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XF Publications Alert
July 2016
Welcome to the latest edition of the Agilent Seahorse XF Publications Alert for July 2016. This issue lists a selection of the most recent publications that contain Seahorse XF data. To get the publications that matter most to you, fill in the form on the right to update your primary research area. Still looking for more? Visit our updated Cell Reference Database to search publications by author, research area, or cell type.
Aging Research
Does p49/STRAP, a SRF-binding protein (SRFBP1), Modulate Cardiac Mitochondrial Function in Aging?
Zhang, X. Williams, E. D. Azhar, G. Rogers, S. C. and Wei, J. Y.
Exp Gerontol. 2016 Jun 20, [epub ahead of print]
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P. Laue, K. Ferron, M. Confavreux, C. Wei, J. Galan-Diez, M. Lacampagne, A. Mitchell, S. J. Mattison, J. A. Chen, Y. Bacchetta, J. Szulc, P. Kitsis, R. N. de Cabo, R. Friedman, R. A. Torsitano, C. McGraw, T. E. Puchowicz, M. Kurland, I. and Karsenty, G.
Cell Metab. 2016 Jun 14, 23 (6): 1078-92.
Cancer Research
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma
Penny, L. Sieow, J. L. Adriani G. Yeap, W. H. See Chi Ee, P. San Luis, B. Lee, B. Lee, T. Mak, S. Y. Ho, Y. S. Ong, C. K. Huang, R. Y. J. Ginhoux, F. Rotzschke, O. Kamm R. D. and Wong, S. C.
OncoImmunology. 2016 Jun 21, [epub ahead of print]
Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy
Zhu, Q. Qi, H. Long, Z. Liu, S. Huang, Z. Zhang, J. Wang, C. and Dong, L.
Sci Rep. 2016 Jun 23, 6(28596).
CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells
Gao, D. Rahbar, R. and Fish, E. N.
Open Biol. 2016 Jun 1, 6(6).
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
Banh, S. Iorio, C. Marcotte, R. Xu, Y. Cojocari, D. Rahman, A. A. Pawling, J. Zhang, W. Sinha, A. Rose, C. M. Isasa, M. Zhang, S. Wu, R. Virtanen, C. Hitomi, T. Habu, T. Sidhu, S. S. Koizumi, A. Wilkins, S. E. Kislinger, T. Gygi, S. P. Schofield, C. J. Dennis, J. W. Wouters B. G. and Neel, B. G.
Nat Cell Biol. 2016 Jul 18, 18 (7): 803-13.
RhoC GTPase Is a Potent Regulator of Glutamine Metabolism and N-Acetylaspartate Production in Inflammatory Breast Cancer Cells
Wynn, L. Yates, J. A. Evans, C. R. Van Wassenhove, L. D. Wu, Z. F. Bridges, S. Bao, L. Fournier, C. Ashrafzadeh, S. Merrins, M. J. Satin, L. S. Schnell, S. Burant C. F. and Merajver, S. D.
J Biol Chem. 2016 Jun 24, 291 (26): 13715-29.
Downregulation of GLUT4 contributes to effective intervention of estrogen receptor-negative/HER2-overexpressing early stage breast disease progression by lapatinib
Acharya, S. Xu, J. Wang, X. Jain, S. Wang, H. Zhang, Q. Chang, C. C. Bower, J. Arun, B. Seewaldt, V. and Yu, D.
Am J Cancer Res. 2016 May 1, 6 (5): 981-95.
Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors
Tan, Q. Wang, M. Yu, M. Zhang, J.Bristow, R. G. Hill, R. P. and Tannock, I. F.
Neoplasia. 2016 Jun 1, 18 (6): 347-55.
Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelial-Mesenchymal Transition: Effects on Anoikis
Farris, C. Pifer, P. M. Zheng, L. Gottlieb, E. Denvir J. and Frisch, S. M.
Mol Cancer Res. 2016 Jun 1, 14 (6): 528-38.
Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption
Hou, J. Wright, H. J. Chan, N. Tran, R. Razorenova, O. V. Potma, E. O. and Tromberg, B. J.
J Biomed Opt. 2016 Jun 1, 21 (6): 60503.
Fenofibrate Suppresses Oral Tumorigenesis via Reprogramming Metabolic Processes: Potential Drug Repurposing for Oral Cancer
Jan, I. Tsai, M. H. Chiu, C. F. Huang, Y. P. Liu, C. J. and Chang, N. W.
Int J Biol Sci. 2016 May 15, 12 (7): 786-98.
Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics
Navarro, P. Bueno, M. J. Zagorac, I. Mondejar, T. Sanchez, J. Mouron, S. Munoz, J. Gomez-Lopez, G. Jimenez-Renard, V. Mulero, F. Chandel, N. S. and Quintela-Fandino, M.
Cell Rep. 2016 Jun 21, 15 (12): 2705-18.
PHGDH Expression is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance and Lung Metastasis
Samanta, D. Park, Y. Andrabi, S. A. Shelton, L. M. Gilkes, D. M. and Semenza, G. L.
Cancer Res. 2016 Jun 8, [epub ahead of print]
Cystathionine: A novel oncometabolite in human breast cancer
Sen, S. Kawahara, B. Mahata, S. K. Tsai, R. Yoon, A. Hwang, L. Hu-Moore, K. Villanueva, C. Vajihuddin, A. Parameshwar, P. You, M. Bhaskar, D. Gomez, O. Faull, K. F. Farias-Eisner, R. and Chaudhuri, G.
Arch Biochem Biophys. 2016 Jun 13, [epub ahead of print]
Bedaquiline, an FDA-approved antibiotic, inhibits mitochondrial function and potently blocks the proliferative expansion of stem-like cancer cells (CSCs)
Fiorillo, M. Lamb, R. Tanowitz, H. B. Cappello, A. R. Martinez-Outschoorn, U. E. Sotgia, F. and Lisanti, M. P.
Aging (Albany NY). 2016 Jun 22, [epub ahead of print]
Sirtuin 1-dependent resveratrol cytotoxicity and pro-differentiation activity on breast cancer cells
Deus, M. Serafim, T. L. Magalhaes-Novais, S. Vilaca, A. Moreira, A. C. Sardao, V. A. Cardoso, S. M. and Oliveira, P. J.
Arch Toxicol. 2016 Jun 29, [epub ahead of print]
Diverging Novobiocin Anti-cancer Activity from Neuroprotective Activity through Modification of the Amide Tail
Ghosh, S. Liu, Y. Garg, G. Anyika, M. McPherson, N. T. Ma, J. Dobrowsky, R. T. and Blagg, B. S. J.
ACS Medicinal Chemistry Letters. 2016 Jul 5, [epub ahead of print]
Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia
Leek, R. Grimes, D. R. Harris, A. L. and McIntyre, A.
Adv Exp Med Biol. 2016 Jul 1, 899: 167-96.
High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism
Subedi, A. Futamura, Y. Nishi, M. Ryo, A. Watanabe, N. and Osada, H.
Biochem Biophys Res Commun. 2016 Jun 27, [epub ahead of print]
Cardiovascular Research
Does p49/STRAP, a SRF-binding protein (SRFBP1), Modulate Cardiac Mitochondrial Function in Aging?
Zhang, X. Williams, E. D. Azhar, G. Rogers, S. C. and Wei, J. Y.
Exp Gerontol. 2016 Jun 20, [epub ahead of print]
Increased expression of estrogen-related receptor beta during adaptation of adult cardiomyocytes to sustained hypoxia
Cunningham, F. Beeson, G. C. Beeson, C. C. and McDermott, P. J.
Am J Cardiovasc Dis. 2016 May 18, 6 (2): 46-54.
Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages
Miao, L. Shen, X. Whiteman, M. Xin, H. Shen, Y. Xin, X. Moore, P. K. and Zhu, Y.
Antioxid Redox Signal. 2016 Jun 13, [epub ahead of print]
Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine
Matsa, E. Ahrens, J. H. and Wu, J. C.
Physiol Rev. 2016 Jul 1, 96 (3): 1093-126.
Cell Metabolism in Technology
Correlating two-photon excited fluorescence imaging of breast cancer cellular redox state with seahorse flux analysis of normalized cellular oxygen consumption
Hou, J. Wright, H. J. Chan, N. Tran, R. Razorenova, O. V. Potma, E. O. and Tromberg, B. J.
J Biomed Opt. 2016 Jun 1, 21 (6): 60503.
Cell Physiology Research
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Mera, P. Laue, K. Ferron, M. Confavreux, C. Wei, J. Galan-Diez, M. Lacampagne, A. Mitchell, S. J. Mattison, J. A. Chen, Y. Bacchetta, J. Szulc, P. Kitsis, R. N. de Cabo, R. Friedman, R. A. Torsitano, C. McGraw, T. E. Puchowicz, M. Kurland, I. and Karsenty, G.
Cell Metab. 2016 Jun 14, 23 (6): 1078-92.
A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast
Collard, F. Baldin, F. Gerin, I. Bolsee, J. Noel, G. Graff, J. Veiga-da-Cunha, M. Stroobant, V. Vertommen, D. Houddane, A. Rider, M. H. Linster, C. L. Van Schaftingen, E. and Bommer, G. T.
Nat Chem Biol. 2016 Jun 13, [epub ahead of print]
Time-dependent loss of mitochondrial function precedes progressive histologic cartilage degeneration in a rabbit meniscal destabilization model
Goetz, E. Coleman, M. C. Fredericks, D. C. Petersen, E. Martin, J. A. McKinley, T. O. and Tochigi, Y.
J Orthop Res. 2016 Jun 9, [epub ahead of print]
Mitochondrial dysfunction remodels one-carbon metabolism in human cells
Bao, R. Ong, S. E. Goldberger, O. Peng, J. Sharma, R. Thompson, D. A. Vafai, S. B. Cox, A. G. Marutani, E. Ichinose, F. Goessling, W. Regev, A. Carr, S. A. Clish, C. B. and Mootha, V. K.
Elife. 2016 Jun 16, 5.
Anti- and Pro-apoptotic Bcl2 Proteins Distribution and Metabolic Profile in Human Coronary Aorta Endothelial Cells Before and After HypPDT
Maslanakova, M. Balogova, L. Miskovsky, P. Tkacova, R. and Stroffekova, K.
Cell Biochem Biophys. 2016 Jun 17, [epub ahead of print]
Pigment epithelium-derived factor stimulates skeletal muscle glycolytic activity through NADPH oxidase-dependent reactive oxygen species production
Carnagarin, R. Carlessi, R. Newsholme, P. Dharmarajan, A. M. and Dass, C. R.
Int J Biochem Cell Biol. 2016 Jun 22, [epub ahead of print]
Immunology Research
Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma
Penny, L. Sieow, J. L. Adriani G. Yeap, W. H. See Chi Ee, P. San Luis, B. Lee, B. Lee, T. Mak, S. Y. Ho, Y. S. Ong, C. K. Huang, R. Y. J. Ginhoux, F. Rotzschke, O. Kamm R. D. and Wong, S. C.
OncoImmunology. 2016 Jun 21, [epub ahead of print]
Hydrogen Sulfide Mitigates Myocardial Infarction via Promotion of Mitochondrial Biogenesis-Dependent M2 Polarization of Macrophages
Miao, L. Shen, X. Whiteman, M. Xin, H. Shen, Y. Xin, X. Moore, P. K. and Zhu, Y.
Antioxid Redox Signal. 2016 Jun 13, [epub ahead of print]
Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function
Wu, D. Sanin, D. E. Everts, B. Chen, Q. Qiu, J. Buck, M. D. Patterson, A. Smith, A. M. Chang, C. H. Liu, Z. Artyomov, M. N. Pearce, E. L. Cella, M. and Pearce, E. J.
Immunity. 2016 Jun 21, 44 (6): 1325-36.
Characterizing the Mechanistic Pathways of the Instant Blood-Mediated Inflammatory Reaction in Xenogeneic Neonatal Islet Cell Transplantation
Liuwantara, D. Chew, Y. V. Favaloro, E. J. Hawkes, J. M. Burns, H. L. O'Connell, P. J. and Hawthorne, W. J.
Transplantation Direct. 2016 Jun 1, 2 (6): e77.
Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism
Vacaflores, A. Chapman, N. M. Harty, J. T. Richer, M. J. and Houtman, J. C.
PLoS One. 2016 Jun 9, 11 (6): e0157175.
Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
He, L. Weber, K. J. Diwan, A. and Schilling, J. D.
J Leukoc Biol. 2016 Jun 16, [epub ahead of print]
Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality
Saha, A. O'Connor, R. S. Thangavelu, G. Lovitch, S. B. Dandamudi, D. B. Wilson, C. B. Vincent, B. G. Tkachev, V. Pawlicki, J. M. Furlan, S. N. Kean, L. S. Aoyama, K. Taylor, P. A. Panoskaltsis-Mortari, A. Foncea, R. Ranganathan, P. Devine, S. M. Burrill, J. S. Guo, L. Sacristan, C. Snyder, N. W. Blair, I. A. Milone, M. C. Dustin, M. L. Riley, J. L. Bernlohr, D. A. Murphy, W. J. Fife, B. T. Munn, D. H. Miller, J. S. Serody, J. S. Freeman, G. J. Sharpe, A. H. Turka, L. A. and Blazar, B. R.
J Clin Invest. 2016 Jun 13, [epub ahead of print]
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Buck, D. O'Sullivan, D. Klein Geltink, R. I. Curtis, J. D. Chang, C. H. Sanin, D. E. Qiu, J. Kretz, O. Braas, D. van der Windt, G. J. Chen, Q. Huang, S. C. O'Neill, C. M. Edelson, B. T. Pearce, E. J. Sesaki, H. Huber, T. B. Rambold, A. S. and Pearce, E. L.
Cell. 2016 Jun 8, [epub ahead of print]
Pleiotropic effects of 4-hydroxynonenal on oxidative burst and phagocytosis in neutrophils
Chacko, K. Wall, S. B. Kramer, P. A. Ravi, S. Mitchell, T. Johnson, M. S. Wilson, L. Barnes, S. Landar, A. and Darley-Usmar, V. M.
Redox Biology. 2016 Oct 1, 9: 57-66.
Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease
Raha, S. Raud, B. Oberdorfer, L. Castro, C. N. Schreder, A. Freitag, J. Longerich, T. Lochner, M. Sparwasser, T. Berod, L. Koenecke, C. and Prinz, I.
Eur J Immunol. 2016 Jun 24, [epub ahead of print]
Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation
Matheoud, D. Sugiura, A. Bellemare-Pelletier, A. Laplante, A. Rondeau, C. Chemali, M. Fazel, A. Bergeron, J. J. Trudeau, L. E. Burelle, Y. Gagnon, E. McBride, H. M. and Desjardins, M.
Cell. 2016 Jun 21, [epub ahead of print]
Mitochondrial dysfunction in the liver and antiphospholipid antibody production precede disease onset and respond to rapamycin in lupus-prone mice
Oaks, Z. Winans, T. Caza, T. Fernandez, D. Liu, Y. Landas, S. K. Banki, K. and Perl, A.
Arthritis Rheumatol. 2016 Jun 22, [epub ahead of print]
Infectious Disease Research
Bioenergetic profiling of Trypanosoma cruzi life stages using Seahorse extracellular flux technology
Shah-Simpson, S. Pereira, C. F. Dumoulin, P. C. Caradonna, K. L. and Burleigh, B. A.
Mol Biochem Parasitol. 2016 Jul 5, [epub ahead of print]
Mitochondrial Disease Research
Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3
Van Haute, L. Dietmann, S. Kremer, L. Hussain, S. Pearce, S. F. Powell, C. A. Rorbach, J. Lantaff, R. Blanco, S. Sauer, S. Kotzaeridou, U. Hoffmann, G. F. Memari, Y. Kolb-Kokocinski, A. Durbin, R. Mayr, J. A. Frye, M. Prokisch, H. and Minczuk, M.
Nat Commun. 2016 Jun 30, 7: 12039.
Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion
Stiles, R. Simon, M. T. Stover, A. Eftekharian, S. Khanlou, N. Wang, H. L. Magaki, S. Lee, H. Partynski, K. Dorrani, N. Chang, R. Martinez-Agosto, J. A. and Abdenur, J. E.
Molecular Genetics and Metabolism. 2016 Jul 4, [epub ahead of print]
Model Organisms
Arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans
Luz, L. Godebo, T. R. Bhatt, D. P. Ilkayeva, O. R. Maurer, L. L. Hirschey, M. D. and Meyer, J. N.
Toxicol Sci. 2016 May 20, [epub ahead of print]
Assessing bioenergetic functions from isolated mitochondria in Drosophila melanogaster
Aw, C. Bajracharya, R. Towarnicki, S. G. and Ballard, J. W. O.
Journal of Biological Methods. 2016 Jul 1, 3 (2): 42.
Nephrology Research
Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells
Song, H. Yoon, S. P. and Kim, J.
Anat Cell Biol. 2016 Jun 24, 49 (2): 79-87.
Neurobiology Research
Nucleus accumbens deep-brain stimulation efficacy in ACTH-pretreated rats: alterations in mitochondrial function relate to antidepressant-like effects
Kim, Y. McGee, S. Czeczor, J. K. Walker, A. J. Kale, R. P. Kouzani, A. Z. Walder, K. Berk, M. and Tye, S. J.
Transl Psychiatry. 2016 Jun 21, 6 (6): e842.
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (alpha-Synuclein)-Environment (Paraquat) Interactions
Anandhan, A. Lei, S. Levytskyy, R. Pappa, A. Panayiotidis, M. I. Cerny, R. L. Khalimonchuk, O. Powers, R. and Franco, R.
Mol Neurobiol. 2016 Jun 20, [epub ahead of print]
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
Zheng, X. Boyer, L. Jin, M. Mertens, J. Kim, Y. Ma, L. Ma, L. Hamm, M. Gage, F. H. and Hunter, T.
Elife. 2016 Jun 10, [epub ahead of print]
A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-beta Modulating Mitochondrial Energy Metabolism
Mei, Q. Pan, Z. F. Chen, W. T. Xu, M. H. Zhu, D. Y. Yu, Y. P. and Lou, Y. J.
PLoS One. 2016 Jun 17, 11 (6): e0157747.
BDNF pro-peptide regulates dendritic spines via caspase-3
Guo, J. Ji, Y. Ding, Y. Jiang, W. Sun, Y. Lu, B. and Nagappan, G.
Cell Death Dis. 2016 Jun 16, 7 (e2264).
Hypoxia promotes noncanonical autophagy in nucleus pulposus cells independent of MTOR and HIF1A signaling
Choi, H. Merceron, C. Mangiavini, L. Seifert, E. L. Schipani, E. Shapiro, I. M. and Risbud, M. V.
Autophagy. 2016 Jun 17, [epub ahead of print]
Parkinson's Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation
Matheoud, D. Sugiura, A. Bellemare-Pelletier, A. Laplante, A. Rondeau, C. Chemali, M. Fazel, A. Bergeron, J. J. Trudeau, L. E. Burelle, Y. Gagnon, E. McBride, H. M. and Desjardins, M.
Cell. 2016 Jun 21, [epub ahead of print]
Can human pluripotent stem cell-derived cardiomyocytes advance understanding of Muscular Dystrophies
Kalra, S. Montanaro, F. and Denning, C.
Journal of Neuromuscular Diseases. 2016 Jun 23, 1-24.
Gene Therapy Corrects Mitochondrial Dysfunction in Hematopoietic Progenitor Cells and Fibroblasts from Coq9R239X Mice
Barriocanal-Casado, E. Cueto-Urena, C. Benabdellah, K. Gutierrez-Guerrero, A. Cobo, M. Hidalgo-Gutierrez, A. Rodriguez-Sevilla, J. J. Martin, F. and Lopez, L. C.
PLoS One. 2016 Jun 234, 11 (6): e0158344.
Fatty acid oxidation is required for the respiration and proliferation of malignant glioma cells
Lin, H. Patel, S. Affleck, V. S. Wilson, I. Turnbull, D. M.A. R. Joshi, A. R. Maxwell, R. and Stoll, E. A.
Neuro Oncol. 2016 Jun 29, [epub ahead of print]
A reduction in Drp1-mediated fission compromises mitochondrial health in autosomal recessive spastic ataxia of Charlevoix Saguenay
Bradshaw, Y. Romano, L. E. Duncan, E. J. Nethisinghe, S. Abeti, R. Michael, G. J. Giunti, P. Vermeer, S. and Chapple, J. P.
Hum Mol Genet. 2016 Jun 10, [epub ahead of print]
Diverging Novobiocin Anti-cancer Activity from Neuroprotective Activity through Modification of the Amide Tail
Ghosh, S. Liu, Y. Garg, G. Anyika, M. McPherson, N. T. Ma, J. Dobrowsky, R. T. and Blagg, B. S. J.
ACS Medicinal Chemistry Letters. 2016 Jul 5, [epub ahead of print]
The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity
Wang, W. Wang, L. Lu, J. Siedlak, S. L. Fujioka, H. Liang, J. Jiang, S. Ma, X. Jiang, Z. da Rocha, E. L. Sheng, M. Choi, H. Lerou, P. H. Li, H. and Wang, X.
Nat Med. 2016 Jun 27, [epub ahead of print]
SLC25A46 is required for mitochondrial lipid homeostasis and cristae maintenance and is responsible for Leigh syndrome
Janer, A. Prudent, J. Paupe, V. Fahiminiya, S. Majewski, J. Sgarioto, N. Des Rosiers, C. Forest, A. Lin, Z. Y. Gingras, A. C. Mitchell, G. McBride, H. M. and Shoubridge, E. A.
EMBO Mol Med. 2016 Jul 7, [epub ahead of print]
Obesity, Diabetes, & Metabolic Disorders
Characterizing the Mechanistic Pathways of the Instant Blood-Mediated Inflammatory Reaction in Xenogeneic Neonatal Islet Cell Transplantation
Liuwantara, D. Chew, Y. V. Favaloro, E. J. Hawkes, J. M. Burns, H. L. O'Connell, P. J. and Hawthorne, W. J.
Transplantation Direct. 2016 Jun 1, 2 (6): e77.
Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism
He, L. Weber, K. J. Diwan, A. and Schilling, J. D.
J Leukoc Biol. 2016 Jun 16, [epub ahead of print]
A PPARgamma-Bnip3 axis couples adipose mitochondrial fusion-fission balance to systemic insulin sensitivity
Tol, J. Ottenhoff, R. van Eijk, M. Zelcer, N. Aten, J. Houten, S. M. Geerts, D. van Roomen, C. Bierlaagh, M. C. Scheij, S. Hoeksema, M. A. Aerts, J. M. Bogan, J. S. Dorn 2nd, G. W. Argmann, C. A. and Verhoeven, A. J.
Diabetes. 2016 Jun 20, [epub ahead of print]
Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor alpha
Chen, X. Zhang, F. Gong, Q. Cui, A. Zhuo, S. Hu, Z. Han, Y. Gao, J. Sun, Y. Liu, Z. Yang, Z. Le, Y. Gao, X. Dong, L. Q. Gao, X. and Li, Y.
Diabetes. 2016 Jul 1, 65 (7): 1904-15.
AMP-Activated Kinase (AMPK) Activation by AICAR in Human White Adipocytes Derived from Pericardial White Adipose Tissue Stem Cells Induces a Partial Beige-Like Phenotype
Abdul-Rahman, O. Kristof, E. Doan-Xuan, Q. M. Vida, A. Nagy, L. Horvath, A. Simon, J. Maros, T. Szentkiralyi, I. Palotas, L. Debreceni, T. Csizmadia, P. Szerafin, T. Fodor, T. Szanto, M. Toth, A. Kiss, B. Bacso, Z. and Bai, P.
PLoS One. 2016 Jun 20, 11 (6): e0157644.
Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects from Diet-Induced Obesity Via Increased Mitochondrial Uncoupling and Biogenesis
Han, H. Buffolo, M. Pires, K. M. Pei, S. Scherer, P. E. and Boudina, S.
Diabetes. 2016 Jun 9, [epub ahead of print]
Bezafibrate improves insulin sensitivity and metabolic flexibility in STZ-treated diabetic mice
Franko, A. Huypens, P. Neschen, S. Irmler, M. Rozman, J. Rathkolb, B. Neff, F. Prehn, C. Dubois, G. Baumann, M. Massinger, R. Gradinger, D. Przemeck, G. K. Repp, B. Aichler, M. Feuchtinger, A. Schommers, P. Stohr, O. Sanchez-Lasheras, C. Adamski, J. Peter, A. Prokisch, H. Beckers, J. Walch, A. K. Fuchs, H. Wolf, E. Schubert, M. Wiesner, R. J. and Hrabe de Angelis, M.
Diabetes. 2016 Jun 9, [epub ahead of print]
miR-125b affects mitochondrial biogenesis and impairs brite adipocyte formation and function
Giroud, M. Pisani, D. F. Karbiener, M. Barquissau, V. Ghandour, R. A. Tews, D. Fischer-Posovszky, P. Chambard, J.-C. Knippschild, U. Niemi, T. Taittonen, M. Nuutila, P. Wabitsch, M. Herzig, S. Virtanen, K. A. Langin, D. Scheideler, M. and Amri, E.-Z.
Molecular Metabolism. 2016 Jun 15, [epub ahead of print]
Restoring Mitochondrial Function: A Small Molecule-mediated Approach to Enhance Glucose Stimulated Insulin Secretion in Cholesterol Accumulated Pancreatic beta cells
Asalla, S. Girada, S. B. Kuna, R. S. Chowdhury, D. Kandagatla, B. Oruganti, S. Bhadra, U. Bhadra, M. P. Kalivendi, S. V. Rao, S. P. Row, A. Ibrahim, A. Ghosh, P. P. and Mitra, P.
Sci Rep. 2016 Jun 10, 6 (27513).
Chronic hyperinsulinemia reduces insulin sensitivity and metabolic functions of brown adipocyte
Rajan, S. Shankar, K. Beg, M. Varshney, S. Gupta, A. Srivastava, A. Kumar, D. Mishra, R. K. Hossain, Z. Gayen, J. R. and Gaikwad, A. N.
J Endocrinol. 2016 Jun 23, [epub ahead of print]
Thioredoxin reductase 1 suppresses adipocyte differentiation and insulin responsiveness
Peng, X. Gimenez-Cassina, A. Petrus, P. Conrad, M. Ryden, M. and Arner, E. S.
Sci Rep. 2016 Jun 27, 6(28080).
Let-7i-5p represses brite adipocyte function in mice and humans
Giroud, M. Karbiener, M. Pisani, D. F. Ghandour, R. A. Beranger, G. E. Niemi, T. Taittonen, M. Nuutila, P. Virtanen, K. A. Langin, D. Scheideler, M. and Amri, E. Z.
Sci Rep. 2016 Jun 27, 6(28613).
The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria
Long, Z. Svensson, K. J. Bateman, L. A. Lin, H. Kamenecka, T. Lokurkar, I. A. Lou, J. Rao, R. R. Chang, M. R. Jedrychowski, M. P. Paulo, J. A. Gygi, S. P. Griffin, P. R. Nomura, D. K. and Spiegelman, B. M.
Cell. 2016 Jun 29, [epub ahead of print]
miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle
Zhang, D. Li, Y. Yao, X. Wang, H. Zhao, L. Jiang, H. Yao, X. Zhang, S. Ye, C. Liu, W. Cao, H. Yu, S. Wang, Y. C. Li, Q. Jiang, J. Liu, Y. Zhang, L. Liu, Y. Iwai, N. Wang, H. Li, J. Li, J. Li, X. Jin, Z. B. and Ying, H.
Cell Rep. 2016 Jul 5, [epub ahead of print]
Oleate protects beta-cells from the toxic effect of palmitate by activating pro-survival pathways of the ER stress response
Sargsyan, E. Artemenko, K. Manukyan, L. Bergquist, J. and Bergsten, P.
Biochim Biophys Acta. 2016 Jun 22, 1861 (9 Pt A) 1151-1160.
Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice
Costa, K. Huckestein, B. R. Edmunds, L. R. Petersen, M. C. Nasiri, A. Butrico, G. M. Abulizi, A. Harmon, D. B. Lu, C. Mantell, B. S. Hartman, D. J. Camporez, J. P. O'Doherty, R. M. Cline, G. W. Shulman, G. I. and Jurczak, M. J.
Am J Physiol Endocrinol Metab. 2016 Jul 1, 311 (1): E105-16.
Perilipin 5 is dispensable for normal substrate metabolism and in the adaptation of skeletal muscle to exercise training
Mohktar, A. Montgomery, M. K. Murphy, R. M. and Watt, M. J.
Am J Physiol Endocrinol Metab. 2016 Jul 1, 311 (1): E128-37.
Review Articles
Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine
Matsa, E. Ahrens, J. H. and Wu, J. C.
Physiol Rev. 2016 Jul 1, 96 (3): 1093-126.
Can human pluripotent stem cell-derived cardiomyocytes advance understanding of Muscular Dystrophies
Kalra, S. Montanaro, F. and Denning, C.
Journal of Neuromuscular Diseases. 2016 Jun 23, 1-24.
Methods: Using Three-Dimensional Culture (Spheroids) as an In Vitro Model of Tumour Hypoxia
Leek, R. Grimes, D. R. Harris, A. L. and McIntyre, A.
Adv Exp Med Biol. 2016 Jul 1, 899: 167-96.
Stem Cell Biology
A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-beta Modulating Mitochondrial Energy Metabolism
Mei, Q. Pan, Z. F. Chen, W. T. Xu, M. H. Zhu, D. Y. Yu, Y. P. and Lou, Y. J.
PLoS One. 2016 Jun 17, 11 (6): e0157747.
Embryonic Stem Cell Proliferation Stimulated By Altered Anabolic Metabolism From Glucose Transporter 2-Transported Glucosamine
Jung, H. Iwabuchi, K. Yang, Z. and Loeken, M. R.
Sci Rep. 2016 Jun 17, 6 (28452).
Human Induced Pluripotent Stem Cells as a Platform for Personalized and Precision Cardiovascular Medicine
Matsa, E. Ahrens, J. H. and Wu, J. C.
Physiol Rev. 2016 Jul 1, 96 (3): 1093-126.
Can human pluripotent stem cell-derived cardiomyocytes advance understanding of Muscular Dystrophies
Kalra, S. Montanaro, F. and Denning, C.
Journal of Neuromuscular Diseases. 2016 Jun 23, 1-24.
Hyaluronan Upregulates Mitochondrial Biogenesis and Reduces Adenoside Triphosphate Production for Efficient Mitochondrial Function in Slow-Proliferating Human Mesenchymal Stem Cells
Solis, A. Wei, Y. H. Chang, C. H. Yu, C. H. Kuo, P. L. and Huang, L. L.
Stem Cells. 2016 Jun 29, [epub ahead of print]
Techniques & Methods
Assessing bioenergetic functions from isolated mitochondria in Drosophila melanogaster
Aw, C. Bajracharya, R. Towarnicki, S. G. and Ballard, J. W. O.
Journal of Biological Methods. 2016 Jul 1, 3 (2): 42.
Bioenergetic profiling of Trypanosoma cruzi life stages using Seahorse extracellular flux technology
Shah-Simpson, S. Pereira, C. F. Dumoulin, P. C. Caradonna, K. L. and Burleigh, B. A.
Mol Biochem Parasitol. 2016 Jul 5, [epub ahead of print]
Toxicology & Hepatobiology Research
Extracellular control of intracellular drug release for enhanced safety of anti-cancer chemotherapy
Zhu, Q. Qi, H. Long, Z. Liu, S. Huang, Z. Zhang, J. Wang, C. and Dong, L.
Sci Rep. 2016 Jun 23, 6(28596).
Arsenite uncouples mitochondrial respiration and induces a Warburg-like effect in Caenorhabditis elegans
Luz, L. Godebo, T. R. Bhatt, D. P. Ilkayeva, O. R. Maurer, L. L. Hirschey, M. D. and Meyer, J. N.
Toxicol Sci. 2016 May 20, [epub ahead of print]
Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (alpha-Synuclein)-Environment (Paraquat) Interactions
Anandhan, A. Lei, S. Levytskyy, R. Pappa, A. Panayiotidis, M. I. Cerny, R. L. Khalimonchuk, O. Powers, R. and Franco, R.
Mol Neurobiol. 2016 Jun 20, [epub ahead of print]
Microbial biotransformation of DON: molecular basis for reduced toxicity
Pierron, A. Mimoun, S. Murate, L. S. Loiseau, N. Lippi, Y. Bracarense, A. P. Schatzmayr, G. He, J. W. Zhou, T. Moll, W. D. and Oswald, I. P.
Sci Rep. 2016 Jul 6, 6(29105).
Translational Research
Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion
Stiles, R. Simon, M. T. Stover, A. Eftekharian, S. Khanlou, N. Wang, H. L. Magaki, S. Lee, H. Partynski, K. Dorrani, N. Chang, R. Martinez-Agosto, J. A. and Abdenur, J. E.
Molecular Genetics and Metabolism. 2016 Jul 4, [epub ahead of print]
Mitochondrial Function in an In Vitro Model of Skeletal Muscle of Patients With Protracted Critical Illness and Intensive Care Unit-Acquired Weakness
Jiroutkova, K. Krajcova, A. Ziak, J. Fric, M. Gojda, J. Dzupa, V. Kalous, M. Tumova, J. Trnka, J. and Duska, F.
JPEN J Parenter Enteral Nutr. 2016 Jun 29, [epub ahead of print]
