XF Publications Alert

December 2017

Welcome to the latest edition of the Agilent Seahorse XF Publications Alert for December 2017. This issue lists a selection of the most recent publications that contain Seahorse XF data. Still looking for more? Visit our updated Cell Reference Database to search publications by author, research area, or cell type.

 

Aging Research

Autophagy maintains the metabolism and function of young and old stem cells
Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E. and Passegue, E.
Nature. 2017 Mar 9, 543 (7644):205-210.

Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes
Ren, X., Chen, L., Xie, J., Zhang, Z., Dong, G., Liang, J., Liu, L., Zhou, H. and Luo, P.
Oxid Med Cell Longev. 2017 Oct 22, [epub ahead of print]

Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles
Sonntag, K. C., Ryu, W. I., Amirault, K. M., Healy, R. A., Siegel, A. J., McPhie, D. L., Forester, B. and Cohen, B. M.
Sci Rep. 2017 Oct 25, 7 (1):14038.

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D. and Mair, W. B.
Cell Metab. 2017 Dec 5, 26 (6):884-896 e5.

Cancer Research

Targeting the metabolic axis ACSL/SCD in colorectal cancer progression by therapeutic miRNAs: miR-19b-1 role
Cruz-Gil, S., Sanchez-Martinez, R., Gomez de Cedron, M., Martin-Hernandez, R., Vargas, T., Molina, S., Herranz, J., Davalos, A., Reglero, G. and Ramirez de Molina, A.
J Lipid Res. 2017 Oct 26, [epub ahead of print]

CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, S., Daenthanasanmak, A., Chakraborty, P., Wyatt, M. W., Dhar, P., Selvam, S. P., Fu, J., Zhang, J., Nguyen, H., Kang, I., Toth, K., Al-Homrani, M., Husain, M., Beeson, G., Ball, L., Helke, K., Husain, S., Garrett-Mayer, E., Hardiman, G., Mehrotra, M., Nishimura, M. I., Beeson, C. C., Bupp, M. G., Wu, J., Ogretmen, B., Paulos, C. M., Rathmell, J., Yu, X. Z. and Mehrotra, S.
Cell Metab. 2017 Nov 9, [epub ahead of print]

Inhibition of retinoic acid receptor beta signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells
Abildgaard, C., Dahl, C., Abdul-Al, A., Christensen, A. and Guldberg, P.
Oncotarget. 2017 Oct 13, 8 (48):84210-84223.

Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells
Geoghegan, F., Buckland, R. J., Rogers, E. T., Khalifa, K., O'Connor, E. B., Rooney, M. F., Behnam-Motlagh, P., Nilsson, T. K., Grankvist, K. and Porter, R. K.
Oncotarget. 2017 Nov 7, 8 (55):94711-94725.

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
An, M. X., Li, S., Yao, H. B., Li, C., Wang, J. M., Sun, J., Li, X. Y., Meng, X. N. and Wang, H. Q.
J Cell Biol. 2017 Dec 4, 216 (12):4091-4105.

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
Rao, S., Sigl, V., Wimmer, R. A., Novatchkova, M., Jais, A., Wagner, G., Handschuh, S., Uribesalgo, I., Hagelkruys, A., Kozieradzki, I., Tortola, L., Nitsch, R., Cronin, S. J., Orthofer, M., Branstetter, D., Canon, J., Rossi, J., D'Arcangelo, M., Botling, J., Micke, P., Fleur, L., Edlund, K., Bergqvist, M., Ekman, S., Lendl, T., Popper, H., Takayanagi, H., Kenner, L., Hirsch, F. R., Dougall, W. and Penninger, J. M.
Genes Dev. 2017 Oct 15, 31 (20):2099-2112.

Chemotherapeutic agents induce mitochondrial superoxide production and toxicity but do not alter respiration in skeletal muscle in vitro
Rybalka, E., Timpani, C. A., Cheregi, B. D., Sorensen, J. C., Nurgali, K. and Hayes, A.
Mitochondrion. 2017 Oct 25, [epub ahead of print]

The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells
Plitzko, B., Kaweesa, E. N. and Loesgen, S.
J Biol Chem. 2017 Oct 26, [epub ahead of print]

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines
Mingard, C., Paech, F., Bouitbir, J. and Krahenbuhl, S.
J Appl Toxicol. 2017 Oct 26, [epub ahead of print]

Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence
Rios Garcia, M., Steinbauer, B., Srivastava, K., Singhal, M., Mattijssen, F., Maida, A., Christian, S., Hess-Stumpp, H., Augustin, H. G., Muller-Decker, K., Nawroth, P. P., Herzig, S. and Berriel Diaz, M.
Cell Metab. 2017 Dec 5, 26 (6):842-855 e5.

Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis
Shirure, V. S., Sewell-Loftin, M. K., Lam, S. F., Todd, T. D., Hwang, P. Y. and George, S. C.
Tumor Organoids. 2017 Oct 21, [epub ahead of print]

The STAT-ROS cycle extends IFNinduced cancer cell apoptosis
Wang, Y., Yu, X., Song, H., Feng, D., Jiang, Y., Wu, S. and Geng, J.
Int J Oncol. 2018 Jan 01, 52 (1):305-313.

Drug resistance induces the upregulation of H2S-producing enzymes in HCT116 colon cancer cells
Untereiner, A. A., Pavlidou, A., Druzhyna, N., Papapetropoulos, A., Hellmich, M. R. and Szabo, C.
Biochem Pharmacol. 2017 Oct 20, [epub ahead of print]

Novel combination of histone methylation modulators with therapeutic synergy against acute myeloid leukemia in vitro and in vivo
Wen, S., Wang, J., Liu, P., Li, Y., Lu, W., Hu, Y., Liu, J., He, Z. and Huang, P.
Cancer Lett. 2018 Jan 28, 413:35-45.

NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
Shanmugasundaram, K., Nayak, B. K., Friedrichs, W. E., Kaushik, D., Rodriguez, R. and Block, K.
Nat Commun. 2017 Oct 19, 8 (1):997.

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Tyrakis, P. A., Yurkovich, M. E., Sciacovelli, M., Papachristou, E. K., Bridges, H. R., Gaude, E., Schreiner, A., D'Santos, C., Hirst, J., Hernandez-Fernaud, J., Springett, R., Griffiths, J. R. and Frezza, C.
Cell Rep. 2017 Oct 24, 21 (4):1036-1047.

Involvement of autophagy in the outcome of mitotic catastrophe
Sorokina, I. V., Denisenko, T. V., Imreh, G., Tyurin-Kuzmin, P. A., Kaminskyy, V. O., Gogvadze, V. and Zhivotovsky, B.
Sci Rep. 2017 Nov 6, 7 (1):14571.

Cardiovascular Research

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status
Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M., Foster, D. B., Aon, M. A., Tsui, B., O’Rourke, B. and Abraham, M. R.
JACC: Basic to Translational Science. 2017 Oct 01, 2 (5):543-560.

Vascular endothelial growth factor signaling requires glycine to promote angiogenesis
Guo, D., Murdoch, C. E., Xu, H., Shi, H., Duan, D. D., Ahmed, A. and Gu, Y.
Sci Rep. 2017 Nov 7, 7 (1):14749.

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies
Kanaan, G. N., Ichim, B., Gharibeh, L., Maharsy, W., Patten, D. A., Xuan, J. Y., Reunov, A., Marshall, P., Veinot, J., Menzies, K., Nemer, M. and Harper, M. E.
Redox Biol. 2018 Apr 01, 14:509-521.

Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults with Coronary Artery Disease
Kizilay Mancini, O., Lora, M., Cuillerier, A., Shum-Tim, D., Hamdy, R. C., Burelle, Y., Servant, M. J., Stochaj, U. and Colmegna, I.
Circ Res. 2017 Nov 7, [epub ahead if print]

Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes
Ren, X., Chen, L., Xie, J., Zhang, Z., Dong, G., Liang, J., Liu, L., Zhou, H. and Luo, P.
Oxid Med Cell Longev. 2017 Oct 22, [epub ahead of print]

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients
Michelakis, E. D., Gurtu, V., Webster, L., Barnes, G., Watson, G., Howard, L., Cupitt, J., Paterson, I., Thompson, R. B., Chow, K., O'Regan, D. P., Zhao, L., Wharton, J., Kiely, D. G., Kinnaird, A., Boukouris, A. E., White, C., Nagendran, J., Freed, D. H., Wort, S. J., Gibbs, J. S. R. and Wilkins, M. R.
Sci Transl Med. 2017 Oct 25, 9 (413).

Mdivi-1 Protects Human W8B2(+) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury
Rosdah, A. A., Bond, S. T., Sivakumaran, P., Hoque, A., Oakhill, J. S., Drew, B. G., Delbridge, L. M. D. and Lim, S. Y.
Stem Cells Dev. 2017 Dec 15, 26 (24):1771-1780.

Dual ETA/ETB blockade with macitentan improves both vascular remodeling and angiogenesis in pulmonary arterial hypertension
Nadeau, V., Potus, F., Boucherat, O., Paradis, R., Tremblay, E., Iglarz, M., Paulin, R., Bonnet, S. and Provencher, S.
Pulm Circ. 2017 Oct 24, [epub ahead of print]

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission
Tsushima, K., Bugger, H., Wende, A. R., Soto, J., Jenson, G. A., Tor, A. R., McGlauflin, R., Kenny, H. C., Zhang, Y., Souvenir, R., Hu, X. X., Black, C. L., Pereira, R. O., Lira, V. A., Spitzer, K., Sharp, T. L., Shoghi, K. I., Sparagna, G. C., Rog-Zielinska, E. A., Kohl, P., Khalimonchuk, O., Schaffer, J. E. and Abel, E. D.
Circ Res. 2017 Nov 1, [epub ahead of print]

Cell Metabolism in Screening

Targeting the metabolic axis ACSL/SCD in colorectal cancer progression by therapeutic miRNAs: miR-19b-1 role
Cruz-Gil, S., Sanchez-Martinez, R., Gomez de Cedron, M., Martin-Hernandez, R., Vargas, T., Molina, S., Herranz, J., Davalos, A., Reglero, G. and Ramirez de Molina, A.
J Lipid Res. 2017 Oct 26, [epub ahead of print]

Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture
Fernandez-Martell, A., Johari, Y. B. and James, D. C.
Biotechnol Bioeng. 2017 Oct 28, [epub ahead of print]

Cell Physiology Research

Identification of Dual Mechanisms Mediating 5-hydroxytryptamine Receptor 1F Induced Mitochondrial Biogenesis
Gibbs, W. S., Garrett, S. M., Beeson, C. C. and Schnellmann, R. G.
Am J Physiol Renal Physiol. 2017 Oct 18, [epub ahead of print]

H55N polymorphism is associated with low citrate synthase activity which regulates lipid metabolism in mouse muscle cells
Gabriel, B. M., Al-Tarrah, M., Alhindi, Y., Kilikevicius, A., Venckunas, T., Gray, S. R., Lionikas, A. and Ratkevicius, A.
PLoS One. 2017 Nov 02, 12 (11):e0185789.

Temporal fluxomics reveals oscillations in TCA cycle flux throughout the mammalian cell cycle
Ahn, E., Kumar, P., Mukha, D., Tzur, A. and Shlomi, T.
Mol Syst Biol. 2017 Nov 6, 13 (11):953.

Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis
Chan, S., Lian, Q., Chen, M. P., Jiang, D., Ho, J. T. K., Cheung, Y. F. and Chan, G. C.
Toxicol Appl Pharmacol. 2017 Nov 10, 338:148-158.

Autophagy maintains the metabolism and function of young and old stem cells
Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E. and Passegue, E.
Nature. 2017 Mar 9, 543 (7644):205-210.

Glucose-regulated protein 75 determines ER–mitochondrial coupling and sensitivity to oxidative stress in neuronal cells
Honrath, B., Metz, I., Bendridi, N., Rieusset, J., Culmsee, C. and Dolga, A. M.
Cell Death Discovery. 2017 Nov 06, [epub ahead of print]

Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells
Jiang, Q., Liu, G., Wang, X., Hou, Y., Duan, Y., Wu, G., Yin, Y. and Yao, K.
Oncotarget. 2017 Sep 26, 8 (43):74820-74835.

CDK4 Phosphorylates AMPKalpha2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Lopez-Mejia, I. C., Lagarrigue, S., Giralt, A., Martinez-Carreres, L., Zanou, N., Denechaud, P. D., Castillo-Armengol, J., Chavey, C., Orpinell, M., Delacuisine, B., Nasrallah, A., Collodet, C., Zhang, L., Viollet, B., Hardie, D. G. and Fajas, L.
Mol Cell. 2017 Oct 19, 68 (2):336-349 e6.

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses
Hos, N. J., Ganesan, R., Gutierrez, S., Hos, D., Klimek, J., Abdullah, Z., Kronke, M. and Robinson, N.
J Cell Biol. 2017 Dec 4, 216 (12):4107-4121.

DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction
Hogarth, K. A., Costford, S. R., Yoon, G., Sondheimer, N. and Maynes, J. T.
Biochem Genet. 2017 Nov 6, [epub ahead of print]

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice
Holland, R., McIntosh, A. L., Finucane, O. M., Mela, V., Rubio-Araiz, A., Timmons, G., McCarthy, S. A., Gun'ko, Y. K. and Lynch, M. A.
Brain Behav Immun. 2017 Oct 20, [epub ahead of print]

Resveratrol Ameliorates Mitochondrial Elongation via Drp1/Parkin/PINK1 Signaling in Senescent-Like Cardiomyocytes
Ren, X., Chen, L., Xie, J., Zhang, Z., Dong, G., Liang, J., Liu, L., Zhou, H. and Luo, P.
Oxid Med Cell Longev. 2017 Oct 22, [epub ahead of print]

Mdivi-1 Protects Human W8B2(+) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury
Rosdah, A. A., Bond, S. T., Sivakumaran, P., Hoque, A., Oakhill, J. S., Drew, B. G., Delbridge, L. M. D. and Lim, S. Y.
Stem Cells Dev. 2017 Dec 15, 26 (24):1771-1780.

System-wide Benefits of Intermeal Fasting by Autophagy
Martinez-Lopez, N., Tarabra, E., Toledo, M., Garcia-Macia, M., Sahu, S., Coletto, L., Batista-Gonzalez, A., Barzilai, N., Pessin, J. E., Schwartz, G. J., Kersten, S. and Singh, R.
Cell Metab. 2017 Dec 5, 26 (6):856-871 e5.

NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice
Meimaridou, E., Goldsworthy, M., Chortis, V., Fragouli, E., Foster, P. A., Arlt, W., Cox, R. and Metherell, L. A.
J Endocrinol. 2017 Oct 18, [epub ahead of print]

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D. and Mair, W. B.
Cell Metab. 2017 Dec 5, 26 (6):884-896 e5.

Involvement of autophagy in the outcome of mitotic catastrophe
Sorokina, I. V., Denisenko, T. V., Imreh, G., Tyurin-Kuzmin, P. A., Kaminskyy, V. O., Gogvadze, V. and Zhivotovsky, B.
Sci Rep. 2017 Nov 6, 7 (1):14571.

Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission
Tsushima, K., Bugger, H., Wende, A. R., Soto, J., Jenson, G. A., Tor, A. R., McGlauflin, R., Kenny, H. C., Zhang, Y., Souvenir, R., Hu, X. X., Black, C. L., Pereira, R. O., Lira, V. A., Spitzer, K., Sharp, T. L., Shoghi, K. I., Sparagna, G. C., Rog-Zielinska, E. A., Kohl, P., Khalimonchuk, O., Schaffer, J. E. and Abel, E. D.
Circ Res. 2017 Nov 1, [epub ahead of print]

Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells
Shi, T. T., Yang, F. Y., Liu, C., Cao, X., Lu, J., Zhang, X. L., Yuan, M. X., Chen, C. and Yang, J. K.
Biochem Biophys Res Commun. 2017 Nov 9, [epub ahead of print]

Immunology Research

CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, S., Daenthanasanmak, A., Chakraborty, P., Wyatt, M. W., Dhar, P., Selvam, S. P., Fu, J., Zhang, J., Nguyen, H., Kang, I., Toth, K., Al-Homrani, M., Husain, M., Beeson, G., Ball, L., Helke, K., Husain, S., Garrett-Mayer, E., Hardiman, G., Mehrotra, M., Nishimura, M. I., Beeson, C. C., Bupp, M. G., Wu, J., Ogretmen, B., Paulos, C. M., Rathmell, J., Yu, X. Z. and Mehrotra, S.
Cell Metab. 2017 Nov 9, [epub ahead of print]

The T-cell fingerprint of MALT1 paracaspase revealed by selective inhibition
Bardet, M., Unterreiner, A., Malinverni, C., Lafossas, F., Vedrine, C., Boesch, D., Kolb, Y., Kaiser, D., Glück, A., Schneider, M. A., Katopodis, A., Renatus, M., Simic, O., Schlapbach, A., Quancard, J., Régnier, C. H., Bold, G., Pissot-Soldermann, C., Carballido, J. M., Kovarik, J., Calzascia, T. and Bornancin, F.
Immunology and Cell Biology. 2017 Oct 13, [epub ahead of print]

Srebp-controlled glucose metabolism is essential for NK cell functional responses
Assmann, N., O'Brien, K. L., Donnelly, R. P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R. M., Heinrich, P., Oefner, P. J., Lynch, L., Gardiner, C. M., Dettmer, K. and Finlay, D. K.
Nat Immunol. 2017 Nov 01, 18 (11):1197-1206.

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
Baldanta, S., Fernandez-Escobar, M., Acin-Perez, R., Albert, M., Camafeita, E., Jorge, I., Vazquez, J., Enriquez, J. A. and Guerra, S.
PLoS Pathog. 2017 Oct 27, 13 (10):e1006651.

Autophagy maintains the metabolism and function of young and old stem cells
Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E. and Passegue, E.
Nature. 2017 Mar 9, 543 (7644):205-210.

Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults with Coronary Artery Disease
Kizilay Mancini, O., Lora, M., Cuillerier, A., Shum-Tim, D., Hamdy, R. C., Burelle, Y., Servant, M. J., Stochaj, U. and Colmegna, I.
Circ Res. 2017 Nov 7, [epub ahead if print]

Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells
Jiang, Q., Liu, G., Wang, X., Hou, Y., Duan, Y., Wu, G., Yin, Y. and Yao, K.
Oncotarget. 2017 Sep 26, 8 (43):74820-74835.

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses
Hos, N. J., Ganesan, R., Gutierrez, S., Hos, D., Klimek, J., Abdullah, Z., Kronke, M. and Robinson, N.
J Cell Biol. 2017 Dec 4, 216 (12):4107-4121.

Inflammatory microglia are glycolytic and iron retentive and typify the microglia in APP/PS1 mice
Holland, R., McIntosh, A. L., Finucane, O. M., Mela, V., Rubio-Araiz, A., Timmons, G., McCarthy, S. A., Gun'ko, Y. K. and Lynch, M. A.
Brain Behav Immun. 2017 Oct 20, [epub ahead of print]

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1
He, N., Fan, W., Henriquez, B., Yu, R. T., Atkins, A. R., Liddle, C., Zheng, Y., Downes, M. and Evans, R. M.
Proc Natl Acad Sci U S A. 2017 Nov 21, 114 (47):12542-12547.

Legionella pneumophila CsrA regulates a metabolic switch from amino acid to glycerolipid metabolism
Hauslein, I., Sahr, T., Escoll, P., Klausner, N., Eisenreich, W. and Buchrieser, C.
Open Biol. 2017 Nov 01, 7 (11).

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
Li, J., Diao, B., Guo, S., Huang, X., Yang, C., Feng, Z., Yan, W., Ning, Q., Zheng, L., Chen, Y. and Wu, Y.
Nat Commun. 2017 Nov 6, 8 (1):1322.

AMPK regulates immunometabolism in sepsis
Huang, J., Liu, K., Zhu, S., Xie, M., Kang, R., Cao, L. and Tang, D.
Brain Behav Immun. 2017 Nov 3, [epub ahead of print]

CREB/CRTC2 controls GLP-1-dependent regulation of glucose homeostasis
Lee, J. H., Wen, X., Cho, H. and Koo, S. H.
FASEB J. 2017 Nov 8, [epub ahead of print]

Glucose-6-Phosphatase Catalytic Subunit 3 (G6PC3) Deficiency Associated With Autoinflammatory Complications
Mistry, A., Scambler, T., Parry, D., Wood, M., Barcenas-Morales, G., Carter, C., Doffinger, R. and Savic, S.
Front Immunol. 2017 Nov 06, 8:1485.

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease
Sarkar, S., Malovic, E., Harishchandra, D. S., Ghaisas, S., Panicker, N., Charli, A., Palanisamy, B. N., Rokad, D., Jin, H., Anantharam, V., Kanthasamy, A. and Kanthasamy, A. G.
NPJ Parkinsons Dis. 2017 Oct 17, 3:30.

The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-gamma) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
Minchenberg, S. B. and Massa, P. T.
J Neuroimmunol. 2017 Oct 28, [epub ahead of print]

Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections
Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K. and Palmer, C. S.
Front Immunol. 2017 Oct 16, 8:1311.

Macrophages sensing oxidized DAMPs reprogram their metabolism to support redox homeostasis and inflammation through a TLR2-Syk-ceramide dependent mechanism
Serbulea, V., Upchurch, C. M., Ahern, K. W., Bories, G., Voigt, P., DeWeese, D. E., Meher, A. K., Harris, T. E. and Leitinger, N.
Mol Metab. 2017 Nov 7, [epub ahead of print]

Infectious Disease Research

ISG15 governs mitochondrial function in macrophages following vaccinia virus infection
Baldanta, S., Fernandez-Escobar, M., Acin-Perez, R., Albert, M., Camafeita, E., Jorge, I., Vazquez, J., Enriquez, J. A. and Guerra, S.
PLoS Pathog. 2017 Oct 27, 13 (10):e1006651.

Mitochondrial pathway is involved in the protective effects of alpha-ketoglutarate on hydrogen peroxide induced damage to intestinal cells
Jiang, Q., Liu, G., Wang, X., Hou, Y., Duan, Y., Wu, G., Yin, Y. and Yao, K.
Oncotarget. 2017 Sep 26, 8 (43):74820-74835.

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses
Hos, N. J., Ganesan, R., Gutierrez, S., Hos, D., Klimek, J., Abdullah, Z., Kronke, M. and Robinson, N.
J Cell Biol. 2017 Dec 4, 216 (12):4107-4121.

Legionella pneumophila CsrA regulates a metabolic switch from amino acid to glycerolipid metabolism
Hauslein, I., Sahr, T., Escoll, P., Klausner, N., Eisenreich, W. and Buchrieser, C.
Open Biol. 2017 Nov 01, 7 (11).

AMPK regulates immunometabolism in sepsis
Huang, J., Liu, K., Zhu, S., Xie, M., Kang, R., Cao, L. and Tang, D.
Brain Behav Immun. 2017 Nov 3, [epub ahead of print]

Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections
Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K. and Palmer, C. S.
Front Immunol. 2017 Oct 16, 8:1311.

Mitochondrial Disease Research

Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis
Chan, S., Lian, Q., Chen, M. P., Jiang, D., Ho, J. T. K., Cheung, Y. F. and Chan, G. C.
Toxicol Appl Pharmacol. 2017 Nov 10, 338:148-158.

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria
Akman, G., Desai, R., Bailey, L. J., Yasukawa, T., Dalla Rosa, I., Durigon, R., Holmes, J. B., Moss, C. F., Mennuni, M., Houlden, H., Crouch, R. J., Hanna, M. G., Pitceathly, R. D. S., Spinazzola, A. and Holt, I. J.
Proceedings of the National Academy of Sciences. 2016 Jun 07, 113 (30):E4276-E4285.

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism
Friesen, M. and Cowan, C. A.
Biochem Biophys Res Commun. 2017 Nov 3, [epub ahead of print]

The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-gamma) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
Minchenberg, S. B. and Massa, P. T.
J Neuroimmunol. 2017 Oct 28, [epub ahead of print]

Model Organisms

High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration
Osuma, E. A., Riggs, D. W., Gibb, A. A. and Hill, B. G.
Regeneration. 2017 Nov 02, [epub ahead of print]

Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling
Weir, H. J., Yao, P., Huynh, F. K., Escoubas, C. C., Goncalves, R. L., Burkewitz, K., Laboy, R., Hirschey, M. D. and Mair, W. B.
Cell Metab. 2017 Dec 5, 26 (6):884-896 e5.

Mitochondrial bioenergetics and locomotor activity are altered in zebrafish (Danio rerio) after exposure to the bipyridylium herbicide diquat
Wang, X. H., Souders, C. L., 2nd, Zhao, Y. H. and Martyniuk, C. J.
Toxicol Lett. 2017 Nov 1, 283:13-20.

Beyond the polymerase-gamma theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity
Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., van Kampen, A. H. C., Brul, S. and van der Spek, H.
PLoS One. 2017 Nov 02, 12 (11):e0187424.

Cell Biology of the Mitochondrion
van der Bliek, A. M., Sedensky, M. M. and Morgan, P. G.
Genetics. 2017 Nov 01, 207 (3):843-871.

Neurobiology Research

Paracrine and Intracrine Angiotensin 1-7/Mas Receptor Axis in the Substantia Nigra of Rodents, Monkeys, and Humans
Costa-Besada, M. A., Valenzuela, R., Garrido-Gil, P., Villar-Cheda, B., Parga, J. A., Lanciego, J. L. and Labandeira-Garcia, J. L.
Mol Neurobiol. 2017 Oct 30, [epub ahead of print]

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. and Hayden, M. R.
Hum Mol Genet. 2017 Nov 7, [epub ahead of print]

Current technical approaches to brain energy metabolism
Barros, L. F., Bolanos, J. P., Bonvento, G., Bouzier-Sore, A. K., Brown, A., Hirrlinger, J., Kasparov, S., Kirchhoff, F., Murphy, A. N., Pellerin, L., Robinson, M. B. and Weber, B.
Glia. 2017 Nov 7, [epub ahead of print]

Glucose-regulated protein 75 determines ER–mitochondrial coupling and sensitivity to oxidative stress in neuronal cells
Honrath, B., Metz, I., Bendridi, N., Rieusset, J., Culmsee, C. and Dolga, A. M.
Cell Death Discovery. 2017 Nov 06, [epub ahead of print]

DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction
Hogarth, K. A., Costford, S. R., Yoon, G., Sondheimer, N. and Maynes, J. T.
Biochem Genet. 2017 Nov 6, [epub ahead of print]

A graphene–polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells
Huang, C.-T., Kumar Shrestha, L., Ariga, K. and Hsu, S.-h.
Journal of Materials Chemistry B. 2017 Nov 06, 5 (44):8854-8864.

Graphene quantum dots prevent alpha-synuclein transmission in Parkinson’s disease
Kim, D., Yoo, J. M., Hwang, H., Lee, S. H., Yun, S. P., Park, M. J., Choi, S., Kwon, S. H., Lee, M., Shin, S., Hong, B. H. and Ko, H. S.
Cornell University. 2017 Oct 17, [epub ahead of print]

Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson's disease
Sarkar, S., Malovic, E., Harishchandra, D. S., Ghaisas, S., Panicker, N., Charli, A., Palanisamy, B. N., Rokad, D., Jin, H., Anantharam, V., Kanthasamy, A. and Kanthasamy, A. G.
NPJ Parkinsons Dis. 2017 Oct 17, 3:30.

The control of oligodendrocyte bioenergetics by interferon-gamma (IFN-gamma) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)
Minchenberg, S. B. and Massa, P. T.
J Neuroimmunol. 2017 Oct 28, [epub ahead of print]

Associations Between Microbiota, Mitochondrial Function, and Cognition in Chronic Marijuana Users
Panee, J., Gerschenson, M. and Chang, L.
J Neuroimmune Pharmacol. 2017 Nov 4, [epub ahead of print]

Late-onset Alzheimer's disease is associated with inherent changes in bioenergetics profiles
Sonntag, K. C., Ryu, W. I., Amirault, K. M., Healy, R. A., Siegel, A. J., McPhie, D. L., Forester, B. and Cohen, B. M.
Sci Rep. 2017 Oct 25, 7 (1):14038.

Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons
Schwab, A. J., Sison, S. L., Meade, M. R., Broniowska, K. A., Corbett, J. A. and Ebert, A. D.
Stem Cell Reports. 2017 Oct 31, [epub ahead of print]

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS
Straub, I. R., Janer, A., Weraarpachai, W., Zinman, L., Robertson, J., Rogaeva, E. and Shoubridge, E. A.
Hum Mol Genet. 2017 Nov 7, [epub ahead of print]

Obesity, Diabetes, & Metabolic Disorders

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism
Friesen, M. and Cowan, C. A.
Biochem Biophys Res Commun. 2017 Nov 3, [epub ahead of print]

VSIG4 inhibits proinflammatory macrophage activation by reprogramming mitochondrial pyruvate metabolism
Li, J., Diao, B., Guo, S., Huang, X., Yang, C., Feng, Z., Yan, W., Ning, Q., Zheng, L., Chen, Y. and Wu, Y.
Nat Commun. 2017 Nov 6, 8 (1):1322.

CREB/CRTC2 controls GLP-1-dependent regulation of glucose homeostasis
Lee, J. H., Wen, X., Cho, H. and Koo, S. H.
FASEB J. 2017 Nov 8, [epub ahead of print]

Ketone body 3-hydroxybutyrate mimics calorie restriction via the Nrf2 activator, fumarate, in the retina
Izuta, Y., Imada, T., Hisamura, R., Oonishi, E., Nakamura, S., Inagaki, E., Ito, M., Soga, T. and Tsubota, K.
Aging Cell. 2017 Nov 9, [epub ahead of print]

Glucocorticoids suppressing the browning of adipose tissue via miR-19b in male mice
Lv, Y., Yu, J., Sheng, Y., Huang, M., Kong, X., Di, W., Liu, J., Zhou, H., Liang, H. and Ding, G.
Endocrinology. 2017 Oct 24, [epub ahead of print]

System-wide Benefits of Intermeal Fasting by Autophagy
Martinez-Lopez, N., Tarabra, E., Toledo, M., Garcia-Macia, M., Sahu, S., Coletto, L., Batista-Gonzalez, A., Barzilai, N., Pessin, J. E., Schwartz, G. J., Kersten, S. and Singh, R.
Cell Metab. 2017 Dec 5, 26 (6):856-871 e5.

Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells
Shi, T. T., Yang, F. Y., Liu, C., Cao, X., Lu, J., Zhang, X. L., Yuan, M. X., Chen, C. and Yang, J. K.
Biochem Biophys Res Commun. 2017 Nov 9, [epub ahead of print]

Review Articles

Current technical approaches to brain energy metabolism
Barros, L. F., Bolanos, J. P., Bonvento, G., Bouzier-Sore, A. K., Brown, A., Hirrlinger, J., Kasparov, S., Kirchhoff, F., Murphy, A. N., Pellerin, L., Robinson, M. B. and Weber, B.
Glia. 2017 Nov 7, [epub ahead of print]

Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis
Shirure, V. S., Sewell-Loftin, M. K., Lam, S. F., Todd, T. D., Hwang, P. Y. and George, S. C.
Tumor Organoids. 2017 Oct 21, [epub ahead of print]

Cell Biology of the Mitochondrion
van der Bliek, A. M., Sedensky, M. M. and Morgan, P. G.
Genetics. 2017 Nov 01, 207 (3):843-871.

Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections
Shehata, H. M., Murphy, A. J., Lee, M. K. S., Gardiner, C. M., Crowe, S. M., Sanjabi, S., Finlay, D. K. and Palmer, C. S.
Front Immunol. 2017 Oct 16, 8:1311.

Stem Cell Biology

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status
Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M., Foster, D. B., Aon, M. A., Tsui, B., O’Rourke, B. and Abraham, M. R.
JACC: Basic to Translational Science. 2017 Oct 01, 2 (5):543-560.

FPLD2 LMNA mutation R482W dysregulates iPSC-derived adipocyte function and lipid metabolism
Friesen, M. and Cowan, C. A.
Biochem Biophys Res Commun. 2017 Nov 3, [epub ahead of print]

Paracrine and Intracrine Angiotensin 1-7/Mas Receptor Axis in the Substantia Nigra of Rodents, Monkeys, and Humans
Costa-Besada, M. A., Valenzuela, R., Garrido-Gil, P., Villar-Cheda, B., Parga, J. A., Lanciego, J. L. and Labandeira-Garcia, J. L.
Mol Neurobiol. 2017 Oct 30, [epub ahead of print]

Autophagy maintains the metabolism and function of young and old stem cells
Ho, T. T., Warr, M. R., Adelman, E. R., Lansinger, O. M., Flach, J., Verovskaya, E. V., Figueroa, M. E. and Passegue, E.
Nature. 2017 Mar 9, 543 (7644):205-210.

Mitochondrial Oxidative Stress Reduces the Immunopotency of Mesenchymal Stromal Cells in Adults with Coronary Artery Disease
Kizilay Mancini, O., Lora, M., Cuillerier, A., Shum-Tim, D., Hamdy, R. C., Burelle, Y., Servant, M. J., Stochaj, U. and Colmegna, I.
Circ Res. 2017 Nov 7, [epub ahead if print]

CDK4 Phosphorylates AMPKalpha2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Lopez-Mejia, I. C., Lagarrigue, S., Giralt, A., Martinez-Carreres, L., Zanou, N., Denechaud, P. D., Castillo-Armengol, J., Chavey, C., Orpinell, M., Delacuisine, B., Nasrallah, A., Collodet, C., Zhang, L., Viollet, B., Hardie, D. G. and Fajas, L.
Mol Cell. 2017 Oct 19, 68 (2):336-349 e6.

A graphene–polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells
Huang, C.-T., Kumar Shrestha, L., Ariga, K. and Hsu, S.-h.
Journal of Materials Chemistry B. 2017 Nov 06, 5 (44):8854-8864.

Chemotherapeutic agents induce mitochondrial superoxide production and toxicity but do not alter respiration in skeletal muscle in vitro
Rybalka, E., Timpani, C. A., Cheregi, B. D., Sorensen, J. C., Nurgali, K. and Hayes, A.
Mitochondrion. 2017 Oct 25, [epub ahead of print]

Mdivi-1 Protects Human W8B2(+) Cardiac Stem Cells from Oxidative Stress and Simulated Ischemia-Reperfusion Injury
Rosdah, A. A., Bond, S. T., Sivakumaran, P., Hoque, A., Oakhill, J. S., Drew, B. G., Delbridge, L. M. D. and Lim, S. Y.
Stem Cells Dev. 2017 Dec 15, 26 (24):1771-1780.

Decreased Sirtuin Deacetylase Activity in LRRK2 G2019S iPSC-Derived Dopaminergic Neurons
Schwab, A. J., Sison, S. L., Meade, M. R., Broniowska, K. A., Corbett, J. A. and Ebert, A. D.
Stem Cell Reports. 2017 Oct 31, [epub ahead of print]

RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., Eichin, F., Gabriel, H., Schoberleitner, I., Huang, A., Piatti, P., Nat, R., Troppmair, J. and Lusser, A.
Cell Mol Life Sci. 2017 Nov 4, [epub ahead of print]

Techniques & Methods

Cardiosphere-Derived Cells Demonstrate Metabolic Flexibility That Is Influenced by Adhesion Status
Afzal, J., Chan, A., Karakas, M. F., Woldemichael, K., Vakrou, S., Guan, Y., Rathmell, J., Wahl, R., Pomper, M., Foster, D. B., Aon, M. A., Tsui, B., O’Rourke, B. and Abraham, M. R.
JACC: Basic to Translational Science. 2017 Oct 01, 2 (5):543-560.

Metabolic phenotyping of CHO cells varying in cellular biomass accumulation and maintenance during fed-batch culture
Fernandez-Martell, A., Johari, Y. B. and James, D. C.
Biotechnol Bioeng. 2017 Oct 28, [epub ahead of print]

Monitoring of reactions catalyzed by lytic polysaccharide monooxygenases using highly-sensitive fluorimetric assay of the oxygen consumption rate
Gusakov, A. V., Bulakhov, A. G., Demin, I. N. and Sinitsyn, A. P.
Carbohydr Res. 2017 Nov 27, 452:156-161.

A graphene–polyurethane composite hydrogel as a potential bioink for 3D bioprinting and differentiation of neural stem cells
Huang, C.-T., Kumar Shrestha, L., Ariga, K. and Hsu, S.-h.
Journal of Materials Chemistry B. 2017 Nov 06, 5 (44):8854-8864.

Graphene quantum dots prevent alpha-synuclein transmission in Parkinson’s disease
Kim, D., Yoo, J. M., Hwang, H., Lee, S. H., Yun, S. P., Park, M. J., Choi, S., Kwon, S. H., Lee, M., Shin, S., Hong, B. H. and Ko, H. S.
Cornell University. 2017 Oct 17, [epub ahead of print]

High throughput measurement of metabolism in planarians reveals activation of glycolysis during regeneration
Osuma, E. A., Riggs, D. W., Gibb, A. A. and Hill, B. G.
Regeneration. 2017 Nov 02, [epub ahead of print]

Building Better Tumor Models: Organoid Systems to Investigate Angiogenesis
Shirure, V. S., Sewell-Loftin, M. K., Lam, S. F., Todd, T. D., Hwang, P. Y. and George, S. C.
Tumor Organoids. 2017 Oct 21, [epub ahead of print]

Cell Biology of the Mitochondrion
van der Bliek, A. M., Sedensky, M. M. and Morgan, P. G.
Genetics. 2017 Nov 01, 207 (3):843-871.

Toxicology & Hepatobiology

Deferiprone inhibits iron overload-induced tissue factor bearing endothelial microparticle generation by inhibition oxidative stress induced mitochondrial injury, and apoptosis
Chan, S., Lian, Q., Chen, M. P., Jiang, D., Ho, J. T. K., Cheung, Y. F. and Chan, G. C.
Toxicol Appl Pharmacol. 2017 Nov 10, 338:148-158.

Srebp-controlled glucose metabolism is essential for NK cell functional responses
Assmann, N., O'Brien, K. L., Donnelly, R. P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R. M., Heinrich, P., Oefner, P. J., Lynch, L., Gardiner, C. M., Dettmer, K. and Finlay, D. K.
Nat Immunol. 2017 Nov 01, 18 (11):1197-1206.

Metformin ameliorates arsenic trioxide hepatotoxicity via inhibiting mitochondrial complex I
Ling, S., Shan, Q., Liu, P., Feng, T., Zhang, X., Xiang, P., Chen, K., Xie, H., Song, P., Zhou, L., Liu, J., Zheng, S. and Xu, X.
Cell Death Dis. 2017 Nov 2, 8 (11):e3159.

The high-production volume fungicide pyraclostrobin induces triglyceride accumulation associated with mitochondrial dysfunction, and promotes adipocyte differentiation independent of PPARgamma activation, in 3T3-L1 cells
Luz, A. L., Kassotis, C. D., Stapleton, H. M. and Meyer, J. N.
Toxicology. 2017 Nov 7, 393:150-159.

Chemotherapeutic agents induce mitochondrial superoxide production and toxicity but do not alter respiration in skeletal muscle in vitro
Rybalka, E., Timpani, C. A., Cheregi, B. D., Sorensen, J. C., Nurgali, K. and Hayes, A.
Mitochondrion. 2017 Oct 25, [epub ahead of print]

The Natural Product Mensacarcin Induces Mitochondrial Toxicity and Apoptosis in Melanoma Cells
Plitzko, B., Kaweesa, E. N. and Loesgen, S.
J Biol Chem. 2017 Oct 26, [epub ahead of print]

Mechanisms of toxicity associated with six tyrosine kinase inhibitors in human hepatocyte cell lines
Mingard, C., Paech, F., Bouitbir, J. and Krahenbuhl, S.
J Appl Toxicol. 2017 Oct 26, [epub ahead of print]

Alterations of sirtuins in mitochondrial cytochrome c-oxidase deficiency
Potthast, A. B., Heuer, T., Warneke, S. J. and Das, A. M.
PLoS One. 2017 Oct 23, 12 (10):e0186517.

Mitochondrial bioenergetics and locomotor activity are altered in zebrafish (Danio rerio) after exposure to the bipyridylium herbicide diquat
Wang, X. H., Souders, C. L., 2nd, Zhao, Y. H. and Martyniuk, C. J.
Toxicol Lett. 2017 Nov 1, 283:13-20.

Beyond the polymerase-gamma theory: Production of ROS as a mode of NRTI-induced mitochondrial toxicity
Smith, R. L., Tan, J. M. E., Jonker, M. J., Jongejan, A., Buissink, T., Veldhuijzen, S., van Kampen, A. H. C., Brul, S. and van der Spek, H.
PLoS One. 2017 Nov 02, 12 (11):e0187424.

Translational Research

CD38-NAD(+)Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
Chatterjee, S., Daenthanasanmak, A., Chakraborty, P., Wyatt, M. W., Dhar, P., Selvam, S. P., Fu, J., Zhang, J., Nguyen, H., Kang, I., Toth, K., Al-Homrani, M., Husain, M., Beeson, G., Ball, L., Helke, K., Husain, S., Garrett-Mayer, E., Hardiman, G., Mehrotra, M., Nishimura, M. I., Beeson, C. C., Bupp, M. G., Wu, J., Ogretmen, B., Paulos, C. M., Rathmell, J., Yu, X. Z. and Mehrotra, S.
Cell Metab. 2017 Nov 9, [epub ahead of print]

Inhibition of retinoic acid receptor beta signaling confers glycolytic dependence and sensitization to dichloroacetate in melanoma cells
Abildgaard, C., Dahl, C., Abdul-Al, A., Christensen, A. and Guldberg, P.
Oncotarget. 2017 Oct 13, 8 (48):84210-84223.

Bioenergetics of acquired cisplatin resistant H1299 non-small cell lung cancer and P31 mesothelioma cells
Geoghegan, F., Buckland, R. J., Rogers, E. T., Khalifa, K., O'Connor, E. B., Rooney, M. F., Behnam-Motlagh, P., Nilsson, T. K., Grankvist, K. and Porter, R. K.
Oncotarget. 2017 Nov 7, 8 (55):94711-94725.

Srebp-controlled glucose metabolism is essential for NK cell functional responses
Assmann, N., O'Brien, K. L., Donnelly, R. P., Dyck, L., Zaiatz-Bittencourt, V., Loftus, R. M., Heinrich, P., Oefner, P. J., Lynch, L., Gardiner, C. M., Dettmer, K. and Finlay, D. K.
Nat Immunol. 2017 Nov 01, 18 (11):1197-1206.

HACE1 is essential for astrocyte mitochondrial function and influences Huntington disease phenotypes in vivo
Ehrnhoefer, D. E., Southwell, A. L., Sivasubramanian, M., Qiu, X., Villanueva, E. B., Xie, Y., Waltl, S., Anderson, L., Fazeli, A., Casal, L., Felczak, B., Tsang, M. and Hayden, M. R.
Hum Mol Genet. 2017 Nov 7, [epub ahead of print]

BAG3 directly stabilizes Hexokinase 2 mRNA and promotes aerobic glycolysis in pancreatic cancer cells
An, M. X., Li, S., Yao, H. B., Li, C., Wang, J. M., Sun, J., Li, X. Y., Meng, X. N. and Wang, H. Q.
J Cell Biol. 2017 Dec 4, 216 (12):4091-4105.

Glutaredoxin-2 controls cardiac mitochondrial dynamics and energetics in mice, and protects against human cardiac pathologies
Kanaan, G. N., Ichim, B., Gharibeh, L., Maharsy, W., Patten, D. A., Xuan, J. Y., Reunov, A., Marshall, P., Veinot, J., Menzies, K., Nemer, M. and Harper, M. E.
Redox Biol. 2018 Apr 01, 14:509-521.

Glucose-regulated protein 75 determines ER–mitochondrial coupling and sensitivity to oxidative stress in neuronal cells
Honrath, B., Metz, I., Bendridi, N., Rieusset, J., Culmsee, C. and Dolga, A. M.
Cell Death Discovery. 2017 Nov 06, [epub ahead of print]

CDK4 Phosphorylates AMPKalpha2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Lopez-Mejia, I. C., Lagarrigue, S., Giralt, A., Martinez-Carreres, L., Zanou, N., Denechaud, P. D., Castillo-Armengol, J., Chavey, C., Orpinell, M., Delacuisine, B., Nasrallah, A., Collodet, C., Zhang, L., Viollet, B., Hardie, D. G. and Fajas, L.
Mol Cell. 2017 Oct 19, 68 (2):336-349 e6.

Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses
Hos, N. J., Ganesan, R., Gutierrez, S., Hos, D., Klimek, J., Abdullah, Z., Kronke, M. and Robinson, N.
J Cell Biol. 2017 Dec 4, 216 (12):4107-4121.

DNM1L Variant Alters Baseline Mitochondrial Function and Response to Stress in a Patient with Severe Neurological Dysfunction
Hogarth, K. A., Costford, S. R., Yoon, G., Sondheimer, N. and Maynes, J. T.
Biochem Genet. 2017 Nov 6, [epub ahead of print]

Metabolic control of regulatory T cell (Treg) survival and function by Lkb1
He, N., Fan, W., Henriquez, B., Yu, R. T., Atkins, A. R., Liddle, C., Zheng, Y., Downes, M. and Evans, R. M.
Proc Natl Acad Sci U S A. 2017 Nov 21, 114 (47):12542-12547.

CREB/CRTC2 controls GLP-1-dependent regulation of glucose homeostasis
Lee, J. H., Wen, X., Cho, H. and Koo, S. H.
FASEB J. 2017 Nov 8, [epub ahead of print]

RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer
Rao, S., Sigl, V., Wimmer, R. A., Novatchkova, M., Jais, A., Wagner, G., Handschuh, S., Uribesalgo, I., Hagelkruys, A., Kozieradzki, I., Tortola, L., Nitsch, R., Cronin, S. J., Orthofer, M., Branstetter, D., Canon, J., Rossi, J., D'Arcangelo, M., Botling, J., Micke, P., Fleur, L., Edlund, K., Bergqvist, M., Ekman, S., Lendl, T., Popper, H., Takayanagi, H., Kenner, L., Hirsch, F. R., Dougall, W. and Penninger, J. M.
Genes Dev. 2017 Oct 15, 31 (20):2099-2112.

Glucocorticoids suppressing the browning of adipose tissue via miR-19b in male mice
Lv, Y., Yu, J., Sheng, Y., Huang, M., Kong, X., Di, W., Liu, J., Zhou, H., Liang, H. and Ding, G.
Endocrinology. 2017 Oct 24, [epub ahead of print]

Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins
Samandi, S., Roy, A. V., Delcourt, V., Lucier, J. F., Gagnon, J., Beaudoin, M. C., Vanderperre, B., Breton, M. A., Motard, J., Jacques, J. F., Brunelle, M., Gagnon-Arsenault, I., Fournier, I., Ouangraoua, A., Hunting, D. J., Cohen, A. A., Landry, C. R., Scott, M. S. and Roucou, X.
Elife. 2017 Oct 30, 6.

The lignan manassantin is a potent and specific inhibitor of mitochondrial complex I and bioenergetic activity in mammals
Ma, Y., Min, H. K., Oh, U., Hawkridge, A. M., Wang, W., Mohsin, A. A., Chen, Q., Sanyal, A., Lesnefsky, E. J. and Fang, X.
J Biol Chem. 2017 Oct 18, [epub ahead of print]

NNT is a key regulator of adrenal redox homeostasis and steroidogenesis in male mice
Meimaridou, E., Goldsworthy, M., Chortis, V., Fragouli, E., Foster, P. A., Arlt, W., Cox, R. and Metherell, L. A.
J Endocrinol. 2017 Oct 18, [epub ahead of print]

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
Tyrakis, P. A., Yurkovich, M. E., Sciacovelli, M., Papachristou, E. K., Bridges, H. R., Gaude, E., Schreiner, A., D'Santos, C., Hirst, J., Hernandez-Fernaud, J., Springett, R., Griffiths, J. R. and Frezza, C.
Cell Rep. 2017 Oct 24, 21 (4):1036-1047.

Loss of CHCHD10-CHCHD2 complexes required for respiration underlies the pathogenicity of a CHCHD10 mutation in ALS
Straub, I. R., Janer, A., Weraarpachai, W., Zinman, L., Robertson, J., Rogaeva, E. and Shoubridge, E. A.
Hum Mol Genet. 2017 Nov 7, [epub ahead of print]

RNA cytosine methyltransferase Nsun3 regulates embryonic stem cell differentiation by promoting mitochondrial activity
Trixl, L., Amort, T., Wille, A., Zinni, M., Ebner, S., Hechenberger, C., Eichin, F., Gabriel, H., Schoberleitner, I., Huang, A., Piatti, P., Nat, R., Troppmair, J. and Lusser, A.
Cell Mol Life Sci. 2017 Nov 4, [epub ahead of print]

The Human Knockout Gene CLYBL Connects Itaconate to Vitamin B12
Shen, H., Campanello, G. C., Flicker, D., Grabarek, Z., Hu, J., Luo, C., Banerjee, R. and Mootha, V. K.
Cell. 2017 Nov 2, 171 (4):771-782 e11.

For Research Use Only. Not for use in diagnostic procedures.