T cells perform critical roles to promote or suppress immunity and inflammation. To perform these functions, inflammatory effector T cells (Teff) undergo metabolic reprogramming upon activation to increase glycolysis and anabolic metabolism. In contrast, suppressive regulatory T cells (Treg) are metabolically heterogeneous and balance the use of glycolysis with mitochondrial oxidative metabolism. These metabolic programs are highly regulated and exert strong influences on T cell function and fate. This talk will discuss the distinct metabolic programs of T cell subsets and how these programs influence Teff and Treg function in inflammatory disease and in the tumor setting.
In this webinar we will discuss:
For Research Use Only. Not for use in diagnostic procedures.
Thursday, December 14, 2017
9:00 PDT (Los Angeles)
12:00 EDT (New York)
17:00 GMT (London)
Available On Demand after December 14
All registrants will be notified when available
Jeffrey Rathmell, PhD
Co-Leader, Host-Tumor Interactions Research Program, Cornelius Vanderbilt Professor of Immunobiology in Pathology, Microbiology and Immunology
Professor of Cancer Biology
Director, Vanderbilt Center for Immunobiology