Fueling T cells in Immunity and Cancer

T cells perform critical roles to promote or suppress immunity and inflammation. To perform these functions, inflammatory effector T cells (Teff) undergo metabolic reprogramming upon activation to increase glycolysis and anabolic metabolism. In contrast, suppressive regulatory T cells (Treg) are metabolically heterogeneous and balance the use of glycolysis with mitochondrial oxidative metabolism.  These metabolic programs are highly regulated and exert strong influences on T cell function and fate. This talk will discuss the distinct metabolic programs of T cell subsets and how these programs influence Teff and Treg function in inflammatory disease and in the tumor setting.

In this webinar we will discuss:

  • T cell metabolic reprogramming and the distinct metabolic programs of T cell subsets
  • Metabolic requirements for T cell function
  • Metabolic vulnerabilities of T cells in inflammatory diseases and in tumors

For Research Use Only.  Not for use in diagnostic procedures.

Thursday, December 14, 2017
9:00 PDT (Los Angeles)
12:00 EDT (New York)

17:00 GMT (London)

Available On Demand after December 14 
All registrants will be notified when available

Presented by:

Jeffrey Rathmell, PhD 
Co-Leader, Host-Tumor Interactions Research Program, Cornelius Vanderbilt Professor of Immunobiology in Pathology, Microbiology and Immunology
Professor of Cancer Biology
Director, Vanderbilt Center for Immunobiology

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