Metabolic Plasticity as a Therapeutic Target

As cells adapt to their changing environment their metabolic programs experience changing demands to serve both changes in energy demand and the need to channel metabolites into new synthetic pathways. This requires a metabolic plasticity as the cell changes function and as such provides a new opportunity to identify metabolic targets amenable to therapeutic intervention. The prototypical example for this behavior is the frequently cited “Warburg” effect in which cancer cells exhibit a more pronounced reliance on aerobic glycolysis. Importantly, it is now becoming clear that this metabolic response is a biological strategy employed by a broad range of non-cancer cells as they respond to specific cellular signals which change their function. In the webinar we will discuss several examples, including fibrosis, platelet activation and immune cell activation, and the potential to develop novel metabolotherapies targeted specifically at the ability of cells to exhibit metabolic plasticity. We will introduce the example of acquired metabolic plasticity through exosome mediated mitochondrial transfer and its potential impact on the control of inflammation.

What you will learn during the eSeminar:

  • Understand the concept of metabolic plasticity.
  • See examples of the methods through which this can be tested.
  • Discussion of potential therapeutic strategies and assessment of metabolotherapies.

For Research Use Only.  Not for use in diagnostic procedures.

Wednesday, September 26, 2018
1:30pm PDT (Los Angeles)
4:30pm EDT (New York)

Available On Demand after September 26
All registrants will be notified when available

Presented by:

Victor M. Darley-Usmar, PhD
Director, UAB Mitochondrial Medicine Laboratory
The University of Alabama at Birmingham

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