781.

Targeting glutaminase-mediated glutamine dependence in papillary thyroid cancer
Yu, Y., Yu, X., Fan, C., Wang, H., Wang, R., Feng, C. and Guan, H.
J Mol Med (Berl). 2018 Aug 01, 96 (8):777-790.

Apoptotic Cell-Derived Extracellular Vesicles Promote Malignancy of Glioblastoma Via Intercellular Transfer of Splicing Factors
Pavlyukov, M. S., Yu, H., Bastola, S., Minata, M., Shender, V. O., Lee, Y., Zhang, S., Wang, J., Komarova, S., Wang, J., Yamaguchi, S., Alsheikh, H. A., Shi, J., Chen, D., Mohyeldin, A., Kim, S. H., Shin, Y. J., Anufrieva, K., Evtushenko, E. G., Antipova, N. V., Arapidi, G. P., Govorun, V., Pestov, N. B., Shakhparonov, M. I., Lee, L. J., Nam, D. H. and Nakano, I.
Cancer Cell. 2018 Jul 9, 34 (1):119-135 e10.

IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells
Abel, A. M., Tiwari, A. A., Gerbec, Z. J., Siebert, J. R., Yang, C., Schloemer, N. J., Dixon, K. J., Thakar, M. S. and Malarkannan, S.
Front Immunol. 2018 May 28, 9:1168.

Cardiovascular Research
Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research
Sakamuri, S., Sperling, J. A., Sure, V. N., Dholakia, M. H., Peterson, N. R., Rutkai, I., Mahalingam, P. S., Satou, R. and Katakam, P. V. G.
Geroscience. 2018 Jun 02, 40 (3):347-356.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Hitzel, J., Lee, E., Zhang, Y., Bibli, S. I., Li, X., Zukunft, S., Pfluger, B., Hu, J., Schurmann, C., Vasconez, A. E., Oo, J. A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C. E., Kroll, J., Jo, H., Landmesser, U., Lusis, A. J., Namgaladze, D., Fleming, I., Leisegang, M. S., Zhu, J. and Brandes, R. P.
Nat Commun. 2018 Jun 12, 9 (1):2292.

Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization
Smith, C. O., Wang, Y. T., Nadtochiy, S. M., Miller, J. H., Jonas, E. A., Dirksen, R. T., Nehrke, K. and Brookes, P. S.
FASEB J. 2018 Jun 4, [epub ahead of print]

Adropin regulates pyruvate dehydrogenase in cardiac cells via a novel GPCR-MAPK-PDK4 signaling pathway
Thapa, D., Stoner, M. W., Zhang, M., Xie, B., Manning, J. R., Guimaraes, D., Shiva, S., Jurczak, M. J. and Scott, I.
Redox Biol. 2018 Sep, 01 18:25-32.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. R. and Hollenberg, M. D.
Vascul Pharmacol. 2018 Oct 01, 109:56-71.

Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin
Park, J. H., Ku, H. J., Kim, J. K., Park, J. W. and Lee, J. H.
Sci Rep. 2018 Jun 21, 8 (1):9464.

Rapamycin increases oxidative metabolism and enhances metabolic flexibility in human cardiac fibroblasts
Nacarelli, T., Azar, A., Altinok, O., Orynbayeva, Z. and Sell, C.
Geroscience. 2018 Jun 21, [epub ahead of print]

Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation
van der Pluijm, I., Burger, J., van Heijningen, P. M., A, I. J., van Vliet, N., Milanese, C., Schoonderwoerd, K., Sluiter, W., Ringuette, L. J., Dekkers, D. H. W., Que, I., Kaijzel, E. L., Te Riet, L., MacFarlane, E., Das, D., van der Linden, R., Vermeij, M., Demmers, J. A., Mastroberardino, P. G., Davis, E. C., Yanagisawa, H., Dietz, H., Kanaar, R. and Essers, J.
Cardiovasc Res. 2018 Jun 21, [epub ahead of print]

Cell Physiology Research
COMP-prohibitin 2 interaction maintains mitochondrial homeostasis and controls smooth muscle cell identity

Jia, Y., Wang, M., Mao, C., Yu, F., Wang, Y., Xiao, R., Jiang, C., Zheng, L., Xu, Q., Zheng, M., Fu, Y., Hu, Q. and Kong, W.
Cell Death Dis. 2018 Jun 4, 9 (6):676.

Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells
Hitzel, J., Lee, E., Zhang, Y., Bibli, S. I., Li, X., Zukunft, S., Pfluger, B., Hu, J., Schurmann, C., Vasconez, A. E., Oo, J. A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C. E., Kroll, J., Jo, H., Landmesser, U., Lusis, A. J., Namgaladze, D., Fleming, I., Leisegang, M. S., Zhu, J. and Brandes, R. P.
Nat Commun. 2018 Jun 12, 9 (1):2292.

Cardiac metabolic effects of KNa1.2 channel deletion and evidence for its mitochondrial localization
Smith, C. O., Wang, Y. T., Nadtochiy, S. M., Miller, J. H., Jonas, E. A., Dirksen, R. T., Nehrke, K. and Brookes, P. S.
FASEB J. 2018 Jun 4, [epub ahead of print]

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence
Kim, Y. M., Youn, S. W., Sudhahar, V., Das, A., Chandhri, R., Cuervo Grajal, H., Kweon, J., Leanhart, S., He, L., Toth, P. T., Kitajewski, J., Rehman, J., Yoon, Y., Cho, J., Fukai, T. and Ushio-Fukai, M.
Cell Rep. 2018 Jun 19, 23 (12):3565-3578.

Influence of Pulsed Electric Fields and Mitochondria-Cytoskeleton Interactions on Cell Respiration
Goswami, I., Perry, J. B., Allen, M. E., Brown, D. A., von Spakovsky, M. R. and Verbridge, S. S.
Biophys J. 2018 Jun 19, 114 (12):2951-2964.

Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats
Wang, D., Wei, L., Yang, Y. and Liu, H.
Skelet Muscle. 2018 May 31, 8 (1):18.

Inactivation of glycogen synthase kinase 3beta (GSK-3beta) enhances mitochondrial biogenesis during myogenesis
Theeuwes, W. F., Gosker, H. R., Langen, R. C. J., Pansters, N. A. M., Schols, A. and Remels, A. H. V.
Biochim Biophys Acta Mol Basis Dis. 2018 Jun 06, [epub ahead of print]

Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints
Bezawork-Geleta, A., Wen, H., Dong, L., Yan, B., Vider, J., Boukalova, S., Krobova, L., Vanova, K., Zobalova, R., Sobol, M., Hozak, P., Novais, S. M., Caisova, V., Abaffy, P., Naraine, R., Pang, Y., Zaw, T., Zhang, P., Sindelka, R., Kubista, M., Zuryn, S., Molloy, M. P., Berridge, M. V., Pacak, K., Rohlena, J., Park, S. and Neuzil, J.
Nat Commun. 2018 Jun 7, 9 (1):2221.

Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells
Gerencser, A. A.
Biochim Biophys Acta Bioenerg. 2018 Sep 01, 1859 (9):817-828.

IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells
Abel, A. M., Tiwari, A. A., Gerbec, Z. J., Siebert, J. R., Yang, C., Schloemer, N. J., Dixon, K. J., Thakar, M. S. and Malarkannan, S.
Front Immunol. 2018 May 28, 9:1168.

Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging
Lin, J. B., Sene, A., Santeford, A., Fujiwara, H., Sidhu, R., Ligon, M. M., Shankar, V. A., Ban, N., Mysorekar, I. U., Ory, D. S. and Apte, R. S.
EBioMedicine. 2018 Jun 01, 32:9-20.

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-gamma1/PKC/ERK Signaling and Microglial Polarization
Mohanraj, M., Sekar, P., Liou, H. H., Chang, S. F. and Lin, W. W.
Mol Neurobiol. 2018 Jun 6, [epub ahead of print]

Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism
Li, Q., Lei, F., Tang, Y., Pan, J. S., Tong, Q., Sun, Y. and Sheikh-Hamad, D.
Cell Mol Life Sci. 2018 Nov 01, 75 (21):4021-4040.

Numb Depletion Promotes Drp1-Mediated Mitochondrial Fission and Exacerbates Mitochondrial Fragmentation and Dysfunction in Acute Kidney Injury
Liu, Z., Li, H., Su, J., Xu, S., Zhu, F., Ai, J., Hu, Z., Zhou, M., Tian, J., Su, Z., Yang, P. and Nie, J.
Antioxid Redox Signal. 2018 Jul 25, [epub ahead of print]

MicroRNAs mediate the senescence-associated decline of NRF2 in endothelial cells
Kuosmanen, S. M., Sihvola, V., Kansanen, E., Kaikkonen, M. U. and Levonen, A. L.
Redox Biol. 2018 Sep 01, 18:77-83.

Thyroid hormone receptor and ERRalpha coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function
Singh, B. K., Sinha, R. A., Tripathi, M., Mendoza, A., Ohba, K., Sy, J. A. C., Xie, S. Y., Zhou, J., Ho, J. P., Chang, C. Y., Wu, Y., Giguere, V., Bay, B. H., Vanacker, J. M., Ghosh, S., Gauthier, K., Hollenberg, A. N., McDonnell, D. P. and Yen, P. M.
Sci Signal. 2018 Jun 26, 11 (536) .

A novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans
Teo, E., Batchu, K. C., Barardo, D., Xiao, L., Cazenave-Gassiot, A., Tolwinski, N., Wenk, M., Halliwell, B. and Gruber, J.
Sci Rep. 2018 Jun 20, 8 (1):9420.

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle
Wood, J., Tse, M. C. L., Yang, X., Brobst, D., Liu, Z., Pang, B. P. S., Chan, W. S., Zaw, A. M., Chow, B. K. C., Ye, K., Lee, C. W. and Chan, C. B.
Metabolism. 2018 Oct 01, 87:113-122.

Mitoregulin: A lncRNA-Encoded Microprotein that Supports Mitochondrial Supercomplexes and Respiratory Efficiency
Stein, C. S., Jadiya, P., Zhang, X., McLendon, J. M., Abouassaly, G. M., Witmer, N. H., Anderson, E. J., Elrod, J. W. and Boudreau, R. L.
Cell Rep. 2018 Jun 26, 23 (13):3710-3720 e8.

Drug Discovery
Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer
Fujioka, R., Mochizuki, N., Ikeda, M., Sato, A., Nomura, S., Owada, S., Yomoda, S., Tsuchihara, K., Kishino, S. and Esumi, H.
PLoS One. 2018 Jun 01, 13 (6):e0198219.

BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose
Lucantoni, F., Dussmann, H., Llorente-Folch, I. and Prehn, J. H. M.
Oncotarget. 2018 May 25, 9 (40):26046-26063.

Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition
Gu, R., Zhang, M., Meng, H., Xu, D. and Xie, Y.
Biomed Pharmacother. 2018 Sep 01, 105:491-497.

Bioenergetic and proteomic profiling to screen small molecule inhibitors that target cancer metabolisms
Futamura, Y., Muroi, M., Aono, H., Kawatani, M., Hayashida, M., Sekine, T., Nogawa, T. and Osada, H.
Biochim Biophys Acta Proteins Proteom. 2018 Jun 6,  [epub ahead of print]

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro
Dilrukshi Herath, H. M. P., Song, H., Preston, S., Jabbar, A., Wang, T., McGee, S. L., Hofmann, A., Garcia-Bustos, J., Chang, B. C. H., Koehler, A. V., Liu, Y., Ma, Q., Zhang, P., Zhao, Q., Wang, Q. and Gasser, R. B.
Int J Parasitol Drugs Drug Resist. 2018 Jun 4, 8 (3):379-385.

Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention
Baptiste, B. A., Katchur, S. R., Fivenson, E. M., Croteau, D. L., Rumsey, W. L. and Bohr, V. A.
Free Radic Biol Med. 2018 Aug 20, 124:149-162.

Mapping of biguanide transporters in human fat cells and their impact on lipolysis
Arner, P., Kulyte, A., Batchelor, K., Laurencikiene, J., Livingston, J. and Ryden, M.
Diabetes Obes Metab. 2018 Oct 01, 20 (10):2416-2425.

Deferoxamine suppresses esophageal squamous cell carcinoma cell growth via ERK1/2 mediated mitochondrial dysfunction
Lan, L., Wei, W., Zheng, Y., Niu, L., Chen, X., Huang, D., Gao, Y., Mo, S., Lu, J., Guo, M., Liu, Y. and Lu, B.
Cancer Lett. 2018 Sep 28, 432:132-143.

An inhibitor of oxidative phosphorylation exploits cancer vulnerability
Molina, J. R., Sun, Y., Protopopova, M., Gera, S., Bandi, M., Bristow, C., McAfoos, T., Morlacchi, P., Ackroyd, J., Agip, A. A., Al-Atrash, G., Asara, J., Bardenhagen, J., Carrillo, C. C., Carroll, C., Chang, E., Ciurea, S., Cross, J. B., Czako, B., Deem, A., Daver, N., de Groot, J. F., Dong, J. W., Feng, N., Gao, G., Gay, J., Do, M. G., Greer, J., Giuliani, V., Han, J., Han, L., Henry, V. K., Hirst, J., Huang, S., Jiang, Y., Kang, Z., Khor, T., Konoplev, S., Lin, Y. H., Liu, G., Lodi, A., Lofton, T., Ma, H., Mahendra, M., Matre, P., Mullinax, R., Peoples, M., Petrocchi, A., Rodriguez-Canale, J., Serreli, R., Shi, T., Smith, M., Tabe, Y., Theroff, J., Tiziani, S., Xu, Q., Zhang, Q., Muller, F., DePinho, R. A., Toniatti, C., Draetta, G. F., Heffernan, T. P., Konopleva, M., Jones, P., Di Francesco, M. E. and Marszalek, J. R.
Nat Med. 2018 Jul 01, 24 (7):1036-1046.

Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers
Alberdi, E., Sanchez-Gomez, M. V., Ruiz, A., Cavaliere, F., Ortiz-Sanz, C., Quintela-Lopez, T., Capetillo-Zarate, E., Sole-Domenech, S. and Matute, C.
Oxid Med Cell Longev. 2018 Jun 14, [epub ahead of print]

The anti-malarial atovaquone selectively increases chemosensitivity in retinoblastoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition
Ke, F., Yu, J., Chen, W., Si, X., Li, X., Yang, F., Liao, Y. and Zuo, Z.
Biochem Biophys Res Commun. 2018 Oct 2, 504 (2):374-379.

Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin
Park, J. H., Ku, H. J., Kim, J. K., Park, J. W. and Lee, J. H.
Sci Rep. 2018 Jun 21, 8 (1):9464.

The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms
Jakobsen, E., Lange, S. C., Andersen, J. V., Desler, C., Kihl, H. F., Hohnholt, M. C., Stridh, M. H., Rasmussen, L. J., Waagepetersen, H. S. and Bak, L. K.
Biochem Pharmacol. 2018 Sep 01, 155:92-101.

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle
Wood, J., Tse, M. C. L., Yang, X., Brobst, D., Liu, Z., Pang, B. P. S., Chan, W. S., Zaw, A. M., Chow, B. K. C., Ye, K., Lee, C. W. and Chan, C. B.
Metabolism. 2018 Oct 01, 87:113-122.

Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells
Rebollo-Ramirez, S., Krokowski, S., Lobato-Marquez, D., Thomson, M., Pennisi, I., Mostowy, S. and Larrouy-Maumus, G.
Chem Res Toxicol. 2018 Aug 20, 31 (8):688-696.

Mitochondrial-Localized Versus Cytosolic Intracellular CO-Releasing Organic PhotoCORMs: Evaluation of CO Effects Using Bioenergetics
Soboleva, T., Esquer, H. J., Anderson, S. N., Berreau, L. M. and Benninghoff, A. D.
ACS Chem Biol. 2018 Aug 17, 13 (8):2220-2228.

Food and Nutritional Research
Gallic acid targets acute myeloid leukemia via Akt/mTOR-dependent mitochondrial respiration inhibition
Gu, R., Zhang, M., Meng, H., Xu, D. and Xie, Y.
Biomed Pharmacother. 2018 Sep 01, 105:491-497.

Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High-Fat-Diet-Induced Obese Mice
Dos Santos, T. W., Miranda, J., Teixeira, L., Aiastui, A., Matheu, A., Gambero, A., Portillo, M. P. and Ribeiro, M. L.
Mol Nutr Food Res. 2018 May 31, [epub ahead of print]

Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats
Wang, D., Wei, L., Yang, Y. and Liu, H.
Skelet Muscle. 2018 May 31, 8 (1):18.

Amelioration of High Fructose-Induced Cardiac Hypertrophy by Naringin
Park, J. H., Ku, H. J., Kim, J. K., Park, J. W. and Lee, J. H.
Sci Rep. 2018 Jun 21, 8 (1):9464.

Hepatobiology Research
OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism
Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivela, A., Li, S., Karhinen, L., Jaaskelainen, E., Andrews, R., Merilainen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. and Olkkonen, V. M.
Cell Mol Life Sci. 2018 Nov 01, 75 (21):4041-4057.

Numb Depletion Promotes Drp1-Mediated Mitochondrial Fission and Exacerbates Mitochondrial Fragmentation and Dysfunction in Acute Kidney Injury
Liu, Z., Li, H., Su, J., Xu, S., Zhu, F., Ai, J., Hu, Z., Zhou, M., Tian, J., Su, Z., Yang, P. and Nie, J.
Antioxid Redox Signal. 2018 Jul 25, [epub ahead of print]

Immunology Research
Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages
Kim, Y., Gromovsky, A. D., Brown, J. M. and Chung, S.
J Nutr Biochem. 2018 Aug 01, 58:169-177.

Inactivation of glycogen synthase kinase 3beta (GSK-3beta) enhances mitochondrial biogenesis during myogenesis
Theeuwes, W. F., Gosker, H. R., Langen, R. C. J., Pansters, N. A. M., Schols, A. and Remels, A. H. V.
Biochim Biophys Acta Mol Basis Dis. 2018 Jun 06, [epub ahead of print]

IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells
Abel, A. M., Tiwari, A. A., Gerbec, Z. J., Siebert, J. R., Yang, C., Schloemer, N. J., Dixon, K. J., Thakar, M. S. and Malarkannan, S.
Front Immunol. 2018 May 28, 9:1168.

Impaired plasticity of macrophages in X-linked adrenoleukodystrophy
Weinhofer, I., Zierfuss, B., Hametner, S., Wagner, M., Popitsch, N., Machacek, C., Bartolini, B., Zlabinger, G., Ohradanova-Repic, A., Stockinger, H., Kohler, W., Hoftberger, R., Regelsberger, G., Forss-Petter, S., Lassmann, H. and Berger, J.
Brain. 2018 May 30, [epub ahead of print]

Protein Kinase C-beta Dictates B Cell Fate by Regulating Mitochondrial Remodeling, Metabolic Reprogramming, and Heme Biosynthesis
Tsui, C., Martinez-Martin, N., Gaya, M., Maldonado, P., Llorian, M., Legrave, N. M., Rossi, M., MacRae, J. I., Cameron, A. J., Parker, P. J., Leitges, M., Bruckbauer, A. and Batista, F. D.
Immunity. 2018 Jun 19, 48 (6):1144-1159 e5.

Oxysterol Signatures Distinguish Age-Related Macular Degeneration from Physiologic Aging
Lin, J. B., Sene, A., Santeford, A., Fujiwara, H., Sidhu, R., Ligon, M. M., Shankar, V. A., Ban, N., Mysorekar, I. U., Ory, D. S. and Apte, R. S.
EBioMedicine. 2018 Jun 01, 32:9-20.

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-gamma1/PKC/ERK Signaling and Microglial Polarization
Mohanraj, M., Sekar, P., Liou, H. H., Chang, S. F. and Lin, W. W.
Mol Neurobiol. 2018 Jun 6, [epub ahead of print]

Interferon-gamma interferes with host cell metabolism during intracellular Chlamydia trachomatis infection
Shima, K., Kaeding, N., Ogunsulire, I. M., Kaufhold, I., Klinger, M. and Rupp, J.
Cytokine. 2018 Jun 6, [epub ahead of print]

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue
Serbulea, V., Upchurch, C. M., Schappe, M. S., Voigt, P., DeWeese, D. E., Desai, B. N., Meher, A. K. and Leitinger, N.
Proc Natl Acad Sci U S A. 2018 Jul 3, 115 (27):E6254-E6263.

Progressive Upregulation of Oxidative Metabolism Facilitates Plasmablast Differentiation to a T-Independent Antigen
Price, M. J., Patterson, D. G., Scharer, C. D. and Boss, J. M.
Cell Rep. 2018 Jun 12, 23 (11):3152-3159.

Reduced expression but not deficiency of GFI1 causes a fatal myeloproliferative disease in mice
Fraszczak, J., Vadnais, C., Rashkovan, M., Ross, J., Beauchemin, H., Chen, R., Grapton, D., Khandanpour, C. and Moroy, T.
Leukemia. 2018 Jun 20, [epub ahead of print]

Mitochondria maintain controlled activation state of epithelial-resident T lymphocytes
Konjar, S., Frising, U. C., Ferreira, C., Hinterleitner, R., Mayassi, T., Zhang, Q., Blankenhaus, B., Haberman, N., Loo, Y., Guedes, J., Baptista, M., Innocentin, S., Stange, J., Strathdee, D., Jabri, B. and Veldhoen, M.
Sci Immunol. 2018 Jun 22, 3 (24).

Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice
Loftus, R. M., Assmann, N., Kedia-Mehta, N., O'Brien, K. L., Garcia, A., Gillespie, C., Hukelmann, J. L., Oefner, P. J., Lamond, A. I., Gardiner, C. M., Dettmer, K., Cantrell, D. A., Sinclair, L. V. and Finlay, D. K.
Nat Commun. 2018 Jun 14, 9 (1):2341.

Androgen excess in pancreatic beta cells and neurons predisposes female mice to type 2 diabetes
Navarro, G., Allard, C., Morford, J. J., Xu, W., Liu, S., Molinas, A. J., Butcher, S. M., Fine, N. H. F., Blandino-Rosano, M., Sure, V. N., Yu, S., Zhang, R., Munzberg, H., Jacobson, D. A., Katakam, P. V., Hodson, D. J., Bernal-Mizrachi, E., Zsombok, A. and Mauvais-Jarvis, F.
JCI Insight. 2018 Jun 21, 3 (12).

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Divakaruni, A. S., Hsieh, W. Y., Minarrieta, L., Duong, T. N., Kim, K. K. O., Desousa, B. R., Andreyev, A. Y., Bowman, C. E., Caradonna, K., Dranka, B. P., Ferrick, D. A., Liesa, M., Stiles, L., Rogers, G. W., Braas, D., Ciaraldi, T. P., Wolfgang, M. J., Sparwasser, T., Berod, L., Bensinger, S. J. and Murphy, A. N.
Cell Metab. 2018 Sep 4, 28 (3):490-503 e7.

Fatty acid metabolism complements glycolysis in the selective regulatory T cell expansion during tumor growth
Pacella, I., Procaccini, C., Focaccetti, C., Miacci, S., Timperi, E., Faicchia, D., Severa, M., Rizzo, F., Coccia, E. M., Bonacina, F., Mitro, N., Norata, G. D., Rossetti, G., Ranzani, V., Pagani, M., Giorda, E., Wei, Y., Matarese, G., Barnaba, V. and Piconese, S.
Proc Natl Acad Sci U S A. 2018 Jul 10, 115 (28):E6546-E6555.

Effector CD4 T cells with progenitor potential mediate chronic intestinal inflammation
Shin, B., Kress, R. L., Kramer, P. A., Darley-Usmar, V. M., Bellis, S. L. and Harrington, L. E.
J Exp Med. 2018 Jul 2, 215 (7):1803-1812.

Infectious Disease Research
Gene expression to mitochondrial metabolism: Variability among cultured Trypanosoma cruzi strains
Kalem, M. C., Gerasimov, E. S., Vu, P. K. and Zimmer, S. L.
PLoS One. 2018 May 01, 13 (5):e0197983.

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-gamma1/PKC/ERK Signaling and Microglial Polarization
Mohanraj, M., Sekar, P., Liou, H. H., Chang, S. F. and Lin, W. W.
Mol Neurobiol. 2018 Jun 6, [epub ahead of print]

Interferon-gamma interferes with host cell metabolism during intracellular Chlamydia trachomatis infection
Shima, K., Kaeding, N., Ogunsulire, I. M., Kaufhold, I., Klinger, M. and Rupp, J.
Cytokine. 2018 Jun 6, [epub ahead of print]

Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells
Rebollo-Ramirez, S., Krokowski, S., Lobato-Marquez, D., Thomson, M., Pennisi, I., Mostowy, S. and Larrouy-Maumus, G.
Chem Res Toxicol. 2018 Aug 20, 31 (8):688-696.

Mitochondrial Disease Research
Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention
Baptiste, B. A., Katchur, S. R., Fivenson, E. M., Croteau, D. L., Rumsey, W. L. and Bohr, V. A.
Free Radic Biol Med. 2018 Aug 20, 124:149-162.

Inhibition of the ER stress IRE1alpha inflammatory pathway protects against cell death in mitochondrial complex I mutant cells
Soustek, M. S., Balsa, E., Barrow, J. J., Jedrychowski, M., Vogel, R., Jan, S., Gygi, S. P. and Puigserver, P.
Cell Death Dis. 2018 May 31, 9 (6):658.

Model Organisms
Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro
Dilrukshi Herath, H. M. P., Song, H., Preston, S., Jabbar, A., Wang, T., McGee, S. L., Hofmann, A., Garcia-Bustos, J., Chang, B. C. H., Koehler, A. V., Liu, Y., Ma, Q., Zhang, P., Zhao, Q., Wang, Q. and Gasser, R. B.
Int J Parasitol Drugs Drug Resist. 2018 Jun 4, 8 (3):379-385.

Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
Bond, S. T., McEwen, K. A., Yoganantharajah, P. and Gibert, Y.
Methods Mol Biol. 2018 Jun 01, 1797:393-401.

A novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans
Teo, E., Batchu, K. C., Barardo, D., Xiao, L., Cazenave-Gassiot, A., Tolwinski, N., Wenk, M., Halliwell, B. and Gruber, J.
Sci Rep. 2018 Jun 20, 8 (1):9420.

Nephrology Research
Dietary supplementation with ketoacids protects against CKD-induced oxidative damage and mitochondrial dysfunction in skeletal muscle of 5/6 nephrectomised rats
Wang, D., Wei, L., Yang, Y. and Liu, H.
Skelet Muscle. 2018 May 31, 8 (1):18.

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation
Centini, R., Tsang, M., Iwata, T., Park, H., Delrow, J., Margineantu, D., Iritani, B. M., Gu, H., Liggitt, H. D., Kang, J., Kang, L., Hockenbery, D. M., Raftery, D. and Iritani, B. M.
PLoS One. 2018 Jun 13, 13 (6):e0197973.

Metabolic Phenotyping of Anks3 Depletion in mIMCD-3 cells - a Putative Nephronophthisis Candidate
Schlimpert, M., Lagies, S., Budnyk, V., Muller, B., Walz, G. and Kammerer, B.
Sci Rep. 2018 Jun 13, 8 (1):9022.

Neurobiology Research
Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events
Singh, N., Lawana, V., Luo, J., Phong, P., Abdalla, A., Palanisamy, B., Rokad, D., Sarkar, S., Jin, H., Anantharam, V., Kanthasamy, A. G. and Kanthasamy, A.
Neurobiol Dis. 2018 Sep 01, 117:82-113.

Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington's Disease
Ferreira, I. L., Carmo, C., Naia, L., S, I. M. and Cristina Rego, A.
Methods Mol Biol. 2018 Oct 01, 1780:415-442.

The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease
Schondorf, D. C., Ivanyuk, D., Baden, P., Sanchez-Martinez, A., De Cicco, S., Yu, C., Giunta, I., Schwarz, L. K., Di Napoli, G., Panagiotakopoulou, V., Nestel, S., Keatinge, M., Pruszak, J., Bandmann, O., Heimrich, B., Gasser, T., Whitworth, A. J. and Deleidi, M.
Cell Rep. 2018 Jun 5, 23 (10):2976-2988.

Evaluation of Rhodiola crenulata on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line
Wong, K. E., Mora, M. C., Sultana, N., Moriarty, K. P., Arenas, R. B., Yadava, N., Schneider, S. S. and Tirabassi, M. V.
Tumour Biol. 2018 Jun 01, 40 (6):1010428318779515.

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-gamma1/PKC/ERK Signaling and Microglial Polarization
Mohanraj, M., Sekar, P., Liou, H. H., Chang, S. F. and Lin, W. W.
Mol Neurobiol. 2018 Jun 6, [epub ahead of print]

Mangiferin and Morin Attenuate Oxidative Stress, Mitochondrial Dysfunction, and Neurocytotoxicity, Induced by Amyloid Beta Oligomers
Alberdi, E., Sanchez-Gomez, M. V., Ruiz, A., Cavaliere, F., Ortiz-Sanz, C., Quintela-Lopez, T., Capetillo-Zarate, E., Sole-Domenech, S. and Matute, C.
Oxid Med Cell Longev. 2018 Jun 14, [epub ahead of print]

The m.11778 A>G variant associated with the coexistence of Leber's hereditary optic neuropathy and multiple sclerosis-like illness dysregulates the metabolic interplay between mitochondrial oxidative phosphorylation and glycolysis
Uittenbogaard, M., Brantner, C. A., Fang, Z., Wong, L. J., Gropman, A. and Chiaramello, A.
Mitochondrion. 2018 Jun 8, [epub ahead of print]

Mitochondrial therapy promotes regeneration of injured hippocampal neurons
Chien, L., Liang, M. Z., Chang, C. Y., Wang, C. and Chen, L.
Biochim Biophys Acta Mol Basis Dis. 2018 Sep 01, 1864 (9 Pt B):3001-3012.

Androgen excess in pancreatic beta cells and neurons predisposes female mice to type 2 diabetes
Navarro, G., Allard, C., Morford, J. J., Xu, W., Liu, S., Molinas, A. J., Butcher, S. M., Fine, N. H. F., Blandino-Rosano, M., Sure, V. N., Yu, S., Zhang, R., Munzberg, H., Jacobson, D. A., Katakam, P. V., Hodson, D. J., Bernal-Mizrachi, E., Zsombok, A. and Mauvais-Jarvis, F.
JCI Insight. 2018 Jun 21, 3 (12).

Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase
Finelli, M. J., Paramo, T., Pires, E., Ryan, B. J., Wade-Martins, R., Biggin, P. C., McCullagh, J. and Oliver, P. L.
Mol Neurobiol. 2018 Jun 15, [epub ahead of print]

The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms
Jakobsen, E., Lange, S. C., Andersen, J. V., Desler, C., Kihl, H. F., Hohnholt, M. C., Stridh, M. H., Rasmussen, L. J., Waagepetersen, H. S. and Bak, L. K.
Biochem Pharmacol. 2018 Sep 01, 155:92-101.

Obesity, Diabetes, & Metabolic Disorders
Mapping of biguanide transporters in human fat cells and their impact on lipolysis
Arner, P., Kulyte, A., Batchelor, K., Laurencikiene, J., Livingston, J. and Ryden, M.
Diabetes Obes Metab. 2018 Oct 01, 20 (10):2416-2425.

Yerba Mate Stimulates Mitochondrial Biogenesis and Thermogenesis in High-Fat-Diet-Induced Obese Mice
Dos Santos, T. W., Miranda, J., Teixeira, L., Aiastui, A., Matheu, A., Gambero, A., Portillo, M. P. and Ribeiro, M. L.
Mol Nutr Food Res. 2018 May 31, [epub ahead of print]

Gamma-tocotrienol attenuates the aberrant lipid mediator production in NLRP3 inflammasome-stimulated macrophages
Kim, Y., Gromovsky, A. D., Brown, J. M. and Chung, S.
J Nutr Biochem. 2018 Aug 01, 58:169-177.

Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte
Shoucri, B. M., Hung, V. T., Chamorro-Garcia, R., Shioda, T. and Blumberg, B.
Endocrinology. 2018 Aug 1, 159 (8):2863-2883.

Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells
Gerencser, A. A.
Biochim Biophys Acta Bioenerg. 2018 Sep 01, 1859 (9):817-828.

OSBP-related protein-2 (ORP2): a novel Akt effector that controls cellular energy metabolism
Kentala, H., Koponen, A., Vihinen, H., Pirhonen, J., Liebisch, G., Pataj, Z., Kivela, A., Li, S., Karhinen, L., Jaaskelainen, E., Andrews, R., Merilainen, L., Matysik, S., Ikonen, E., Zhou, Y., Jokitalo, E. and Olkkonen, V. M.
Cell Mol Life Sci. 2018 Nov 01, 75 (21):4041-4057.

Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis
Sustarsic, E. G., Ma, T., Lynes, M. D., Larsen, M., Karavaeva, I., Havelund, J. F., Nielsen, C. H., Jedrychowski, M. P., Moreno-Torres, M., Lundh, M., Plucinska, K., Jespersen, N. Z., Grevengoed, T. J., Kramar, B., Peics, J., Hansen, J. B., Shamsi, F., Forss, I., Neess, D., Keipert, S., Wang, J., Stohlmann, K., Brandslund, I., Christensen, C., Jorgensen, M. E., Linneberg, A., Pedersen, O., Kiebish, M. A., Qvortrup, K., Han, X., Pedersen, B. K., Jastroch, M., Mandrup, S., Kjaer, A., Gygi, S. P., Hansen, T., Gillum, M. P., Grarup, N., Emanuelli, B., Nielsen, S., Scheele, C., Tseng, Y. H., Faergeman, N. J. and Gerhart-Hines, Z.
Cell Metab. 2018 Jul 3, 28 (1):159-174 e11.

Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM
Evers, M., Salma, N., Osseiran, S., Casper, M., Birngruber, R., Evans, C. L. and Manstein, D.
Sci Rep. 2018 Jun 8, 8 (1):8757.

Browning of white adipose tissue induced by the ss3 agonist CL-316,243 after local and systemic treatment - PK-PD relationship
Danysz, W., Han, Y., Li, F., Nicoll, J., Buch, P., Hengl, T., Ruitenberg, M. and Parsons, C.
Biochim Biophys Acta Mol Basis Dis. 2018 Sep 01, 1864 (9 Pt B):2972-2982.

Macrophage phenotype and bioenergetics are controlled by oxidized phospholipids identified in lean and obese adipose tissue
Serbulea, V., Upchurch, C. M., Schappe, M. S., Voigt, P., DeWeese, D. E., Desai, B. N., Meher, A. K. and Leitinger, N.
Proc Natl Acad Sci U S A. 2018 Jul 3, 115 (27):E6254-E6263.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress
El-Daly, M., Pulakazhi Venu, V. K., Saifeddine, M., Mihara, K., Kang, S., Fedak, P. W. M., Alston, L. A., Hirota, S. A., Ding, H., Triggle, C. R. and Hollenberg, M. D.
Vascul Pharmacol. 2018 Oct 01, 109:56-71.

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence
Kim, Y. M., Youn, S. W., Sudhahar, V., Das, A., Chandhri, R., Cuervo Grajal, H., Kweon, J., Leanhart, S., He, L., Toth, P. T., Kitajewski, J., Rehman, J., Yoon, Y., Cho, J., Fukai, T. and Ushio-Fukai, M.
Cell Rep. 2018 Jun 19, 23 (12):3565-3578.

Androgen excess in pancreatic beta cells and neurons predisposes female mice to type 2 diabetes
Navarro, G., Allard, C., Morford, J. J., Xu, W., Liu, S., Molinas, A. J., Butcher, S. M., Fine, N. H. F., Blandino-Rosano, M., Sure, V. N., Yu, S., Zhang, R., Munzberg, H., Jacobson, D. A., Katakam, P. V., Hodson, D. J., Bernal-Mizrachi, E., Zsombok, A. and Mauvais-Jarvis, F.
JCI Insight. 2018 Jun 21, 3 (12).

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation
Held, N. M., Kuipers, E. N., van Weeghel, M., van Klinken, J. B., Denis, S. W., Lombes, M., Wanders, R. J., Vaz, F. M., Rensen, P. C. N., Verhoeven, A. J., Boon, M. R. and Houtkooper, R. H.
Sci Rep. 2018 Jun 22, 8 (1):9562.

BDNF mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle
Wood, J., Tse, M. C. L., Yang, X., Brobst, D., Liu, Z., Pang, B. P. S., Chan, W. S., Zaw, A. M., Chow, B. K. C., Ye, K., Lee, C. W. and Chan, C. B.
Metabolism. 2018 Oct 01, 87:113-122.

Review Papers
Evaluation of Respiration with Clark-Type Electrode in Isolated Mitochondria and Permeabilized Animal Cells
Silva, A. M. and Oliveira, P. J.
Methods Mol Biol. 2018 Oct 01, 1782:7-29.

Stem Cell Biology
The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease
Schondorf, D. C., Ivanyuk, D., Baden, P., Sanchez-Martinez, A., De Cicco, S., Yu, C., Giunta, I., Schwarz, L. K., Di Napoli, G., Panagiotakopoulou, V., Nestel, S., Keatinge, M., Pruszak, J., Bandmann, O., Heimrich, B., Gasser, T., Whitworth, A. J. and Deleidi, M.
Cell Rep. 2018 Jun 5, 23 (10):2976-2988.

Retinoid X Receptor Activation During Adipogenesis of Female Mesenchymal Stem Cells Programs a Dysfunctional Adipocyte
Shoucri, B. M., Hung, V. T., Chamorro-Garcia, R., Shioda, T. and Blumberg, B.
Endocrinology. 2018 Aug 1, 159 (8):2863-2883.

Human mesenchymal-stem-cells-derived exosomes are important in enhancing porcine islet resistance to hypoxia
Nie, W., Ma, X., Yang, C., Chen, Z., Rong, P., Wu, M., Jiang, J., Tan, M., Yi, S. and Wang, W.
Xenotransplantation. 2018 Sep 01, 25 (5):e12405.

OCIAD1 Controls Electron Transport Chain Complex I Activity to Regulate Energy Metabolism in Human Pluripotent Stem Cells
Shetty, D. K., Kalamkar, K. P. and Inamdar, M. S.
Stem Cell Reports. 2018 Jul 10, 11 (1):128-141.

Integrative multi-omics analysis of intestinal organoid differentiation
Lindeboom, R. G., van Voorthuijsen, L., Oost, K. C., Rodriguez-Colman, M. J., Luna-Velez, M. V., Furlan, C., Baraille, F., Jansen, P. W., Ribeiro, A., Burgering, B. M., Snippert, H. J. and Vermeulen, M.
Mol Syst Biol. 2018 Jun 26, 14 (6):e8227.

Techniques & Methods
Measurement of respiratory function in isolated cardiac mitochondria using Seahorse XFe24 Analyzer: applications for aging research
Sakamuri, S., Sperling, J. A., Sure, V. N., Dholakia, M. H., Peterson, N. R., Rutkai, I., Mahalingam, P. S., Satou, R. and Katakam, P. V. G.
Geroscience. 2018 Jun 02, 40 (3):347-356.

Assessing Mitochondrial Function in In Vitro and Ex Vivo Models of Huntington's Disease
Ferreira, I. L., Carmo, C., Naia, L., S, I. M. and Cristina Rego, A.
Methods Mol Biol. 2018 Oct 01, 1780:415-442.

Evaluation of Respiration with Clark-Type Electrode in Isolated Mitochondria and Permeabilized Animal Cells
Silva, A. M. and Oliveira, P. J.
Methods Mol Biol. 2018 Oct 01, 1782:7-29.

Enhanced quantification of metabolic activity for individual adipocytes by label-free FLIM
Evers, M., Salma, N., Osseiran, S., Casper, M., Birngruber, R., Evans, C. L. and Manstein, D.
Sci Rep. 2018 Jun 8, 8 (1):8757.

Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
Bond, S. T., McEwen, K. A., Yoganantharajah, P. and Gibert, Y.
Methods Mol Biol. 2018 Jun 01, 1797:393-401.

Influence of Pulsed Electric Fields and Mitochondria-Cytoskeleton Interactions on Cell Respiration
Goswami, I., Perry, J. B., Allen, M. E., Brown, D. A., von Spakovsky, M. R. and Verbridge, S. S.
Biophys J. 2018 Jun 19, 114 (12):2951-2964.

Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis
Divakaruni, A. S., Hsieh, W. Y., Minarrieta, L., Duong, T. N., Kim, K. K. O., Desousa, B. R., Andreyev, A. Y., Bowman, C. E., Caradonna, K., Dranka, B. P., Ferrick, D. A., Liesa, M., Stiles, L., Rogers, G. W., Braas, D., Ciaraldi, T. P., Wolfgang, M. J., Sparwasser, T., Berod, L., Bensinger, S. J. and Murphy, A. N.
Cell Metab. 2018 Sep 4, 28 (3):490-503 e7.

Mitochondrial-Localized Versus Cytosolic Intracellular CO-Releasing Organic PhotoCORMs: Evaluation of CO Effects Using Bioenergetics
Soboleva, T., Esquer, H. J., Anderson, S. N., Berreau, L. M. and Benninghoff, A. D.
ACS Chem Biol. 2018 Aug 17, 13 (8):2220-2228.

Toxicology Research
BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose
Lucantoni, F., Dussmann, H., Llorente-Folch, I. and Prehn, J. H. M.
Oncotarget. 2018 May 25, 9 (40):26046-26063.

Arylpyrrole and fipronil analogues that inhibit the motility and/or development of Haemonchus contortus in vitro
Dilrukshi Herath, H. M. P., Song, H., Preston, S., Jabbar, A., Wang, T., McGee, S. L., Hofmann, A., Garcia-Bustos, J., Chang, B. C. H., Koehler, A. V., Liu, Y., Ma, Q., Zhang, P., Zhao, Q., Wang, Q. and Gasser, R. B.
Int J Parasitol Drugs Drug Resist. 2018 Jun 4, 8 (3):379-385.

Organophosphate pesticide chlorpyrifos impairs STAT1 signaling to induce dopaminergic neurotoxicity: Implications for mitochondria mediated oxidative stress signaling events
Singh, N., Lawana, V., Luo, J., Phong, P., Abdalla, A., Palanisamy, B., Rokad, D., Sarkar, S., Jin, H., Anantharam, V., Kanthasamy, A. G. and Kanthasamy, A.
Neurobiol Dis. 2018 Sep 01, 117:82-113.

Evaluation of Rhodiola crenulata on growth and metabolism of NB-1691, an MYCN-amplified neuroblastoma cell line
Wong, K. E., Mora, M. C., Sultana, N., Moriarty, K. P., Arenas, R. B., Yadava, N., Schneider, S. S. and Tirabassi, M. V.
Tumour Biol. 2018 Jun 01, 40 (6):1010428318779515.

Metabolic activation-driven mitochondrial hyperpolarization predicts insulin secretion in human pancreatic beta-cells
Gerencser, A. A.
Biochim Biophys Acta Bioenerg. 2018 Sep 01, 1859 (9):817-828.

Metabolomics and cytotoxicity of monomethylhydrazine (MMH) and (E)-1,1,4,4-tetramethyl-2-tetrazene (TMTZ), two liquid propellants
Guyot, L., Machon, C., Honorat, M., Manship, B., Bouard, C., Vigneron, A., Puisieux, A., Labarthe, E., Jacob, G., Dhenain, A., Guitton, J. and Payen, L.
Toxicol In Vitro. 2018 Oct 01, 52:70-86.

The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms
Jakobsen, E., Lange, S. C., Andersen, J. V., Desler, C., Kihl, H. F., Hohnholt, M. C., Stridh, M. H., Rasmussen, L. J., Waagepetersen, H. S. and Bak, L. K.
Biochem Pharmacol. 2018 Sep 01, 155:92-101.

Intact Cell Lipidomics Reveal Changes to the Ratio of Cardiolipins to Phosphatidylinositols in Response to Kanamycin in HeLa and Primary Cells
Rebollo-Ramirez, S., Krokowski, S., Lobato-Marquez, D., Thomson, M., Pennisi, I., Mostowy, S. and Larrouy-Maumus, G.
Chem Res Toxicol. 2018 Aug 20, 31 (8):688-696.

Translational Research
Change in plasma lactate concentration during arctigenin administration in a phase I clinical trial in patients with gemcitabine-refractory pancreatic cancer
Fujioka, R., Mochizuki, N., Ikeda, M., Sato, A., Nomura, S., Owada, S., Yomoda, S., Tsuchihara, K., Kishino, S. and Esumi, H.
PLoS One. 2018 Jun 01, 13 (6):e0198219.

For Research Use Only. Not for use in diagnostic procedures.