XF出版物快报

2018年8

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Aging Research
Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
McLaughlin, T., Falkowski, M., Park, J. W., Keegan, S., Elliott, M., Wang, J. J. and Zhang, S. X.
Mol Neurodegener. 2018 Apr 4, 13 (1):16.

Assays under Hypoxia
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Sim, J., Cowburn, A. S., Palazon, A., Madhu, B., Tyrakis, P. A., Macias, D., Bargiela, D. M., Pietsch, S., Gralla, M., Evans, C. E., Kittipassorn, T., Chey, Y. C. J., Branco, C. M., Rundqvist, H., Peet, D. J. and Johnson, R. S.
Cell Metab. 2018 Apr 3, 27 (4):898-913 e7.

Cancer Research
Propofol Disrupts Aerobic Glycolysis in Colorectal Cancer Cells via Inactivation of the NMDAR-CAMKII-ERK Pathway
Xiangyuan Chena, Qichao Wua, Changhong Miao, Pengfei Suna, Yanjun Zhao and Minmin Zhu
Cell Physiol Biochem. 2018 Jun 27, [epub ahead of print]

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Cascone, T., McKenzie, J. A., Mbofung, R. M., Punt, S., Wang, Z., Xu, C., Williams, L. J., Wang, Z., Bristow, C. A., Carugo, A., Peoples, M. D., Li, L., Karpinets, T., Huang, L., Malu, S., Creasy, C., Leahey, S. E., Chen, J., Chen, Y., Pelicano, H., Bernatchez, C., Gopal, Y. N. V., Heffernan, T. P., Hu, J., Wang, J., Amaria, R. N., Garraway, L. A., Huang, P., Yang, P., Wistuba, II, Woodman, S. E., Roszik, J., Davis, R. E., Davies, M. A., Heymach, J. V., Hwu, P. and Peng, W.
Cell Metab. 2018 May 1, 27 (5):977-987 e4.

Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery
Chin, R. M., Panavas, T., Brown, J. M. and Johnson, K. K.
BMC Res Notes. 2018 Mar 27, 11 (1):205.

Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
Fiorillo, M., Peiris-Pages, M., Sanchez-Alvarez, R., Bartella, L., Di Donna, L., Dolce, V., Sindona, G., Sotgia, F., Cappello, A. R. and Lisanti, M. P.
Biochim Biophys Acta. 2018 Sep 01, 1859 (9):984-996.

Classical NF-kappaB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2
Londhe, P., Yu, P. Y., Ijiri, Y., Ladner, K. J., Fenger, J. M., London, C., Houghton, P. J. and Guttridge, D. C.
Front Oncol. 2018 April 11, 8:104.

Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells
Naguib, A., Mathew, G., Reczek, C. R., Watrud, K., Ambrico, A., Herzka, T., Salas, I. C., Lee, M. F., El-Amine, N., Zheng, W., Di Francesco, M. E., Marszalek, J. R., Pappin, D. J., Chandel, N. S. and Trotman, L. C.
Cell Rep. 2018 Apr 3, 23 (1):58-67.

Targeting glutaminolysis in chondrosarcoma in context of the IDH1/2 mutation
Peterse, E. F. P., Niessen, B., Addie, R. D., de Jong, Y., Cleven, A. H. G., Kruisselbrink, A. B., van den Akker, B., Molenaar, R. J., Cleton-Jansen, A. M. and Bovee, J.
Br J Cancer. 2018 Apr 01, 118 (8):1074-1083

miR-126-5p targets Malate Dehydrogenase 1 in non-small cell lung carcinomas
Lima Queiroz, A., Zhang, B., Comstock, D. E., Hao, Y., Eriksson, M., Hydbring, P., Vakifahmetoglu-Norberg, H. and Norberg, E.
Biochem Biophys Res Commun. 2018 May 5, 499 (2):314-320.

Increased formate overflow is a hallmark of oxidative cancer
Meiser, J., Schuster, A., Pietzke, M., Vande Voorde, J., Athineos, D., Oizel, K., Burgos-Barragan, G., Wit, N., Dhayade, S., Morton, J. P., Dornier, E., Sumpton, D., Mackay, G. M., Blyth, K., Patel, K. J., Niclou, S. P. and Vazquez, A.
Nat Commun. 2018 Apr 10, 9 (1):1368.

Effect of pistachio kernel extracts in MCF-7 breast cancer cells: Inhibition of cell proliferation, induction of ROS production, modulation of glycolysis and of mitochondrial respiration
Reboredo-Rodríguez, P., González-Barreiro, C., Cancho-Grande, B., Simal-Gándara, J., Giampieri, F., Forbes-Hernández, T. Y., Gasparrini, M., Afrin, S., Cianciosi, D., Manna, P. P., Varela-López, A., Ojeda-Amador, R. M., Fregapane, G., Desamparados Salvador, M. and Battino, M.
Journal of Functional Foods. 2018 Jun 01, 45:155-164.

B cell lymphoma with different metabolic characteristics show distinct sensitivities to metabolic inhibitors
Liu, X., Wang, L., Jiang, W., Lu, W., Yang, J. and Yang, W.
J Cancer. 2018 Apr 12, 9 (9):1582-1591.

Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo
He, L., Wang, K. N., Zheng, Y., Cao, J. J., Zhang, M. F., Tan, C. P., Ji, L. N. and Mao, Z. W.
Dalton Trans. 2018 May 22, 47 (20):6942-6953.

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer
Fernandez, H. R., Gadre, S. M., Tan, M., Graham, G. T., Mosaoa, R., Ongkeko, M. S., Kim, K. A., Riggins, R. B., Parasido, E., Petrini, I., Pacini, S., Cheema, A., Varghese, R., Ressom, H. W., Zhang, Y., Albanese, C., Uren, A., Paige, M., Giaccone, G. and Avantaggiati, M. L.
Cell Death Differ. 2018 Jul 01, 25 (7):1239-1258.

The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts
Visweswaran, M., Keane, K. N., Arfuso, F., Dilley, R. J., Newsholme, P. and Dharmarajan, A.
Cancer Microenviron. 2018 Jun 01, 11 (1):71-84.

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
Huang, J., Duran, A., Reina-Campos, M., Valencia, T., Castilla, E. A., Muller, T. D., Tschop, M. H., Moscat, J. and Diaz-Meco, M. T.
Cancer Cell. 2018 Apr 9, 33 (4):770-784 e6.

Cooperative STAT/NF-kappaB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
Feist, M., Schwarzfischer, P., Heinrich, P., Sun, X., Kemper, J., von Bonin, F., Perez-Rubio, P., Taruttis, F., Rehberg, T., Dettmer, K., Gronwald, W., Reinders, J., Engelmann, J. C., Dudek, J., Klapper, W., Trumper, L., Spang, R., Oefner, P. J. and Kube, D.
Nat Commun. 2018 Apr 17, 9 (1):1514.

Effects of Dahuang zhechong pill on doxorubicin-resistant SMMC-7721 xenografts in mice
Wu, L., Cao, K. X., Ni, Z. H., Li, W. D., Chen, Z. P., Cheng, H. B. and Liu, X.
J Ethnopharmacol. 2018 Aug 10, 222:71-78.

Recent advances in cancer metabolism: a technological perspective
Kang, Y. P., Ward, N. P. and DeNicola, G. M.
Exp Mol Med. 2018 Apr 16, 50 (4):31.

Nicotinamide Nucleotide Transhydrogenase as a Novel Treatment Target in Adrenocortical Carcinoma
Chortis, V., Taylor, A. E., Doig, C. L., Walsh, M. D., Meimaridou, E., Jenkinson, C., Rodriguez-Blanco, G., Ronchi, C. L., Jafri, A., Metherell, L. A., Hebenstreit, D., Dunn, W. B., Arlt, W. and Foster, P. A.
Endocrinology. 2018 Aug 1, 159 (8):2836-2849.

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments
Ecker, C., Guo, L., Voicu, S., Gil-de-Gomez, L., Medvec, A., Cortina, L., Pajda, J., Andolina, M., Torres-Castillo, M., Donato, J. L., Mansour, S., Zynda, E. R., Lin, P. Y., Varela-Rohena, A., Blair, I. A. and Riley, J. L.
Cell Rep. 2018 Apr 17, 23 (3):741-755.

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
Ye, H., Zhou, Q., Zheng, S., Li, G., Lin, Q., Wei, L., Fu, Z., Zhang, B., Liu, Y., Li, Z. and Chen, R.
Cell Death Dis. 2018 May 1, 9 (5):453.

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells
Yamamoto, K., Yasui, H., Bo, T., Yamamori, T., Hiraoka, W., Yamasaki, T., Yamada, K.-i. and Inanami, O.
Applied Magnetic Resonance. 2018 Apr 21, 49 (8):837-851.

Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation
Nogueira, V., Patra, K. C. and Hay, N.
Elife. 2018 Apr 24, 7.

Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function
Zhuo, M., Gorgun, M. F. and Englander, E. W.
Free Radic Biol Med. 2018 Jun 01, 121: 9-19.

HOXA9 inhibits HIF-1alpha-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development
Zhou, L., Wang, Y., Zhou, M., Zhang, Y., Wang, P., Li, X., Yang, J., Wang, H. and Ding, Z.
Nat Commun. 2018 Apr 16, 9 (1):1480.

Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer
Lv, Z., Yan, X., Lu, L., Su, C. and He, Y.
J Bioenerg Biomembr. 2018 Aug 01, 50 (4):263-270.

CBX3 promotes proliferation and regulates glycolysis via suppressing FBP1 in pancreatic cancer
Chen, L. Y., Cheng, C. S., Qu, C., Wang, P., Chen, H., Meng, Z. Q. and Chen, Z.
Biochem Biophys Res Commun. 2018 Jun 7, 500 (3):691-697.

MPC1 is essential for PGC-1alpha-induced mitochondrial respiration and biogenesis
Koh, E., Kim, Y. K., Shin, D. and Kim, K. S.
Biochem J. 2018 May 18, 475 (10):1687-1699.

Cardiovascular Research
Ablation of the stress protease OMA1 protects against heart failure in mice
Acin-Perez, R., Lechuga-Vieco, A. V., Del Mar Munoz, M., Nieto-Arellano, R., Torroja, C., Sanchez-Cabo, F., Jimenez, C., Gonzalez-Guerra, A., Carrascoso, I., Beninca, C., Quiros, P. M., Lopez-Otin, C., Castellano, J. M., Ruiz-Cabello, J., Jimenez-Borreguero, L. J. and Enriquez, J. A.
Sci Transl Med. 2018 Mar 28, 10 (434).

Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction
Cheung, J. Y., Wang, J., Zhang, X. Q., Song, J., Davidyock, J. M., Prado, F. J., Shanmughapriya, S., Worth, A. M., Madesh, M., Judenherc-Haouzi, A. and Haouzi, P.
Cardiovasc Toxicol. 2018 Mar 30,  [epub ahead if print]

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes
Cunha-Oliveira, T., Ferreira, L. L., Coelho, A. R., Deus, C. M. and Oliveira, P. J.
Toxicol Appl Pharmacol. 2018 Jun 1, 348:1-13.

Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung
Rafikova, O., Srivastava, A., Desai, A. A., Rafikov, R. and Tofovic, S. P.
Respir Res. 2018 Apr 23, 19 (1):69.

Cell Physiology Research
Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction
Cheung, J. Y., Wang, J., Zhang, X. Q., Song, J., Davidyock, J. M., Prado, F. J., Shanmughapriya, S., Worth, A. M., Madesh, M., Judenherc-Haouzi, A. and Haouzi, P.
Cardiovasc Toxicol. 2018 Mar 30,  [epub ahead if print]

Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction
Auger, C., Sivayoganathan, T., Abdullahi, A., Parousis, A., Pang, B. W. and Jeschke, M. G.
Sci Rep. 2018 Apr 4, 8 (1):5646.

The targeted anti-oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue
Gottwald, E. M., Duss, M., Bugarski, M., Haenni, D., Schuh, C. D., Landau, E. M. and Hall, A. M.
Physiol Rep. 2018 Apr 01, 6 (7):e13667.

Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats
Evans, L. C., Dayton, A., Yang, C., Liu, P., Kurth, T., Ahn, K. W., Komas, S., Stingo, F. C., Laud, P. W., Vannucci, M., Liang, M. and Cowley, A. W., Jr.
Physiol Genomics. 2018 Jun 1, 50 (6):440-447.

Characterization of a Spontaneously Immortalized Murine Muller Glial Cell Line QMMuC-1
Augustine, J., Pavlou, S., O'Hare, M., Harkin, K., Stitt, A., Curtis, T., Xu, H. and Chen, M.
Invest Ophthalmol Vis Sci. 2018 Mar 1, 59 (3):1666-1674.

Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
Benador, I. Y., Veliova, M., Mahdaviani, K., Petcherski, A., Wikstrom, J. D., Assali, E. A., Acin-Perez, R., Shum, M., Oliveira, M. F., Cinti, S., Sztalryd, C., Barshop, W. D., Wohlschlegel, J. A., Corkey, B. E., Liesa, M. and Shirihai, O. S.
Cell Metab. 2018 Apr 3, 27 (4):869-885 e6.

Revisiting the putative role of heme as a trigger of inflammation

Vallelian, F., Schaer, C. A., Deuel, J. W., Ingoglia, G., Humar, R., Buehler, P. W. and Schaer, D. J.
Pharmacol Res Perspect. 2018 Mar 30, 6 (2):e00392.

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Sim, J., Cowburn, A. S., Palazon, A., Madhu, B., Tyrakis, P. A., Macias, D., Bargiela, D. M., Pietsch, S., Gralla, M., Evans, C. E., Kittipassorn, T., Chey, Y. C. J., Branco, C. M., Rundqvist, H., Peet, D. J. and Johnson, R. S.
Cell Metab. 2018 Apr 3, 27 (4):898-913 e7.

Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally
Meng, F., Kassa, T., Jana, S., Wood, F., Zhang, X., Jia, Y., D'Agnillo, F. and Alayash, A. I.
Bioconjug Chem. 2018 May 16, 29 (5):1560-1575.

Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging
Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnson, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., Pope-Varsalona, H., Gurkar, A. U., Nasto, L. A., Robinson, R. A. S., Fuhrmann-Stroissnigg, H., Czerwinska, J., McGowan, S. J., Cantu-Medellin, N., Harris, J. B., Maniar, S., Ross, M. A., Trussoni, C. E., LaRusso, N. F., Cifuentes-Pagano, E., Pagano, P. J., Tudek, B., Vo, N. V., Rigatti, L. H., Opresko, P. L., Stolz, D. B., Watkins, S. C., Burd, C. E., Croix, C. M. S., Siuzdak, G., Yates, N. A., Robbins, P. D., Wang, Y., Wipf, P., Kelley, E. E. and Niedernhofer, L. J.
Redox Biol. 2018 Jul 01, 17:259-273.

Zmynd17 controls muscle mitochondrial quality and whole-body metabolism
Fujita, R., Yoshioka, K., Seko, D., Suematsu, T., Mitsuhashi, S., Senoo, N., Miura, S., Nishino, I. and Ono, Y.
FASEB J. 2018 Apr 13, [epub ahead of print]

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Rodriguez-Nuevo, A., Diaz-Ramos, A., Noguera, E., Diaz-Saez, F., Duran, X., Munoz, J. P., Romero, M., Plana, N., Sebastian, D., Tezze, C., Romanello, V., Ribas, F., Seco, J., Planet, E., Doctrow, S. R., Gonzalez, J., Borras, M., Liesa, M., Palacin, M., Vendrell, J., Villarroya, F., Sandri, M., Shirihai, O. and Zorzano, A.
EMBO J. 2018 May 15, 37 (10).

Proteome-wide analysis of cysteine oxidation reveals metabolic sensitivity to redox stress
van der Reest, J., Lilla, S., Zheng, L., Zanivan, S. and Gottlieb, E.
Nat Commun. 2018 Apr 20, 9 (1):1581.

Loss of tafazzin results in decreased myoblast differentiation in C2C12 cells: A myoblast model of Barth syndrome and cardiolipin deficiency
Lou, W., Reynolds, C. A., Li, Y., Liu, J., Huttemann, M., Schlame, M., Stevenson, D., Strathdee, D. and Greenberg, M. L.
Biochim Biophys Acta. 2018 Aug 01, 1863 (8):857-865.

A novel role of endocan in alleviating LPS-induced acute lung injury
Zhang, X., Zhuang, R., Wu, H., Chen, J., Wang, F., Li, G. and Wu, C.
Life Sci. 2018 Jun 1, 202: 89-97.

Down-regulated let-7b-5p represses glycolysis metabolism by targeting AURKB in asthenozoospermia
Zhou, R., Zhang, Y., Du, G., Han, L., Zheng, S., Liang, J., Huang, X., Qin, Y., Wu, W., Chen, M., Wu, D., Song, L., Fu, G., Lv, S., Xia, Y., Lu, C. and Wang, X.
Gene. 2018 Jul 15, 663:83-87.

Drug Discovery
Propofol Disrupts Aerobic Glycolysis in Colorectal Cancer Cells via Inactivation of the NMDAR-CAMKII-ERK Pathway
Xiangyuan Chena, Qichao Wua, Changhong Miao, Pengfei Suna, Yanjun Zhao and Minmin Zhu
Cell Physiol Biochem. 2018 Jun 27, [epub ahead of print]

Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Cascone, T., McKenzie, J. A., Mbofung, R. M., Punt, S., Wang, Z., Xu, C., Williams, L. J., Wang, Z., Bristow, C. A., Carugo, A., Peoples, M. D., Li, L., Karpinets, T., Huang, L., Malu, S., Creasy, C., Leahey, S. E., Chen, J., Chen, Y., Pelicano, H., Bernatchez, C., Gopal, Y. N. V., Heffernan, T. P., Hu, J., Wang, J., Amaria, R. N., Garraway, L. A., Huang, P., Yang, P., Wistuba, II, Woodman, S. E., Roszik, J., Davis, R. E., Davies, M. A., Heymach, J. V., Hwu, P. and Peng, W.
Cell Metab. 2018 May 1, 27 (5):977-987 e4.

Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery
Chin, R. M., Panavas, T., Brown, J. M. and Johnson, K. K.
BMC Res Notes. 2018 Mar 27, 11 (1):205.

Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction
Cheung, J. Y., Wang, J., Zhang, X. Q., Song, J., Davidyock, J. M., Prado, F. J., Shanmughapriya, S., Worth, A. M., Madesh, M., Judenherc-Haouzi, A. and Haouzi, P.
Cardiovasc Toxicol. 2018 Mar 30,  [epub ahead if print]

Metformin adapts its cellular effects to bioenergetic status in a model of metabolic dysfunction
Auger, C., Sivayoganathan, T., Abdullahi, A., Parousis, A., Pang, B. W. and Jeschke, M. G.
Sci Rep. 2018 Apr 4, 8 (1):5646.

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Kornberg, M. D., Bhargava, P., Kim, P. M., Putluri, V., Snowman, A. M., Putluri, N., Calabresi, P. A. and Snyder, S. H.
Science. 2018 Apr 27, 360 (6387):449-453.

Mitochondria-Targeting Peptoids
Nam, H. Y., Hong, J. A., Choi, J., Shin, S., Cho, S. K., Seo, J. and Lee, J.
Bioconjug Chem. 2018 May 16, 29 (5):1669-1676.

High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

Cyclometalated iridium(iii) complexes induce mitochondria-derived paraptotic cell death and inhibit tumor growth in vivo
He, L., Wang, K. N., Zheng, Y., Cao, J. J., Zhang, M. F., Tan, C. P., Ji, L. N. and Mao, Z. W.
Dalton Trans. 2018 May 22, 47 (20):6942-6953.

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes
Cunha-Oliveira, T., Ferreira, L. L., Coelho, A. R., Deus, C. M. and Oliveira, P. J.
Toxicol Appl Pharmacol. 2018 Jun 1, 348:1-13.

Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway
Sharikova, A. V., Quaye, E., Park, J. Y., Maloney, M. C., Desta, H., Thiyagarajan, R., Seldeen, K. L., Parikh, N. U., Sandhu, P., Khmaladze, A., Troen, B. R., Schwartz, S. A. and Mahajan, S. D.
J Neuroimmune Pharmacol. 2018 Sep 01, 13 (3):396-411.

Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro
Jing, Y. H., Yan, J. L., Wang, Q. J., Chen, H. C., Ma, X. Z., Yin, J. and Gao, L. P.
Exp Gerontol. 2018 Jul 15, 108:77-86.

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes
de Ligt, M., Bruls, Y. M. H., Hansen, J., Habets, M. F., Havekes, B., Nascimento, E. B. M., Moonen-Kornips, E., Schaart, G., Schrauwen-Hinderling, V. B., van Marken Lichtenbelt, W. and Schrauwen, P.
Mol Metab. 2018 Jun 01, 12:39-47.

Atovaquone enhances doxorubicin's efficacy via inhibiting mitochondrial respiration and STAT3 in aggressive thyroid cancer
Lv, Z., Yan, X., Lu, L., Su, C. and He, Y.
J Bioenerg Biomembr. 2018 Aug 01, 50 (4):263-270.

Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling
Verheijen, M., Schrooders, Y., Gmuender, H., Nudischer, R., Clayton, O., Hynes, J., Niederer, S., Cordes, H., Kuepfer, L., Kleinjans, J. and Caiment, F.
Toxicol Lett. 2018 Sep 15, 294:184-192.

Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity
Zhang, Z., You, Z., Dobrowsky, R. T. and Blagg, B. S. J.
Bioorg Med Chem Lett. 2018 Mar 26, [epub ahead of print]

Immunology Research
Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy
Cascone, T., McKenzie, J. A., Mbofung, R. M., Punt, S., Wang, Z., Xu, C., Williams, L. J., Wang, Z., Bristow, C. A., Carugo, A., Peoples, M. D., Li, L., Karpinets, T., Huang, L., Malu, S., Creasy, C., Leahey, S. E., Chen, J., Chen, Y., Pelicano, H., Bernatchez, C., Gopal, Y. N. V., Heffernan, T. P., Hu, J., Wang, J., Amaria, R. N., Garraway, L. A., Huang, P., Yang, P., Wistuba, II, Woodman, S. E., Roszik, J., Davis, R. E., Davies, M. A., Heymach, J. V., Hwu, P. and Peng, W.
Cell Metab. 2018 May 1, 27 (5):977-987 e4.

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation
Anan, K., Hino, S., Shimizu, N., Sakamoto, A., Nagaoka, K., Takase, R., Kohrogi, K., Araki, H., Hino, Y., Usuki, S., Oki, S., Tanaka, H., Nakamura, K., Endo, F. and Nakao, M.
Nucleic Acids Res. 2018 Jun 20, 46 (11):5441-5454.

Second signals rescue B cells from activation-induced mitochondrial dysfunction and death
Akkaya, M., Traba, J., Roesler, A. S., Miozzo, P., Akkaya, B., Theall, B. P., Sohn, H., Pena, M., Smelkinson, M., Kabat, J., Dahlstrom, E., Dorward, D. W., Skinner, J., Sack, M. N. and Pierce, S. K.
Nat Immunol. 2018 Jul 9, [epub ahead of print]

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells
Adeosun, S. O., Gordon, D. M., Weeks, M. F., Moore, K. H., Hall, J. E., Hinds, T. D., Jr. and Stec, D. E.
Am J Physiol Renal Physiol. 2018 Aug 1, 315 (2):F323-F331.

Revisiting the putative role of heme as a trigger of inflammation
Vallelian, F., Schaer, C. A., Deuel, J. W., Ingoglia, G., Humar, R., Buehler, P. W. and Schaer, D. J.
Pharmacol Res Perspect. 2018 Mar 30, 6 (2):e00392.

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
Kornberg, M. D., Bhargava, P., Kim, P. M., Putluri, V., Snowman, A. M., Putluri, N., Calabresi, P. A. and Snyder, S. H.
Science. 2018 Apr 27, 360 (6387):449-453.

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
Mills, E. L., Ryan, D. G., Prag, H. A., Dikovskaya, D., Menon, D., Zaslona, Z., Jedrychowski, M. P., Costa, A. S. H., Higgins, M., Hams, E., Szpyt, J., Runtsch, M. C., King, M. S., McGouran, J. F., Fischer, R., Kessler, B. M., McGettrick, A. F., Hughes, M. M., Carroll, R. G., Booty, L. M., Knatko, E. V., Meakin, P. J., Ashford, M. L. J., Modis, L. K., Brunori, G., Sevin, D. C., Fallon, P. G., Caldwell, S. T., Kunji, E. R. S., Chouchani, E. T., Frezza, C., Dinkova-Kostova, A. T., Hartley, R. C., Murphy, M. P. and O'Neill, L. A.
Nature. 2018 Apr 5, 556 (7699):113-117.

LP-BM5 Retrovirus–Expanded Monocytic Myeloid-Derived Suppressor Cells Alter B Cell Phenotype and Function
Rastad, J. L. and Green, W. R.
ImmunoHorizons. 2018 Mar 01, 2 (3):87-106.

B cell lymphoma with different metabolic characteristics show distinct sensitivities to metabolic inhibitors
Liu, X., Wang, L., Jiang, W., Lu, W., Yang, J. and Yang, W.
J Cancer. 2018 Apr 12, 9 (9):1582-1591.

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency
Rodriguez-Nuevo, A., Diaz-Ramos, A., Noguera, E., Diaz-Saez, F., Duran, X., Munoz, J. P., Romero, M., Plana, N., Sebastian, D., Tezze, C., Romanello, V., Ribas, F., Seco, J., Planet, E., Doctrow, S. R., Gonzalez, J., Borras, M., Liesa, M., Palacin, M., Vendrell, J., Villarroya, F., Sandri, M., Shirihai, O. and Zorzano, A.
EMBO J. 2018 May 15, 37 (10).

Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture
Redmann, M., Benavides, G. A., Wani, W. Y., Berryhill, T. F., Ouyang, X., Johnson, M. S., Ravi, S., Mitra, K., Barnes, S., Darley-Usmar, V. M. and Zhang, J.
Redox Biol. 2018 Jul 01, 17:59-69.

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
Lim, H., Lim, Y. M., Kim, K. H., Jeon, Y. E., Park, K., Kim, J., Hwang, H. Y., Lee, D. J., Pagire, H., Kwon, H. J., Ahn, J. H. and Lee, M. S.
Nat Commun. 2018 Apr 12, 9 (1):1438.

Heat acclimation increases mitochondrial respiration capacity of C2C12 myotubes and protects against LPS-mediated energy deficit
Patton, M. G., Gillum, T. L., Szymanski, M. C., Gould, L. M., Lauterbach, C. J., Vaughan, R. A. and Kuennen, M. R.
Cell Stress Chaperones. 2018 Apr 11, [epub ahead of print]

Cooperative STAT/NF-kappaB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
Feist, M., Schwarzfischer, P., Heinrich, P., Sun, X., Kemper, J., von Bonin, F., Perez-Rubio, P., Taruttis, F., Rehberg, T., Dettmer, K., Gronwald, W., Reinders, J., Engelmann, J. C., Dudek, J., Klapper, W., Trumper, L., Spang, R., Oefner, P. J. and Kube, D.
Nat Commun. 2018 Apr 17, 9 (1):1514.

Differential Reliance on Lipid Metabolism as a Salvage Pathway Underlies Functional Differences of T Cell Subsets in Poor Nutrient Environments
Ecker, C., Guo, L., Voicu, S., Gil-de-Gomez, L., Medvec, A., Cortina, L., Pajda, J., Andolina, M., Torres-Castillo, M., Donato, J. L., Mansour, S., Zynda, E. R., Lin, P. Y., Varela-Rohena, A., Blair, I. A. and Riley, J. L.
Cell Rep. 2018 Apr 17, 23 (3):741-755.

Tumor-associated macrophages promote progression and the Warburg effect via CCL18/NF-kB/VCAM-1 pathway in pancreatic ductal adenocarcinoma
Ye, H., Zhou, Q., Zheng, S., Li, G., Lin, Q., Wei, L., Fu, Z., Zhang, B., Liu, Y., Li, Z. and Chen, R.
Cell Death Dis. 2018 May 1, 9 (5):453.

Estrogen receptor alpha contributes to T cell-mediated autoimmune inflammation by promoting T cell activation and proliferation
Mohammad, I., Starskaia, I., Nagy, T., Guo, J., Yatkin, E., Vaananen, K., Watford, W. T. and Chen, Z.
Sci Signal. 2018 Apr 17, 11 (526).

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
O'Connor, R. S., Guo, L., Ghassemi, S., Snyder, N. W., Worth, A. J., Weng, L., Kam, Y., Philipson, B., Trefely, S., Nunez-Cruz, S., Blair, I. A., June, C. H. and Milone, M. C.
Sci Rep. 2018 Apr 19, 8 (1):6289.

Reduced oxidative capacity in macrophages results in systemic insulin resistance
Jung, S. B., Choi, M. J., Ryu, D., Yi, H. S., Lee, S. E., Chang, J. Y., Chung, H. K., Kim, Y. K., Kang, S. G., Lee, J. H., Kim, K. S., Kim, H. J., Kim, C. S., Lee, C. H., Williams, R. W., Kim, H., Lee, H. K., Auwerx, J. and Shong, M.
Nat Commun. 2018 Apr 19, 9 (1):1551.

Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis
Sherrill, J. D., Kc, K., Wang, X., Wen, T., Chamberlin, A., Stucke, E. M., Collins, M. H., Abonia, J. P., Peng, Y., Wu, Q., Putnam, P. E., Dexheimer, P. J., Aronow, B. J., Kottyan, L. C., Kaufman, K. M., Harley, J. B., Huang, T. and Rothenberg, M. E.
JCI Insight. 2018 Apr 19, 3 (8).

Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Rajamani, U., Gross, A. R., Hjelm, B. E., Sequeira, A., Vawter, M. P., Tang, J., Gangalapudi, V., Wang, Y., Andres, A. M., Gottlieb, R. A. and Sareen, D.
Cell Stem Cell. 2018 May 3, 22 (5):698-712 e9.

Control of pancreatic beta-cell bioenergetics
Affourtit, C., Alberts, B., Barlow, J., Carre, J. E. and Wynne, A. G.
Biochem Soc Trans. 2018 Jun 19, 46 (3):555-564.

Jak-TGFbeta cross-talk links transient adipose tissue inflammation to beige adipogenesis
Babaei, R., Schuster, M., Meln, I., Lerch, S., Ghandour, R. A., Pisani, D. F., Bayindir-Buchhalter, I., Marx, J., Wu, S., Schoiswohl, G., Billeter, A. T., Krunic, D., Mauer, J., Lee, Y. H., Granneman, J. G., Fischer, L., Muller-Stich, B. P., Amri, E. Z., Kershaw, E. E., Heikenwalder, M., Herzig, S. and Vegiopoulos, A.
Sci Signal. 2018 Apr 24, 11 (527).

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism
Lu, X., Altshuler-Keylin, S., Wang, Q., Chen, Y., Henrique Sponton, C., Ikeda, K., Maretich, P., Yoneshiro, T. and Kajimura, S.
Sci Signal. 2018 Apr 24, 11 (527).

The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism
Fensterheim, B. A., Young, J. D., Luan, L., Kleinbard, R. R., Stothers, C. L., Patil, N. K., McAtee-Pereira, A. G., Guo, Y., Trenary, I., Hernandez, A., Fults, J. B., Williams, D. L., Sherwood, E. R. and Bohannon, J. K.
J Immunol. 2018 Jun 1, 200 (11):3777-3789.

Infectious Disease Research
The inflammasome potentiates influenza/Staphylococcus aureus superinfection in mice
Robinson, K. M., Ramanan, K., Clay, M. E., McHugh, K. J., Pilewski, M. J., Nickolich, K. L., Corey, C., Shiva, S., Wang, J., Muzumdar, R. and Alcorn, J. F.
JCI Insight. 2018 Apr 5, 3 (7).

Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses
Pal, V. K., Bandyopadhyay, P. and Singh, A.
IUBMB Life. 2018 May 01, 70 (5):393-410.

The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism
Fensterheim, B. A., Young, J. D., Luan, L., Kleinbard, R. R., Stothers, C. L., Patil, N. K., McAtee-Pereira, A. G., Guo, Y., Trenary, I., Hernandez, A., Fults, J. B., Williams, D. L., Sherwood, E. R. and Bohannon, J. K.
J Immunol. 2018 Jun 1, 200 (11):3777-3789.

Mitochondrial Disease Research
Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery
Chin, R. M., Panavas, T., Brown, J. M. and Johnson, K. K.
BMC Res Notes. 2018 Mar 27, 11 (1):205.

High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung
Rafikova, O., Srivastava, A., Desai, A. A., Rafikov, R. and Tofovic, S. P.
Respir Res. 2018 Apr 23, 19 (1):69.

Model Organisms
High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

Nephrology Research
The targeted anti-oxidant MitoQ causes mitochondrial swelling and depolarization in kidney tissue
Gottwald, E. M., Duss, M., Bugarski, M., Haenni, D., Schuh, C. D., Landau, E. M. and Hall, A. M.
Physiol Rep. 2018 Apr 01, 6 (7):e13667.

Transcriptomic analysis reveals inflammatory and metabolic pathways that are regulated by renal perfusion pressure in the outer medulla of Dahl-S rats
Evans, L. C., Dayton, A., Yang, C., Liu, P., Kurth, T., Ahn, K. W., Komas, S., Stingo, F. C., Laud, P. W., Vannucci, M., Liang, M. and Cowley, A. W., Jr.
Physiol Genomics. 2018 Jun 1, 50 (6):440-447.

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells
Adeosun, S. O., Gordon, D. M., Weeks, M. F., Moore, K. H., Hall, J. E., Hinds, T. D., Jr. and Stec, D. E.
Am J Physiol Renal Physiol. 2018 Aug 1, 315 (2):F323-F331.

Neurobiology Research
Characterization of a Spontaneously Immortalized Murine Muller Glial Cell Line QMMuC-1
Augustine, J., Pavlou, S., O'Hare, M., Harkin, K., Stitt, A., Curtis, T., Xu, H. and Chen, M.
Invest Ophthalmol Vis Sci. 2018 Mar 1, 59 (3):1666-1674.

Microglia activation in Niemann-Pick disease, type C1 is amendable to therapeutic intervention
Cougnoux, A., Drummond, R. A., Collar, A. L., Iben, J. R., Salman, A., Westgarth, H., Wassif, C. A., Cawley, N. X., Farhat, N. Y., Ozato, K., Lionakis, M. S. and Porter, F. D.
Hum Mol Genet. 2018 Jun 15, 27 (12):2076-2089.

Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration
McLaughlin, T., Falkowski, M., Park, J. W., Keegan, S., Elliott, M., Wang, J. J. and Zhang, S. X.
Mol Neurodegener. 2018 Apr 4, 13 (1):16.

Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway
Sharikova, A. V., Quaye, E., Park, J. Y., Maloney, M. C., Desta, H., Thiyagarajan, R., Seldeen, K. L., Parikh, N. U., Sandhu, P., Khmaladze, A., Troen, B. R., Schwartz, S. A. and Mahajan, S. D.
J Neuroimmune Pharmacol. 2018 Sep 01, 13 (3):396-411.

Spermidine ameliorates the neuronal aging by improving the mitochondrial function in vitro
Jing, Y. H., Yan, J. L., Wang, Q. J., Chen, H. C., Ma, X. Z., Yin, J. and Gao, L. P.
Exp Gerontol. 2018 Jul 15, 108:77-86.

DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders
Jouroukhin, Y., Kageyama, Y., Misheneva, V., Shevelkin, A., Andrabi, S., Prandovszky, E., Yolken, R. H., Dawson, V. L., Dawson, T. M., Aja, S., Sesaki, H. and Pletnikov, M. V.
Transl Psychiatry. 2018 Apr 12, 8 (1):76.

Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Rajamani, U., Gross, A. R., Hjelm, B. E., Sequeira, A., Vawter, M. P., Tang, J., Gangalapudi, V., Wang, Y., Andres, A. M., Gottlieb, R. A. and Sareen, D.
Cell Stem Cell. 2018 May 3, 22 (5):698-712 e9.

NF-kappaB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program
FitzPatrick, L. M., Hawkins, K. E., Delhove, J., Fernandez, E., Soldati, C., Bullen, L. F., Nohturfft, A., Waddington, S. N., Medina, D. L., Bolanos, J. P. and McKay, T. R.
Stem Cell Reports. 2018 Jun 5, 10 (6):1766-1781.

The c-Abl inhibitor, Radotinib HCl, is neuroprotective in a preclinical Parkinson's disease mouse model
Lee, S., Kim, S., Park, Y. J., Yun, S. P., Kwon, S. H., Kim, D., Kim, D. Y., Shin, J. S., Cho, D. J., Lee, G. Y., Ju, H. S., Yun, H. J., Park, J. H., Kim, W. R., Jung, E. A., Lee, S. and Ko, H. S.
Hum Mol Genet. 2018 Jul 1, 27 (13):2344-2356.

Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function
Zhuo, M., Gorgun, M. F. and Englander, E. W.
Free Radic Biol Med. 2018 Jun 01, 121: 9-19.

Loss of tafazzin results in decreased myoblast differentiation in C2C12 cells: A myoblast model of Barth syndrome and cardiolipin deficiency
Lou, W., Reynolds, C. A., Li, Y., Liu, J., Huttemann, M., Schlame, M., Stevenson, D., Strathdee, D. and Greenberg, M. L.
Biochim Biophys Acta. 2018 Aug 01, 1863 (8):857-865.

Synthesis and evaluation of a ring-constrained Hsp90 C-terminal inhibitor that exhibits neuroprotective activity
Zhang, Z., You, Z., Dobrowsky, R. T. and Blagg, B. S. J.
Bioorg Med Chem Lett. 2018 Mar 26, [epub ahead of print]

Mitochondrial dysfunction is implicated in retinoic acid-induced spina bifida aperta in rat fetuses
Xue, J., Gu, H., Liu, D., Ma, W., Wei, X., Zhao, L., Liu, Y., Zhang, C. and Yuan, Z.
Int J Dev Neurosci. 2018 Apr 22, 68:39-44.

The idebenone metabolite QS10 restores electron transfer in complex I and coenzyme Q defects
Giorgio, V., Schiavone, M., Galber, C., Carini, M., Da Ros, T., Petronilli, V., Argenton, F., Carelli, V., Acosta Lopez, M. J., Salviati, L., Prato, M. and Bernardi, P.
Biochim Biophys Acta. 2018 Sep 01, 1859 (9):901-908.

Obesity, Diabetes, & Metabolic Disorders
Mitochondria Bound to Lipid Droplets Have Unique Bioenergetics, Composition, and Dynamics that Support Lipid Droplet Expansion
Benador, I. Y., Veliova, M., Mahdaviani, K., Petcherski, A., Wikstrom, J. D., Assali, E. A., Acin-Perez, R., Shum, M., Oliveira, M. F., Cinti, S., Sztalryd, C., Barshop, W. D., Wohlschlegel, J. A., Corkey, B. E., Liesa, M. and Shirihai, O. S.
Cell Metab. 2018 Apr 3, 27 (4):869-885 e6.

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells
Adeosun, S. O., Gordon, D. M., Weeks, M. F., Moore, K. H., Hall, J. E., Hinds, T. D., Jr. and Stec, D. E.
Am J Physiol Renal Physiol. 2018 Aug 1, 315 (2):F323-F331.

Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance
Fan, S., Wang, Y., Wang, C., Jin, H., Wu, Z., Lu, J., Zhang, Z., Sun, C., Shan, Q., Wu, D., Zhuang, J., Sheng, N., Xie, Y., Li, M., Hu, B., Fang, J., Zheng, Y. and Qin, W.
Free Radic Biol Med. 2018 May 20, 120:330-341.

Evaluation and optimization of differentiation conditions for human primary brown adipocytes
Wang, X., You, L., Cui, X., Li, Y., Wang, X., Xu, P., Zhu, L., Wen, J., Pang, L., Guo, X. and Ji, C.
Sci Rep. 2018 Mar 28, 8 (1):5304.

Enhanced Hepatic PPARalpha Activity Links GLUT8 Deficiency to Augmented Peripheral Fasting Responses in Male Mice
Mayer, A. L., Zhang, Y., Feng, E. H., Higgins, C. B., Adenekan, O., Pietka, T. A., Beatty, W. L. and DeBosch, B. J.
Endocrinology. 2018 May 1, 159 (5):2110-2126.

Adipocyte p62/SQSTM1 Suppresses Tumorigenesis through Opposite Regulations of Metabolism in Adipose Tissue and Tumor
Huang, J., Duran, A., Reina-Campos, M., Valencia, T., Castilla, E. A., Muller, T. D., Tschop, M. H., Moscat, J. and Diaz-Meco, M. T.
Cancer Cell. 2018 Apr 9, 33 (4):770-784 e6.

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes
Lim, H., Lim, Y. M., Kim, K. H., Jeon, Y. E., Park, K., Kim, J., Hwang, H. Y., Lee, D. J., Pagire, H., Kwon, H. J., Ahn, J. H. and Lee, M. S.
Nat Commun. 2018 Apr 12, 9 (1):1438.

NAD(+)-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism
Porter, L. C., Franczyk, M. P., Pietka, T., Yamaguchi, S., Lin, J. B., Sasaki, Y., Verdin, E., Apte, R. S. and Yoshino, J.
Am J Physiol Endocrinol Metab. 2018 Apr 10, [epub ahead of print]

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes
de Ligt, M., Bruls, Y. M. H., Hansen, J., Habets, M. F., Havekes, B., Nascimento, E. B. M., Moonen-Kornips, E., Schaart, G., Schrauwen-Hinderling, V. B., van Marken Lichtenbelt, W. and Schrauwen, P.
Mol Metab. 2018 Jun 01, 12:39-47.

Reduced oxidative capacity in macrophages results in systemic insulin resistance
Jung, S. B., Choi, M. J., Ryu, D., Yi, H. S., Lee, S. E., Chang, J. Y., Chung, H. K., Kim, Y. K., Kang, S. G., Lee, J. H., Kim, K. S., Kim, H. J., Kim, C. S., Lee, C. H., Williams, R. W., Kim, H., Lee, H. K., Auwerx, J. and Shong, M.
Nat Commun. 2018 Apr 19, 9 (1):1551.

Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Rajamani, U., Gross, A. R., Hjelm, B. E., Sequeira, A., Vawter, M. P., Tang, J., Gangalapudi, V., Wang, Y., Andres, A. M., Gottlieb, R. A. and Sareen, D.
Cell Stem Cell. 2018 May 3, 22 (5):698-712 e9.

Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch
Abe, Y., Fujiwara, Y., Takahashi, H., Matsumura, Y., Sawada, T., Jiang, S., Nakaki, R., Uchida, A., Nagao, N., Naito, M., Kajimura, S., Kimura, H., Osborne, T. F., Aburatani, H., Kodama, T., Inagaki, T. and Sakai, J.
Nat Commun. 2018 Apr 19, 9 (1):1566.

Sennoside A protects mitochondrial structure and function to improve high-fat diet-induced hepatic steatosis by targeting VDAC1
Le, J., Jia, W. and Sun, Y.
Biochem Biophys Res Commun. 2018 Jun 2, 500 (2):484-489.

Jak-TGFbeta cross-talk links transient adipose tissue inflammation to beige adipogenesis
Babaei, R., Schuster, M., Meln, I., Lerch, S., Ghandour, R. A., Pisani, D. F., Bayindir-Buchhalter, I., Marx, J., Wu, S., Schoiswohl, G., Billeter, A. T., Krunic, D., Mauer, J., Lee, Y. H., Granneman, J. G., Fischer, L., Muller-Stich, B. P., Amri, E. Z., Kershaw, E. E., Heikenwalder, M., Herzig, S. and Vegiopoulos, A.
Sci Signal. 2018 Apr 24, 11 (527).

Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism
Lu, X., Altshuler-Keylin, S., Wang, Q., Chen, Y., Henrique Sponton, C., Ikeda, K., Maretich, P., Yoneshiro, T. and Kajimura, S.
Sci Signal. 2018 Apr 24, 11 (527).

NAD(+)-dependent deacetylase SIRT3 in adipocytes is dispensable for maintaining normal adipose tissue mitochondrial function and whole-body metabolism
Porter, L. C., Franczyk, M. P., Pietka, T., Yamaguchi, S., Lin, J. B., Sasaki, Y., Verdin, E., Apte, R. S. and Yoshino, J.
Am J Physiol Endocrinol Metab. 2018 Apr 10, [epub ahead of print]

Derivation and characterization of a UCP1 reporter human ES cell line
Mukherjee, S., Zhang, T., Lacko, L. A., Tan, L., Xiang, J. Z., Butler, J. M. and Chen, S.
Stem Cell Res. 2018 Jul 01, 30:12-21.

A negative feedback loop between microRNA-378 and Nrf1 promotes the development of hepatosteatosis in mice treated with a high fat diet
Zhang, T., Zhao, X., Steer, C. J., Yan, G. and Song, G.
Metabolism. 2018 Aug 01, 85:183-191.

Maternal folic acid supplementation with vitamin B12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet
Henderson, A. M., Tai, D. C., Aleliunas, R. E., Aljaadi, A. M., Glier, M. B., Xu, E. E., Miller, J. W., Verchere, C. B., Green, T. J. and Devlin, A. M.
FASEB J. 2018 Apr 17, [epub ahead of print]

Review Papers
High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

Hydrogen sulfide in physiology and pathogenesis of bacteria and viruses
Pal, V. K., Bandyopadhyay, P. and Singh, A.
IUBMB Life. 2018 May 01, 70 (5):393-410.

Microsensor systems for cell metabolism - from 2D culture to organ-on-chip
Kieninger, J., Weltin, A., Flamm, H. and Urban, G. A.
Lab Chip. 2018 May 1, 18 (9):1274-1291.

Recent advances in cancer metabolism: a technological perspective
Kang, Y. P., Ward, N. P. and DeNicola, G. M.
Exp Mol Med. 2018 Apr 16, 50 (4):31.

Current and future perspectives of functional metabolomics in disease studies–A review
Yan, M. and Xu, G.
Analytica Chimica Acta. 2018 Apr 12, [epub ahead of print]

Stem Cell Biology
Bergamot natural products eradicate cancer stem cells (CSCs) by targeting mevalonate, Rho-GDI-signalling and mitochondrial metabolism
Fiorillo, M., Peiris-Pages, M., Sanchez-Alvarez, R., Bartella, L., Di Donna, L., Dolce, V., Sindona, G., Sotgia, F., Cappello, A. R. and Lisanti, M. P.
Biochim Biophys Acta. 2018 Sep 01, 1859 (9):984-996.

Analysis of Metabolomic Changes in Mesenchymal Stem Cells on Treatment with Desferrioxamine as a Hypoxia Mimetic Compared with Hypoxic Conditions
Fujisawa, K., Takami, T., Okada, S., Hara, K., Matsumoto, T., Yamamoto, N., Yamasaki, T. and Sakaida, I.
Stem Cells. 2018 Mar 25, [epub ahead of print]

Evaluation of the effects of ascorbic acid on metabolism of human mesenchymal stem cells
Fujisawa, K., Hara, K., Takami, T., Okada, S., Matsumoto, T., Yamamoto, N. and Sakaida, I.
Stem Cell Res Ther. 2018 Apr 6, 9 (1):93.

Treatment of Arsenite Intoxication-Induced Peripheral Vasculopathy with Mesenchymal Stem Cells
Chiang, Y. H., Lin, C. C., Chen, Y. C. and Lee, O. K.
Int J Mol Sci. 2018 Mar 29, 19 (4).

High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer
Fernandez, H. R., Gadre, S. M., Tan, M., Graham, G. T., Mosaoa, R., Ongkeko, M. S., Kim, K. A., Riggins, R. B., Parasido, E., Petrini, I., Pacini, S., Cheema, A., Varghese, R., Ressom, H. W., Zhang, Y., Albanese, C., Uren, A., Paige, M., Giaccone, G. and Avantaggiati, M. L.
Cell Death Differ. 2018 Jul 01, 25 (7):1239-1258.

The Influence of Breast Tumour-Derived Factors and Wnt Antagonism on the Transformation of Adipose-Derived Mesenchymal Stem Cells into Tumour-Associated Fibroblasts
Visweswaran, M., Keane, K. N., Arfuso, F., Dilley, R. J., Newsholme, P. and Dharmarajan, A.
Cancer Microenviron. 2018 Jun 01, 11 (1):71-84.

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes
Cunha-Oliveira, T., Ferreira, L. L., Coelho, A. R., Deus, C. M. and Oliveira, P. J.
Toxicol Appl Pharmacol. 2018 Jun 1, 348:1-13.

Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria
Shen, Y., Wu, L., Qin, D., Xia, Y., Zhou, Z., Zhang, X. and Wu, X.
Part Fibre Toxicol. 2018 Apr 12, 15 (1):16.

The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium
Liu, W., Ren, Z., Lu, K., Song, C., Cheung, E. C. W., Zhou, Z. and Chen, G.
Int J Biol Sci. 2018 Apr 05, 14 (5):485-496.

Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses
Rajamani, U., Gross, A. R., Hjelm, B. E., Sequeira, A., Vawter, M. P., Tang, J., Gangalapudi, V., Wang, Y., Andres, A. M., Gottlieb, R. A. and Sareen, D.
Cell Stem Cell. 2018 May 3, 22 (5):698-712 e9.

NF-kappaB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program
FitzPatrick, L. M., Hawkins, K. E., Delhove, J., Fernandez, E., Soldati, C., Bullen, L. F., Nohturfft, A., Waddington, S. N., Medina, D. L., Bolanos, J. P. and McKay, T. R.
Stem Cell Reports. 2018 Jun 5, 10 (6):1766-1781.

Mitochondrial dysfunction is implicated in retinoic acid-induced spina bifida aperta in rat fetuses
Xue, J., Gu, H., Liu, D., Ma, W., Wei, X., Zhao, L., Liu, Y., Zhang, C. and Yuan, Z.
Int J Dev Neurosci. 2018 Apr 22, 68:39-44.

Derivation and characterization of a UCP1 reporter human ES cell line
Mukherjee, S., Zhang, T., Lacko, L. A., Tan, L., Xiang, J. Z., Butler, J. M. and Chen, S.
Stem Cell Res. 2018 Jul 01, 30:12-21.

Techniques & Methods
Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery
Chin, R. M., Panavas, T., Brown, J. M. and Johnson, K. K.
BMC Res Notes. 2018 Mar 27, 11 (1):205.

Mitochondria-Targeting Peptoids
Nam, H. Y., Hong, J. A., Choi, J., Shin, S., Cho, S. K., Seo, J. and Lee, J.
Bioconjug Chem. 2018 May 16, 29 (5):1669-1676.

High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

Evaluation and optimization of differentiation conditions for human primary brown adipocytes
Wang, X., You, L., Cui, X., Li, Y., Wang, X., Xu, P., Zhu, L., Wen, J., Pang, L., Guo, X. and Ji, C.
Sci Rep. 2018 Mar 28, 8 (1):5304.

Microsensor systems for cell metabolism - from 2D culture to organ-on-chip
Kieninger, J., Weltin, A., Flamm, H. and Urban, G. A.
Lab Chip. 2018 May 1, 18 (9):1274-1291.


RNA-Based dCas9–VP64 System Improves the Viability of Cryopreserved Mammalian Cells
Hu, Y., Li, L., Yu, Y., Huang, H., Uygun, B. E. and Yarmush, M. L.
Nano LIFE. 2018 May 08, [epub ahead of print]

Methods for assessing mitochondrial quality control mechanisms and cellular consequences in cell culture
Redmann, M., Benavides, G. A., Wani, W. Y., Berryhill, T. F., Ouyang, X., Johnson, M. S., Ravi, S., Mitra, K., Barnes, S., Darley-Usmar, V. M. and Zhang, J.
Redox Biol. 2018 Jul 01, 17:59-69.

The Suppression of Medium Acidosis Improves the Maintenance and Differentiation of Human Pluripotent Stem Cells at High Density in Defined Cell Culture Medium
Liu, W., Ren, Z., Lu, K., Song, C., Cheung, E. C. W., Zhou, Z. and Chen, G.
Int J Biol Sci. 2018 Apr 05, 14 (5):485-496.

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
O'Connor, R. S., Guo, L., Ghassemi, S., Snyder, N. W., Worth, A. J., Weng, L., Kam, Y., Philipson, B., Trefely, S., Nunez-Cruz, S., Blair, I. A., June, C. H. and Milone, M. C.
Sci Rep. 2018 Apr 19, 8 (1):6289.

Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling
Verheijen, M., Schrooders, Y., Gmuender, H., Nudischer, R., Clayton, O., Hynes, J., Niederer, S., Cordes, H., Kuepfer, L., Kleinjans, J. and Caiment, F.
Toxicol Lett. 2018 Sep 15, 294:184-192.

Toxicology Research
Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction
Cheung, J. Y., Wang, J., Zhang, X. Q., Song, J., Davidyock, J. M., Prado, F. J., Shanmughapriya, S., Worth, A. M., Madesh, M., Judenherc-Haouzi, A. and Haouzi, P.
Cardiovasc Toxicol. 2018 Mar 30,  [epub ahead if print]

Loss of biliverdin reductase-A promotes lipid accumulation and lipotoxicity in mouse proximal tubule cells
Adeosun, S. O., Gordon, D. M., Weeks, M. F., Moore, K. H., Hall, J. E., Hinds, T. D., Jr. and Stec, D. E.
Am J Physiol Renal Physiol. 2018 Aug 1, 315 (2):F323-F331.

Treatment of Arsenite Intoxication-Induced Peripheral Vasculopathy with Mesenchymal Stem Cells
Chiang, Y. H., Lin, C. C., Chen, Y. C. and Lee, O. K.
Int J Mol Sci. 2018 Mar 29, 19 (4).

High-throughput assessment of oxidative respiration in fish embryos: Advancing adverse outcome pathways for mitochondrial dysfunction
Souders, C. L., 2nd, Liang, X., Wang, X., Ector, N., Zhao, Y. H. and Martyniuk, C. J.
Aquat Toxicol. 2018 Jun 01, 199:162-173.

Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes
Cunha-Oliveira, T., Ferreira, L. L., Coelho, A. R., Deus, C. M. and Oliveira, P. J.
Toxicol Appl Pharmacol. 2018 Jun 1, 348:1-13.

Methamphetamine Induces Apoptosis of Microglia via the Intrinsic Mitochondrial-Dependent Pathway
Sharikova, A. V., Quaye, E., Park, J. Y., Maloney, M. C., Desta, H., Thiyagarajan, R., Seldeen, K. L., Parikh, N. U., Sandhu, P., Khmaladze, A., Troen, B. R., Schwartz, S. A. and Mahajan, S. D.
J Neuroimmune Pharmacol. 2018 Sep 01, 13 (3):396-411.

Carbon black suppresses the osteogenesis of mesenchymal stem cells: the role of mitochondria
Shen, Y., Wu, L., Qin, D., Xia, Y., Zhou, Z., Zhang, X. and Wu, X.
Part Fibre Toxicol. 2018 Apr 12, 15 (1):16.

Genotoxic Responses of Mitochondrial Oxygen Consumption Rate and Mitochondrial Semiquinone Radicals in Tumor Cells
Yamamoto, K., Yasui, H., Bo, T., Yamamori, T., Hiraoka, W., Yamasaki, T., Yamada, K.-i. and Inanami, O.
Applied Magnetic Resonance. 2018 Apr 21, 49 (8):837-851.

The CPT1a inhibitor, etomoxir induces severe oxidative stress at commonly used concentrations
O'Connor, R. S., Guo, L., Ghassemi, S., Snyder, N. W., Worth, A. J., Weng, L., Kam, Y., Philipson, B., Trefely, S., Nunez-Cruz, S., Blair, I. A., June, C. H. and Milone, M. C.
Sci Rep. 2018 Apr 19, 8 (1):6289.

Neurotoxicity of cytarabine (Ara-C) in dorsal root ganglion neurons originates from impediment of mtDNA synthesis and compromise of mitochondrial function
Zhuo, M., Gorgun, M. F. and Englander, E. W.
Free Radic Biol Med. 2018 Jun 01, 121: 9-19.

A novel role of endocan in alleviating LPS-induced acute lung injury
Zhang, X., Zhuang, R., Wu, H., Chen, J., Wang, F., Li, G. and Wu, C.
Life Sci. 2018 Jun 1, 202: 89-97.

Bringing in vitro analysis closer to in vivo: Studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling
Verheijen, M., Schrooders, Y., Gmuender, H., Nudischer, R., Clayton, O., Hynes, J., Niederer, S., Cordes, H., Kuepfer, L., Kleinjans, J. and Caiment, F.
Toxicol Lett. 2018 Sep 15, 294:184-192.

Translational Research
Maternal folic acid supplementation with vitamin B12 deficiency during pregnancy and lactation affects the metabolic health of adult female offspring but is dependent on offspring diet
Henderson, A. M., Tai, D. C., Aleliunas, R. E., Aljaadi, A. M., Glier, M. B., Xu, E. E., Miller, J. W., Verchere, C. B., Green, T. J. and Devlin, A. M.
FASEB J. 2018 Apr 17, [epub ahead of print]

For Research Use Only. Not for use in diagnostic procedures.